All Stories

  1. Blood plasma biomarkers for Alzheimer’s disease: Aβ1–42/1–40 vs. AβX–42/X–40

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), October 2023, De Gruyter

    Oliver Wirths

  2. Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer’s disease

    Article • Expert Opinion on Therapeutic Targets, December 2019, Taylor & Francis

    Oliver Wirths

  3. N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo

    Article • Journal of Alzheimer s Disease, February 2019, IOS Press

    Oliver Wirths

  4. Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer’s Disease

    Article • ASN NEURO, January 2019, SAGE Publications

    Oliver Wirths

  5. A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

    Article • Alzheimer s Research & Therapy, December 2018, Springer Science + Business Media

    Oliver Wirths

  6. The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

    Article • Acta Neuropathologica, November 2018, Springer Science + Business Media

    Oliver Wirths, Steffen E. Storck

  7. Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

    Article • Acta Neuropathologica Communications, October 2018, Springer Science + Business Media

    Oliver Wirths

  8. The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease

    Article • Acta Neuropathologica Communications, July 2018, Springer Science + Business Media

    Oliver Wirths

  9. Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

    Article • Frontiers in Aging Neuroscience, March 2018, Frontiers

    Oliver Wirths

  10. N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

    Article • Alzheimer s Research & Therapy, October 2017, Springer Science + Business Media

    Oliver Wirths

  11. Altered neurogenesis in mouse models of Alzheimer disease

    Article • Neurogenesis, January 2017, Taylor & Francis

    Oliver Wirths, Oliver Wirths

  12. Extraction of Soluble and Insoluble Protein Fractions from Mouse Brains and Spinal Cords

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Oliver Wirths

  13. Preparation of Crude Synaptosomal Fractions from Mouse Brains and Spinal Cords

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Oliver Wirths

  14. Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice

    Article • Frontiers in Molecular Neuroscience, August 2016, Frontiers

    Oliver Wirths

  15. Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

    Article • Translational Psychiatry, May 2016, Springer Science + Business Media

    Oliver Wirths

  16. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models

    Article • Acta Neuropathologica Communications, March 2016, Springer Science + Business Media

    Oliver Wirths

  17. The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte DifferentiationIn Vitroand Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination

    Article • CNS Neuroscience & Therapeutics, February 2016, Wiley

    Oliver Wirths

  18. Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer’s Disease

    Article • Molecular Neurobiology, January 2016, Springer Science + Business Media

    Oliver Wirths

  19. Alzheimer’s Disease

    Article • January 2016, Springer Science + Business Media

    Oliver Wirths

  20. Immunotherapy Against N-Truncated Amyloid-β Oligomers

    Article • January 2016, Springer Science + Business Media

    Oliver Wirths

  21. Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s Disease

    Article • Journal of Alzheimer s Disease, November 2015, IOS Press

    Oliver Wirths

  22. N-Truncated Aβ2-X Starting with Position Two in Sporadic Alzheimer’s Disease Cases and Two Alzheimer Mouse Models

    Article • Journal of Alzheimer s Disease, September 2015, IOS Press

    Oliver Wirths

  23. Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease

    Article • Journal of Alzheimer s Disease, April 2015, IOS Press

    Oliver Wirths

  24. Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease

    Article • Journal of Alzheimer s Disease, February 2015, IOS Press

    Oliver Wirths

  25. I716F AβPP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-β and α-Synucleinopathy with Lewy Bodies

    Article • Journal of Alzheimer s Disease, January 2015, IOS Press

    Oliver Wirths

  26. Immunocytochemical Detection of Intraneuronal Aβ Peptides in Mouse Models of Alzheimer’s Disease

    Article • January 2015, Springer Science + Business Media

    Oliver Wirths

  27. Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

    Article • Frontiers in Aging Neuroscience, June 2014, Frontiers

    Oliver Wirths

  28. Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease

    Article • Acta Neuropathologica, May 2014, Springer Science + Business Media

    Oliver Wirths

  29. Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing

    Article • Frontiers in Aging Neuroscience, April 2014, Frontiers

    Oliver Wirths

  30. Aβ38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

    Article • Journal of Alzheimer s Disease, February 2014, IOS Press

    Oliver Wirths

  31. Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice

    Article • Neuropathology and Applied Neurobiology, January 2014, Wiley

    Oliver Wirths

  32. Abundance of Aβ5-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

    Article • Molecular Neurodegeneration, January 2014, Springer Science + Business Media

