All Stories

  1. Animal Models in Neuroscience: What Is the “Culture of Care”?

    Article • Encyclopedia, February 2024, MDPI AG

    Paola Bonsi

  2. Animal Models in Neuroscience: What “Culture of Care”?

    Article • November 2023, MDPI AG

    Paola Bonsi

  3. Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human

    Article • Biomedicines, May 2023, MDPI AG

    Paola Bonsi

  4. Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease From Mice to Human

    Article • May 2023, MDPI AG

    Paola Bonsi

  5. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Paola Bonsi

  6. Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson

    Article • March 2023, MDPI AG

    Paola Bonsi

  7. Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson

    Article • February 2023, MDPI AG

    Paola Bonsi

  8. Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction

    Article • Movement Disorders, April 2022, Wiley

    Paola Bonsi

  9. Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission

    Article • International Journal of Molecular Sciences, March 2022, MDPI AG

    Paola Bonsi

  10. Postsynaptic autism spectrum disorder genes and synaptic dysfunction

    Article • Neurobiology of Disease, January 2022, Elsevier

    Paola Bonsi

  11. Exploitation of Thermal Sensitivity and Hyperalgesia in a Mouse Model of Dystonia

    Article • Life, September 2021, MDPI AG

    Paola Bonsi

  12. Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia

    Article • Movement Disorders, June 2021, Wiley

    Paola Bonsi

  13. Effect of Gabapentin in a Neuropathic Pain Model in Mice Overexpressing Human Wild-Type or Human Mutated Torsin A

    Article • Life, January 2021, MDPI AG

    Paola Bonsi

  14. The neuroligins and the synaptic pathway in Autism Spectrum Disorder

    Article • Neuroscience & Biobehavioral Reviews, December 2020, Elsevier

    Paola Bonsi

  15. Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data

    Article • Parkinsonism & Related Disorders, May 2020, Elsevier

    Paola Bonsi

  16. Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia

    Article • Cell Reports, May 2020, Elsevier

    Paola Bonsi

  17. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia

    Article • Neurobiology of Disease, October 2019, Elsevier

    Paola Bonsi

  18. The neurobiological basis for novel experimental therapeutics in dystonia

    Article • Neurobiology of Disease, July 2019, Elsevier

    Paola Bonsi

  19. Novel therapeutic target in DYT1 dystonia

    Article • EMBO Molecular Medicine, December 2018, EMBO

    Paola Bonsi

  20. Synaptic Plasticity Changes: Hallmark for Neurological and Psychiatric Disorders

    Article • Neural Plasticity, October 2018, Hindawi Publishing Corporation

    Paola Bonsi, Professor Angelo Quartarone

  21. Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum

    Article • eLife, March 2018, eLife

    Paola Bonsi

  22. Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition

    Article • Neurobiology of Disease, December 2017, Elsevier

    Paola Bonsi

  23. Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia

    Article • Movement Disorders, November 2017, Wiley

    Paola Bonsi

  24. Synaptic plasticity alterations in the dorsal striatum of the R451C-Neuroligin3 model of ASD

    Article • European Journal of Neuroscience, October 2017, Wiley

    Paola Bonsi

  25. Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia

    Article • Journal of Neuroscience, January 2017, Society for Neuroscience

    Paola Bonsi

  26. Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

    Article • Neurobiology of Disease, July 2016, Elsevier

    PhD Georgia Mandolesi, Paola Bonsi

  27. Dopamine-dependent CB 1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice

    Article • Neuropharmacology, February 2016, Elsevier

    Paola Bonsi

  28. Optogenetic stimulation reveals distinct modulatory properties of thalamostriatal vs corticostriatal glutamatergic inputs to fast-spiking interneurons

    Article • Scientific Reports, November 2015, Nature

    PhD Georgia Mandolesi, Paola Bonsi

  29. Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia

    Article • Experimental Neurology, September 2015, Elsevier

    PhD Georgia Mandolesi, Paola Bonsi

  30. Rhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons

    Article • Neurobiology of Disease, June 2015, Elsevier

    Paola Bonsi

  31. Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia

    Article • Progress in Neurobiology, April 2015, Elsevier

    Paola Bonsi

  32. Opposite changes of Phosphodiesterase-10A in striato-pallidal and striato-entopeduncular pathways of TorsinA DYT1 transgenic mice

