All Stories

  1. Somatically mutated ABL1 is an actionable and essential NSCLC survival gene
  2. Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
  3. Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges
  4. Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability
  5. Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor
  6. Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
  7. Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell‐Defective Apoptosis and Hyperproliferation
  8. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
  9. Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region