All Stories

  1. Microglia in Parkinson’s Disease

    Article • Journal of Parkinson s Disease, September 2022, IOS Press

    Nadia Stefanova

  2. Host oligodendrogliopathy and ɑ-synuclein strains dictate disease severity in multiple system atrophy

    Article • Brain, February 2022, Oxford University Press (OUP)

    Nadia Stefanova

  3. The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy

    Article • Journal of Parkinson s Disease, January 2022, IOS Press

    Nadia Stefanova

  4. Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices

    Article • Biomolecules, January 2022, MDPI AG

    Nadia Stefanova

  5. Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy

    Article • Neurobiology of Disease, November 2021, Elsevier

    Nadia Stefanova

  6. The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders

    Article • Frontiers in Neurology, October 2021, Frontiers

    Nadia Stefanova

  7. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease

    Article • Parkinsonism & Related Disorders, October 2021, Elsevier

    Nadia Stefanova

  8. Is Multiple System Atrophy a Prion-like Disorder?

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Nadia Stefanova

  9. Current experimental disease-modifying therapeutics for multiple system atrophy

    Article • Journal of Neural Transmission, August 2021, Springer Science + Business Media

    Nadia Stefanova

  10. Neuropathology of multiple system atrophy: Kurt Jellinger`s legacy

    Article • Journal of Neural Transmission, July 2021, Springer Science + Business Media

    Nadia Stefanova

  11. ATH434 Reduces α‐Synuclein‐Related Neurodegeneration in a Murine Model of Multiple System Atrophy

    Article • Movement Disorders, July 2021, Wiley

    Nadia Stefanova

  12. Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit α2δ-2 Mutant (Ducky) and α2δ Double Knockout Mice

    Article • Frontiers in Synaptic Neuroscience, February 2021, Frontiers

    Nadia Stefanova

  13. Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease

    Article • Movement Disorders, October 2020, Wiley

    Nadia Stefanova

  14. Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

    Article • Translational Neurodegeneration, September 2020, Springer Science + Business Media

    Nadia Stefanova

  15. From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein

    Article • Frontiers in Synaptic Neuroscience, September 2020, Frontiers

    Nadia Stefanova

  16. Signs of early cellular dysfunction in multiple system atrophy

    Article • Neuropathology and Applied Neurobiology, September 2020, Wiley

    Nadia Stefanova

  17. Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies

    Article • Frontiers in Synaptic Neuroscience, September 2020, Frontiers

    Nadia Stefanova

  18. Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α‐Synucleinopathies

    Article • Movement Disorders, September 2020, Wiley

    Nadia Stefanova

  19. Shock waves promote spinal cord repair via TLR3

    Article • JCI Insight, August 2020, American Society for Clinical Investigation

    Nadia Stefanova

  20. Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases

    Article • Investigative Ophthalmology & Visual Science, June 2020, Association for Research in Vision and Ophthalmology (ARVO)

    Nadia Stefanova

  21. Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

    Article • Acta Neuropathologica Communications, June 2020, Springer Science + Business Media

    Nadia Stefanova

  22. MSA: From basic mechanisms to experimental therapeutics

    Article • Parkinsonism & Related Disorders, April 2020, Elsevier

    Nadia Stefanova

  23. Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy

    Article • Journal of Neural Transmission, February 2020, Springer Science + Business Media

    Nadia Stefanova

  24. High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy

    Article • Journal of Neuroinflammation, January 2020, Springer Science + Business Media

    Nadia Stefanova

  25. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2019, Elsevier

    Nadia Stefanova

  26. Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies

    Article • Frontiers in Cellular Neuroscience, June 2019, Frontiers

    Nadia Stefanova

  27. Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges

    Article • Clinical Autonomic Research, June 2019, Springer Science + Business Media

    Nadia Stefanova

  28. L-dopa response pattern in a rat model of mild striatonigral degeneration

    Article • PLoS ONE, June 2019, PLOS

    Nadia Stefanova

  29. Increased anxiety-like behavior following circuit-specific catecholamine denervation in mice

    Article • Neurobiology of Disease, May 2019, Elsevier

    Nadia Stefanova

  30. Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

    Article • Movement Disorders, November 2018, Wiley

    Nadia Stefanova

  31. Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

    Article • Frontiers in Neuroscience, July 2018, Frontiers

    Nadia Stefanova

  32. Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

    Article • BMC Neuroscience, May 2018, Springer Science + Business Media

    Nadia Stefanova

  33. Translational therapies for multiple system atrophy: Bottlenecks and future directions

    Article • Autonomic Neuroscience, May 2018, Elsevier

    Nadia Stefanova

  34. The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint

    Article • Journal of Alzheimer s Disease, January 2018, IOS Press

    Nadia Stefanova

  35. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies

    Article • Acta Neuropathologica Communications, January 2018, Springer Science + Business Media

