All Stories

  1. Development of efficient genetic toolkits and heterologous chassis for bioprospecting of myxobacteria
  2. Successive waves of transcriptional repression and de-repression license cell cycle progression in an archaeon
  3. Modulation of Hachiman defence by a type II toxin-antitoxin system via balancing trade-off between the fitness cost and antiphage activity
  4. Phosphorylation of the α subunit inhibits proteasome assembly and regulates cell cycle in an archaeon
  5. An Lrs14 family protein functions as a nucleoid-associated protein regulating cell cycle progression in Sulfolobales
  6. Cran1, member of a new class of OLD family ATPases, functions in cell cycle progression in an archaeon
  7. Substrate-induced remodeling of protein disordered loops activates Csm DNases
  8. Control of the archaeal DNA damage-responsive pathway by phosphorylation of Orc1-2, the global regulator in Saccharolobus islandicus
  9. TrmB1, a novel nucleoid-associated protein orchestrates dynamic chromatin organization and cell cycle progression in archaea
  10. Phosphorylation of the α subunit inhibits proteasome assembly and regulates cell division in an archaeon
  11. Universal Amplification-Free RNA Detection by Integrating CRISPR-Cas10 with Aptameric Graphene Field-Effect Transistor
  12. Base-modified nucleotides mediate immune signaling in bacteria
  13. A new class of OLD family ATPases Cran1 functions in cell cycle progression in an archaeon
  14. Rational design of unrestricted pRN1 derivatives and their application in the construction of a dual plasmid vector system for Saccharolobus islandicus
  15. Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays
  16. Catalytically inactive long prokaryotic Argonaute systems employ distinct effectors to confer immunity via abortive infection
  17. Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system forSaccharolobus islandicus
  18. The FHA domain protein ArnA functions as a global DNA damage response repressor in the hyperthermophilic archaeon Saccharolobus islandicus
  19. The abortive infection functions of CRISPR-Cas and Argonaute
  20. Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader-over cryptic promoters
  21. Inactive long prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection
  22. Harnessing the LdCsm RNA Detection Platform for Efficient microRNA Detection
  23. A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea
  24. Sulfolobus islandicus Employs Orc1-2-Mediated DNA Damage Response in Defense against Infection by SSV2
  25. Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator
  26. Remodeling of a tripartite substrate-binding motif in the HD domain provides the mechanism for activation of CRISPR-Cas10 DNases
  27. Genomics, Transcriptomics, and Proteomics of SSV1 and Related Fusellovirus: A Minireview
  28. Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus
  29. A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis
  30. Enzymatic Switching Between Archaeal DNA Polymerases Facilitates Abasic Site Bypass
  31. Genome editing from Cas9 to IscB: Backwards and forwards towards new breakthroughs
  32. A well conserved archaeal B-family polymerase functions as a mismatch and lesion extender
  33. A type III-A CRISPR–Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors
  34. Evolutionary Trajectory of the Replication Mode of Bacterial Replicons
  35. Purification and characterization of ribonucleoprotein effector complexes of Sulfolobus islandicus CRISPR-Cas systems
  36. Recombinant protein expression in Sulfolobus islandicus
  37. Antiviral Defense Mechanisms in Archaea
  38. CRISPR-Cas adaptive immune systems in Sulfolobales: genetic studies and molecular mechanisms
  39. A Membrane-Associated DHH-DHHA1 Nuclease Degrades Type III CRISPR Second Messenger
  40. Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas
  41. A Unique B-Family DNA Polymerase Facilitating Error-Prone DNA Damage Tolerance in Crenarchaeota
  42. Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas
  43. Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase
  44. A Membrane-Associated Nuclease Degrades Cyclic Oligo-Adenylate and Deactivates Type III CRISPR Ribonuclease
  45. Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase
  46. Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
  47. Crenarchaeal 3D Genome: A Prototypical Chromosome Architecture for Eukaryotes
  48. Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system
  49. A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system
  50. Comparative genomics for non-O1/O139 Vibrio cholerae isolates recovered from the Yangtze River Estuary versus V. cholerae representative isolates from serogroup O1
  51. Molecular mechanisms of III-B CRISPR–Cas systems in archaea
  52. A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding
  53. Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families
  54. An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea
  55. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea
  56. Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus
  57. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea
  58. Diversity and Contributions to Nitrogen Cycling and Carbon Fixation of Soil Salinity Shaped Microbial Communities in Tarim Basin