    Article • Frontiers in Neurology, January 2015, Frontiers

    Paola Bonsi

  33. Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia

    Article • Neuropharmacology, October 2014, Elsevier

    Paola Bonsi

  34. Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1muscarinic receptors

    Article • Movement Disorders, September 2014, Wiley

    Paola Bonsi

  35. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia

    Article • Neurobiology of Disease, May 2014, Elsevier

    PhD Georgia Mandolesi, Paola Bonsi

  36. Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum

    Article • Neuropharmacology, December 2013, Elsevier

    Paola Bonsi

  37. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity

    Article • Movement Disorders, October 2013, Wiley

    Dr Mauro Federici, Paola Bonsi

  38. Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry

    Article • PLoS ONE, June 2013, PLOS

    PhD Georgia Mandolesi, Paola Bonsi

  39. Critical role of calcitonin gene-related peptide receptors in cortical spreading depression

    Article • Proceedings of the National Academy of Sciences, October 2012, Proceedings of the National Academy of Sciences

    Paola Bonsi

  40. Cholinergic Dysfunction Alters Synaptic Integration between Thalamostriatal and Corticostriatal Inputs in DYT1 Dystonia

    Article • Journal of Neuroscience, August 2012, Society for Neuroscience

    PhD Georgia Mandolesi, Paola Bonsi

  41. Aberrant striatal synaptic plasticity in monogenic parkinsonisms

    Article • Neuroscience, June 2012, Elsevier

    Paola Bonsi

  42. Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia

    Article • PLoS ONE, September 2011, PLOS

    PhD Georgia Mandolesi, Paola Bonsi

  43. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission

    Article • Neuropharmacology, September 2011, Elsevier

    Paola Bonsi

  44. Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease

    Article • Neuroscience, March 2011, Elsevier

    Paola Bonsi

  45. Experimental Models of Dystonia

    Article • January 2011, Elsevier

    Paola Bonsi

  46. Centrality of Striatal Cholinergic Transmission in Basal Ganglia Function

    Article • Frontiers in Neuroanatomy, January 2011, Frontiers

    Paola Bonsi

  47. Electrophysiology of 5-HT6 Receptors

    Article • January 2010, Elsevier

    Paola Bonsi

  48. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine

    Article • Brain, July 2009, Oxford University Press (OUP)

    Paola Bonsi

  49. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+currents and intracellular Ca2+increase in rat cortical neurons in vitro

    Article • Epilepsia, April 2009, Wiley

    Paola Bonsi

  50. Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia

    Article • Neurobiology of Disease, April 2009, Elsevier

    Paola Bonsi

  51. Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin

    Article • Experimental Neurology, February 2009, Elsevier

    Paola Bonsi

  52. Distinct roles of group I mGlu receptors in striatal function

    Article • Neuropharmacology, September 2008, Elsevier

    Paola Bonsi

  53. Loss of Muscarinic Autoreceptor Function Impairs Long-Term Depression But Not Long-Term Potentiation in the Striatum

    Article • Journal of Neuroscience, June 2008, Society for Neuroscience

    Paola Bonsi

  54. Age-related functional changes of high-voltage-activated calcium channels in different neuronal subtypes of mouse striatum

    Article • Neuroscience, March 2008, Elsevier

    Paola Bonsi

  55. Impaired dopamine release and synaptic plasticity in the striatum of PINK1 -deficient mice

    Article • Proceedings of the National Academy of Sciences, July 2007, Proceedings of the National Academy of Sciences

    Paola Bonsi

  56. Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons

    Article • European Journal of Neuroscience, April 2007, Wiley

    Paola Bonsi

  57. Endogenous Serotonin Excites Striatal Cholinergic Interneurons via the Activation of 5-HT 2C, 5-HT6 and 5-HT7 Serotonin Receptors: Implications for Extrapyramidal Side Effects of Serotonin Reuptake Inhibitors

    Article • Neuropsychopharmacology, January 2007, Nature

    Paola Bonsi

  58. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia

    Article • Neurobiology of Disease, November 2006, Elsevier

    Paola Bonsi

  59. NR2B Subunit Exerts a Critical Role in Postischemic Synaptic Plasticity

    Article • Stroke, July 2006, Wolters Kluwer Health

    Paola Bonsi

  60. Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson’s disease

    Article • Amino Acids, May 2006, Springer Science + Business Media

    Paola Bonsi

  61. Plastic and behavioral abnormalities in experimental Huntington's disease: A crucial role for cholinergic interneurons

