Professor Rafael Moreno-Sanchez

All Stories

1. 
   Celecoxib and Dimethylcelecoxib Block Oxidative Phosphorylation, Epithelial-Mesenchymal Transition and Invasiveness in Breast Cancer Stem Cells

   Article • Current Medicinal Chemistry, May 2022, Bentham Science Publishers

   Professor Rafael Moreno-Sanchez, Juan Carlos Gallardo Pérez, Professor Rafael Moreno-Sanchez

2. 
   Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling

   Article • Current Medicinal Chemistry, September 2018, Bentham Science Publishers

   Professor Rafael Moreno-Sanchez, Zabdi Gonzalez

3. 
   Mutant p53R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

   Article • Journal of Cellular Physiology, September 2018, Wiley

   Professor Rafael Moreno-Sanchez

4. 
   Understanding the cancer cell phenotype beyond the limitations of current omics analyses

   Article • FEBS Journal, October 2015, Wiley

   Professor Rafael Moreno-Sanchez

5. 
   Cancer energy metabolism under hypoglycemia

   Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2014, Elsevier

   Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

6. 
   Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms

   Article • FEBS Journal, July 2014, Wiley

   Professor Rafael Moreno-Sanchez

7. 
   GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids

   Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 2014, Elsevier

   Professor Rafael Moreno-Sanchez

8. 
   Canonical and new generation anticancer drugs also target energy metabolism

   Article • Archives of Toxicology, May 2014, Springer Science + Business Media

   Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

9. 
   Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

   Article • The International Journal of Biochemistry & Cell Biology, May 2014, Elsevier

   Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

10. 
    Zn-bis-glutathionate is the best co-substrate of the monomeric phytochelatin synthase from the photosynthetic heavy metal-hyperaccumulator Euglena gracilis

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Professor Rafael Moreno-Sanchez

11. 
    The 2-oxoglutarate supply exerts significant control on the lysine synthesis flux inSaccharomyces cerevisiae

    Article • FEBS Journal, September 2013, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

12. 
    Systems Biology Approaches to Cancer Energy Metabolism

    Article • August 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

13. 
    Anti-mitochondrial therapy in human breast cancer multi-cellular spheroids

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2013, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

14. 
    Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I

    Article • FEBS Journal, January 2013, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

15. 
    Metabolic Control Analysis, Drug-Target Identification

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

16. 
    Metabolic Control Theory

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

17. 
    Elasticity Coefficient

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

18. 
    Summation Theorem

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

19. 
    Rate-limiting Step

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

20. 
    Regulation Analysis

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

21. 
    Response Coefficient

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

22. 
    Flux Control Coefficient

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

23. 
    Concentration Control Coefficient

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

24. 
    Connectivity Theorem

    Article • January 2013, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

25. 
    The bifunctional aldehyde–alcohol dehydrogenase controls ethanol and acetate production in Entamoeba histolytica under aerobic conditions

    Article • FEBS Letters, November 2012, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

26. 
    Sulfate uptake in photosynthetic Euglena gracilis. Mechanisms of regulation and contribution to cysteine homeostasis

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2012, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

27. 
    Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2012, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

28. 
    Drug target validation of the trypanothione pathway enzymes through metabolic modelling

    Article • FEBS Journal, April 2012, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

29. 
    Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation

    Article • Archives of Toxicology, February 2012, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Marina Macias-Silva, Professor Rafael Moreno-Sanchez

30. 
    The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae

    Article • Molecular Microbiology, September 2011, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

31. 
    Multi-biomarker pattern for tumor identification and prognosis

    Article • Journal of Cellular Biochemistry, September 2011, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

32. 
    Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

    Article • Pharmaceutical Research, August 2011, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

33. 
    Oxidative Phosphorylation as a Target to Arrest Malignant Neoplasias

    Article • Current Medicinal Chemistry, July 2011, Bentham Science Publishers

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

34. 
    Modeling cancer glycolysis

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, June 2011, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

35. 
    Phosphofructokinase type 1 kinetics, isoform expression and gene polymorphisms in cancer cells

    Article • Journal of Cellular Biochemistry, January 2011, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

