All Stories

  1. Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024–March 2025) of a Prospective, Multicenter, Epidemiological Study

    Article • Infectious Diseases and Therapy, April 2026, Springer Science + Business Media

    Takahiro Takazono, Dr. Norihito Kaku

  2. Clinical characteristics of respiratory syncytial virus and human metapneumovirus pneumonia in adults: A multicenter retrospective cohort study in Japan

    Article • Respiratory Investigation, March 2026, Elsevier

    Takahiro Takazono, Dr. Norihito Kaku

  3. Efficacy of cefiderocol in murine models of ventilator-associated pneumonia caused by carbapenem-resistant non-fermenting Gram-negative bacilli, with pharmacokinetic evaluation

    Article • Microbiology Spectrum, December 2025, ASM Journals

    Takahiro Takazono, Dr. Norihito Kaku

  4. Antimicrobial susceptibility and resistance mechanisms to antipseudomonal β-lactams in Pseudomonas aeruginosa isolates from blood

    Article • Microbiology Spectrum, May 2025, ASM Journals

    Dr. Norihito Kaku

  5. Clinical Evaluation of a Rapid Reciprocal-Flow PCR Assay and Real-Time PCR Assay with Quenching Probe for Detection of Mycobacterium tuberculosis Complex

    Article • Microorganisms, January 2025, MDPI AG

    Dr. Norihito Kaku

  6. Long-term impact of molecular epidemiology shifts of methicillin-resistant Staphylococcus aureus on severity and mortality of bloodstream infection

    Article • Emerging Microbes & Infections, January 2025, Taylor & Francis

    Dr. Norihito Kaku

  7. Comparison of the effectiveness of core genome multilocus sequence typing and polymerase chain reaction-based open reading frame typing in tracing nosocomial methicillin-resistant Staphylococcus aureus transmission

    Article • Journal of Infection and Chemotherapy, January 2025, Elsevier

    Dr. Norihito Kaku

  8. Impact of Education on Inappropriate Antibiotic Prescription for Respiratory Tract Infection Based on Physicians’ Justifications: A Web-Based Survey in Japan

    Article • Antibiotics, October 2024, MDPI AG

    Dr. Norihito Kaku

  9. Impact of Educational Films on Antibiotic Prescription among Physicians: A Web-Based Survey in Japan

    Article • Antibiotics, August 2024, MDPI AG

    Dr. Norihito Kaku

  10. Long-Term Impact of Molecular Epidemiology Shifts of Methicillin-resistantStaphylococcus aureuson Severity and Mortality of Bloodstream Infection

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Dr. Norihito Kaku

  11. Regulation of epithelial transitional states in murine and human pulmonary fibrosis

    Article • Journal of Clinical Investigation, November 2023, American Society for Clinical Investigation

    Dr. Norihito Kaku

  12. Gargle sample is an effective option in a novel fully automated molecular point-of-care test for influenza: a multicenter study

    Article • Virology Journal, March 2023, Springer Science + Business Media

    Dr. Norihito Kaku

  13. Clinical evaluation of a fully automated and high-throughput molecular testing system for detection of influenza virus

    Article • Virology Journal, November 2022, Springer Science + Business Media

    Dr. Norihito Kaku

  14. Investigation on the virulence of non-encapsulated Streptococcus pneumoniae using liquid agar pneumonia model

    Article • Journal of Infection and Chemotherapy, November 2022, Elsevier

    Dr. Norihito Kaku

  15. Gargle sample is an effective option in a novel fully automated molecular point-of-care test for influenza: a multicenter study

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Dr. Norihito Kaku

  16. Changing molecular epidemiology and characteristics of MRSA isolated from bloodstream infections: nationwide surveillance in Japan in 2019

    Article • Journal of Antimicrobial Chemotherapy, May 2022, Oxford University Press (OUP)

    Dr. Norihito Kaku

  17. The surveillance of colistin resistance and mobilized colistin resistance genes in multidrug-resistant Enterobacteriaceae isolated in Japan

    Article • International Journal of Antimicrobial Agents, January 2022, Elsevier

    Dr. Norihito Kaku

  18. Changing molecular epidemiology and characteristics of methicillin-resistant Staphylococcus aureus isolated from bloodstream infections: nationwide surveillance in Japan in 2019

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr. Norihito Kaku

  19. Performance of anti-SARS-CoV-2 antibody testing in asymptomatic or mild COVID-19 patients: A retrospective study in outbreak on a cruise ship

