Dr Ofer Levy

All Stories

1. Article

   Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations
   Dr Ofer Levy
2. Article

   Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts
   Dr Ofer Levy
3. Article

   OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines
   Federico Martinon-TorresDr Ofer Levy
4. Article

   Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
   Dr Ofer Levy
5. Article

   Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro
   Dr Ofer Levy
6. Article

   Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro
   Dr Ofer Levy
7. Article

   Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut
   Dr Ofer Levy
8. Article

   First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
   Dr Ofer Levy
9. Article

   Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
   Dr Ofer Levy
10. Article

    Anti-infective proteins and peptides differ in their activities in human newborn blood.
    Dr Ofer Levy
11. Article

    Correction: Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis
    Dr Ofer Levy
12. Article

    Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
    Dr Ofer Levy
13. Article

    A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation
    Dr Ofer Levy
14. Article

    Neonatal Immunization: Rationale, Current State, and Future Prospects
    Dr Ofer Levy
15. Article

    Hepatic Legionella pneumophila Infection in an Infant With Severe Combined Immunodeficiency
    Dr Ofer Levy
16. Article

    Adjuvant Effect of Bacille Calmette–Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn
    Dr Ofer Levy
17. Article

    Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization
    Dr Ofer Levy
18. Article

    Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
    Dr Ofer Levy
19. Article

    Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases
    Dr Ofer Levy
20. Article

    Human newborn B cells mount an interferon-α/β receptor-dependent humoral response to respiratory syncytial virus
    Dr Ofer Levy
21. Article

    Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis
    Dr Ofer Levy
22. Article

    Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny
    Dr Ofer Levy
23. Article

    Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns
    Dr Ofer Levy
24. Article

    Mononuclear Phagocyte System
    Dr Ofer Levy
25. Article

    Use of cidofovir in pediatric patients with adenovirus infection
    Dr Ofer Levy
26. Article

    A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
    Dr Ofer Levy
27. Article

    Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization
    Dr Ofer Levy
28. Article

    Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities
    Dr Ofer Levy
29. Article

    Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells
    Dr Ofer Levy
30. Article

    Heterologous vaccine effects
    Dr Ofer Levy
31. Article

    In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant
    Dr Ofer Levy
32. Article

    Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
    Dr Ofer Levy
33. Article

    Harnessing the beneficial heterologous effects of vaccination
    Dr Ofer Levy
34. Article

    Use of cidofovir in pediatric patients with adenovirus infection
    Dr Ofer LevyDionne A Graham
35. Article

    Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage
    Dr Ofer Levy
36. Article

    Changing oral vaccine to inactivated polio vaccine might increase mortality
    Dr Ofer Levy
37. Article

    Pilot experience with opebacan/rBPI21 in myeloablative hematopoietic cell transplantation
    Dr Ofer Levy
38. Article

    Pediatric Vaccine Adjuvants
    Dr Ofer Levy
39. Article

    Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
    Dr Ofer Levy
40. Article

    The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
    Dr Ofer Levy
41. Article

    Systems vaccinology: a promise for the young and the poor
    Dr Ofer Levy
42. Article

    Staphylococcus epidermidisBacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways
    Dr Ofer Levy
43. Article

    Ready to benefit from training: heterologous effects of early life immunization
    Dr Ofer Levy
44. Article

    The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells
    Dr Ofer Levy
45. Article

    Soluble Mediators Regulating Immunity in Early Life
    Dr Ofer Levy
46. Article

    Infection-induced inflammation and cerebral injury in preterm infants
    Dr Ofer Levy
47. Article

    Ontogeny of early life immunity
    Dr Ofer Levy
48. Article

    A Prime Time for Trained Immunity: Innate Immune Memory in Newborns and Infants
    Dr Ofer Levy
49. Article

    Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity
    Dr Ofer Levy
50. Article

    Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
    Dr Ofer Levy
51. Article

    Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin
    Dr Ofer Levy
52. Article

    Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine
    Dr Ofer Levy
53. Article

    Vaccine-induced immunity in early life
    Dr Ofer Levy
54. Article

    Immune response to vaccine adjuvants during the first year of life
    Dr Ofer Levy
55. Article

    Heterologous ("Nonspecific") and Sex-Differential Effects of Vaccines: Epidemiology, Clinical Trials, and Emerging Immunologic Mechanisms
    Dr Ofer Levy
56. Article

    The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
    Dr Ofer Levy
57. Article

    Role of Innate Immunity in Neonatal Infection
    Dr Ofer Levy
58. Article

    Neonatal Host Defense against Staphylococcal Infections
    Dr Ofer Levy
59. Article

    Plasma‐mediated immune suppression: a neonatal perspective
    Dr Ofer Levy
60. Article

    Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
    Dr Ruth R MontgomeryDr Ofer Levy
61. Article

    A Neonatal Model of Intravenous Staphylococcus epidermidis Infection in Mice <24 h Old Enables Characterization of Early Innate Immune Responses
    Dr Ofer Levy
62. Article

    Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
    Dr Ofer Levy
63. Article

    Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation
    Dr Ofer Levy
64. Article

    Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation
    Professor Peter C RichmondDr Ofer Levy
65. Article

    Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors
    Dr Ofer Levy
66. Article

    Potential Role of Coagulase-negative Staphylococcus Infection in Preterm Brain Injury
    Dr Ofer Levy
67. Article

    Bactericidal/Permeability-Increasing Protein (rBPI 21 ) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death
    Dr Ofer Levy
68. Article

    Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake
    Dr Ofer Levy
69. Article

    Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy
    Dr Ofer Levy
70. Article

    Development of Newborn and Infant Vaccines
    Dr Ofer Levy
71. Article

    17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and liveE. coli
    Dr Ofer Levy
72. Article