36. 
    Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites

    Article • Current Drug Targets, December 2010, Bentham Science Publishers

    Professor Rafael Moreno-Sanchez

37. 
    Metabolic control analysis indicates a change of strategy in the treatment of cancer

    Article • Mitochondrion, November 2010, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

38. 
    Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma

    Article • The International Journal of Biochemistry & Cell Biology, October 2010, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

39. 
    Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica

    Article • FEBS Journal, August 2010, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

40. 
    The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

    Article • Molecular Aspects of Medicine, April 2010, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

41. 
    Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

    Article • Molecular Aspects of Medicine, February 2010, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

42. 
    Kinetics of transport and phosphorylation of glucose in cancer cells

    Article • Journal of Cellular Physiology, August 2009, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

43. 
    HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

    Article • Mini-Reviews in Medicinal Chemistry, August 2009, Bentham Science Publishers

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

44. 
    Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3‐phosphoglycerate kinase

    Article • FEBS Journal, March 2009, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

45. 
    The bioenergetics of cancer: Is glycolysis the main ATP supplier in all tumor cells?

    Article • BioFactors, March 2009, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

46. 
    Targeting of cancer energy metabolism

    Article • Molecular Nutrition & Food Research, January 2009, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

47. 
    Glycolysis inUstilago maydis

    Article • FEMS Yeast Research, December 2008, Oxford University Press (OUP)

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

48. 
    Gene Cloning and Biochemical Characterization of an Alcohol Dehydrogenase from Euglena gracilis1

    Article • Journal of Eukaryotic Microbiology, November 2008, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

49. 
    Experimental validation of metabolic pathway modeling

    Article • FEBS Journal, June 2008, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

50. 
    Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways

    Article • Journal of Biomedicine and Biotechnology, January 2008, Hindawi Publishing Corporation

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

51. 
    Enhanced alternative oxidase and antioxidant enzymes under Cd2+ stress in Euglena

    Article • Journal of Bioenergetics and Biomembranes, September 2007, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

52. 
    Kinetic modeling can describe in vivo glycolysis in Entamoeba histolytica

    Article • FEBS Journal, August 2007, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

53. 
    Energy metabolism in tumor cells

    Article • FEBS Journal, February 2007, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

54. 
    Phytochelatin–cadmium–sulfide high‐molecular‐mass complexes of Euglena gracilis

    Article • FEBS Journal, November 2006, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

55. 
    Control of cellular proliferation by modulation of oxidative phosphorylation in human and rodent fast-growing tumor cells

    Article • Toxicology and Applied Pharmacology, September 2006, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

56. 
    Determining and understanding the control of glycolysis in fast‐growth tumor cells

    Article • FEBS Journal, April 2006, Wiley

    Professor Rafael Moreno-Sanchez, Marina Macias-Silva, Professor Rafael Moreno-Sanchez

57. 
    Physiological role of rhodoquinone in Euglena gracilis mitochondria

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, December 2005, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

58. 
    The bacterial-like lactate shuttle components from heterotrophic Euglena gracilis

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2005, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

59. 
    Structural and functional changes in heart mitochondria from sucrose-fed hypertriglyceridemic rats

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2005, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

60. 
    Glycolysis in Entamoeba histolytica

    Article • FEBS Journal, March 2005, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

61. 
    The Alternative Respiratory Pathway of Euglena Mitochondria

    Article • Journal of Bioenergetics and Biomembranes, October 2004, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

62. 
    Control of superoxide production in mitochondria from maize mesocotyls

    Article • FEBS Letters, June 2004, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

63. 
    Entamoeba histolytica: kinetic and molecular evidence of a previously unidentified pyruvate kinase

    Article • Experimental Parasitology, January 2004, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

64. 
    Cytosol–mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena

    Article • European Journal of Biochemistry, December 2003, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

65. 
    The Membrane-Bound - and -Lactate Dehydrogenase Activities in Mitochondria from Euglena gracilis

    Article • Archives of Biochemistry and Biophysics, June 2001, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

