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  1. Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

    Article • Frontiers in Immunology, July 2023, Frontiers

    Nicolas Degauque

  2. System-level immune monitoring reveals new pathophysiological features in hepatitis-associated aplastic anemia

    Article • Blood Advances, July 2023, American Society of Hematology

    Nicolas Degauque

  3. Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation

    Article • Frontiers in Immunology, July 2023, Frontiers

    Nicolas Degauque, Dr Philippe SAAS

  4. Kidney allograft rejection is associated with an imbalance of B cells, regulatory T cells and differentiated CD28-CD8+ T cells: analysis of a cohort of 1095 graft biopsies

    Article • Frontiers in Immunology, April 2023, Frontiers

    Nicolas Degauque

  5. A gene-expression module in circulating immune cells is associated with cell migration during immune diseases

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Nicolas Degauque

  6. Regulation of CD8 T cell by B-cells: A narrative review

    Article • Frontiers in Immunology, March 2023, Frontiers

    Nicolas Degauque

  7. Effector Memory–Expressing CD45RA (TEMRA) CD8+T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses

    Article • Journal of the American Society of Nephrology, October 2022, American Society of Nephrology

    Nicolas Degauque

  8. Antibody-mediated allograft rejection is associated with an increase in peripheral differentiated CD28-CD8+ T cells – Analyses of a cohort of 1032 kidney transplant recipients

    Article • EBioMedicine, September 2022, Elsevier

    Nicolas Degauque

  9. Peripheral blood immune cell profiling of acute corneal transplant rejection

    Article • American Journal of Transplantation, June 2022, Wiley

    Nicolas Degauque

  10. Pathogénie des vascularites associées aux ANCA en 2021 : mise au point

    Article • La Revue de Médecine Interne, February 2022, Elsevier

    Nicolas Degauque

  11. Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells

    Article • Frontiers in Immunology, October 2021, Frontiers

    Nicolas Degauque

  12. Endothelial cell, myeloid, and adaptive immune responses in SARS‐CoV‐2 infection

    Article • The FASEB Journal, April 2021, Wiley

    Nicolas Degauque

  13. Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial

    Article • Trials, March 2021, Springer Science + Business Media

    Nicolas Degauque

  14. Efficient Expansion of Human Granzyme B–Expressing B Cells with Potent Regulatory Properties

    Article • The Journal of Immunology, November 2020, The American Association of Immunologists

    Nicolas Degauque

  15. Transcriptional meta‐analysis of regulatory B cells

    Article • European Journal of Immunology, June 2020, Wiley

    Nicolas Degauque

  16. Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure

    Article • Journal of the American Society of Nephrology, March 2020, American Society of Nephrology

    Nicolas Degauque

  17. CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation

    Article • Frontiers in Immunology, September 2019, Frontiers

    Nicolas Degauque

  18. Dampening of CD8+ T Cell Response by B Cell Depletion Therapy in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

    Article • Arthritis & Rheumatology, March 2019, Wiley

    Nicolas Degauque

  19. Cytotoxic CD8 + T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

    Article • Proceedings of the National Academy of Sciences, January 2019, Proceedings of the National Academy of Sciences

    Nicolas Degauque

  20. IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

    Article • Nature Communications, October 2018, Springer Science + Business Media

    Nicolas Degauque

  21. Regulation of the Immune Response by the Inflammatory Metabolic Microenvironment in the Context of Allotransplantation

