All Stories

  1. Renal adverse events in EGFR-TKI treatment: Comprehensive characterization of clinical patterns and molecular underpinnings
  2. Correspondence to “Which came first, the cannabis or the depression?”
  3. PESSA: A web tool for pathway enrichment score-based survival analysis in cancer
  4. The Evaluation of Generative AI Should Include Repetition to Assess Stability
  5. Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma
  6. CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer
  7. ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity
  8. Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases
  9. MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level
  10. Development and validation of a radiosensitivity model to evaluate radiotherapy benefits in pan‐cancer
  11. Potential of Large Language Models as Tools Against Medical Disinformation
  12. SPCS, a Novel Classifier System Based on Senescence Axis Regulators Reveals Tumor Microenvironment Heterogeneity and Guides Frontline Therapy for Clear Cell Renal Carcinoma
  13. MOCS, a novel classifier system integrated multimoics analysis refining molecular subtypes and prognosis for skin melanoma
  14. Language and cultural bias in AI: comparing the performance of large language models developed in different countries on Traditional Chinese Medicine highlights the need for localized models
  15. Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies
  16. CTLs heterogeneity and plasticity: implications for cancer immunotherapy
  17. Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review
  18. OralExplorer: a web server for exploring the mechanisms of oral inflammatory diseases
  19. PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness
  20. The Evaluation of Generative AI Should Include Repetition to Assess Stability (Preprint)
  21. Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity
  22. Body mass index, weight change, and cancer prognosis: a meta-analysis and systematic review of 73 cohort studies
  23. Can DALL-E 3 Reliably Generate 12-Lead ECGs and Teaching Illustrations?
  24. IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research
  25. TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy
  26. Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma
  27. The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma
  28. Cellular Ligand–Receptor Perturbations Unravel MEIS2 as a Key Factor for the Aggressive Progression and Prognosis in Stage II/III Colorectal Cancer
  29. Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma
  30. Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients
  31. THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research
  32. Multimodal ChatGPT-4V for ECG Interpretation: Promise and Limitations (Preprint)
  33. The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors
  34. A tumor-infiltrating immune cells-related pseudogenes signature based on machine-learning predicts outcomes and immunotherapy responses in ovarian cancer
  35. BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors
  36. Oncogenic pathways refine a new perspective on the classification of hepatocellular carcinoma
  37. A TGF‐β signaling‐related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response
  38. PD-L1-related IncRNAs are associated with malignant characteristics and immune microenvironment in glioma
  39. The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study
  40. Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials
  41. Association of cannabis use with depression among cancer patients
  42. Global burden of neoplasms attributable to specific occupational carcinogens over 30 years: a population-based study
  43. Immune perturbation network identifies an EMT subtype with chromosomal instability and tumor immune-desert microenvironment
  44. TCCIA: A Comprehensive Resource for Exploring CircRNA in Cancer Immunotherapy
  45. Artificial intelligence learning landscape of triple-negative breast cancer uncovers new opportunities for enhancing outcomes and immunotherapy responses
  46. CACNA1C Mutation as a Prognosis Predictor of Immune Checkpoint Inhibitor in Skin Cutaneous Melanoma
  47. Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis
  48. HPVTIMER: A shiny web application for tumor immune estimation in human papillomavirus‐associated cancers
  49. Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small‐cell lung cancer and enhance the efficacy of platinum‐based chemotherapy
  50. Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity
  51. Profiles of immune infiltration in seasonal allergic rhinitis and related genes and pathways
  52. Burden of cardiovascular disease among elderly: based on the Global Burden of Disease Study 2019
  53. Identification of a single cell-based signature for predicting prognosis risk and immunotherapy response in patients with glioblastoma
  54. Immunosenescence: molecular mechanisms and diseases
  55. Psychiatric disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
  56. Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma
  57. Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma
  58. Mutations Status of NOTCH Signaling Pathway Predict Prognosis of Immune Checkpoint Inhibitors in Colorectal Cancer
  59. Reply to: Comments on “Adverse reactions associated with immune checkpoint inhibitors and bevacizumab: A pharmacovigilance analysis”
  60. PI3K pathway mutation predicts an activated immune microenvironment and better immunotherapeutic efficacy in head and neck squamous cell carcinoma
  61. An artificial intelligence network‐guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine learning algorithms
  62. Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment
  63. Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma
  64. Comprehensive analysis of pyroptosis‐related gene signatures for glioblastoma immune microenvironment and target therapy
  65. Editorial: Combining chemo/radio therapy and immunotherapy for cancers—perfect mix of old and new
  66. RNA modification pattern‐based subtypes reveal heterogenous clinical outcomes and tumor immunity of clear cell renal cell carcinoma
  67. A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma
  68. PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application
  69. A pan-cancer and single-cell sequencing analysis of CD161, a promising onco-immunological biomarker in tumor microenvironment and immunotherapy
  70. Activation of the TGF-β Pathway Enhances the Efficacy of Platinum-Based Chemotherapy in Small Cell Lung Cancer Patients
  71. Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma
  72. Glioblastoma glycolytic signature predicts unfavorable prognosis, immunological heterogeneity, and ENO1 promotes microglia M2 polarization and cancer cell malignancy
  73. Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role
  74. Machine learning-based identification of SOX10 as an immune regulator of macrophage in gliomas
  75. A novel thinking: DDR axis refines the classification of ccRCC with distinctive prognosis, multi omics landscape and management strategy