66. 
    Multisite control of the Crabtree effect in ascites hepatoma cells

    Article • European Journal of Biochemistry, April 2001, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

67. 
    Oxidative phosphorylation supported by an alternative respiratory pathway in mitochondria from Euglena

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 2000, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

68. 
    Substrate Oxidation and ATP Supply in AS-30D Hepatoma Cells

    Article • Archives of Biochemistry and Biophysics, March 2000, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

69. 
    A Method for the Isolation of Tegument Syncytium Mitochondria from Taenia crassiceps Cysticerci and Partial Characterization of Their Aerobic Metabolism

    Article • Journal of Parasitology, June 1998, JSTOR

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

70. 
    The Content of Alternative Oxidase of Euglena Mitochondria is Increased by Growth in the Presence of Cyanide and is not Cytochrome o.

    Article • Journal of Eukaryotic Microbiology, January 1998, Wiley

    Professor Rafael Moreno-Sanchez

71. 
    Potassium Collapses the ΔPin Yeast Mitochondria While the Rate of ATP Synthesis Is Inhibited Only Partially: Modulation by Phosphate

    Article • Archives of Biochemistry and Biophysics, October 1997, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

72. 
    Effect of intramitochondrial Mg2 on citrulline synthesis in rat liver mitochondria

    Article • IUBMB Life, January 1997, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

73. 
    On the mechanism by which 6-ketocholestanol protects mitochondria against uncoupling-induced Ca2+efflux

    Article • FEBS Letters, February 1996, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

74. 
    Modulation of matrix Ca2+ content by the ADP/ATP carrier in brown adipose tissue mitochondria. Influence of membrane lipid composition

    Article • Journal of Bioenergetics and Biomembranes, February 1996, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

75. 
    Modulation of matrix Ca2+ content by the ADP/ATP carrier in brown adipose tissue mitochondria. Influence of membrane lipid composition

    Article • Journal of Bioenergetics and Biomembranes, February 1996, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

76. 
    Modulation of 2-Oxoglutarate Dehydrogenase and Oxidative Phosphorylation by Ca2+ in Pancreas and Adrenal Cortex Mitochondria

    Article • Archives of Biochemistry and Biophysics, June 1995, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

77. 
    Characterization of Ca2+ transport in Euglena gracilis mitochondria

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, June 1994, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

78. 
    The proton pumping activity of H+-ATPases: An improved fluorescence assay

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, November 1993, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

79. 
    Control of oxidative phosphorylation in AS-30D hepatoma mitochondria

    Article • International Journal of Biochemistry, March 1993, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

80. 
    Energy-dependent reactions supported by several substrates in coupled Euglena gracilis mitochondria

    Article • Plant Science, January 1992, Elsevier

    Professor Rafael Moreno-Sanchez

81. 
    Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, November 1991, Elsevier

    Professor Rafael Moreno-Sanchez

82. 
    Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086

    Article • Biochemical Pharmacology, May 1991, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

83. 
    Control of oxidative phosphorylation in mitochondria, cells and tissues

    Article • International Journal of Biochemistry, January 1991, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

84. 
    Release of Ca2+ from heart and kidney mitochondria by peripheral-type benodiazepine receptor ligands

    Article • International Journal of Biochemistry, January 1991, Elsevier

    Professor Rafael Moreno-Sanchez

85. 
    Activation of Pyruvate Dehydrogenase Complex by Ca2+in Intact Heart, Cardiac Myocytes, and Cardiac Mitochondria

    Article • Annals of the New York Academy of Sciences, December 1989, Wiley

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez

86. 
    Control of Respiration and ATP Hydrolysis in Uncoupled Mitochondria

    Article • January 1988, Springer Science + Business Media

    Professor Rafael Moreno-Sanchez

87. 
    Preparation of coupled mitochondria from Euglena by sonication

    Article • Plant Science, January 1987, Elsevier

    Professor Rafael Moreno-Sanchez, Professor Rafael Moreno-Sanchez