All Stories

  1. Impact of Bipyridine and Phenanthroline Incorporation into the Macropa Scaffold on Ba(II)/Ra(II) Chelation

    Article • Inorganic Chemistry, July 2026, American Chemical Society (ACS)

    Dr Nicolas Lepareur

  2. [90Y]Y-L4-Lipo/ ethyl esters of Iodized fatty acids of poppy seed oil (lipiodol® ultra-fluid), a new TARE formulation, designed from a lipophilic ligand for stability and safety

    Article • EJNMMI Radiopharmacy and Chemistry, June 2025, Springer Science + Business Media

    Dr Nicolas Lepareur

  3. [90Y]Y-L4-Lipo/ Ethyl esters of iodized fatty acids of poppy seed oil (Lipiodol® Ultra-Fluid), a new TARE formulation, designed from a lipophilic ligand for stability and safety

    Article • May 2025, Springer Science + Business Media

    Dr Nicolas Lepareur

  4. [natY/90Y]Yttrium and [natLu/177Lu]Lutetium Complexation by Rigid H4OCTAPA Derivatives. Effect of Ligand Topology

    Article • Chemistry - A European Journal, April 2025, Wiley

    Dr Nicolas Lepareur

  5. « Optimizing Imaging and Dose–Reponse in Radiotherapies » XVIe édition de l’atelier organisé par le réseau « Vectorisation, Imagerie, Radiothérapies » du Cancéropôle Grand-Ouest – 4–7 octobre 2023, Erquy, France

    Article • Bulletin du Cancer, April 2025, Elsevier

    Dr Nicolas Lepareur

  6. An overview of current phase 3 radiopharmaceutical therapy clinical trials

    Article • Frontiers in Medicine, February 2025, Frontiers

    Dr Nicolas Lepareur

  7. Efficient internalization of poly(benzyl malate) and poly(ethylene glycol)-b-poly(benzyl malate) copolymer based nanoparticles by human hepatic HepaRG cells and macrophages : Impact of nanoparticle functionalization by GBVA10-9 peptide on cell uptake.

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr Nicolas Lepareur

  8. Editorial: Recent advances in nanoradiopharmaceuticals for molecular imaging and radiotherapy

    Article • Frontiers in Medicine, April 2024, Frontiers

    Dr Nicolas Lepareur

  9. « New Modalities in Cancer Imaging and Therapy » XVe édition de l’atelier organisé par le réseau « Vectorisation, Imagerie, Radiothérapies » du Cancéropôle Grand-Ouest, 5–8 octobre 2022, Erquy, France

    Article • Bulletin du Cancer, December 2023, Elsevier

    Dr Nicolas Lepareur

  10. Clinical Advances and Perspectives in Targeted Radionuclide Therapy

    Article • Pharmaceutics, June 2023, MDPI AG

    Dr Nicolas Lepareur

  11. Clinical Advances and Perspectives in Targeted Radionuclide Therapy

    Article • May 2023, MDPI AG

    Dr Nicolas Lepareur

  12. 188Re-SSS Lipiodol Radioembolization in HCC Patients: Results of a Phase 1 Trial (Lip-Re-01 Study)

    Article • Cancers, April 2023, MDPI AG

    Dr Nicolas Lepareur

  13. Study of radiolabeled hepatotropic peptide derivatives for the diagnosis and treatment of hepatocellular carcinoma

    Article • Nuclear Medicine and Biology, November 2022, Elsevier

    Dr Nicolas Lepareur

  14. Hepatotropic Peptides Grafted onto Maleimide-Decorated Nanoparticles: Preparation, Characterization and In Vitro Uptake by Human HepaRG Hepatoma Cells

    Article • Polymers, June 2022, MDPI AG

    Dr Nicolas Lepareur

  15. Gallium-68 and Copper-64 radiolabelling of hepatotropic GBVA10-9 or CPB peptide derivatives for hepatocellular carcinoma imaging

    Article • Nuclear Medicine and Biology, May 2022, Elsevier

    Dr Nicolas Lepareur

  16. Versatile Macrocyclic Platform for the Complexation of [natY/90Y]Yttrium and Lanthanide Ions

    Article • Inorganic Chemistry, April 2022, American Chemical Society (ACS)

    Dr Nicolas Lepareur

  17. Circumsporozoite Protein of Plasmodium berghei- and George Baker Virus A-Derived Peptides Trigger Efficient Cell Internalization of Bioconjugates and Functionalized Poly(ethylene glycol)-b-poly(benzyl malate)-Based Nanoparticles in Human Hepatoma Cells

    Article • Pharmaceutics, April 2022, MDPI AG

    Dr Nicolas Lepareur

  18. Cold Kit Labeling: The Future of 68Ga Radiopharmaceuticals?

    Article • Frontiers in Medicine, February 2022, Frontiers

    Dr Nicolas Lepareur

  19. Receptor-Specific Radionuclide Therapy

    Article • January 2022, Springer Science + Business Media

    Dr Nicolas Lepareur

  20. Tuning the lipophilic nature of pyclen-based 90Y3+ radiopharmaceuticals for β-radiotherapy

    Article • Metallomics, November 2021, Oxford University Press (OUP)

    Dr Nicolas Lepareur

  21. Labeling of Hinokitiol with 90Y for Potential Radionuclide Therapy of Hepatocellular Carcinoma

    Article • Processes, May 2021, MDPI AG

    Dr Nicolas Lepareur

  22. Comparison of [68Ga]Ga precursors for blood cell radiolabeling

    Article • Nuclear Medicine and Biology, May 2021, Elsevier

    Dr Nicolas Lepareur

  23. Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells

    Article • Nanomaterials, April 2021, MDPI AG

    Dr Nicolas Lepareur

  24. Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy

    Article • Molecules, September 2020, MDPI AG

    Dr Nicolas Lepareur

  25. 188Re-SSS/Lipiodol for HCC treatment: from (radio)chemistry to preliminary clinical results

    Article • Nuclear Medicine and Biology, July 2019, Elsevier

    Dr Nicolas Lepareur

  26. Rhenium-188 Labeled Radiopharmaceuticals: Current Clinical Applications in Oncology and Promising Perspectives

    Article • Frontiers in Medicine, June 2019, Frontiers

    Dr Nicolas Lepareur

  27. Preliminary results of the Phase 1 Lip-Re I clinical trial: biodistribution and dosimetry assessments in hepatocellular carcinoma patients treated with 188Re-SSS Lipiodol radioembolization

    Article • European Journal of Pediatrics, February 2019, Springer Science + Business Media

    Dr Nicolas Lepareur

  28. Review on potential therapeutic modalities for liver cancers

    Article • BioMed Research International, December 2018, Hindawi Publishing Corporation

    Dr Nicolas Lepareur

  29. Cell Uptake and Biocompatibility of Nanoparticles Prepared from Poly(benzyl malate) (Co)polymers Obtained through Chemical and Enzymatic Polymerization in Human HepaRG Cells and Primary Macrophages

    Article • Polymers, November 2018, MDPI AG

    Dr Nicolas Lepareur

  30. Study of Binding Kinetics and Specificity of 99mTc-SSS-Complex and 99mTc-HMPAO to Blood Cells

    Article • Contrast Media & Molecular Imaging, October 2018, Hindawi Publishing Corporation

    Alberto Signore, Dr Nicolas Lepareur

  31. Stable and Inert Yttrium(III) Complexes with Pyclen-Based Ligands Bearing Pendant Picolinate Arms: Toward New Pharmaceuticals for β-Radiotherapy

    Article • Inorganic Chemistry, February 2018, American Chemical Society (ACS)

    Dr Nicolas Lepareur

  32. Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

    Article • European Journal of Inorganic Chemistry, September 2017, Wiley

    Dr Nicolas Lepareur

  33. Transarterial Radionuclide Therapy with 188Re-Labelled Lipiodol

    Article • International Journal of Nuclear Medicine Research, July 2017, Cosmos Scholars Publishing House

    Dr Nicolas Lepareur

  34. Automatisation de la production de nanocapsules lipidiques chargées en technétium-99 m

    Article • Médecine Nucléaire, May 2017, Elsevier

    Dr Nicolas Lepareur

  35. Locoregional Confinement and Major Clinical Benefit of 188Re-Loaded CXCR4-Targeted Nanocarriers in an Orthotopic Human to Mouse Model of Glioblastoma

    Article • Theranostics, January 2017, Ivyspring International Publisher

    Dr Nicolas Lepareur

  36. The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Dr Nicolas Lepareur

  37. Rhenium Complexes Based on an N2O Tridentate Click Scaffold: From Synthesis, Structural and Theoretical Characterization to a Radiolabelling Study

    Article • European Journal of Inorganic Chemistry, November 2016, Wiley

    Dr Nicolas Lepareur

  38. Characterization of the distribution, retention, and efficacy of internal radiation of 188Re-lipid nanocapsules in an immunocompromised human glioblastoma model

    Article • Journal of Neuro-Oncology, October 2016, Springer Science + Business Media

    Dr Nicolas Lepareur

  39. 68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies

    Article • PLOS One, October 2016, PLOS

    Dr Nicolas Lepareur

  40. Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to 90Y Radiolabeling

    Article • Inorganic Chemistry, August 2016, American Chemical Society (ACS)

    Dr Nicolas Lepareur

  41. Microparticules à base d’amidon radiomarquées au 188Re et 68Ga comme agent théranostique pour la radiothérapie interne sélective du carcinome hépatocellulaire

    Article • Médecine Nucléaire, May 2016, Elsevier

    Dr Nicolas Lepareur

  42. Occupational radiation exposure of medical staff performing 90Y-loaded microsphere radioembolization

    Article • European Journal of Pediatrics, December 2015, Springer Science + Business Media

    Dr Nicolas Lepareur

  43. Main applications of hybrid PET-MRI contrast agents: a review

    Article • Contrast Media & Molecular Imaging, December 2015, Wiley

    Dr Nicolas Lepareur

  44. Gemcitabine and Oxaliplatin, but Not Sorafenib or Paclitaxel, Have a Synergistic Effect with Yttrium-90 in Reducing Hepatocellular Carcinoma and Cholangiocarcinoma Cell Line Viability

    Article • Journal of Vascular and Interventional Radiology, December 2015, Elsevier

    Dr Nicolas Lepareur

  45. Radiopharmaceutcials radiolabelled with 188Re as potential therapeutic tools for hepatocellular carcinoma targeting

    Article • November 2015, MDPI AG

    Dr Nicolas Lepareur

  46. Development of Biocompatible and Functional Polymeric Nanoparticles for Site-Specific Delivery of Radionuclides

    Article • Frontiers in Medicine, September 2015, Frontiers

    Dr Nicolas Lepareur

  47. Biodistribution et toxicité des nanocapsules chargées en 188Re après injection intratumorale par convection enhanced delivery chez la souris

    Article • Médecine Nucléaire, May 2015, Elsevier

    Dr Nicolas Lepareur

  48. Escalade de dose et efficacité des nanocapsules chargées en 188Re dans un modèle d’adénocarcinome de l’endomètre chez la souris

    Article • Médecine Nucléaire, May 2015, Elsevier

    Dr Nicolas Lepareur

  49. Mixed-ligand complexes of yttrium-90 dialkyldithiocarbamates with 1,10-phenanthroline as a possible agent for therapy of hepatocellular carcinoma

    Article • Applied Radiation and Isotopes, December 2014, Elsevier

    Dr Nicolas Lepareur

  50. 120: From bench to bedside: development and early clinical results of 188Re-SSS/Lipiodol for HCC treatment

    Article • Radiotherapy and Oncology, February 2014, Elsevier

    Dr Nicolas Lepareur

  51. Optimization of Hepatocarcinoma Uptake with Radiolabeled Lipiodol: Development of New Lipiodol Formulations with Increased Viscosity

    Article • Cancer Biotherapy & Radiopharmaceuticals, March 2012, Mary Ann Liebert Inc

    Dr Nicolas Lepareur

  52. Reduction of β-radiation exposure during preparation of 188Re-labelled Lipiodol for hepatocellular carcinoma treatment

    Article • Nuclear Medicine Communications, February 2012, Wolters Kluwer Health

    Dr Nicolas Lepareur

  53. Looking for synergy or additivity between 188Re and sorafenib on hepatoma cell lines.

    Article • Journal of Clinical Oncology, February 2012, American Society of Clinical Oncology (ASCO)

    Dr Nicolas Lepareur

  54. -SSS/Lipiodol: Development of a Potential Treatment for HCC from Bench to Bedside

    Article • International Journal of Molecular Imaging, January 2012, Hindawi Publishing Corporation

    Dr Nicolas Lepareur

  55. Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with 188Re-lipid nanocapsules

    Article • Biomaterials, October 2011, Elsevier

    Dr Nicolas Lepareur

  56. Lipid Nanocapsules Loaded with Rhenium-188 Reduce Tumor Progression in a Rat Hepatocellular Carcinoma Model

    Article • PLOS One, March 2011, PLOS

    Dr Nicolas Lepareur

  57. Automation of labelling of Lipiodol with high-activity generator-produced 188Re

    Article • Applied Radiation and Isotopes, February 2011, Elsevier

    Dr Nicolas Lepareur

  58. Increased Lipiodol uptake in hepatocellular carcinoma possibly due to increased membrane fluidity by dexamethasone and tamoxifen

    Article • Nuclear Medicine and Biology, October 2010, Elsevier

    Dr Nicolas Lepareur

  59. Labeling Techniques with 123I

    Article • January 2009, Elsevier

    Dr Nicolas Lepareur

  60. 188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas

    Article • European Journal of Pediatrics, May 2008, Springer Science + Business Media

    Dr Nicolas Lepareur

  61. Therapy of Hepatocellular Carcinoma with Rhenium-188 Lipiodol

    Article • Current Radiopharmaceuticals, May 2008, Bentham Science Publishers

    Dr Nicolas Lepareur

  62. Spectroscopic Investigations of Fine‐Tuned Energy Differences in a Series of Substituted Rhenium and Technetium Complexes [M(RPhCS3)2(RPhCS2)] {M=Re,99Tc; R=H, F, Me, Et, OMe}

    Article • Spectroscopy Letters, March 2006, Taylor & Francis

    Dr Nicolas Lepareur

  63. Description and technical pitfalls of a hepatoma model and of intra-arterial injection of radiolabelled lipiodol in the rat

    Article • Laboratory Animals, July 2005, SAGE Publications

    Dr Nicolas Lepareur

  64. Effect of Stabilized Iodized Oil Emulsion on Experimentally Induced Hepatocellular Carcinoma in Rats

    Article • Journal of Vascular and Interventional Radiology, June 2005, Elsevier

    Dr Nicolas Lepareur

  65. Syntheses and reactivity of ‘sulfur rich’ Re(iii) and Tc(iii) complexes containing trithioperoxybenzoate, dithiobenzoate and dithiocarbamate ligands

    Article • Dalton Transactions, January 2005, Royal Society of Chemistry

    Dr Nicolas Lepareur

  66. A kit formulation for the labelling of lipiodol with generator-produced188Re

    Article • Journal of Labelled Compounds, October 2004, Wiley

    Dr Nicolas Lepareur

  67. 188Re-SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma

    Article • Nuclear Medicine Communications, October 2004, Wolters Kluwer Health

    Dr Nicolas Lepareur

  68. Development and biodistribution of 188 Re-SSS lipiodol following injection into the hepatic artery of healthy pigs

    Article • European Journal of Pediatrics, April 2004, Springer Science + Business Media

    Dr Nicolas Lepareur

  69. Development of 99mTc labelled Lipiodol: biodistribution following injection into the hepatic artery of the healthy pig

    Article • Nuclear Medicine Communications, March 2004, Wolters Kluwer Health

    Dr Nicolas Lepareur

  70. Chelated Hydrazido(3−)rhenium(V) Complexes:  On the Way to the Nitrido−M(V) Core (M = Tc, Re)

    Article • Inorganic Chemistry, March 2002, American Chemical Society (ACS)

    Dr Nicolas Lepareur