    Article • Frontiers in Immunology, June 2018, Frontiers

    Nicolas Degauque

  22. High circulating CD4 + CD25 hi FOXP3 + T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome

    Article • The Journal of Heart and Lung Transplantation, June 2018, Elsevier

    Nicolas Degauque

  23. Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance

    Article • Kidney International, May 2018, Elsevier

    Nicolas Degauque

  24. Corrigendum: Broad Impairment of Natural Killer Cells From Operationally Tolerant Kidney Transplanted Patients

    Article • Frontiers in Immunology, March 2018, Frontiers

    Nicolas Degauque

  25. An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8 + T cells involved in multiple sclerosis

    Article • Journal of Autoimmunity, March 2018, Elsevier

    Nicolas Degauque

  26. Fate of transplanted lungs is controlled by immune cells encounter within pulmonary allografts

    Article • American Journal of Transplantation, January 2018, Elsevier

    Nicolas Degauque

  27. Broad Impairment of Natural Killer Cells From Operationally Tolerant Kidney Transplanted Patients

    Article • Frontiers in Immunology, December 2017, Frontiers

    Nicolas Degauque

  28. IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients

    Article • Frontiers in Immunology, June 2017, Frontiers

    Nicolas Degauque

  29. Blood biomarkers of kidney transplant rejection, an endless search?

    Article • Expert Review of Molecular Diagnostics, June 2017, Taylor & Francis

    Nicolas Degauque

  30. Renal Operational Tolerance Is Associated With a Defect of Blood Tfh Cells That Exhibit Impaired B Cell Help

    Article • American Journal of Transplantation, January 2017, Wiley

    Nicolas Degauque

  31. Sialylation of antibodies in kidney recipients with de novo donor specific antibody, with or without antibody mediated rejection

    Article • Human Immunology, November 2016, Elsevier

    Nicolas Degauque

  32. Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis

    Article • Clinical Immunology, May 2016, Elsevier

    Nicolas Degauque

  33. Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation

    Article • Frontiers in Immunology, March 2016, Frontiers

    Nicolas Degauque

  34. Benefits of Using CD45RA and CD28 to Investigate CD8 Subsets in Kidney Transplant Recipients

    Article • American Journal of Transplantation, March 2016, Elsevier

    Nicolas Degauque

  35. Targeting CD8 T-Cell Metabolism in Transplantation

    Article • Frontiers in Immunology, October 2015, Frontiers

    Nicolas Degauque

  36. Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties

    Article • Journal of the American Society of Nephrology, October 2015, Wolters Kluwer Health

    Nicolas Degauque

  37. Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients

    Article • Liver International, August 2015, Wiley

    Nicolas Degauque

  38. Central Role of CD45RA− Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance

    Article • Journal of the American Society of Nephrology, August 2015, Wolters Kluwer Health

    Nicolas Degauque

  39. Regulatory T Cells in Kidney Transplantation: New Directions?

    Article • American Journal of Transplantation, July 2015, Wiley

    Nicolas Degauque

  40. A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft

    Article • Kidney International, May 2015, Elsevier

    Nicolas Degauque

  41. Expanded CD 8 T‐cell sharing between periphery and CNS in multiple sclerosis

    Article • Annals of Clinical and Translational Neurology, April 2015, Wiley

    david laplaud, Nicolas Degauque

  42. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis

    Article • Journal of Immunology Research, January 2015, Hindawi Publishing Corporation

    Nicolas Degauque

  43. Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis

    Article • Clinical Immunology, December 2014, Elsevier

    Nicolas Degauque

  44. Expansion of Highly Differentiated Cytotoxic Terminally Differentiated Effector Memory CD8+ T Cells in a Subset of Clinically Stable Kidney Transplant Recipients

    Article • Journal of the American Society of Nephrology, August 2014, Wolters Kluwer Health

    Nicolas Degauque

  45. Correction: Characterization of Antigen-Specific B Cells Using Nominal Antigen-Coated Flow-Beads

    Article • PLOS One, July 2014, PLOS

    Nicolas Degauque

  46. Fragile TIM-4–expressing tissue resident macrophages are migratory and immunoregulatory

    Article • Journal of Clinical Investigation, July 2014, American Society for Clinical Investigation

    Nicolas Degauque

  47. The immunomodulatory properties of mesenchymal stromal cells isolated from the synovial fluid of human osteoarthritic joints