    Article • Neurobiology of Disease, April 2006, Elsevier

    Paola Bonsi

  62. Mitochondrial Toxins in Basal Ganglia Disorders: From Animal Models to Therapeutic Strategies

    Article • Current Neuropharmacology, January 2006, Bentham Science Publishers

    Paola Bonsi

  63. Pathological Synaptic Plasticity in the Striatum: Implications for Parkinson's Disease

    Article • NeuroToxicology, October 2005, Elsevier

    Paola Bonsi

  64. Inhibition of Persistent Sodium Current Fraction and Voltage-gated L-type Calcium Current by Propofol in Cortical Neurons: Implications for Its Antiepileptic Activity

    Article • Epilepsia, May 2005, Wiley

    Paola Bonsi

  65. Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons

    Article • Neuropharmacology, January 2005, Elsevier

    Paola Bonsi

  66. Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons

    Article • Learning & Memory, November 2004, Cold Spring Harbor Laboratory Press

    Paola Bonsi

  67. Calcium signaling and neuronal vulnerability to ischemia in the striatum

    Article • Cell Calcium, September 2004, Elsevier

    Paola Bonsi

  68. Intracellular Calcium Increase in Epileptiform Activity: Modulation by Levetiracetam and Lamotrigine

    Article • Epilepsia, July 2004, Wiley

    Paola Bonsi

  69. Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons

    Article • Experimental Neurology, January 2004, Elsevier

    Paola Bonsi

  70. Targeting striatal cholinergic interneurons in Parkinson's disease: Focus on metabotropic glutamate receptors

    Article • Neuropharmacology, July 2003, Elsevier

    Paola Bonsi

  71. Stimulus frequency, calcium levels and striatal synaptic plasticity

    Article • Neuroreport, March 2003, Wolters Kluwer Health

    Paola Bonsi

  72. Behavioural learning-induced increase in spontaneous GABAA-dependent synaptic activity in rat striatal cholinergic interneurons

    Article • European Journal of Neuroscience, December 2002, Wiley

    Paola Bonsi

  73. Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes

    Article • Neuroreport, April 2002, Wolters Kluwer Health

    Paola Bonsi

  74. Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation

    Article • Neuroreport, January 2002, Wolters Kluwer Health

    Paola Bonsi

  75. Dopamine-Dependent Long-Term Potentiation Induced by 3-Nitropropionic Acid in Striatal Medium Spiny Neurons

    Article • January 2002, Springer Science + Business Media

    Paola Bonsi

  76. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons

    Article • Neuroscience, September 2001, Elsevier

    Paola Bonsi

  77. Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells

    Article • Neuroscience Letters, September 2001, Elsevier

    Paola Bonsi

  78. Selective involvement of mGlu1 receptors in corticostriatal LTD

    Article • Neuropharmacology, June 2001, Elsevier

    Paola Bonsi

  79. Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

    Article • Neuropharmacology, March 2001, Elsevier

    Paola Bonsi

  80. An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease

    Article • Neurological Sciences, February 2001, Springer Science + Business Media

    Paola Bonsi

  81. Role of tonically-active neurons in the control of striatal function: Cellular mechanisms and behavioral correlates

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, January 2001, Elsevier

    Paola Bonsi

  82. Cell-type specificity of mGluR activation in striatal neuronal subtypes

    Article • Amino Acids, August 2000, Springer Science + Business Media

    Paola Bonsi

  83. Involvement of Intracellular Calcium Stores during Oxygen/Glucose Deprivation in Striatal Large Aspiny Interneurons

    Article • Journal of Cerebral Blood Flow & Metabolism, May 2000, SAGE Publications

    Paola Bonsi

  84. Toxicity of Selected Plant Volatiles in Microbial and Mammalian Short-term Assays

    Article • Food and Chemical Toxicology, August 1999, Elsevier

    Paola Bonsi

  85. Aflatoxin B1 is an inhibitor of cyclic nucleotide

    Article • General Pharmacology The Vascular System, May 1999, Elsevier

    Paola Bonsi

  86. Activities of 3′:5′ cyclic nucleotide phosphodiesterases in the superior cervical ganglion of rat: Characterization, compartmentalization and observations in young and old animals

    Article • Neurochemistry International, November 1994, Elsevier

    Paola Bonsi

  87. Short and Long Term Modulation of Synaptic Activity in Striatal Cholinergic Interneurons

    Article • Springer Science + Business Media

    Paola Bonsi