All Stories

  1. From Obscurity to Opportunity: LpxH Emerges as a Promising Antibiotic Target in the Battle against Gram-Negative Pathogens

    Article • ACS Infectious Diseases, October 2025, American Chemical Society (ACS)

    Professor Pei Zhou

  2. Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales

    Article • JACS Au, November 2024, American Chemical Society (ACS)

    Professor Pei Zhou

  3. Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction

    Article • The EMBO Journal, June 2024, Springer Science + Business Media

    Professor Pei Zhou

  4. The landscape of small-molecule prodrugs

    Article • Nature Reviews Cancer, April 2024, Springer Science + Business Media

    Professor Pei Zhou

  5. Bacterial pathogens deliver water- and solute-permeable channels to plant cells

    Article • Nature, September 2023, Springer Science + Business Media

    Professor Pei Zhou

  6. Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens

    Article • Science Translational Medicine, August 2023, American Association for the Advancement of Science

    Professor Pei Zhou

  7. Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY

    Article • Nature Communications, March 2023, Springer Science + Business Media

    Professor Pei Zhou

  8. Structural basis of NPR1 in activating plant immunity

    Article • Nature, May 2022, Springer Science + Business Media

    Professor Pei Zhou

  9. Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors

    Article • Bioorganic Chemistry, September 2020, Elsevier

    Professor Pei Zhou

  10. MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis

    Article • Nature Metabolism, March 2020, Springer Science + Business Media

    Professor Pei Zhou

  11. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics

    Article • Proceedings of the National Academy of Sciences, February 2020, Proceedings of the National Academy of Sciences

    Professor Pei Zhou

  12. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

    Article • Cell, June 2019, Elsevier

    Professor Pei Zhou

  13. Structure–Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay

    Article • ACS Infectious Diseases, February 2019, American Chemical Society (ACS)

    Professor Pei Zhou

  14. Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC

    Article • mBio, July 2017, ASM Journals

    Professor Pei Zhou

  15. Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis

    Article • Nature Microbiology, August 2016, Springer Science + Business Media

    Professor Pei Zhou

  16. The Missing Link in C. trachomatis Lipid A Biosynthesis

    Article • mBio, March 2016, ASM Journals

    Professor Pei Zhou

  17. The UDP-diacylglucosamine Pyrophosphohydrolase LpxH in Lipid A Biosynthesis Utilizes Mn2+ Cluster for Catalysis

    Article • Journal of Biological Chemistry, September 2013, Elsevier

    Professor Pei Zhou