    Nadia Stefanova

  36. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting

    Article • Neurology, December 2017, Wolters Kluwer Health

    Nadia Stefanova

  37. Multiple system atrophy: experimental models and reality

    Article • Acta Neuropathologica, October 2017, Springer Science + Business Media

    Nadia Stefanova

  38. Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

    Article • Molecular Neurodegeneration, July 2017, Springer Science + Business Media

    Nadia Stefanova

  39. Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease

    Article • Journal of Neuroscience, June 2017, Society for Neuroscience

    Nadia Stefanova

  40. Very late-onset pure autonomic failure

    Article • Movement Disorders, April 2017, Wiley

    Nadia Stefanova

  41. Distinct Parameters in the EEG of the PLP α-SYN Mouse Model for Multiple System Atrophy Reinforce Face Validity

    Article • Frontiers in Behavioral Neuroscience, January 2017, Frontiers

    Nadia Stefanova

  42. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy

    Article • Neurotherapeutics, June 2016, Springer Science + Business Media

    Nadia Stefanova

  43. Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy

    Article • Frontiers in Neuroscience, March 2016, Frontiers

    Nadia Stefanova

  44. Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications

    Article • PLoS ONE, March 2016, PLOS

    Nadia Stefanova

  45. Microglia activation as a therapeutic target in multiple system atrophy: the timing, the good and the bad

    Article • Macrophage, March 2016, Smart Science and Technology, LLC

    Nadia Stefanova

  46. Preface

    Article • Movement Disorders, February 2016, Wiley

    Nadia Stefanova

  47. Review: Multiple system atrophy: emerging targets for interventional therapies

    Article • Neuropathology and Applied Neurobiology, February 2016, Wiley

    Nadia Stefanova

  48. Toward disease modification in multiple system atrophy: Pitfalls, bottlenecks, and possible remedies

    Article • Movement Disorders, January 2016, Wiley

    Nadia Stefanova

  49. Glia and alpha-synuclein in neurodegeneration: A complex interaction

    Article • Neurobiology of Disease, January 2016, Elsevier

    Nadia Stefanova

  50. Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity

    Article • BMC Neuroscience, December 2015, Springer Science + Business Media

    Nadia Stefanova

  51. Shock Wave Treatment Protects From Neuronal Degeneration via a Toll‐Like Receptor 3 Dependent Mechanism: Implications of a First‐Ever Causal Treatment for Ischemic Spinal Cord Injury

    Article • Journal of the American Heart Association, October 2015, Wolters Kluwer Health

    Nadia Stefanova

  52. Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype

    Article • PLoS ONE, October 2015, PLOS

    Nadia Stefanova

  53. Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

    Article • Neurology, October 2015, Wolters Kluwer Health

    Nadia Stefanova

  54. Alpha-synuclein immunoreactivity patterns in the enteric nervous system

    Article • Neuroscience Letters, August 2015, Elsevier

    Nadia Stefanova

  55. Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications

    Article • Neurotoxicity Research, July 2015, Springer Science + Business Media

    Nadia Stefanova

  56. Animal models of multiple system atrophy

    Article • Clinical Autonomic Research, January 2015, Springer Science + Business Media

    Nadia Stefanova

  57. Multiple System Atrophy: Genetic or Epigenetic?

    Article • Experimental Neurobiology, December 2014, The Korean Society for Brain and Neural Science (KAMJE)

    Nadia Stefanova

  58. Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies

    Article • Parkinsonism & Related Disorders, August 2014, Elsevier

    Nadia Stefanova

  59. Towards translational therapies for multiple system atrophy

    Article • Progress in Neurobiology, July 2014, Elsevier

    Nadia Stefanova

  60. CaV1.2 Calcium Channel Expression in Reactive Astrocytes is associated with the Formation of Amyloid-β Plaques in an Alzheimer's Disease Mouse Model

