All Stories

  1. Rapid reorganization of serotonin projections and antidepressant response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant cF1ko mice
  2. CaMKIV-Mediated Phosphorylation Inactivates Freud-1/CC2D1A Repression for Calcium-Dependent 5-HT1A Receptor Gene Induction
  3. Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety–Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice
  4. Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β
  5. Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models
  6. Rewiring of the Serotonin System in Major Depression
  7. Influence of functional gene polymorphisms on human behaviour: the case of CCR5
  8. Depression, dementia and immune dysregulation
  9. Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression
  10. Orphans to the rescue: orphan G-protein coupled receptors as new antidepressant targets
  11. The Transcription Factor Deaf1 Modulates Engrailed-1 Expression to Regulate Skin Appendage Fate
  12. Targeting Homer1a for Rapid Antidepressant Effects
  13. Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential
  14. The 5-HT1A receptor: Signaling to behavior
  15. Adult neuroplasticity: A new “cure” for major depression?
  16. Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm
  17. Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity
  18. Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment
  19. A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression
  20. Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes
  21. Is poststroke depression the same as major depression?
  22. Chronic Fluoxetine Induces Activity Changes in Recovery From Poststroke Anxiety, Depression, and Cognitive Impairment
  23. Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior
  24. Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression
  25. The adaptive brain in mental health: overcoming inherited risk factors
  26. Recruitment by the Repressor Freud-1 of Histone Deacetylase-Brg1 Chromatin Remodeling Complexes to Strengthen HTR1A Gene Repression
  27. Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice
  28. Persistent post-stroke depression in mice following unilateral medial prefrontal cortical stroke
  29. The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription
  30. Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies
  31. Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site
  32. COMT polymorphism modulates the resting‐state EEG alpha oscillatory response to acute nicotine in male non‐smokers
  33. Why is depression more prevalent in women?
  34. Evidence Revealing Deregulation of The KLF11-Mao A Pathway in Association with Chronic Stress and Depressive Disorders
  35. Genetic and Epigenetic Methods for Analysis of the Dopamine D2 Receptor Gene
  36. Editorial
  37. Stress-induced alterations in 5-HT1A receptor transcriptional modulators NUDR and Freud-1
  38. Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression
  39. Transcriptional Dys-regulation in Anxiety and Major Depression: 5-HT1A Gene Promoter Architecture as a Therapeutic Opportunity
  40. Light up your life: Optogenetics for depression?
  41. The Expression of KLF11 (TIEG2), a Monoamine Oxidase B Transcriptional Activator in the Prefrontal Cortex of Human Alcohol Dependence
  42. DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA*
  43. Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors
  44. Role of protein kinase C in agonist-induced desensitization of 5-HT1A receptor coupling to calcium channels in F11 cells
  45. The neurobiology of depression--revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies
  46. Drugs for kids: Good or bad?
  47. The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms
  48. Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
  49. Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression
  50. 17β-Estradiol-Induced Regulation of the Novel 5-HT1A-Related Transcription Factors NUDR and Freud-1 in SH SY5Y Cells
  51. Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice
  52. Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine‐induced adenylyl cyclase sensitization but not mitogen‐activated protein kinase phosphorylation
  53. What is a functional genetic polymorphism? Defining classes of functionality
  54. Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease
  55. The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder
  56. The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine
  57. Neurotensin Triggers Dopamine D2 Receptor Desensitization through a Protein Kinase C and β-Arrestin1-dependent Mechanism