    Article • Osteoarthritis and Cartilage, April 2014, Elsevier

    Nicolas Degauque

  48. Unique B Cell Differentiation Profile in Tolerant Kidney Transplant Patients

    Article • American Journal of Transplantation, January 2014, Elsevier

    Nicolas Degauque

  49. Characterization of Antigen-Specific B Cells Using Nominal Antigen-Coated Flow-Beads

    Article • PLOS One, December 2013, PLOS

    Nicolas Degauque

  50. Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity

    Article • Immunity, May 2013, Elsevier

    Nicolas Degauque

  51. Expression of miR-142-5p in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Chronic Antibody-Mediated Rejection

    Article • PLOS One, April 2013, PLOS

    Nicolas Degauque

  52. Regulatory B Cells and Tolerance in Transplantation: From Animal Models to Human

    Article • Frontiers in Immunology, January 2013, Frontiers

    Nicolas Degauque

  53. A phenotypic, transcriptional and TCR Vβ repertoire signature of CD8+ T cells define a population at-risk of long-term kidney graft dysfunction

    Article • Journal of Translational Medicine, November 2012, Springer Science + Business Media

    Nicolas Degauque

  54. No lack of regulatory B cells in patients with Multiple Sclerosis

    Article • Journal of Translational Medicine, November 2012, Springer Science + Business Media

    Nicolas Degauque

  55. Upregulation of miR-142-3p in Peripheral Blood Mononuclear Cells of Operationally Tolerant Patients with a Renal Transplant

    Article • Journal of the American Society of Nephrology, April 2012, Wolters Kluwer Health

    Nicolas Degauque

  56. Loss of IL-10 secretion by regulatory B lymphocytes in multiple sclerosis patients

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Nicolas Degauque

  57. Natalizumab alters the TCR repertoire after one year of treatment in four MS patients

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Nicolas Degauque

  58. The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vß repertoire but with an unmodified phenotype

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Nicolas Degauque

  59. The Blood of Healthy Individuals Exhibits CD8 T Cells with a Highly Altered TCR Vb Repertoire but with an Unmodified Phenotype

    Article • PLOS One, June 2011, PLOS

    Nicolas Degauque

  60. Analysis of the peripheral T-cell repertoire in kidney transplant patients

    Article • European Journal of Immunology, October 2010, Wiley

    Nicolas Degauque

  61. Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype

    Article • Kidney International, September 2010, Elsevier

    Nicolas Degauque

  62. Cross-Reactivity of Herpesvirus-Specific CD8 T Cell Lines Toward Allogeneic Class I MHC Molecules

    Article • PLOS One, August 2010, PLOS

    Nicolas Degauque

  63. AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance

    Article • Journal of Cellular Biochemistry, July 2010, Wiley

    Nicolas Degauque

  64. T cell recognition of self-antigen presenting cells by protein transfer assay reveals a high frequency of anti-myelin T cells in multiple sclerosis

    Article • Brain, April 2010, Oxford University Press (OUP)

    Nicolas Degauque

  65. A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice

    Article • Arthritis & Rheumatism, December 2009, Wiley

    Nicolas Degauque

  66. TIM-1: A New Player in Transplant Immunity

    Article • Transplantation, May 2009, Wolters Kluwer Health

    Nicolas Degauque

  67. Indirect CD4+ TH1 Response, Antidonor Antibodies and Diffuse C4d Graft Deposits in Long-Term Recipients Conditioned by Donor Antigens Priming

    Article • American Journal of Transplantation, April 2009, Elsevier

    Nicolas Degauque

  68. Tim-1 Signaling Substitutes for Conventional Signal 1 and Requires Costimulation to Induce T Cell Proliferation

    Article • The Journal of Immunology, February 2009, The American Association of Immunologists

    Nicolas Degauque

  69. Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Nicolas Degauque

  70. The Innate NK Cells, Allograft Rejection, and a Key Role for IL-15

    Article • The Journal of Immunology, June 2008, The American Association of Immunologists