  59. Conserved accessory proteins encoded with archaeal and bacterial Type III CRISPR-Cas gene cassettes that may specifically modulate, complement or extend interference activity
  60. Type III CRISPR-Cas System: Introduction And Its Application for Genetic Manipulations
  61. In vivo and in vitro protein imaging in thermophilic archaea by exploiting a novel protein tag
  62. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA
  63. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail
  64. NQO-Induced DNA-Less Cell Formation Is Associated with Chromatin Protein Degradation and Dependent on A0A1-ATPase in Sulfolobus
  65. Coupling transcriptional activation of CRISPR–Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus
  66. The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications
  67. Reverse Gyrase Functions in Genome Integrity Maintenance by Protecting DNA Breaks In Vivo
  68. Genomic and transcriptomic analyses reveal distinct biological functions for cold shock proteins (VpaCspA and VpaCspD) in Vibrio parahaemolyticus CHN25 during low-temperature survival
  69. Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea
  70. Type III CRISPR-Cas System: Introduction And Its Application for Genetic Manipulations
  71. CRISPR History: Discovery, Characterization, and Prosperity
  72. A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction
  73. CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation in the dependence of Csa3b
  74. Major and minor crRNA annealing sites facilitate low stringency DNA protospacer binding prior to Type I-A CRISPR-Cas interference in Sulfolobus
  75. Diverse CRISPR-Cas responses and dramatic cellular DNA changes and cell death in pKEF9-conjugatedSulfolobusspecies
  76. Theapt/6-Methylpurine Counterselection System and Its Applications in Genetic Studies of the Hyperthermophilic Archaeon Sulfolobus islandicus
  77. Construction and characterization of three protein-targeting expression system inLactobacillus casei
  78. Heterologous Expression of Mannanase and Developing a New Reporter Gene System in Lactobacillus casei and Escherichia coli
  79. Transcriptome analysis of Sulfolobus solfataricus infected with two related fuselloviruses reveals novel insights into the regulation of CRISPR-Cas system
  80. Harnessing Type I and Type III CRISPR-Cas systems for genome editing
  81. Unravelling the Role of the F55 Regulator in the Transition from Lysogeny to UV Induction of Sulfolobus Spindle-Shaped Virus 1
  82. CRISPR-Cas Adaptive Immune Systems of the Sulfolobales: Unravelling Their Complexity and Diversity
  83. Archaeal Extrachromosomal Genetic Elements
  84. Genetic analysis of the Holliday junction resolvases Hje and Hjc in Sulfolobus islandicus
  85. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition
  86. Efficient 5′-3′ DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeon Sulfolobus islandicus
  87. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference
  88. Sulfolobus Replication Factor C Stimulates the Activity of DNA Polymerase B1
  89. Characterization of pMC11, a plasmid with dual origins of replication isolated from Lactobacillus casei MCJ and construction of shuttle vectors with each replicon
  90. Molecular biology of fuselloviruses and their satellites
  91. Nanobiomotors of archaeal DNA repair machineries: current research status and application potential
  92. A novel single-tailed fusiform Sulfolobus virus STSV2 infecting model Sulfolobus species
  93. Knockouts of RecA-Like Proteins RadC1 and RadC2 Have Distinct Responses to DNA Damage Agents in Sulfolobus islandicus
  94. Transcriptomic analysis of the SSV2 infection of Sulfolobus solfataricus with and without the integrative plasmid pSSVi
  95. Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon
  96. Novel insights into gene regulation of the rudivirus SIRV2 infectingSulfolobuscells
  97. Tlys, a Newly Identified Sulfolobus Spindle-Shaped Virus 1 Transcript Expressed in the Lysogenic State, Encodes a DNA-Binding Protein Interacting at the Promoters of the Early Genes
  98. Genetic determinants of PAM-dependent DNA targeting and pre-crRNA processing inSulfolobus islandicus
  99. A novel interference mechanism by a type IIIB CRISPR-Cmr module inSulfolobus
  100. Genetic manipulation inSulfolobus islandicusand functional analysis of DNA repair genes
  101. Specificity and Function of Archaeal DNA Replication Initiator Proteins
  102. A novel carboxyl-terminal protease derived from Paenibacillus lautus CHN26 exhibiting high activities at multiple sites of substrates
  103. Molecular cloning of a novel bioH gene from an environmental metagenome encoding a carboxylesterase with exceptional tolerance to organic solvents
  104. An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease
  105. A Synthetic Arabinose-Inducible Promoter Confers High Levels of Recombinant Protein Expression in Hyperthermophilic Archaeon Sulfolobus islandicus
  106. Archaeal viruses—novel, diverse and enigmatic
  107. Dissection of the functional domains of an archaeal Holliday junction helicase
  108. Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus
  109. Development of a Simvastatin Selection Marker for a Hyperthermophilic Acidophile, Sulfolobus islandicus
