All Stories

  1. Advances in LC: bioanalytical method transfer

    Article • Bioanalysis, September 2016, Future Science

    Dr Patricia A Wright

  2. Predicting collision-induced dissociation mass spectra: understanding the role of the mobile proton in small molecule fragmentation

    Article • Rapid Communications in Mass Spectrometry, April 2016, Wiley

    Dr Patricia A Wright

  3. Can computational chemistry be used to predict CID fragmentation of anions?

    Article • Rapid Communications in Mass Spectrometry, November 2015, Wiley

    Dr Patricia A Wright

  4. How useful is molecular modelling in combination with ion mobility mass spectrometry for ‘small molecule’ ion mobility collision cross-sections?

    Article • The Analyst, January 2015, Royal Society of Chemistry

    Mr Cris Lapthorn, Dr Patricia A Wright

  5. Predicting collision-induced dissociation spectra: Semi-empirical calculations as a rapid and effective tool in software-aided mass spectral interpretation

    Article • Rapid Communications in Mass Spectrometry, April 2014, Wiley

    Dr Patricia A Wright

  6. 3D thinking: computational aids for the bioanalyst

    Article • Bioanalysis, February 2013, Future Science

    Dr Patricia A Wright

  7. Understanding collision-induced dissociation of dofetilide: a case study in the application of density functional theory as an aid to mass spectral interpretation

    Article • The Analyst, January 2013, Royal Society of Chemistry

    Dr Patricia A Wright

  8. The low-energy collision-induced dissociation product ion spectra of protonated beta-blockers reveal an analogy to fragmentation behaviour under electron ionisation conditions

    Article • Journal of Mass Spectrometry, November 2011, Wiley

    Dr Patricia A Wright

  9. Metabolite identification by mass spectrometry: forty years of evolution

    Article • Xenobiotica, March 2011, Taylor & Francis

    Dr Patricia A Wright

  10. Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

    Article • Bioanalysis, July 2010, Future Science

    Dr Patricia A Wright

  11. Using density functional theory to rationalise the mass spectral fragmentation of maraviroc and its metabolites

    Article • Rapid Communications in Mass Spectrometry, April 2010, Wiley

    Dr Patricia A Wright

  12. A Rapid Methodology for the Characterization of Dialkyl Tertiary Amine- N -Oxide Metabolites Using Structurally Dependent Dissociation Pathways and Reconstructed Ion Current Chromatograms

    Article • Analytical Chemistry, March 2010, American Chemical Society (ACS)

    Dr Patricia A Wright

  13. Evidence for site-specific intra-ionic hydrogen/deuterium exchange in the low-energy collision-induced dissociation product ion spectra of protonated small molecules generated by electrospray ionisation

    Article • Journal of Mass Spectrometry, January 2010, Wiley

    Dr Patricia A Wright

  14. Chapter 4. Primary, Secondary and Tertiary Amines and their Isosteres

    Article • January 2010, Royal Society of Chemistry

    Dr Patricia A Wright

  15. A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

    Article • Chemical Research in Toxicology, October 2009, American Chemical Society (ACS)

    Dr Patricia A Wright

  16. Can density functional theory (DFT) be used as an aid to a deeper understanding of tandem mass spectrometric fragmentation pathways?

    Article • Rapid Communications in Mass Spectrometry, September 2009, Wiley

    Dr Patricia A Wright

  17. SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

    Article • Bioorganic & Medicinal Chemistry Letters, August 2009, Elsevier

    Dr Patricia A Wright

  18. High‐throughput approaches towards the definitive identification of pharmaceutical drug metabolites. 2. An example of how unexpected dissociation behaviour could preclude correct assignment of sites of metabolism

    Article • Rapid Communications in Mass Spectrometry, July 2009, Wiley

    Dr Patricia A Wright

  19. Metabolite quantitation: detector technology and MIST implications

    Article • Bioanalysis, July 2009, Future Science

    Dr Patricia A Wright

  20. High‐throughput approaches towards the definitive identification of pharmaceutical drug metabolites. 1. Evidence for anorthoeffect on the fragmentation of 4‐benzenesulfinyl‐3‐methylphenylamine using electrospray ionisation mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, August 2008, Wiley

    Dr Patricia A Wright

  21. Evolution of an open-access quantitative bioanalytical mass spectrometry service in a drug discovery environment

    Article • Biomedical Chromatography, January 2006, Wiley

    Dr Patricia A Wright

  22. Characterisation of sulphoxides by atmospheric pressure ionisation mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 2005, Wiley

    Dr Patricia A Wright

  23. Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog

    Article • Xenobiotica, January 2001, Taylor & Francis

    Dr Patricia A Wright

  24. Direct analysis of crude plasma samples by turbulent flow chromatography/tandem mass spectrometry

    Article • Chromatographia, February 2000, Springer Science + Business Media

    Dr Patricia A Wright

  25. Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

    Article • Xenobiotica, January 1999, Taylor & Francis

    Dr Patricia A Wright

  26. Chlorpromazine inhibition of melatonin metabolism by normal and induced rat liver microsomes

    Article • European Journal of Drug Metabolism and Pharmacokinetics, October 1987, Springer Science + Business Media

    Dr Patricia A Wright