All Stories

  1. Sulfonyl fluorides

    Article • European Journal of Organic Chemistry, July 2018, Wiley

    Professor Per I Arvidsson

  2. An unexpected re-arrangement of the antibiotic carbapenem core to new 1,4-diazepin-5-one scaffolds

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    Professor Per I Arvidsson

  3. On the bridge over the translational valley of death: interview with Per I Arvidsson

    Article • Future Science OA, May 2017, Future Science

    Professor Per I Arvidsson

  4. Sulfonimidamide in medizinischer Chemie und Agrochemie

    Article • Angewandte Chemie, February 2017, Wiley

    Professor Per I Arvidsson

  5. Sulfonimidamides in Medicinal and Agricultural Chemistry

    Article • Angewandte Chemie International Edition, February 2017, Wiley

    Professor Per I Arvidsson

  6. A Synthesis of “Dual Warhead” β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams

    Article • Organic Letters, January 2017, American Chemical Society (ACS)

    Professor Per I Arvidsson

  7. Open for collaboration: an academic platform for drug discovery and development at SciLifeLab

    Article • Drug Discovery Today, June 2016, Elsevier

    Professor Per I Arvidsson

  8. Towards a stereoselective synthesis of α,α-disubstituted proline analogues

    Article • Tetrahedron Letters, September 2015, Elsevier

    Professor Per I Arvidsson

  9. Cu(OAc)2-Catalysed Oxidative Dual C-H/N-H Activation of Terminal Alkynes andN-Deprotected Sulfonimidamides: An Easy Access toN-Alkynylated Sulfonimidamides

    Article • European Journal of Organic Chemistry, March 2015, Wiley

    Professor Per I Arvidsson

  10. Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

    Article • ChemMedChem, January 2015, Wiley

    Professor Per I Arvidsson

  11. NOTA: a potent metallo-β-lactamase inhibitor

    Article • Journal of Antimicrobial Chemotherapy, January 2015, Oxford University Press (OUP)

    Professor Sabiha Yusuf Essack, Professor Per I Arvidsson

  12. Pd-catalyzed C–N coupling of vinylbromides and sulfonimidamides: a facile synthesis of N′-vinylsulfonimidamides

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Professor Per I Arvidsson

  13. Applied Enantioselective Aminocatalysis: α-Heteroatom Functionalization Reactions on the Carbapenem (β-Lactam Antibiotic) Core

    Article • European Journal of Organic Chemistry, December 2014, Wiley

    Professor Per I Arvidsson

  14. Synthesis of Vinyl- and Aryl-Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)6as ex situ CO Source

    Article • European Journal of Organic Chemistry, November 2014, Wiley

    Professor Per I Arvidsson

  15. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production

    Article • FEBS Journal, November 2014, Wiley

    Professor Per I Arvidsson

  16. Cu(OAc)2 promoted Chan–Evans–Lam C–N cross coupling reactions on the N- and N′-nitrogen atoms of sulfonimidamides with aryl boronic acids

    Article • Tetrahedron, September 2014, Elsevier

    Professor Per I Arvidsson

  17. l-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores

    Article • Tetrahedron Asymmetry, July 2014, Elsevier

    Professor Per I Arvidsson

  18. Organocatalytic Mannich Reactions on a Carbapenem Core - Synthesis of Mannich Bases and Bicyclic Diazanonanes

    Article • European Journal of Organic Chemistry, February 2014, Wiley

    Professor Per I Arvidsson

  19. Proline N-oxides: modulators of the 3D conformation of linear peptides through “NO-turns”

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Per I Arvidsson

  20. Organocatalyzed stereospecific C–C bond formation of β-lactams

    Article • Organic & Biomolecular Chemistry, November 2013, Royal Society of Chemistry

    Professor Per I Arvidsson

  21. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

    Article • Journal of Neurochemistry, March 2013, Wiley

    Professor Per I Arvidsson

  22. Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor

    Article • Organic Letters, March 2013, American Chemical Society (ACS)

    Professor Per I Arvidsson

  23. Organocatalytic asymmetric cross-aldol reaction of 2-chloroethoxy acetaldehyde: diversity-oriented synthesis of chiral substituted 1,4-dioxanes and morpholines

    Article • Tetrahedron Asymmetry, February 2013, Elsevier

    Professor Per I Arvidsson

  24. Triazolopyrimidinones as γ-secretase modulators: structure–activity relationship, modulator profile, and in vivo profiling

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Professor Per I Arvidsson

  25. Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

    Article • Journal of Neuroscience, November 2012, Society for Neuroscience

    Professor Per I Arvidsson

  26. Imidazopyridine-Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold

    Article • Chemistry & Biodiversity, November 2012, Wiley

    Professor Per I Arvidsson

  27. Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Professor Per I Arvidsson

  28. Synthesis and arylation of unprotected sulfonimidamides

    Article • Tetrahedron, September 2012, Elsevier

    Professor Per I Arvidsson

  29. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles

    Article • Drug Metabolism and Disposition, August 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Per I Arvidsson

  30. 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na V 1.7 with Efficacy in Rat Pain Models

    Article • Journal of Medicinal Chemistry, August 2012, American Chemical Society (ACS)

    Professor Per I Arvidsson

  31. Microwave-Assisted Synthesis of Guanidine Organocatalysts Bearing a Tetrahydroisoquinoline Framework and Their Evaluation in Michael Addition Reactions

    Article • European Journal of Organic Chemistry, May 2012, Wiley

    Professor Per I Arvidsson

  32. Pentacycloundecane-diol-Based HIV-1 Protease Inhibitors: Biological Screening, 2D NMR, and Molecular Simulation Studies

    Article • ChemMedChem, April 2012, Wiley

    Professor Per I Arvidsson

  33. Asymmetric conjugate addition of thioglycolate to a range of chalcones using tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands

    Article • Tetrahedron Asymmetry, April 2012, Elsevier

    Professor Per I Arvidsson

  34. Interaction of β-Amyloid Interactions with Peptide Functionalized Gold Nanoparticles

    Article • Journal of Nanoscience and Nanotechnology, March 2012, American Scientific Publishers

    Professor Per I Arvidsson

  35. Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, February 2012, Taylor & Francis

    Professor Per I Arvidsson

  36. Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors

    Article • ChemMedChem, February 2012, Wiley

    Professor Per I Arvidsson

  37. Tetrahydroisoquinoline-Based N-Oxides as Chiral Organocatalysts for the Asymmetric Allylation of Aldehydes

    Article • European Journal of Organic Chemistry, September 2011, Wiley

    Professor Per I Arvidsson

  38. Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: A hybrid 2D NMR and docking/QM/MM/MD approach

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Professor Per I Arvidsson

  39. Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

    Article • Bioorganic & Medicinal Chemistry Letters, July 2011, Elsevier

    Professor Per I Arvidsson

  40. Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease

    Article • Bioorganic & Medicinal Chemistry Letters, April 2011, Elsevier

    Professor Per I Arvidsson

  41. Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies

    Article • Tetrahedron Asymmetry, December 2010, Elsevier

    Professor Per I Arvidsson

  42. In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

    Article • Bioorganic & Medicinal Chemistry, August 2010, Elsevier

    Professor Per I Arvidsson

  43. Effects of Congo Red on Aβ 1−40 Fibril Formation Process and Morphology

    Article • ACS Chemical Neuroscience, April 2010, American Chemical Society (ACS)

    Professor Per I Arvidsson

  44. Design and study of peptide-based inhibitors of amylin cytotoxicity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2010, Elsevier

    Professor Per I Arvidsson

  45. Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells

    Article • Biopolymers, January 2010, Wiley

    Professor Per I Arvidsson

  46. Synthesis and NMR elucidation of novel pentacycloundecane-based peptides

    Article • Magnetic Resonance in Chemistry, January 2010, Wiley

    Professor Per I Arvidsson

  47. Poly- N -methylated Amyloid β-Peptide (Aβ) C-Terminal Fragments Reduce Aβ Toxicity in Vitro and in Drosophila melanogaster

    Article • Journal of Medicinal Chemistry, December 2009, American Chemical Society (ACS)

    Professor Per I Arvidsson

  48. Synthesis and application of novel imidazole and 1H-tetrazolic acid containing catalysts in enantioselective organocatalyzed Diels–Alder reactions

    Article • Tetrahedron Asymmetry, August 2009, Elsevier

    Professor Per I Arvidsson

  49. Design and Synthesis of Glycosylated β 3 -Peptides Capable of Folding into the 3 14 -Helical Conformation in Water

    Article • The Journal of Organic Chemistry, July 2008, American Chemical Society (ACS)

    Professor Per I Arvidsson

  50. Facile Synthesis of N-protected Amino Acid Esters Assisted by Microwave Irradiation

    Article • International Journal of Peptide Research and Therapeutics, June 2008, Springer Science + Business Media

    Professor Per I Arvidsson

  51. Cobalt-doped β -peptide nanotubes: A class of spintronic materials

    Article • Physical Review B, April 2008, American Physical Society (APS)

    Professor Per I Arvidsson

  52. β- and γ-Di- and Tripeptides as Potential Substrates for the Oligopeptide Transporter hPepT1

    Article • Journal of Medicinal Chemistry, October 2007, American Chemical Society (ACS)

    Professor Per I Arvidsson

  53. Application of novel sulfonamides in enantioselective organocatalyzed cyclopropanation

    Article • Tetrahedron Asymmetry, July 2007, Elsevier

    Professor Per I Arvidsson

  54. Tetrazolic Acid Functionalized Dihydroindol:  Rational Design of a Highly Selective Cyclopropanation Organocatalyst

    Article • The Journal of Organic Chemistry, July 2007, American Chemical Society (ACS)

    Professor Per I Arvidsson

  55. A New Imidazole-Containing Imidazolidinone Catalyst for Organocatalyzed Asymmetric Conjugate Addition of Nitroalkanes to Aldehydes

    Article • Advanced Synthesis & Catalysis, March 2007, Wiley

    Professor Per I Arvidsson

  56. Biomolecular recognition of glycosylated β3-peptides by GalNAc specific lectins

    Article • Journal of Molecular Recognition, January 2007, Wiley

    Professor Per I Arvidsson

  57. Glycosylated foldamers: synthesis of carbohydrate-modified β3hSer and incorporation into β-peptides

    Article • Journal of Peptide Science, January 2007, Wiley

    Professor Per I Arvidsson

  58. Synthesis and Circular Dichroism Spectroscopic Investigations of Oligomeric β-Peptoids with α-Chiral Side Chains

    Article • Organic Letters, September 2006, American Chemical Society (ACS)

    Professor Per I Arvidsson

  59. β 2 -Amino Acids in the Design of Conformationally Homogeneous c yclo -Peptide Scaffolds

    Article • The Journal of Organic Chemistry, September 2006, American Chemical Society (ACS)

    Professor Per I Arvidsson

  60. Organocatalytic synthesis of chiral benzopyrans

    Article • Tetrahedron Asymmetry, July 2006, Elsevier

    Professor Per I Arvidsson

  61. 5-(Pyrrolidine-2-yl)tetrazole: Rationale for the Increased Reactivity of the Tetrazole Analogue of Proline in Organocatalyzed Aldol Reactions

    Article • European Journal of Organic Chemistry, June 2006, Wiley

    Professor Per I Arvidsson

  62. Facile synthesis of Fmoc-N-methylated α- and β-amino acids

    Article • Tetrahedron Letters, March 2006, Elsevier

    Professor Per I Arvidsson

  63. Poly-N-methylated α-peptides: synthesis and X-ray structure determination of β-strand forming foldamers

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Professor Per I Arvidsson

  64. Mechanistic Insights into the Phosphine-Free RuCp*-Diamine-Catalyzed Hydrogenation of Aryl Ketones:  Experimental and Theoretical Evidence for an Alcohol-Mediated Dihydrogen Activation