  110. Exceptional thermal stability and organic solvent tolerance of an esterase expressed from a thermophilic host
  111. Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control
  112. Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles
  113. Sulfolobus Turreted Icosahedral Virus c92 Protein Responsible for the Formation of Pyramid-Like Cellular Lysis Structures
  114. Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)
  115. C68 from theSulfolobus islandicusplasmid–virus pSSVx is a novel member of the AbrB-like transcription factor family
  116. Phenotypic, Proteomic, and Genomic Characterization of a Putative ABC-Transporter Permease Involved inListeria monocytogenesBiofilm Formation
  117. Archaeal promoter architecture and mechanism of gene activation: Figure 1
  118. CRISPR-based immune systems of the Sulfolobales: complexity and diversity
  119. Genome Analyses of Icelandic Strains of Sulfolobus islandicus, Model Organisms for Genetic and Virus-Host Interaction Studies
  120. Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers
  121. Transcription termination in the plasmid/virus hybrid pSSVx from Sulfolobus islandicus
  122. Revealing the essentiality of multiple archaeal pcna genes using a mutant propagation assay based on an improved knockout method
  123. Four newly isolated fuselloviruses from extreme geothermal environments reveal unusual morphologies and a possible interviral recombination mechanism
  124. An upstream activation element exerting differential transcriptional activation on an archaeal promoter
  125. Unmarked gene deletion and host–vector system for the hyperthermophilic crenarchaeon Sulfolobus islandicus
  126. Genetic analyses in the hyperthermophilic archaeonSulfolobus islandicus
  127. A Putative ABC Transporter Is Involved in Negative Regulation of Biofilm Formation by Listeria monocytogenes
  128. Nucleotide sequence of pOLA52: A conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux
  129. Transcriptional Analysis of the Genetic Element pSSVx: Differential and Temporal Regulation of Gene Expression Reveals Correlation between Transcription and Replication
  130. A novel Sulfolobus non-conjugative extrachromosomal genetic element capable of integration into the host genome and spreading in the presence of a fusellovirus
  131. The genome ofHyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 °C
  132. Novel bacterial sulfur oxygenase reductases from bioreactors treating gold-bearing concentrates
  133. Characterization of the Sulfolobus host–SSV2 virus interaction
  134. The Genome of Sulfolobus acidocaldarius, a Model Organism of the Crenarchaeota
  135. Sulfolobus tengchongensis Spindle-Shaped Virus STSV1: Virus-Host Interactions and Genomic Features
  136. Key Role of Cysteine Residues in Catalysis and Subcellular Localization of Sulfur Oxygenase-Reductase of Acidianus tengchongensis
  137. Novel RepA-MCM proteins encoded in plasmids pTAU4, pORA1 and pTIK4 fromSulfolobus neozealandicus
  138. Archaeal integrases and mechanisms of gene capture
  139. Relationships between fuselloviruses infecting the extremely thermophilic archaeon Sulfolobus: SSV1 and SSV2
  140. Genus-Specific Protein Binding to the Large Clusters of DNA Repeats (Short Regularly Spaced Repeats) Present in Sulfolobus Genomes
  141. Archaeal integrative genetic elements and their impact on genome evolution
  142. Mobile elements in archaeal genomes
  143. Mobile elements in archaeal genomes
  144. Sequences and Replication of Genomes of the Archaeal Rudiviruses SIRV1 and SIRV2: Relationships to the Archaeal Lipothrixvirus SIFV and Some Eukaryal Viruses
  145. The complete genome of the crenarchaeon Sulfolobus solfataricus P2
  146. Non-autonomous mobile elements in the crenarchaeon Sulfolobus solfataricus
  147. Genome evolution: Gene capture in archaeal chromosomes
  148. pING Family of Conjugative Plasmids from the Extremely Thermophilic Archaeon Sulfolobus islandicus: Insights into Recombination and Conjugation in Crenarchaeota
  149. Evolution of the family of pRN plasmids and their integrase-mediated insertion into the chromosome of the crenarchaeon Sulfolobus solfataricus
  150. Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon,Sulfolobus solfataricusP2
  151. A Bac Library and Paired-PCR Approach to Mapping and Completing the Genome Sequence ofSulfolobus SolfataricusP2
  152. Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2
  153. The genetic element pSSVx of the extremely thermophilic crenarchaeon Sulfolobus is a hybrid between a plasmid and a virus
  154. Genetic profile of pNOB8 from Sulfolobus : the first conjugative plasmid from an archaeon
  155. Sulfolobus genome: from genomics to biology
  156. Completing the sequence of the Sulfolobus solfataricus P2 genome
  157. Genetic elements in the extremely thermophilic archaeon Sulfolobus
  158. Archaea and the new age of microorganisms
  159. Organization and expression of genes in the genomic region surrounding the glutamine synthetase gene Gln1 from Lotus japonicus
  160. Minimal enhancer elements of the leghemoglobinlba andlbc3 gene promoters fromGlycine max L. have different properties
  161. Comparative sequence analysis of cis elements present in Glycine max L. leghemoglobin lba and lbc3 genes