    Nicolas Degauque

  71. Implication of Matrix Metalloproteinase 7 and the Noncanonical Wingless-Type Signaling Pathway in a Model of Kidney Allograft Tolerance Induced by the Administration of Anti-Donor Class II Antibodies

    Article • The Journal of Immunology, February 2008, The American Association of Immunologists

    Nicolas Degauque

  72. Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

    Article • Journal of Clinical Investigation, February 2008, American Society for Clinical Investigation

    Nicolas Degauque

  73. OX40 costimulation turns off Foxp3+ Tregs

    Article • Blood, October 2007, American Society of Hematology

    Nicolas Degauque

  74. Reciprocal generation of Th1/Th17 and Treg cells by B1 and B2 B cells

    Article • European Journal of Immunology, September 2007, Wiley

    Nicolas Degauque

  75. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

    Article • Proceedings of the National Academy of Sciences, August 2007, Proceedings of the National Academy of Sciences

    Nicolas Degauque

  76. Effects of Cyclosporine on Transplant Tolerance: The Role of IL‐2

    Article • American Journal of Transplantation, August 2007, Elsevier

    Nicolas Degauque

  77. Regulation of T-Cell Immunity by T-Cell Immunoglobulin and Mucin Domain Proteins

    Article • Transplantation, July 2007, Wolters Kluwer Health

    Nicolas Degauque

  78. Functional Compartmentalization Following Induction of Long-Term Graft Survival with Pregraft Donor-Specific Transfusion

    Article • American Journal of Transplantation, March 2007, Elsevier

    Nicolas Degauque

  79. Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases

    Article • Molecular Immunology, February 2007, Elsevier

    Nicolas Degauque

  80. A Novel Cell-based Therapeutic Approach to Prevent and Cure Autoimmune Type I Diabetes in NOD Mice

    Article • Clinical Immunology, January 2007, Elsevier

    Nicolas Degauque

  81. Development of CD25– regulatory T cells following heart transplantation: Evidence for transfer of long-term survival

    Article • European Journal of Immunology, January 2007, Wiley

    Nicolas Degauque

  82. New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses

    Article • Blood, December 2006, American Society of Hematology

    Nicolas Degauque

  83. Blood T-Cell Repertoire in Idiopathic Nephrotic Syndrome Recurrence Following Kidney Transplantation

    Article • American Journal of Transplantation, September 2006, Elsevier

    Nicolas Degauque

  84. Dominant Tolerance to Kidney Allografts Induced by Anti-Donor MHC Class II Antibodies: Cooperation between T and Non-T CD103+ Cells

    Article • The Journal of Immunology, April 2006, The American Association of Immunologists

    Nicolas Degauque

  85. Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity

    Article • The Journal of Immunology, January 2006, The American Association of Immunologists

    Nicolas Degauque

  86. Compartmentalization of TCR repertoire alteration during rejection of an intrabrain xenograft

    Article • Experimental Neurology, April 2005, Elsevier

    Nicolas Degauque

  87. Operationally Tolerant and Minimally Immunosuppressed Kidney Recipients Display Strongly Altered Blood T-Cell Clonal Regulation

    Article • American Journal of Transplantation, February 2005, Elsevier

    Nicolas Degauque

  88. Blood T-cell Vβ transcriptome in melanoma patients

    Article • International Journal of Cancer, March 2004, Wiley

    Nicolas Degauque

  89. Blood T-cell receptor   chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution

    Article • Brain, February 2004, Oxford University Press (OUP)

    Nicolas Degauque

  90. Tolerance induction in rats, using a combination of anti-CD154 and donor splenocytes, given once on the day of transplantation1

    Article • Transplantation, January 2003, Wolters Kluwer Health

    Nicolas Degauque

  91. Direct Recognition of Foreign MHC Determinants by Naive T Cells Mobilizes Specific Vβ Families Without Skewing of the Complementarity-Determining Region 3 Length Distribution

    Article • The Journal of Immunology, September 2001, The American Association of Immunologists

    Nicolas Degauque