All Stories

  1. In vitro growth competition experiments that suggest consequences of the substandard artemisinin epidemic that may be accelerating drug resistance in P. falciparum malaria

    Article • PLoS ONE, March 2021, PLOS

    Paul Roepe

  2. “Drug resistance associated membrane proteins”

    Article • Frontiers in Physiology, March 2014, Frontiers

    Paul Roepe

  3. To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

    Article • Trends in Parasitology, March 2014, Elsevier

    Paul Roepe

  4. A Process Similar to Autophagy Is Associated with Cytocidal Chloroquine Resistance in Plasmodium falciparum

    Article • PLoS ONE, November 2013, PLOS

    Paul Roepe

  5. Anti-Plasmodial Polyvalent Interactions in Artemisia annua L. Aqueous Extract – Possible Synergistic and Resistance Mechanisms

    Article • PLoS ONE, November 2013, PLOS

    Paul Roepe

  6. Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

    Article • Malaria Journal, September 2013, Springer Science + Business Media

    Paul Roepe

  7. Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

    Article • Biochemistry, June 2013, American Chemical Society (ACS)

    Paul Roepe

  8. Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

    Article • Journal of Medicinal Chemistry, April 2013, American Chemical Society (ACS)

    Paul Roepe

  9. Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth

    Article • Antimicrobial Agents and Chemotherapy, October 2012, ASM Journals

    Paul Roepe

  10. Relative to Quinine and Quinidine, Their 9-Epimers Exhibit Decreased Cytostatic Activity and Altered Heme Binding but Similar Cytocidal Activity versus Plasmodium falciparum

    Article • Antimicrobial Agents and Chemotherapy, October 2012, ASM Journals

    Paul Roepe

  11. Autophagy in Apicomplexa: a life sustaining death mechanism?

    Article • Trends in Parasitology, September 2012, Elsevier

    Paul Roepe, Dr Anthony P Sinai

  12. Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum

    Article • Bioorganic & Medicinal Chemistry, May 2012, Elsevier

    Paul Roepe

  13. Autophagy is a cell death mechanism in Toxoplasma gondii

    Article • Cellular Microbiology, February 2012, Hindawi Publishing Corporation

    Paul Roepe, Dr Anthony P Sinai

  14. Analysis of Chloroquine Resistance Transporter (CRT) Isoforms and Orthologues in S. cerevisiae Yeast

    Article • Biochemistry, July 2011, American Chemical Society (ACS)

    Paul Roepe

  15. Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine

    Article • Molecular and Biochemical Parasitology, July 2011, Elsevier

    Paul Roepe

  16. The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex

    Article • Journal of Inorganic Biochemistry, March 2011, Elsevier

    Paul Roepe

  17. PfCRT-Mediated Drug Transport in Malarial Parasites

    Article • Biochemistry, December 2010, American Chemical Society (ACS)

    Paul Roepe

  18. Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

    Article • Molecular and Biochemical Parasitology, October 2010, Elsevier

    Paul Roepe

  19. Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

    Article • Molecular Microbiology, September 2010, Wiley

    Paul Roepe

  20. Reduced Digestive Vacuolar Accumulation of Chloroquine Is Not Linked to Resistance to Chloroquine Toxicity

    Article • Biochemistry, November 2009, American Chemical Society (ACS)

    Paul Roepe

  21. Chloroquine Transport inPlasmodium falciparum. 2. Analysis of PfCRT-Mediated Drug Transport Using Proteoliposomes and a Fluorescent Chloroquine Probe

    Article • Biochemistry, September 2009, American Chemical Society (ACS)

    Paul Roepe

  22. Chloroquine Transport in Plasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe

    Article • Biochemistry, September 2009, American Chemical Society (ACS)

    Paul Roepe

  23. Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain

    Article • Bioorganic & Medicinal Chemistry, September 2009, Elsevier

    Paul Roepe

  24. Molecular and physiologic basis of quinoline drug resistance inPlasmodium falciparummalaria

    Article • Future Microbiology, May 2009, Future Medicine

    Paul Roepe

  25. Antimalarial drugs and heme in detergent micelles: An NMR study

    Article • Journal of Inorganic Biochemistry, May 2009, Elsevier

    Paul Roepe

  26. Malarial parasite pathogenesis and drug targets

    Article • F1000 Biology Reports, February 2009, F1000Research

    Paul Roepe

  27. Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas

    Article • Bioorganic & Medicinal Chemistry, January 2009, Elsevier

    Paul Roepe

  28. Photoaffinity Labeling of the Plasmodium falciparum Chloroquine Resistance Transporter with a Novel Perfluorophenylazido Chloroquine

    Article • Biochemistry, September 2008, American Chemical Society (ACS)

    Paul Roepe

  29. Quinine and Chloroquine Differentially Perturb Heme Monomer−Dimer Equilibrium

    Article • Inorganic Chemistry, June 2008, American Chemical Society (ACS)

    Paul Roepe

  30. 4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria

    Article • Journal of Medicinal Chemistry, May 2008, American Chemical Society (ACS)

    Paul Roepe

  31. Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy

    Article • Molecular and Biochemical Parasitology, May 2008, Elsevier

    Paul Roepe

  32. Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Paul Roepe

  33. A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform

    Article • Molecular and Biochemical Parasitology, January 2008, Elsevier

    Paul Roepe

  34. Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance

    Article • Molecular and Biochemical Parasitology, May 2007, Elsevier

    Paul Roepe

  35. Heterologous Expression and ATPase Activity of Mutant versus Wild Type PfMDR1 Protein

    Article • Biochemistry, May 2007, American Chemical Society (ACS)

    Paul Roepe

  36. Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms

    Article • Molecular and Biochemical Parasitology, December 2006, Elsevier

    Paul Roepe, Professor David A Fidock

  37. Spinning Disk Confocal Microscopy of Live, Intraerythrocytic Malarial Parasites. 2. Altered Vacuolar Volume Regulation in Drug Resistant Malaria

    Article • Biochemistry, September 2006, American Chemical Society (ACS)

    Paul Roepe

  38. Spinning Disk Confocal Microscopy of Live, Intraerythrocytic Malarial Parasites. 1. Quantification of Hemozoin Development for Drug Sensitive versus Resistant Malaria

    Article • Biochemistry, September 2006, American Chemical Society (ACS)

    Paul Roepe

  39. Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells

    Article • Molecular and Biochemical Parasitology, February 2005, Elsevier

    Paul Roepe

  40. Structure of the Amodiaquine−FPIX μ Oxo Dimer Solution Complex at Atomic Resolution

    Article • Inorganic Chemistry, November 2004, American Chemical Society (ACS)

    Paul Roepe

  41. The Antimalarial Drug Resistance Protein Plasmodium falciparum Chloroquine Resistance Transporter Binds Chloroquine

    Article • Biochemistry, June 2004, American Chemical Society (ACS)

    Paul Roepe

  42. NMR Studies of Chloroquine−Ferriprotoporphyrin IX Complex

    Article • The Journal of Physical Chemistry A, July 2003, American Chemical Society (ACS)

    Paul Roepe

  43. Purified Human MDR 1 Modulates Membrane Potential in Reconstituted Proteoliposomes

    Article • Biochemistry, March 2003, American Chemical Society (ACS)

    Paul Roepe

  44. Chloroquine resistance in the malarial parasite, Plasmodium falciparum

    Article • Medicinal Research Reviews, July 2002, Wiley

    Paul Roepe

  45. Solution Structures of Antimalarial Drug−Heme Complexes

    Article • Biochemistry, July 2002, American Chemical Society (ACS)

    Paul Roepe

  46. Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena

    Article • Molecular and Biochemical Parasitology, January 2001, Elsevier

    Paul Roepe

  47. Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

    Article • Molecular Cell, October 2000, Elsevier

    Paul Roepe, Professor David A Fidock

  48. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine

    Article • Molecular and Biochemical Parasitology, September 2000, Elsevier

    Paul Roepe

  49. Evidence for Altered Ion Transport inSaccharomyces cerevisiaeOverexpressing Human MDR 1 Protein

    Article • Biochemistry, March 1999, American Chemical Society (ACS)

    Paul Roepe

  50. Effects of Ion Gradients on H+ Transport Mediated by Human MDR 1 Protein

    Article • Biochemistry, March 1999, American Chemical Society (ACS)

    Paul Roepe

  51. Are ion-exchange processes central to understanding drug-resistance phenomena?

    Article • Trends in Pharmacological Sciences, February 1999, Elsevier

    Paul Roepe

  52. Analysis of Ion Transport Perturbations Caused by hu MDR 1 Protein Overexpression

    Article • Biochemistry, September 1997, American Chemical Society (ACS)

    Paul Roepe

  53. Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts

    Article • Biochemistry, September 1997, American Chemical Society (ACS)

    Paul Roepe

  54. Biophysical Aspects of P-Glycoprotein-Mediated Multidrug Resistance

    Article • January 1997, Elsevier

    Paul Roepe

  55. Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype

    Article • Biophysical Journal, September 1995, Elsevier

    Paul Roepe

  56. Drug transport mediated by P-glycoprotein may be secondary to electrochemical perturbations of the plasma membrane

    Article • Trends in Pharmacological Sciences, December 1994, Elsevier

    Paul Roepe

  57. Analysis of Drug Transport Kinetics in Multidrug-Resistant Cells Using a Novel Coumarin-Vinblastine Compound

    Article • Biochemistry, October 1994, American Chemical Society (ACS)

    Paul Roepe