All Stories

  1. A Biochemical Explanation of Some Nutritional Truths and Falsehoods

    Article • Annals of Systems Biology, January 2025, Peertechz.com

    Dr Philip Gerard Penketh

  2. A Rapid Fluorescent in vitro Assay Suitable for Studying the Kinetics of O6-Alkylguanine Lesion Progression to DNA Inter-Strand Cross-Links and the Kinetics of the Primary Lesion’s Repair

    Article • Annals of Systems Biology, January 2024, Peertechz.com

    Dr Philip Gerard Penketh

  3. The activity of crude bromoacetyl-L-carnitine preparations against Trypanosoma brucei and the roles of threonine/pyruvate in non-hexose/glycerol ATP production

    Article • Annals of Systems Biology, April 2023, Peertechz.com

    Dr Philip Gerard Penketh

  4. The potential use of O6-benzylg uanine, and O6-methylguanine for the treatment of alzheimer’s disease, and t. brucei group trypanosomes infections

    Article • Annals of Systems Biology, August 2022, Peertechz.com

    Dr Philip Gerard Penketh

  5. Superoxide dismutase (SOD) is a hydroquinone oxidase, SOD activity being secondary to this component

    Article • Reactive Oxygen Species, May 2022, American Innovative Medical Sciences and Technologies (AIMSCI) Inc.

    Dr Philip Gerard Penketh

  6. This paper corrects a 4 decades long error in the biochemical literature.

    Article • Reactive Oxygen Species, March 2022, American Innovative Medical Sciences and Technologies (AIMSCI) Inc.

    Dr Philip Gerard Penketh

  7. Is DNA repair controlled by a biological logic circuit?

    Article • Theory in Biosciences, January 2022, Springer Science + Business Media

    Dr Philip Gerard Penketh

  8. Design Strategy and Approach to Increase the Selectivity of 1,2-Bis(Sulfonyl)-1-Alkylhydrazine Warheads in Tumor-Targeted Applications

    Article • Biomedical Journal of Scientific & Technical Research, March 2021, Biomedical Research Network, LLC

    Dr Philip Gerard Penketh

  9. Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines

    Article • Molecules, January 2021, MDPI AG

    Dr Philip Gerard Penketh

  10. Physicochemical Considerations of Tumor Selective Drug Delivery and Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1- Alkylhydrazines Delivery

    Article • Current Drug Delivery, July 2020, Bentham Science Publishers

    Dr Philip Gerard Penketh

  11. pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs

    Article • Chemical Biology & Drug Design, July 2017, Wiley

    Dr Philip Gerard Penketh

  12. 1,2‐Bis(methylsulfonyl)‐1‐(2‐chloroethyl)‐2‐[[1‐(4‐nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties

    Article • Chemical Biology & Drug Design, September 2011, Wiley

    Dr Philip Gerard Penketh

  13. A Biochemical Explanation of Some Nutritional Truths and Falsehoods

    Article • Annals of Systems Biology, Peertechz.com

    Dr Philip Gerard Penketh