All Stories

  1. SIX1 is required for adult cochlear sensory epithelium homeostasis and auditory function

    Article • Proceedings of the National Academy of Sciences, August 2026, Proceedings of the National Academy of Sciences

    Pin-Xian Xu

  2. Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development

    Article • Frontiers in Cell and Developmental Biology, September 2023, Frontiers

    Pin-Xian Xu

  3. The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood

    Article • Frontiers in Cell and Developmental Biology, April 2023, Frontiers

    Pin-Xian Xu

  4. The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity

    Article • Nucleic Acids Research, September 2022, Oxford University Press (OUP)

    Pin-Xian Xu

  5. Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation

    Article • Frontiers in Cell and Developmental Biology, February 2022, Frontiers

    Pin-Xian Xu

  6. Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance

    Article • Journal of the American Society of Nephrology, October 2021, American Society of Nephrology

    Pin-Xian Xu

  7. SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases

    Article • Annals of Translational Medicine, June 2021, AME Publishing Company

    Pin-Xian Xu

  8. Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm

    Article • Proceedings of the National Academy of Sciences, March 2021, Proceedings of the National Academy of Sciences

    Pin-Xian Xu, Dr. Bernd Fritzsch

  9. Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina

    Article • Journal of Pineal Research, July 2020, Wiley

    Pin-Xian Xu

  10. Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium

    Article • Nucleic Acids Research, January 2020, Oxford University Press (OUP)

    Pin-Xian Xu, Dr. Bernd Fritzsch

  11. The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors

    Article • Developmental Neuroscience, January 2020, Karger Publishers

    Pin-Xian Xu

  12. An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis

    Article • eLife, November 2017, eLife

    Pin-Xian Xu

  13. Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium

    Article • PLoS Genetics, September 2017, PLOS

    Pin-Xian Xu

  14. Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Pin-Xian Xu

  15. EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer

    Article • Molecular and Cellular Biology, October 2016, ASM Journals

    Pin-Xian Xu

  16. A Novel ENU-Induced Mutation in Myo6 Causes Vestibular Dysfunction and Deafness

    Article • PLOS One, May 2016, PLOS

    Pin-Xian Xu

  17. SOX2 in Neurosensory Fate Determination and Differentiation in the Inner Ear

    Article • January 2016, Elsevier

    Pin-Xian Xu

  18. Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation

    Article • Developmental Dynamics, June 2015, Wiley

    Pin-Xian Xu

  19. The Eya1 Phosphatase Promotes Shh Signaling during Hindbrain Development and Oncogenesis

    Article • Developmental Cell, April 2015, Elsevier

    Pin-Xian Xu

  20. Eya1 Interacts with Six2 and Myc to Regulate Expansion of the Nephron Progenitor Pool during Nephrogenesis

    Article • Developmental Cell, November 2014, Elsevier

    Pin-Xian Xu

  21. Smad4 Regulates Ureteral Smooth Muscle Cell Differentiation during Mouse Embryogenesis

    Article • PLOS One, August 2014, PLOS

    Pin-Xian Xu

  22. Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney

    Article • Developmental Biology, July 2014, Elsevier

    Pin-Xian Xu

  23. Distribution Dynamics of Recombinant Lactobacillus in the Gastrointestinal Tract of Neonatal Rats

    Article • PLOS One, March 2013, PLOS

    Pin-Xian Xu

  24. EYA1–SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

    Article • Hearing Research, March 2013, Elsevier

    Pin-Xian Xu

  25. The Phosphatase-Transcription Activator EYA1 Is Targeted by Anaphase-Promoting Complex/Cdh1 for Degradation at M-to-G1 Transition

    Article • Molecular and Cellular Biology, December 2012, ASM Journals

    Pin-Xian Xu

  26. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature

    Article • Nature Cell Biology, November 2012, Springer Science + Business Media

    Pin-Xian Xu

  27. The EYA-SO/SIX complex in development and disease

    Article • Pediatric Nephrology, July 2012, Springer Science + Business Media

    Pin-Xian Xu

  28. EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

    Article • Development, June 2012, The Company of Biologists

    Pin-Xian Xu

  29. Eya1-Six1 Interaction Is Sufficient to Induce Hair Cell Fate in the Cochlea by Activating Atoh1 Expression in Cooperation with Sox2

    Article • Developmental Cell, February 2012, Elsevier

    Pin-Xian Xu

  30. Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

    Article • Developmental Biology, April 2011, Elsevier

    Pin-Xian Xu

  31. Biocompatibility of bacterial magnetosomes: Acute toxicity, immunotoxicity and cytotoxicity

    Article • Nanotoxicology, March 2010, Taylor & Francis

    Pin-Xian Xu

  32. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation

    Article • Development, March 2010, The Company of Biologists

    Pin-Xian Xu

  33. Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation

    Article • BMC Developmental Biology, January 2010, Springer Science + Business Media