  76. Adverse reactions associated with immune checkpoint inhibitors and bevacizumab: A pharmacovigilance analysis
  77. HOXA5: A crucial transcriptional factor in cancer and a potential therapeutic target
  78. Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets
  79. BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors
  80. Tumor buster - where will the CAR-T cell therapy ‘missile’ go?
  81. Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas
  82. Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM
  83. Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma
  84. MOAHIT: a web tool for visualizing tumor multi-omics data with human anatomy heatmaps
  85. Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas
  86. The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
  87. B Cell Receptor Signaling Pathway Mutation as Prognosis Predictor of Immune Checkpoint Inhibitors in Lung Adenocarcinoma by Bioinformatic Analysis
  88. Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
  89. Machine learning algorithm-generated and multi-center validated melanoma prognostic signature with inspiration for treatment management
  90. Identification of a Hypoxia-Angiogenesis lncRNA Signature Participating in Immunosuppression in Gastric Cancer
  91. Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts
  92. Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy
  93. Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study
  94. A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis
  95. A New Thinking: Deciphering the Aberrance and Clinical Implication of IGF Axis Regulation Pattern in Clear Cell Renal Cell Carcinoma
  96. Relationship between ATOH1 and tumor microenvironment in colon adenocarcinoma patients with different microsatellite instability status
  97. A Novel Thrombosis-Related Signature for Predicting Survival and Drug Compounds in Glioblastoma
  98. JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer
  99. Application of ATAC-seq in tumor-specific T cell exhaustion
  100. ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer
  101. Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment
  102. Corrigendum: Antigen Presentation Machinery Signature-Derived CALR Mediates Migration, Polarization of Macrophages in Glioma and Predicts Immunotherapy Response
  103. Genomic and Transcriptomic Analysis of Neuroendocrine Transformation in ALK-Rearranged Lung Adenocarcinoma After Treatments With Sequential ALK Inhibitors: A Brief Report
  104. THSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients
  105. NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process
  106. Activation of the chemokine receptor 3 pathway leads to a better response to immune checkpoint inhibitors in patients with metastatic urothelial carcinoma
  107. Prognostic Factors and Treatment Strategies for Elderly Patients with Malignant Meningioma: A SEER Population-Based Study
  108. Deep Learning Analysis of the Adipose Tissue and the Prediction of Prognosis in Colorectal Cancer
  109. UBE3A deletion enhances the efficiency of immunotherapy in non-small-cell lung cancer
  110. Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC
  111. Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
  112. The Comprehensive Analysis Identified an Autophagy Signature for the Prognosis and the Immunotherapy Efficiency Prediction in Lung Adenocarcinoma
  113. Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis
  114. CAMOIP: a web server for comprehensive analysis on multi-omics of immunotherapy in pan-cancer
  115. Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer
  116. Targeting papain-like protease for broad-spectrum coronavirus inhibition
  117. Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals
  118. Antigen Presentation Machinery Signature-Derived CALR Mediates Migration, Polarization of Macrophages in Glioma and Predicts Immunotherapy Response