    Article • Journal of the American Chemical Society, November 2005, American Chemical Society (ACS)

    Professor Per I Arvidsson

  65. Cyclic β-Tetra- and Pentapeptides: Synthesis through On-Resin Cyclization and Conformational Studies by X-Ray, NMR and CD Spectroscopy and Theoretical Calculations

    Article • Chemistry - A European Journal, October 2005, Wiley

    Professor Per I Arvidsson

  66. 5-(Pyrrolidine-2-yl)tetrazole: Rationale for the Increased Reactivity of the Tetrazole Analogue of Proline in Organocatalyzed Aldol Reactions

    Article • European Journal of Organic Chemistry, October 2005, Wiley

    Professor Per I Arvidsson

  67. An Improved Synthesis of Fmoc- N -methyl-α-amino Acids

    Article • The Journal of Organic Chemistry, August 2005, American Chemical Society (ACS)

    Professor Per I Arvidsson

  68. Exploring the Antibacterial and Hemolytic Activity of Shorter- and Longer-Chain?-,?,?-, and?-Peptides, and of?-Peptides from?2-3-Aza- and?3-2-Methylidene-amino Acids Bearing Proteinogenic Side Chains - A Survey

    Article • Chemistry & Biodiversity, March 2005, Wiley

    Professor Per I Arvidsson

  69. Functionalized foldamers: synthesis and characterization of a glycosylated β-peptide 314-helix conveying the TN-antigen

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Professor Per I Arvidsson

  70. Rational design of asymmetric organocatalysts––increased reactivity and solvent scope with a tetrazolic acid

    Article • Tetrahedron Asymmetry, June 2004, Elsevier

    Professor Per I Arvidsson

  71. Antibiotic and Hemolytic Activity of a β2/β3 Peptide Capable of Folding into a 12/10-Helical Secondary Structure

    Article • ChemBioChem, November 2003, Wiley

    Professor Per I Arvidsson

  72. Syntheses and CD-Spectroscopic Investigations of Longer-Chain -Peptides: Preparation by Solid-Phase Couplings of Single Amino Acids, Dipeptides, and Tripeptides

    Article • Helvetica Chimica Acta, May 2003, Wiley

    Professor Per I Arvidsson

  73. Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Professor Per I Arvidsson

  74. On the Mechanism of Internal ortho-Lithiation in a Mixed Complex Between BuLi and a Chiral Lithium Amide

    Article • Helvetica Chimica Acta, November 2002, Wiley

    Professor Per I Arvidsson

  75. Stereoselective solvent induced 1,3-proton transfer of an allylic alkoxide to a homoallylic alkoxide catalysed by a chiral lithium amideElectronic supplementary information (ESI) available: 1H NMR, 1H,1H-COSY NMR and 1H,1H-NOESY NMR spectra of 6; 1H NM...

    Article • Journal of the Chemical Society Perkin Transactions 2, February 2002, Royal Society of Chemistry

    Professor Per I Arvidsson

  76. The outstanding metabolic stability of a14C-labeled?-nonapeptide in rats -in vitro andin vivo pharmacokinetic studies

    Article • Biopharmaceutics & Drug Disposition, January 2002, Wiley

    Professor Per I Arvidsson

  77. Linear, Peptidase-Resistantβ2/β3-Di- andα/β3-Tetrapeptide Derivatives with Nanomolar Affinities to a Human Somatostatin Receptor, Preliminary Communication

    Article • Helvetica Chimica Acta, November 2001, Wiley

    Professor Per I Arvidsson, Prof daniel hoyer

  78. Computational, ReactIR-, and NMR-Spectroscopic Investigations on the Chiral Formyl Anion EquivalentN-(α-Lithiomethylthiomethyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one and Related Compounds