    Dr. Bernd Fritzsch, Pin-Xian Xu

  34. Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

    Article • Developmental Biology, February 2009, Elsevier

    Pin-Xian Xu

  35. Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear

    Article • Human Molecular Genetics, November 2008, Oxford University Press (OUP)

    Dr. Bernd Fritzsch, Pin-Xian Xu

  36. Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome

    Article • The American Journal of Human Genetics, April 2007, Elsevier

    Pin-Xian Xu

  37. Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo

    Article • Developmental Biology, February 2007, Elsevier

    Pin-Xian Xu

  38. Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear

    Article • Developmental Biology, October 2006, Elsevier

    Pin-Xian Xu

  39. Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

    Article • Developmental Biology, May 2006, Elsevier

    Pin-Xian Xu

  40. Eya1 acts as a critical regulator for specifying the metanephric mesenchyme

    Article • Developmental Biology, August 2005, Elsevier

    Pin-Xian Xu

  41. Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes

    Article • Development, November 2004, The Company of Biologists

    Dr. Bernd Fritzsch, Pin-Xian Xu

  42. Six1 and Eya1 Expression Can Reprogram Adult Muscle from the Slow-Twitch Phenotype into the Fast-Twitch Phenotype

    Article • Molecular and Cellular Biology, July 2004, ASM Journals

    Pin-Xian Xu

  43. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1–SIX1–DNA complexes

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Pin-Xian Xu

  44. The role ofSix1in mammalian auditory system development

    Article • Development, September 2003, The Company of Biologists

    Pin-Xian Xu

  45. Six1is required for the early organogenesis of mammalian kidney

    Article • Development, July 2003, The Company of Biologists

    Pin-Xian Xu

  46. Spermatid nuclear and sperm periaxonemal anomalies in the mouseUbe2b null mutant

    Article • Molecular Reproduction and Development, May 2003, Wiley

    Pin-Xian Xu

  47. Eya1is required for the morphogenesis of mammalian thymus, parathyroid and thyroid

    Article • Development, July 2002, The Company of Biologists

    Pin-Xian Xu

  48. Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome

    Article • Human Molecular Genetics, November 2001, Oxford University Press (OUP)

    Pin-Xian Xu

  49. A modified cryosection method for mouse testis tissue

    Article • Tissue and Cell, April 2001, Elsevier

    Pin-Xian Xu

  50. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B

    Article • Developmental Biology, June 2000, Elsevier

    Pin-Xian Xu

  51. Embryonic silk gland development in Bombyx : molecular cloning and expression of the Bombyx trachealess gene

    Article • Development Genes and Evolution, September 1999, Springer Science + Business Media

    Pin-Xian Xu

  52. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

    Article • Nature Genetics, September 1999, Springer Science + Business Media

    Pin-Xian Xu

  53. Regulation of Pax6 expression is conserved between mice and flies

    Article • Development, January 1999, The Company of Biologists

    Pin-Xian Xu

  54. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function

    Article • Proceedings of the National Academy of Sciences, October 1997, Proceedings of the National Academy of Sciences

    Pin-Xian Xu

  55. Double-segment defining role of even-skipped homologs along the evolution of insect pattern formation

    Article • Embryologia, August 1997, Wiley

    Pin-Xian Xu

  56. Spatial and temporal expression pattern of POU-M1/SGF-3 in Bombyx mori embryogenesis

    Article • Development Genes and Evolution, May 1997, Springer Science + Business Media

    Pin-Xian Xu

  57. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode

    Article • Development, January 1997, The Company of Biologists

    Pin-Xian Xu

  58. Molecular cloning of a zinc finger protein belonging to the GLI-Kruppel family and its expression in the silk gland

    Article • Embryologia, April 1995, Wiley

    Pin-Xian Xu

  59. A maternal homeobox gene, Bombyx caudal, forms both mRNA and protein concentration gradients spanning anteroposterior axis during gastrulation

    Article • Development, February 1994, The Company of Biologists

    Pin-Xian Xu

  60. Promoter of the POU-M1/SGF-3 gene involved in the expression of Bombyx silk genes.

    Article • Journal of Biological Chemistry, January 1994, Elsevier

    Pin-Xian Xu

  61. Molecular cloning of a POU domain-containing factor involved in the regulation of the Bombyx sericin-1 gene.

    Article • Journal of Biological Chemistry, September 1993, Elsevier

    Pin-Xian Xu