  58. Region‐specific regulation of 5‐HT1A receptor expression by Pet‐1‐dependent mechanismsin vivo
  59. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
  60. Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene
  61. TNFAIP8: A new effector for Galpha(i) coupling to reduce cell death and induce cell transformation
  62. Epigenetics in mental illness: Hope or hype?
  63. A functional alternative splicing mutation in human tryptophan hydroxylase-2
  64. Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression
  65. Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism
  66. Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
  67. Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress
  68. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
  69. Human Freud-2/CC2D1B: A Novel Repressor of Postsynaptic Serotonin-1A Receptor Expression
  70. F.86. Deaf1 Isoforms Control Changes in Peripheral Tissue Antigen Gene Expression in the Non-obese Diabetic Mouse Pancreatic Lymph Node during Type I Diabetes Pathogenesis
  71. GAP1(IP4BP)/RASA3 Mediates Gαi-induced Inhibition of Mitogen-activated Protein Kinase
  72. Roles of G protein and β-arrestin in dopamine D 2 receptor-mediated ERK activation
  73. Transcriptional regulation at a HTR1A polymorphism associated with mental illness
  74. HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: Essential role in developmental expression
  75. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder
  76. A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
  77. Differential desensitization of dopamine D2 receptor isoforms by protein kinase C: The importance of receptor phosphorylation and pseudosubstrate sites
  78. Cell‐type specific induction of tryptophan hydroxylase‐2 transcription by calcium mobilization
  79. Characterization of rat rostral raphe primary cultures: Multiplex quantification of serotonergic markers
  80. The mental retardation gene CC2D1A/Freud‐1 encodes a long isoform that binds conserved DNA elements to repress gene transcription
  81. Computerized measurement of facial expression of emotions in schizophrenia
  82. Differential Repression by Freud-1/CC2D1A at a Polymorphic Site in the Dopamine-D2 Receptor Gene
  83. Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease
  84. Differential signaling of dopamine‐D2S and ‐D2L receptors to inhibit ERK1/2 phosphorylation
  85. The Freud‐1/CC2D1A family: Transcriptional regulators implicated in mental retardation
  86. [P123]: Characterization of rat rostral raphe primary cultures: A model for examining pre‐synaptic serotonergic neurons
  87. [P120]: Coordinated actions of Hes1, Hes5, Hes6 and NUDR on 5‐HT1A transcription at a functional polymorphism
  88. [P122]: Neuron‐specific calcium‐dependent induction of tryptophan hydroxylase‐2 (TPH2) transcription
  89. [P121]: Promoter recognition and repression of serotonin‐1A and dopamine‐D2 genes by Freud‐1/CC2D1A, a novel gene linked to mental retardation
  90. RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling
  91. Cell-Specific Repressor or Enhancer Activities of Deaf-1 at a Serotonin 1A Receptor Gene Polymorphism
  92. Molecular Determinants in the Second Intracellular Loop of the 5-Hydroxytryptamine-1A Receptor for G-Protein Coupling
  93. Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death
  94. Coupling of 5‐HT1A autoreceptors to inhibition of mitogen‐activated protein kinase activation via Gβγ subunit signaling
  95. 5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
  96. Association of the C(–1019)G 5-HT1A functional promoter polymorphism with antidepressant response
  97. The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1
  98. RGS17/RGSZ2, a Novel Regulator of Gi/o, Gz, and Gq Signaling
  99. Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells
  100. Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4
  101. Cell type‐dependent recruitment of trichostatin A‐sensitive repression of the human 5‐HT1A receptor gene
  102. 5-HT1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-κB to the nucleus
  103. Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gβγ-subunits in Balb/c-3T3 cells
  104. Growth Hormone-induced Diacylglycerol and Ceramide Formation via Gαi3 and Gβγ in GH4 Pituitary Cells
  105. Dopamine-D2S Receptor Inhibition of Calcium Influx, Adenylyl Cyclase, and Mitogen-Activated Protein Kinase in Pituitary Cells: Distinct Gα and Gβγ Requirements
  106. G Protein Preferences for Dopamine D2 Inhibition of Prolactin Secretion and DNA Synthesis in GH4 Pituitary Cells
  107. G protein specificity
  108. Editorial: Dopamine-D2-Mediated Inhibition of TRH-Induced PLC Activation in Pituitary Cells—Direct or Indirect?
  109. Editorial: Dopamine-D2-Mediated Inhibition of TRH-Induced PLC Activation in Pituitary Cells--Direct or Indirect?
  110. A critical protein kinase C phosphorylation site on the 5‐HT1A receptor controlling coupling to N‐type calcium channels
  111. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
  112. Transcriptional Mechanisms for Induction of 5-HT1AReceptor mRNA and Protein in Activated B and T Lymphocytes
  113. Distinct Roles for Gαi2 and Gβγ in Signaling to DNA Synthesis and Gαi3 in Cellular Transformation by Dopamine D2S Receptor Activation in BALB/c 3T3 Cells
  114. Novel Dual Repressor Elements for Neuronal Cell-specific Transcription of the Rat 5-HT1A Receptor Gene
  115. Constitutive Gi2-dependent Activation of Adenylyl Cyclase Type II by the 5-HT1A Receptor
  116. Stimulation of cAMP Synthesis by Gi-coupled Receptors upon Ablation of Distinct Gαi Protein Expression
  117. TATA‐Driven Transcriptional Initiation and Regulation of the Rat Serotonin 5‐HT1A Receptor Gene
  118. Distinct Roles for Gαi2, Gαi3, and Gβγ in Modulation of Forskolin- or Gs-mediated cAMP Accumulation and Calcium Mobilization by Dopamine D2S Receptors
  119. Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: Role in Desensitization of Endogenous  2C-Adrenergic but Not Serotonin 1B Receptors
  120. A Putative α‐helical Gβγ‐coupling Domain in the Second Intracellular Loop of the 5‐HT1A Receptora
  121. Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium
  122. Correspondence
  123. The 5-HT1A receptor: Signaling, desensitization, and gene transcription
  124. Antisense knockouts: molecular scalpels for the dissection of signal transduction
  125. Heterologous Expression of G Protein-Linked Receptors in Pituitary and Fibroblast Cell Lines
  126. Deletions of the Synenkephalin Domain Which Do Not Alter Cell‐Specific Proteolytic Processing or Secretory Targeting of Human Proenkephalin
  127. Differential Sensitivity of the Short and Long Human Dopamine D2Receptor Subtypes to Protein Kinase C
  128. Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A.
  129. Molecular biology of the 5-HT1A receptor: Low-stringency cloning and eukaryotic expression
  130. The next frontier in the molecular biology of the opioid system