    Oliver Wirths

  33. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, November 2013, Elsevier

    Oliver Wirths

  34. Oligomeric Pyroglutamate Amyloid-β is Present in Microglia and a Subfraction of Vessels in Patients with Alzheimer's Disease: Implications for Immunotherapy

    Article • Journal of Alzheimer s Disease, May 2013, IOS Press

    Oliver Wirths

  35. N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

    Article • Acta Neuropathologica, May 2013, Springer Science + Business Media

    Oliver Wirths

  36. Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias

    Article • Neurobiology of Aging, May 2013, Elsevier

    Oliver Wirths

  37. Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer’s disease

    Article • Acta Neuropathologica, March 2013, Springer Science + Business Media

    Oliver Wirths

  38. N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

    Article • Acta Neuropathologica Communications, January 2013, Springer Science + Business Media

    Oliver Wirths

  39. Problems During Aging (Alzheimer’s and Others)

    Article • January 2013, Springer Science + Business Media

    Oliver Wirths

  40. The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

    Article • Acta Neuropathologica Communications, January 2013, Springer Science + Business Media

    Oliver Wirths

  41. Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

    Article • Life Sciences, December 2012, Elsevier

    Oliver Wirths

  42. Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells

    Article • American Journal Of Pathology, April 2012, Elsevier

    Oliver Wirths

  43. No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, April 2012, Elsevier

    Oliver Wirths

  44. Antibody 9D5 Recognizes Oligomeric Pyroglutamate Amyloid-β in a Fraction of Amyloid-β Deposits in Alzheimer's Disease without Cross-Reactivity with other Protein Aggregates

    Article • Journal of Alzheimer s Disease, March 2012, IOS Press

    Prof. Herbert Budka, Oliver Wirths

  45. AβPP Accumulation and/or Intraneuronal Amyloid-β Accumulation? The 3xTg-AD Mouse Model Revisited

    Article • Journal of Alzheimer s Disease, February 2012, IOS Press

    Oliver Wirths

  46. Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Oliver Wirths

  47. Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice

    Article • Neurobiology of Aging, January 2012, Elsevier

    Oliver Wirths

  48. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, January 2012, Elsevier

    Oliver Wirths

  49. Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

    Article • Journal of Biological Chemistry, September 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Oliver Wirths

  50. Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

    Article • Neurobiology of Aging, August 2011, Elsevier

    Oliver Wirths

  51. Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?

    Article • Biochemical Society Transactions, July 2011, Portland Press Ltd.

    Oliver Wirths

  52. Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

    Article • Journal of Biological Chemistry, December 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Oliver Wirths

  53. Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease

    Article • Journal of Biological Chemistry, October 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Oliver Wirths

  54. Concomitant detection of β-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice

    Article • Journal of Chemical Neuroanatomy, September 2010, Elsevier

    Oliver Wirths

  55. Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, July 2010, Elsevier

    Oliver Wirths

  56. Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, May 2010, Elsevier

    Oliver Wirths

  57. Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients

    Article • The World Journal of Biological Psychiatry, March 2010, Taylor & Francis

    Oliver Wirths

  58. Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein

    Article • Journal of Biological Chemistry, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Oliver Wirths

  59. Intracellular accumulation of amyloid-beta – a predictor for synaptic dysfunction and neuron loss in Alzheimer’s disease

    Article • Frontiers in Aging Neuroscience, January 2010, Frontiers

    Oliver Wirths

  60. Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

    Article • International Journal of Alzheimer s Disease, January 2010, Hindawi Publishing Corporation

    Oliver Wirths

  61. Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Aβ peptides in mouse models of Alzheimer's disease

    Article • Brain Research, November 2009, Elsevier

    Oliver Wirths

  62. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

    Article • Journal of Neural Transmission, October 2009, Springer Science + Business Media

    Oliver Wirths

  63. Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

    Article • Acta Neuropathologica, June 2009, Springer Science + Business Media

    Oliver Wirths

  64. Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease

    Article • Journal of Neural Transmission, May 2009, Springer Science + Business Media

    Oliver Wirths

  65. APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

    Article • Acta Neuropathologica, April 2009, Springer Science + Business Media

    Oliver Wirths

  66. Die modifizierte Amyloid-Hypothese der Alzheimer-Demenz – intraneuronales Abeta induziert Neurodegeneration

    Article • e-Neuroforum, January 2009, De Gruyter

    Oliver Wirths

  67. Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

    Article • Acta Neuropathologica, October 2008, Springer Science + Business Media

    Oliver Wirths

  68. Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial

    Article • Journal of Neural Transmission, October 2008, Springer Science + Business Media

    Oliver Wirths

  69. Early Intraneuronal β-Amyloid Pathology: Do Transgenic Mice Represent Valid Model Systems?

    Article • Open Longevity Science, October 2008, Bentham Science Publishers

    Oliver Wirths

  70. Alzheimer-Demenz

    Article • Der Nervenarzt, September 2008, Springer Science + Business Media

    Oliver Wirths

  71. Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice

    Article • Brain Research, July 2008, Elsevier

    Oliver Wirths

  72. Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

    Article • Neurobiology of Aging, June 2008, Elsevier

    Oliver Wirths

  73. Motor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models

    Article • Genes Brain & Behavior, January 2008, Wiley

    Oliver Wirths

  74. Review on the APP/PS1KI mouse model: intraneuronal Aβ accumulation triggers axonopathy, neuron loss and working memory impairment

    Article • Genes Brain & Behavior, January 2008, Wiley

    Oliver Wirths

  75. Intraneuronal β-Amyloid Is a Major Risk Factor – Novel Evidence from the APP/PS1KI Mouse Model

    Article • Neurodegenerative Diseases, January 2008, Karger Publishers

    Oliver Wirths

  76. Age-dependent axonal degeneration in an Alzheimer mouse model

    Article • Neurobiology of Aging, November 2007, Elsevier

    Oliver Wirths

  77. Altered cholesterol metabolism in APP695-transfected neuroblastoma cells

    Article • Brain Research, June 2007, Elsevier

    Oliver Wirths

  78. Gender dependent APP processing in a transgenic mouse model of Alzheimer’s disease

    Article • Journal of Neural Transmission, October 2006, Springer Science + Business Media

    Oliver Wirths

  79. Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease

    Article • Acta Neuropathologica, March 2006, Springer Science + Business Media

    Oliver Wirths

  80. Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease

    Article • Experimental Gerontology, February 2006, Elsevier

    Oliver Wirths

  81. OTX1 and OTX2 Expression Correlates With the Clinicopathologic Classification of Medulloblastomas

    Article • Journal of Neuropathology & Experimental Neurology, February 2006, Oxford University Press (OUP)

    Oliver Wirths

  82. Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies

    Article • Journal of Neural Transmission, June 2005, Springer Science + Business Media

    Oliver Wirths

  83. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide - the first step of a fatal cascade

    Article • Journal of Neurochemistry, November 2004, Wiley

    Oliver Wirths

  84. Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice

    Article • Experimental Neurology, November 2003, Elsevier

    Oliver Wirths

  85. No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment

    Article • Neurobiology of Disease, March 2003, Elsevier

    Oliver Wirths

  86. α-Synuclein, Aβ and Alzheimer's disease

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, February 2003, Elsevier

    Oliver Wirths

  87. Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic mice

    Article • Neuroscience Letters, December 2001, Elsevier

    Oliver Wirths

  88. Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

    Article • Neuroscience Letters, June 2001, Elsevier

    Oliver Wirths