    Systemic Stimulation of TLR2 Impairs Neonatal Mouse Brain Development
    Lab head - Perinatal Brain Injury Lab Bobbi FleissDr Ofer Levy
73. Article

    Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants
    Dr Ofer Levy
74. Article

    Challenges in infant immunity: implications for responses to infection and vaccines
    Dr Ofer Levy
75. Article

    Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities
    Dr Ofer Levy
76. Article

    Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4/MD2, and MyD88 During Bacterial Infection In Vivo
    Dr Ofer Levy
77. Article

    Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
    Dr Ofer Levy
78. Article

    Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis
    Dr Ofer Levy
79. Article

    Role of Innate Host Defenses in Susceptibility to Early-Onset Neonatal Sepsis
    Dr Ofer Levy
80. Article

    TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia
    Professor Peter C RichmondDr Ofer Levy
81. Article

    Neonatal innate immunity in allergy development
    Dr Ofer Levy
82. Article

    Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life
    Dr Ofer Levy
83. Article

    Neonatal Vaccination
    Dr Ofer Levy
84. Article

    Endotoxin-Directed Innate Immunity in Tracheal Aspirates of Mechanically Ventilated Human Neonates
    Dr Ofer Levy
85. Article

    Developmental Biology of the Innate Immune Response: Implications for Neonatal and Infant Vaccine Development
    Dr Ofer Levy
86. Article

    Antibiotic proteins of polymorphonuclear leukocytes
    Dr Ofer Levy
87. Article

    Reduced levels of antimicrobial proteins and peptides in human cord blood plasma: Table 1
    Dr Ofer Levy
88. Article

    Safety and efficacy of neonatal vaccination
    Dr Ofer Levy
89. Article

    Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-κB essential modulator deficiency
    Dr Ofer Levy
90. Article

    Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites
    Dr Ofer Levy
91. Article

    Novel Vaccines: Bridging Research, Development and Production
    Dr Ofer Levy
92. Article

    Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis
    Dr Ofer Levy
93. Article

    Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists
    Dr Ofer Levy
94. Article

    Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities
    Dr Ofer Levy
95. Article

    Evidence of a bactericidal permeability increasing protein in an invertebrate, theCrassostrea gigas Cg-BPI
    Dr Ofer Levy
96. Article

    Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
    Dr Ofer Levy
97. Article

    Neonatal immune responses to coagulase-negative staphylococci
    Dr Ofer LevyProfessor Peter C Richmond
98. Article

    Innate immunity of the newborn: basic mechanisms and clinical correlates
    Dr Ofer Levy
99. Article

    Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8
    Dr Ofer Levy
100. Article

     Recombinant Bactericidal/Permeability-Increasing Protein rBPI21 Protects against Pneumococcal Disease
     Dr Ofer Levy
101. Article

     Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
     Dr Ofer Levy
102. Article

     Innate Immunity of the Human Newborn Is Polarized Toward a High Ratio of IL-6/TNF-α Production In Vitro and In Vivo
     Dr Ofer Levy
103. Article

     Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein
     Dr Ofer Levy
104. Article

     Neonatal Babesiosis
     Dr Ofer Levy
105. Article

     Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists
     Dr Ofer Levy
106. Article

     Human disease resulting from gene mutations that interfere with appropriate nuclear factor‐κB activation
     Dr Ofer Levy
107. Article

     Human nuclear factor κB essential modulator mutation can result in immunodeficiency without ectodermal dysplasia
     Dr Ofer Levy
108. Article

     Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes
     Dr Ofer Levy
109. Article

     Genetic Screening for Susceptibility to Infection in the NICU Setting: Commentary on the article by Ahrens et al. on page 652
     Dr Ofer Levy
110. Article

     Critical Role of the Complement System in Group B Streptococcus-Induced Tumor Necrosis Factor Alpha Release
     Dr Ofer Levy
111. Article

     Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation
     Dr Ofer Levy
112. Article

     Disseminated Varicella Infection Due to the Vaccine Strain of Varicella‐Zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells
     Dr Ofer Levy
113. Article

     Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia
     Dr Ofer Levy
114. Article

     Impaired Innate Immunity at Birth: Deficiency of Bactericidal/Permeability-Increasing Protein (BPI) in the Neutrophils of Newborns
     Dr Ofer Levy
115. Article

     Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils1
     Dr Ofer Levy
116. Article

     Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia
     Dr Ofer Levy
117. Article

     FATAL DISSEMINATED CANDIDA LUSITANIAE INFECTION IN AN INFANT WITH CHRONIC GRANULOMATOUS DISEASE
     Dr Ofer Levy
118. Article

     Therapeutic potential of the
     Dr Ofer Levy
119. Article

     A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein
     Dr Ofer Levy
120. Article

     Enhancement of Neonatal Innate Defense: Effects of Adding an N-Terminal Recombinant Fragment of Bactericidal/Permeability-Increasing Protein on Growth and Tumor Necrosis Factor-Inducing Activity of Gram-Negative Bacteria Tested in Neonatal Cord Blood E...
     Dr Ofer Levy
121. Article

     Impaired Innate Immunity in the Newborn: Newborn Neutrophils Are Deficient in Bactericidal/Permeability-Increasing Protein
     Dr Ofer Levy
122. Article

     Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.
     Dr Ofer Levy
123. Article

     Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein
     Dr Ofer Levy
124. Article

     Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.
     Dr Ofer Levy
125. Article

     Structural characterization of BPI-modulating 15 kDa proteins from rabbit polymorphonuclear leukocytes: Identification of a novel family of leukocyte proteins
     Dr Ofer Levy