    Article • PLOS One, September 2021, PLOS

    Dr. Norihito Kaku

  20. Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples

    Article • PLOS One, June 2021, PLOS

    Dr. Norihito Kaku

  21. Multicenter evaluation of molecular point-of-care testing and digital immunoassays for influenza virus A/B and respiratory syncytial virus in patients with influenza-like illness

    Article • Journal of Infection and Chemotherapy, June 2021, Elsevier

    Dr. Norihito Kaku

  22. Surveillance of colistin-resistance andmcr genes inmulti-drug resistant Enterobacteriaceae

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr. Norihito Kaku

  23. Had COVID-19 spread in the community before the first confirmed case in Nagasaki, Japan?

    Article • Microbes and Infection, May 2021, Elsevier

    Dr. Norihito Kaku

  24. Safety, efficacy, and analysis of key parameters after prophylactic administration of a sustained-release formulation of azithromycin in lung cancer surgery

    Article • Annals of Palliative Medicine, April 2021, AME Publishing Company

    Dr. Norihito Kaku

  25. Results of the 1<sup>st </sup>Questionnaire Survey on the Gastrointestinal Infection

    Article • Kansenshogaku zasshi, March 2021, The Japanese Association for Infectious Diseases

    Dr. Norihito Kaku

  26. Evaluation of anti-SARS-CoV-2 antibody testing in asymptomatic or mild COVID-19 patients in outbreak on a cruise ship

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Dr. Norihito Kaku

  27. Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples

    Article • European Journal of Clinical Microbiology & Infectious Diseases, February 2021, Springer Science + Business Media

    Dr. Norihito Kaku

  28. A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma

    Article • Molecular Therapy — Methods & Clinical Development, December 2020, Elsevier

    Dr. Norihito Kaku

  29. Efficacy of meropenem and amikacin combination therapy against carbapenemase-producing Klebsiella pneumoniae mouse model of pneumonia

    Article • Journal of Infection and Chemotherapy, December 2020, Elsevier

    Dr. Norihito Kaku

  30. Pathogenic Effect of Prevotella intermedia on a Mouse Pneumonia Model Due to Methicillin-Resistant Staphylococcus aureus With Up-Regulated α-Hemolysin Expression

    Article • Frontiers in Microbiology, October 2020, Frontiers

    Dr. Norihito Kaku

  31. A novel macrolide, solithromycin suppresses mucin overexpression induced by Pseudomonas aeruginosa LPS in airway epithelial cells

    Article • Journal of Infection and Chemotherapy, September 2020, Elsevier

    Dr. Norihito Kaku

  32. Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study

    Article • Journal of Infection and Chemotherapy, August 2020, Elsevier

    Dr. Norihito Kaku

  33. Flow cytometry assay for the detection of single-copy DNA in human lymphocytes

    Article • Nucleic Acids Research, June 2020, Oxford University Press (OUP)

    Dr. Norihito Kaku

  34. Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model

    Article • PLOS One, September 2019, PLOS

    Dr. Norihito Kaku

  35. Molecular characteristics of methicillin‐resistant Staphylococcus aureus isolated from skin and soft tissue infections collected in the Japanese nationwide surveillance

    Article • The Journal of Dermatology, September 2019, Wiley

    Dr. Norihito Kaku

  36. Efficacy and safety of cefditoren pivoxil for exacerbations of chronic obstructive pulmonary disease: A prospective multicenter interventional study

    Article • Journal of Infection and Chemotherapy, September 2019, Elsevier

    Dr. Norihito Kaku, Takahiro Takazono

  37. The Effect of In Vitro Hemolysis on Measurement of Cell-Free DNA

    Article • The Journal of Applied Laboratory Medicine, June 2019, AACC

    Dr. Norihito Kaku

  38. Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, June 2019, ASM Journals

    Dr. Norihito Kaku

  39. Detection of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae using the MALDI Biotyper Selective Testing of Antibiotic Resistance–β-Lactamase (MBT STAR-BL) assay

    Article • Journal of Microbiological Methods, May 2019, Elsevier

    Dr. Norihito Kaku

  40. Molecular and epidemiological analysis of IMP-1 metallo-β-lactamase-producing Klebsiella pneumoniae in a tertiary care hospital in Japan

    Article • Journal of Infection and Chemotherapy, April 2019, Elsevier

    Dr. Norihito Kaku

  41. Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains

    Article • Journal of Infection and Chemotherapy, April 2019, Elsevier

    Dr. Norihito Kaku

  42. Performance evaluation of the MALDI Biotyper Selective Testing of Antibiotic Resistance–β-Lactamase (MBT STAR-BL) assay for the detection of IMP metallo-β-lactamase activity in Enterobacteriaceae