  119. MHC-II Signature Correlates With Anti-Tumor Immunity and Predicts anti-PD-L1 Response of Bladder Cancer
  120. Deep learning analysis of the adipose tissue and the prediction of prognosis in colorectal cancer.
  121. Survival Analysis of TP53 Comutations Should Be Interpreted More Cautiously
  122. CAMSAP1 Mutation Correlates With Improved Prognosis in Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy
  123. A Systematic Review of Neurologic Toxicity and Psychiatric Adverse Events associated with Immune Checkpoint Inhibitors
  124. Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma
  125. Hypoxic Characteristic Genes Predict Response to Immunotherapy for Urothelial Carcinoma
  126. Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes
  127. Mutations Status of Chemokine Signaling Pathway Predict Prognosis of Immune Checkpoint Inhibitors in Colon Adenocarcinoma
  128. The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer
  129. High mutations in fatty acid metabolism contribute to a better prognosis of small‐cell lung cancer patients treated with chemotherapy
  130. TNF-Alpha Pathway Alternation Predicts Survival of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer
  131. Applications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer
  132. Effect of mesenchymal-epithelial transition amplification on immune microenvironment and efficacy of immune checkpoint inhibitors in patients with non-small cell lung cancer
  133. Glycogen Metabolism Predicts the Efficacy of Immunotherapy for Urothelial Carcinoma
  134. Influence of Different Age Cutoff Points on the Prediction of Prognosis of Cancer Patients Receiving ICIs and Potential Mechanistic Exploration
  135. Activation of the DDR Pathway Leads to the Down-Regulation of the TGFβ Pathway and a Better Response to ICIs in Patients With Metastatic Urothelial Carcinoma
  136. Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors
  137. Association Between FSIP2 Mutation and an Improved Efficacy of Immune Checkpoint Inhibitors in Patients With Skin Cutaneous Melanoma
  138. Effect of NCOR1 Mutations on Immune Microenvironment and Efficacy of Immune Checkpoint Inhibitors in Patient with Bladder Cancer
  139. Identification of a novel CpG methylation signature to predict prognosis in lung squamous cell carcinoma
  140. Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets
  141. Age and Mutations as Predictors of the Response to Immunotherapy in Head and Neck Squamous Cell Cancer
  142. Emerging Concern of Scientific Fraud: Deep Learning and Image Manipulation
  143. A comparison of the efficacy of antiangiogenic agents combined with chemotherapy for the treatment of non-small cell lung cancer: a network meta-analysis
  144. Potential predictive value of SCN4A mutation status for immune checkpoint inhibitors in melanoma
  145. Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer
  146. ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment
  147. Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer
  148. Prognosis of Lung Adenocarcinoma Patients With NTRK3 Mutations to Immune Checkpoint Inhibitors
  149. EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma
  150. Current status, challenges and perspectives: immunotherapy and tumour microenvironment in thoracic cancer
  151. ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer
  152. DNAH10 mutation correlates with cisplatin sensitivity and tumor mutation burden in small-cell lung cancer
  153. Alterations in TP53 Are a Potential Biomarker of Bladder Cancer Patients Who Benefit From Immune Checkpoint Inhibition
  154. Comparison of the benefits of celecoxib combined with anticancer therapy in advanced non-small cell lung cancer: A meta-analysis
  155. DDR Pathway Alteration, Tumor Mutation Burden, and Cisplatin Sensitivity in Small Cell Lung Cancer: Difference Detected by Whole Exome and Targeted Gene Sequencing
  156. Association between Circulating Inflammatory Proteins and Clinical Prognosis in Chinese Patients with EGFR Mutation–Positive Non–Small Cell Lung Cancer
  157. Immune Cell Infiltration Is a Strong Prognostic Indicator in Surgical Resection of SCLC
  158. Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
  159. Comparison of the incidence of colorectal cancer in young adults between the USA and Europe
  160. Author's Reply to: Osimertinib and jaw osteonecrosis? A case report
  161. A novel mutation panel for predicting etoposide resistance in small-cell lung cancer
  162. Cervical cancer harboring a Rb1 mutation may sensitize to cisplatin via PI3K/AKT pathway by regulating apoptosis.
  163. Identification of aberrantly methylated differentially expressed genes in breast cancer by integrated bioinformatics analysis
  164. The efficacy of the new medical internship management network system
  165. Efficacy and safety of selective internal radiotherapy versus sorafenib for intermediate-locally advanced hepatocellular carcinoma: a systematic review and meta-analysis
  166. Efficacy and safety of osimertinib in treating EGFR‐mutated advanced NSCLC: A meta‐analysis
  167. CDYL promotes the chemoresistance of small cell lung cancer by regulating H3K27 trimethylation at the CDKN1C promoter
  168. The efficacy and safety of ALK inhibitors in the treatment of ALK‐positive non‐small cell lung cancer: A network meta‐analysis
  169. Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap
  170. Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer
  171. Adjuvant chemoradiotherapy versus radiotherapy alone in high-risk endometrial cancer: A systematic review and meta-analysis
  172. The efficacy and safety of alectinib in the treatment of ALK+ NSCLC: a systematic review and meta-analysis
  173. Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
  174. Efficacy and Safety of Ipilimumab plus Chemotherapy for Advanced Lung Cancer: A Systematic Review and Meta-Analysis
  175. Three-dimensional visualization of the functional fascicular groups of a long-segment peripheral nerve
  176. The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor
  177. The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer
  178. PUB025 Efficacy of ALK Inhibitors in the Treatment of ALK-rearranged Non-small Cell Lung Cancer and Brain Metastases: A Meta-analysis
  179. The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus
  180. Continuous intrathecal administration of liposomal amphotericin B for treatment of refractory Cryptococcus neoformans encephalitis: A case report
  181. Kennedy disease with difficulty in differential diagnosis
  182. The Relationship between Neutrophil-to-Lymphocyte Ratio and Intracerebral Hemorrhage in Type 2 Diabetes Mellitus
  183. Efficiency and safety of roflumilast combined with long-acting bronchodilators on moderate-to-severe stable chronic obstructive pulmonary disease patients: a meta-analysis
  184. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients