All Stories

  1. Influence of type-4 dipeptidyl peptidase inhibition on endothelium-dependent relaxation of aortae from a db/db mouse model of type 2 diabetes: a comparison with the effect of glimepiride
  2. Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases
  3. Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation
  4. Protection against reperfusion injury by 3′,4′-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2
  5. 3′,4′-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice
  6. A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4
  7. New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury
  8. Molecular Sensors of Blood Flow in Endothelial Cells
  9. Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response
  10. Western Diet Chow Consumption in Rats Induces Striatal Neuronal Activation While Reducing Dopamine Levels without Affecting Spatial Memory in the Radial Arm Maze
  11. Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice
  12. The HNO donor Angeli’s salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia–reperfusion injury in the rat heart ex vivo
  13. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Preserves Endothelial Function in Mesenteric Arteries from Type 1 Diabetic Rats without Decreasing Plasma Glucose
  14. Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia–reperfusion injury by 3′,4′-dihydroxyflavonol
  15. Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction
  16. The DPP-4 inhibitor linagliptin and the GLP-1 receptor agonist exendin-4 improve endothelium-dependent relaxation of rat mesenteric arteries in the presence of high glucose
  17. Cardioprotective potential of annexin-A1 mimetics in myocardial infarction
  18. Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress
  19. Microglia are Selectively Activated in Endocrine and Cardiovascular Control Centres in Streptozotocin-Induced Diabetic Rats
  20. The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase‐dependent and ‐independent mechanisms
  21. The flavonols quercetin and 3′,4′-dihydroxyflavonol reduce platelet function and delay thrombus formation in a model of type 1 diabetes
  22. The cardioprotectant 3′,4′-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats
  23. Cardioprotective 3′,4′-dihydroxyflavonol attenuation of JNK and p38MAPKsignalling involves CaMKII inhibition
  24. Effect of type 1 diabetes on the production and vasoactivity of hydrogen sulfide in rat middle cerebral arteries
  25. Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function
  26. Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3′,4′-dihydroxyflavonol and quercetin
  27. Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta
  28. Treatment with quercetin and 3′,4′-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo
  29. Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes
  30. 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition
  31. 3′,4′-Dihydroxyflavonol reduces vascular contraction through Ca2+ desensitization in permeabilized rat mesenteric artery
  32. Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts
  33. The ethanolic extract of Kaempferia parviflora reduces ischaemic injury in rat isolated hearts
  34. Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3′,4′-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury
  35. 3′,4′-Dihydroxyflavonol Antioxidant Attenuates Diastolic Dysfunction and Cardiac Remodeling in Streptozotocin-Induced Diabetic m(Ren2)27 Rats
  36. 3′,4′-Dihydroxyflavonol Reduces Superoxide and Improves Nitric Oxide Function in Diabetic Rat Mesenteric Arteries
  37. 3′,4′-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes
  38. Cardioprotection from ischaemia–reperfusion injury by a novel flavonol that reduces activation of p38 MAPK
  39. Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart
  40. Impairment of both nitric oxide-mediated and EDHF-type relaxation in small mesenteric arteries from rats with streptozotocin-induced diabetes
  41. Comprehensive two-dimensional gas chromatography, retention indices and time-of-flight mass spectra of flavonoids and chalcones
  42. Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids
  43. Effects of resveratrol and flavonols on cardiovascular function: Physiological mechanisms
  44. Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery
  45. High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy
  46. Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening
  47. Effects of 3’,4’-dihydroxyflavonol on vascular contraction in rat aortic rings
  48. 3′,4′-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7days reperfusion in sheep
  49. Antioxidants in the prevention of myocardial ischemia/reperfusion injury
  50. 3′,4′-Dihydroxyflavonol prevents diabetes-induced endothelial dysfunction in rat aorta
  51. Annexin-1 peptide Anx-12-26 protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia
  52. Discovery of Water-Soluble Antioxidant Flavonols without Vasorelaxant Activity
  53. Atrial natriuretic peptide prevents diabetes-induced endothelial dysfunction
  54. Using behaviour to predict stroke severity in conscious rats: Post-stroke treatment with 3′, 4′-dihydroxyflavonol improves recovery
  55. OESTROGEN AND VASCULOPROTECTION
  56. Understanding the Cardioprotective Effects of Flavonols: Discovery of Relaxant Flavonols without Antioxidant Activity
  57. Isoflavones, Equol and Cardiovascular Disease: Pharmacological and Therapeutic Insights
  58. TYPE 1 DIABETES AND HYPERCHOLESTEROLAEMIA REVEAL THE CONTRIBUTION OF ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR TO ENDOTHELIUM-DEPENDENT RELAXATION OF THE RAT AORTA
  59. Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries
  60. The Red Wine Antioxidant Resveratrol Prevents Cardiomyocyte Injury Following Ischemia-Reperfusion Via Multiple Sites and Mechanisms
  61. Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes
  62. Sodium Nitroprusside Protects Adult Rat Cardiac Myocytes From Cellular Injury Induced by Simulated Ischemia
  63. Vasorelaxant and Antioxidant Activity of Flavonols and Flavones: Structure-Activity Relationships
  64. VASCULAR AND ANTI-OXIDANT ACTIONS OF FLAVONOLS AND FLAVONES
  65. Daidzein and 17β-Estradiol Enhance Nitric Oxide Synthase Activity Associated with an Increase in Calmodulin and a Decrease in Caveolin-1
  66. 3′,4′-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep
  67. ISCHAEMIA ENHANCES THE ROLE OF CA2+-ACTIVATED K+ CHANNELS IN ENDOTHELIUM-DEPENDENT AND NITRIC OXIDE-MEDIATED DILATATION OF THE RAT HINDQUARTERS VASCULATURE
  68. Selective vasodilator and chronotropic actions of 3′,4′-dihydroxyflavonol in conscious sheep
  69. Effect of Short-Term Phytoestrogen Treatment in Male Rats on Nitric Oxide-Mediated Responses of Carotid and Cerebral Arteries: Comparison with 17β-Estradiol
  70. Chronic treatment of male rats with daidzein and 17β-oestradiol induces the contribution of EDHF to endothelium-dependent relaxation
  71. 3′, 4′-Dihydroxyflavonol Enhances Nitric Oxide Bioavailability and Improves Vascular Function after Ischemia and Reperfusion Injury in the Rat
  72. Pharmacological approaches to preserving and restoring coronary endothelial function
  73. Relaxation to Flavones and Flavonols in Rat Isolated Thoracic Aorta: Mechanism of Action and Structure-Activity Relationships
  74. Contribution Of Nitric Oxide, Cyclic Gmp And K+ Channels To Acetylcholine-Induced Dilatation Of Rat Conduit And Resistance Arteries
  75. Enhanced role for the opening of potassium channels in relaxant responses to acetylcholine after myocardial ischaemia and reperfusion in dog coronary arteries
  76. Rabbit mononuclear leukocytes cause contraction of isolated aorta by the release of serotonin
  77. PRECONDITIONING IMPROVES MYOCARDIAL FUNCTION AND REFLOW, BUT NOT VASODILATOR REACTIVITY, AFTER ISCHAEMIA AND REPERFUSION IN ANAESTHETIZED DOGS
  78. Prevention of ischaemia-induced coronary vascular dysfunction
  79. Effect of ischaemic preconditioning on vascular dysfunction induced by ischaemia and reperfusion in rat hindquarters
  80. The effect of ischaemia on endothelium-dependent vasodilatation and adrenoceptor-mediated vasoconstriction in rat isolated hearts
  81. MODULATION OF VASOCONSTRICTION BY ENDOTHELIUM-DERIVED NITRIC OXIDE: THE INFLUENCE OF VASCULAR DISEASE
  82. Enhancement of noradrenergic constriction of large coronary arteries by inhibition of nitric oxide synthesis in anaesthetized dogs
  83. Requirement for endothelium-derived nitric oxide in vasodilatation produced by stimulation of cholinergic nerves in rat hindquarters
  84. INVOLVEMENT OF NITRIC OXIDE IN CORONARY VASCULAR RESPONSES TO 5-HYDROXYTRYPTAMINE IN THE ANAESTHETIZED GREYHOUND
  85. Cholinergic neurogenic vasodilatation is mediated by nitric oxide in the dog hindlimb
  86. Ischaemia/Reperfusion Enhances Phenylephrine-Induced Contraction of Rabbit Aorta Due to Impairment of Neuronal Uptake
  87. VASOCONSTRICTOR RESPONSES TO POLYMORPHONUCLEAR LEUCOCYTES FROM ATHEROSCLEROTIC RABBITS
  88. Impaired Vasodilator Function of Nitric Oxide Associated with Developing Neo-lntima in Conscious Rabbits
  89. Myocardial ischaemia: What happens to the coronary arteries?
  90. Allopurinol and amlodipine improve coronary vasodilatation after myocardial ischaemia and reperfusion in anaesthetized dogs
  91. Involvement of dopamine in control of renal blood flow
  92. Baroreceptor reflexes and vascular reactivity during inhibition of nitric oxide synthesis in conscious rabbits
  93. Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol
  94. The effect of hypercholesterolaemia and atherosclerosis on α-adrenoceptor-mediated vasoconstriction in conscious rabbits and rabbit aorta
  95. EFFECT OF TOLERANCE TO GLYCERYL TRINITRATE ON VASCULAR RESPONSES IN CONSCIOUS RABBITS
  96. N-nitro l-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds
  97. ENHANCED VASOCONSTRICTION BY SEROTONIN IN RABBIT CAROTID ARTERIES WITH ATHEROMA-LIKE LESIONS IN VIVO
  98. Kinin receptors mediating the effects of bradykinin on the coronary circulation in anaesthetized greyhounds
  99. Coronary vascular responses to nicotine in the anaesthetized dog
  100. Coronary vascular responses to nicotine In anaesthetized dogs
  101. Endothelium-dependent vasoconstriction induced by rabbit polymorphonuclear leucocytes
  102. Enhanced coronary vasoconstrictor responses to 5-hydroxytryptamine in the presence of a coronary artery stenosis in anaesthetized dogs
  103. Impaired vasodilatation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs
  104. Noradrenaline-induced constriction of large and small coronary arteries in the anaesthetized dog
  105. Adrenoceptor subtypes involved in the baroreceptor reflex constriction of large coronary arteries in the anaesthetized dog
  106. THE EFFECT OF THE CAROTID SINUS REFLEX ON LARGE CORONARY ARTERY DIAMETER IN ANAESTHETIZED DOGS
  107. The role of ?1- and ?2-adrenoceptors in the coronary vasoconstrictor responses to neuronally released and exogenous noradrenaline in the dog
  108. Pericardial Release of Prostacyclin Induced by Bradykinin and Angiotensin II
  109. Prostacyclin produced by the pericardium and its influence on coronary vascular tone
  110. Coronary vasoconstriction induced by leukotrienes in the anaesthetized dog
  111. COMPARISON OF THE VASODILATOR ACTION OF DOPAMINE AND DOPAMINE AGONISTS IN THE RENAL AND CORONARY BEDS OF THE DOG