    Article • Diagnostic Microbiology and Infectious Disease, December 2018, Elsevier

    Dr. Norihito Kaku

  43. Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas aeruginosa

    Article • The Open Microbiology Journal, September 2018, Bentham Science Publishers

    Dr. Norihito Kaku

  44. Evaluation of FilmArray respiratory panel multiplex polymerase chain reaction assay for detection of pathogens in adult outpatients with acute respiratory tract infection

    Article • Journal of Infection and Chemotherapy, September 2018, Elsevier

    Dr. Norihito Kaku

  45. Plasmid-Mediated AmpC β-Lactamase and Underestimation of Extended-Spectrum β-Lactamase in Cefepime-Susceptible Elevated-Ceftazidime-MIC Enterobacteriaceae Isolates

    Article • Japanese Journal of Infectious Diseases, July 2018, Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis

    Dr. Norihito Kaku

  46. Susceptibility of Clostridium species isolated in Japan to fidaxomicin and its major metabolite OP-1118

    Article • Journal of Infection and Chemotherapy, June 2018, Elsevier

    Dr. Norihito Kaku

  47. Results of a Questionnaire Survey on the Genetic Testing for Infectious Diseases

    Article • Kansenshogaku zasshi, May 2018, The Japanese Association for Infectious Diseases

    Dr. Norihito Kaku

  48. In VitroActivity of Lascufloxacin againstStreptococcus pneumoniaewith Mutations in the Quinolone Resistance-Determining Regions

    Article • Antimicrobial Agents and Chemotherapy, February 2018, ASM Journals

    Dr. Norihito Kaku

  49. Performance evaluation of BD Phoenix™, an automated microbiology system, for the screening of IMP-producing Enterobacteriaceae

    Article • Journal of Microbiological Methods, February 2018, Elsevier

    Dr. Norihito Kaku

  50. Inhalation Therapy for Respiratory Tract Infection

    Article • Drug Delivery System, January 2018, Japan Society of Drug Delivery System

    Dr. Norihito Kaku

  51. Fluoroquinolone resistance in extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a Japanese tertiary hospital: silent shifting to CTX-M-15-producing K. pneumoniae

    Article • Journal of Medical Microbiology, October 2017, Society for General Microbiology

    Dr. Norihito Kaku

  52. Performance evaluation of the Verigene ® Clostridium difficile nucleic acid test, an automated multiplex molecular testing system for detection of C. difficile toxin

    Article • Journal of Infection and Chemotherapy, October 2017, Elsevier

    Dr. Norihito Kaku

  53. Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population

    Article • Vaccine, October 2017, Elsevier

    Dr. Norihito Kaku

  54. Usefulness of a Highly Sensitive Detection System for the Influenza Virus

    Article • Kansenshogaku zasshi, September 2017, The Japanese Association for Infectious Diseases

    Dr. Norihito Kaku

  55. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: Genera...

    Article • Journal of Infection and Chemotherapy, September 2017, Elsevier

    Dr. Norihito Kaku

  56. Tedizolid inhibits MUC5AC production induced by methicillin-resistant Staphylococcus aureus in human airway epithelial cells

    Article • Journal of Infection and Chemotherapy, September 2017, Elsevier

    Dr. Norihito Kaku

  57. Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in

    Article • The Open Microbiology Journal, May 2017, Bentham Science Publishers

    Dr. Norihito Kaku

  58. Efficacy and Pharmacokinetics of the Combination of OP0595 and Cefepime in a Mouse Model of Pneumonia Caused by Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, May 2017, ASM Journals

    Dr. Norihito Kaku

  59. TNF-α inhibits the growth of Legionella pneumophila in airway epithelial cells by inducing apoptosis

    Article • Journal of Infection and Chemotherapy, January 2017, Elsevier

    Dr. Norihito Kaku

  60. Efficacy and pharmacokinetics of ME1100, a novel optimized formulation of arbekacin for inhalation, compared with amikacin in a murine model of ventilator-associated pneumonia caused byPseudomonas aeruginosa

    Article • Journal of Antimicrobial Chemotherapy, December 2016, Oxford University Press (OUP)

    Dr. Norihito Kaku

  61. Simultaneous screening for JAK2 and calreticulin gene mutations in myeloproliferative neoplasms with high resolution melting

    Article • Clinica Chimica Acta, November 2016, Elsevier

    Dr. Norihito Kaku

  62. Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection

    Article • International Journal of Medical Microbiology, September 2016, Elsevier

    Dr. Norihito Kaku

  63. Clinical application of a ligation-independent pathway of multiplex ligation-dependent probe amplification for the determination of quinolone susceptibility of Streptococcus pneumoniae

    Article • Journal of Microbiological Methods, September 2016, Elsevier

    Dr. Norihito Kaku

  64. Pseudomonas aeruginosa Bacteremia among Immunocompetent and Immunocompromised Patients: Relation to Initial Antibiotic Therapy and Survival

    Article • Japanese Journal of Infectious Diseases, January 2016, Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis

    Dr. Norihito Kaku

  65. Active Surveillance of Methicillin-Resistant Staphylococcus aureus Using a Fully Automated Molecular Test in an Emergency Medical Center

    Article • Japanese Journal of Infectious Diseases, January 2015, Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis

    Dr. Norihito Kaku

  66. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae

    Article • Clinical Microbiology and Infection, November 2014, Elsevier

    Dr. Norihito Kaku

  67. Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells

    Article • Pulmonary Pharmacology & Therapeutics, August 2014, Elsevier

    Dr. Norihito Kaku

  68. Influence of antimicrobial regimen on decreased in-hospital mortality of patients with MRSA bacteremia

    Article • Journal of Infection and Chemotherapy, June 2014, Elsevier

    Dr. Norihito Kaku

  69. Immunomodulatory Effect of Linezolid on Methicillin-Resistant Staphylococcus aureus Supernatant-Induced MUC5AC Overexpression in Human Airway Epithelial Cells

    Article • Antimicrobial Agents and Chemotherapy, May 2014, ASM Journals

    Dr. Norihito Kaku

  70. Prevotella intermedia Induces Severe Bacteremic Pneumococcal Pneumonia in Mice with Upregulated Platelet-Activating Factor Receptor Expression

    Article • Infection and Immunity, November 2013, ASM Journals

    Dr. Norihito Kaku

  71. In vivo efficacy of biapenem with ME1071, a novel metallo-β-lactamase (MBL) inhibitor, in a murine model mimicking ventilator-associated pneumonia caused by MBL-producing Pseudomonas aeruginosa

    Article • International Journal of Antimicrobial Agents, September 2013, Elsevier

    Dr. Norihito Kaku

  72. Azithromycin Attenuates Lung Inflammation in a Mouse Model of Ventilator-Associated Pneumonia by Multidrug-Resistant Acinetobacter baumannii

    Article • Antimicrobial Agents and Chemotherapy, June 2013, ASM Journals

    Dr. Norihito Kaku

  73. Efficacy of AiiM, anN-Acylhomoserine Lactonase, against Pseudomonas aeruginosa in a Mouse Model of Acute Pneumonia

    Article • Antimicrobial Agents and Chemotherapy, May 2013, ASM Journals

    Dr. Norihito Kaku

  74. In VivoEfficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection

    Article • Antimicrobial Agents and Chemotherapy, March 2013, ASM Journals

    Dr. Norihito Kaku

  75. Macrolides Inhibit Fusobacterium nucleatum-Induced MUC5AC Production in Human Airway Epithelial Cells

    Article • Antimicrobial Agents and Chemotherapy, February 2013, ASM Journals

    Dr. Norihito Kaku

  76. Detection of Legionella pneumophila serogroup 1 in blood cultures from a patient treated with tumor necrosis factor-alpha inhibitor

    Article • Journal of Infection and Chemotherapy, January 2013, Elsevier

    Dr. Norihito Kaku

  77. The definition of healthcare-associated pneumonia (HCAP) is insufficient for the medical environment in Japan: a comparison of HCAP and nursing and healthcare-associated pneumonia (NHCAP)

    Article • Journal of Infection and Chemotherapy, January 2013, Elsevier

    Dr. Norihito Kaku

  78. A Case of Intravascular Large B-cell Lymphoma (IVLBCL) with no Abnormal Findings on Chest Computed Tomography Diagnosed by Random Transbronchial Lung Biopsy

    Article • Internal Medicine, January 2010, Japanese Society of Internal Medicine

    Dr. Norihito Kaku

  79. Detection of Human Papillomavirus Types 16 and 18 in Primary and in Metastatic Lesions of Cervical Carcinomas

    Article • Gynecologic Oncology, May 1994, Elsevier

    Dr. Norihito Kaku