All Stories

  1. Structural insights into biased signaling at chemokine receptor CCR7

    Article • Proceedings of the National Academy of Sciences, April 2026, Proceedings of the National Academy of Sciences

    Dr Naotaka Tsutsumi

  2. Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide

    Article • Communications Biology, February 2026, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  3. Targeting of Kaposi’s sarcoma-associated herpesvirus by immunotoxins directed against the viral G protein-coupled receptor, ORF74

    Article • Biomedicine & Pharmacotherapy, February 2026, Elsevier

    Dr Naotaka Tsutsumi

  4. Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41

    Article • British Journal of Pharmacology, October 2024, Wiley

    Dr Naotaka Tsutsumi

  5. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

    Article • Cell, September 2023, Elsevier

    Dr Naotaka Tsutsumi

  6. Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism

    Article • eLife, August 2023, eLife

    Dr Naotaka Tsutsumi

  7. Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

    Article • Nature Communications, April 2023, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  8. Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination

    Article • Proceedings of the National Academy of Sciences, March 2023, Proceedings of the National Academy of Sciences

    Dr Naotaka Tsutsumi

  9. Structural basis of Janus kinase trans-activation

    Article • Cell Reports, March 2023, Elsevier

    Dr Naotaka Tsutsumi

  10. Viral G Protein–Coupled Receptors Encoded by β- and γ-Herpesviruses

    Article • Annual Review of Virology, September 2022, Annual Reviews

    Dr Naotaka Tsutsumi

  11. Organizing structural principles of the IL-17 ligand–receptor axis

    Article • Nature, July 2022, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  12. Structure of the IL-27 quaternary receptor signaling complex

    Article • eLife, May 2022, eLife

    Dr Naotaka Tsutsumi

  13. Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

    Article • Science, April 2022, American Association for the Advancement of Science

    Dr Naotaka Tsutsumi

  14. Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

    Article • Science Advances, January 2022, American Association for the Advancement of Science

    Dr Naotaka Tsutsumi

  15. Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

    Article • Immunity, July 2021, Elsevier

    Dr Naotaka Tsutsumi

  16. Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10

    Article • Science, March 2021, American Association for the Advancement of Science

    Dr Naotaka Tsutsumi

  17. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Dr Naotaka Tsutsumi

  18. Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

    Article • eLife, August 2020, eLife

    Dr Naotaka Tsutsumi

  19. Structure and selectivity engineering of the M 1 muscarinic receptor toxin complex

    Article • Science, July 2020, American Association for the Advancement of Science

    Dr Naotaka Tsutsumi

  20. An innate interaction between IL-18 and the propeptide that inactivates its precursor form

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  21. Structure of the IFNγ receptor complex guides design of biased agonists

    Article • Nature, February 2019, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  22. Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Article • eLife, June 2018, eLife

    Dr Naotaka Tsutsumi

  23. Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Dr Naotaka Tsutsumi

  24. The structural basis for receptor recognition of human interleukin-18

    Article • Nature Communications, December 2014, Springer Science + Business Media

    Dr Naotaka Tsutsumi

  25. Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2014, International Union of Crystallography

    Dr Naotaka Tsutsumi

  26. Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

    Article • Molecular Immunology, March 2014, Elsevier

    Dr Naotaka Tsutsumi

  27. Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling

    Article • Molecular Immunology, October 2012, Elsevier

    Dr Naotaka Tsutsumi, Dr Yuji O. Kamatari

  28. Expanded π-Electron Systems, Tri(phenanthro)hexaazatriphenylenes and Tri(phenanthrolino)hexaazatriphenylenes, That Are Self-Assembled To Form One-Dimensional Aggregates

    Article • The Journal of Organic Chemistry, September 2010, American Chemical Society (ACS)

    Dr Naotaka Tsutsumi