    Article • Chemistry - A European Journal, October 2001, Wiley

    Professor Per I Arvidsson

  79. On the Antimicrobial and Hemolytic Activities of Amphiphilic β-Peptides

    Article • ChemBioChem, October 2001, Wiley

    Professor Per I Arvidsson

  80. The Outstanding Biological Stability ofβ- andγ-Peptides toward Proteolytic Enzymes: An In Vitro Investigation with Fifteen Peptidases

    Article • ChemBioChem, June 2001, Wiley

    Professor Per I Arvidsson

  81. The Miraculous CD Spectra (and Secondary Structures?) ofβ-Peptides as They Grow Longer, Preliminary Communication

    Article • Helvetica Chimica Acta, February 2001, Wiley

    Professor Per I Arvidsson

  82. Design, machine synthesis, and NMR-solution structure of a β-heptapeptide forming a salt-bridge stabilised 314-helix in methanol and in water

    Article • Chemical Communications, January 2001, Royal Society of Chemistry

    Professor Per I Arvidsson

  83. The Structure of a Chiral Lithium Amidocuprate in Solution Determined by Multinuclear NMR Spectroscopy

    Article • Journal of the American Chemical Society, September 2000, American Chemical Society (ACS)

    Professor Per I Arvidsson

  84. 6Li and 15N NMR Data as a Probe for the Influence of Solvent and Intramolecular Solvation on the Solution-State Structures of Chiral Lithium Amides

    Article • Angewandte Chemie International Edition, April 2000, Wiley

    Professor Per I Arvidsson

  85. Rational Design of Chiral Lithium Amides for Asymmetric Alkylation Reactions-NMR Spectroscopic Studies of Mixed Lithium Amide/Alkyllithium Complexes

    Article • Chemistry - A European Journal, July 1999, Wiley

    Professor Per I Arvidsson

  86. Solution Structure of a Dilithiumamide/Diethylzinc Heterocomplex that Catalyzes Asymmetric Alkylation Reactions

    Article • Chemistry - A European Journal, July 1999, Wiley

    Professor Per I Arvidsson

  87. Intraaggregate Fluxional Lithium and Carbanion Exchanges in a Chiral Lithium Amide/n-Butyllithium Mixed Tetramer Directly Observed by Multinuclear NMR

    Article • Chemistry - A European Journal, April 1999, Wiley

    Professor Per I Arvidsson

  88. Stereoselective Diamine Chelates of a Chiral Lithium Amide Dimer:  New Insights into the Coordination Chemistry of Chiral Lithium Amides

    Article • Journal of the American Chemical Society, March 1999, American Chemical Society (ACS)

    Professor Per I Arvidsson

  89. Enantioselective butylation of aliphatic aldehydes by mixed chiral lithium amide/n-BuLi dimers

    Article • Tetrahedron Asymmetry, February 1999, Elsevier

    Professor Per I Arvidsson

  90. Toward Solution-State Structure. A 6 Li, 1 H HOESY NMR, X-ray Diffraction, Semiempirical (PM3, MNDO), and ab Initio Computational Study of a Chiral Lithium Amide

    Article • Journal of the American Chemical Society, August 1998, American Chemical Society (ACS)

    Professor Per I Arvidsson

  91. Solvent-induced stereospecific isomerization of an allylic alcohol to a homoallylic alcohol catalyzed by a chiral lithium amide

    Article • Canadian Journal of Chemistry, June 1998, Canadian Science Publishing

    Professor Per I Arvidsson

  92. Computational Study of the Mechanism of Isomerization of Allyl Alcohol into Homoallyl Alcohol by Lithium Amide.

    Article • Acta Chemica Scandinavica, January 1998, Danish Chemical Society

    Professor Per I Arvidsson

  93. Chiral Lithium Amide/Solute Complexes:  X-ray Crystallographic and NMR Spectroscopic Studies

    Article • Organometallics, July 1997, American Chemical Society (ACS)

    Professor Per I Arvidsson

  94. Solvent induced isomerization of 2-cyclohexen-1-ol to 3-cyclohexen-1-ol by a chiral lithium amide

    Article • Tetrahedron Asymmetry, February 1996, Elsevier

    Professor Per I Arvidsson