    Article • Journal of Alzheimer s Disease, September 2013, IOS Press

    Nadia Stefanova

  61. Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: Experimental evidence

    Article • Experimental Neurology, September 2013, Elsevier

    Nadia Stefanova

  62. Intact Olfaction in a Mouse Model of Multiple System Atrophy

    Article • PLoS ONE, May 2013, PLOS

    Nadia Stefanova

  63. Bladder dysfunction in a transgenic mouse model of multiple system atrophy

    Article • Movement Disorders, February 2013, Wiley

    Nadia Stefanova

  64. Models of Multiple System Atrophy

    Article • January 2013, Springer Science + Business Media

    Nadia Stefanova

  65. Cell Fate Analysis of Embryonic Ventral Mesencephalic Grafts in the 6-OHDA Model of Parkinson's Disease

    Article • PLoS ONE, November 2012, PLOS

    Nadia Stefanova

  66. Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

    Article • Glia, October 2012, Wiley

    Professor Lars P Klimaschewski, Nadia Stefanova

  67. The Role of Glia in Alpha-Synucleinopathies

    Article • Molecular Neurobiology, September 2012, Springer Science + Business Media

    Nadia Stefanova

  68. Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

    Article • Acta Neuropathologica, April 2012, Springer Science + Business Media

    Nadia Stefanova

  69. Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model

    Article • Neurotoxicity Research, December 2011, Springer Science + Business Media

    Nadia Stefanova

  70. Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

    Article • American Journal Of Pathology, August 2011, Elsevier

    Nadia Stefanova

  71. Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection

    Article • PLoS ONE, May 2011, PLOS

    Nadia Stefanova

  72. Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

    Article • Acta Neuropathologica, May 2011, Springer Science + Business Media

    Nadia Stefanova

  73. Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages

    Article • BMC Research Notes, January 2011, Springer Science + Business Media

    Nadia Stefanova

  74. Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy

    Article • Movement Disorders, January 2011, Wiley

    Nadia Stefanova

  75. Targeted overexpression of human α-synuclein in oligodendroglia induces lesions linked to MSA -like progressive autonomic failure

    Article • Experimental Neurology, August 2010, Elsevier

    Nadia Stefanova

  76. Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection

    Article • Hippocampus, January 2010, Wiley

    Nadia Stefanova

  77. Multiple system atrophy: an update

    Article • The Lancet Neurology, December 2009, Elsevier

    Nadia Stefanova

  78. Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy

    Article • Journal of Neuroscience Research, September 2009, Wiley

    Nadia Stefanova

  79. Striatal transplantation for multiple system atrophy — Are grafts affected by α-synucleinopathy?

    Article • Experimental Neurology, September 2009, Elsevier

    Nadia Stefanova

  80. Recent developments in multiple system atrophy

    Article • Journal of Neurology, May 2009, Springer Science + Business Media

    Nadia Stefanova

  81. Striatal transplantation in a rodent model of multiple system atrophy: Effects on L-Dopa response

    Article • Journal of Neuroscience Research, May 2009, Wiley

    Nadia Stefanova

  82. Multiple system atrophy: A primary oligodendrogliopathy

    Article • Annals of Neurology, September 2008, Wiley

    Nadia Stefanova

  83. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy

    Article • Experimental Neurology, April 2008, Elsevier

    Nadia Stefanova

  84. Axl and Growth Arrest–Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

    Article • Clinical Cancer Research, January 2008, American Association for Cancer Research (AACR)

    Nadia Stefanova

  85. Microglial activation mediates neurodegeneration related to oligodendroglial α-synucleinopathy: Implications for multiple system atrophy

    Article • Movement Disorders, September 2007, Wiley

    Nadia Stefanova

  86. High dose levodopa therapy is not toxic in multiple system atrophy: Experimental evidence

    Article • Movement Disorders, April 2007, Wiley

    Nadia Stefanova

  87. Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy

    Article • Movement Disorders, January 2007, Wiley

    Nadia Stefanova

  88. Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy

    Article • Brain Research Bulletin, December 2005, Elsevier

    Nadia Stefanova

  89. Animal models of multiple system atrophy

    Article • Trends in Neurosciences, September 2005, Elsevier

    Nadia Stefanova

  90. Oxidative Stress in Transgenic Mice with Oligodendroglial α-Synuclein Overexpression Replicates the Characteristic Neuropathology of Multiple System Atrophy

    Article • American Journal Of Pathology, March 2005, Elsevier

    Nadia Stefanova

  91. Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats

    Article • NeuroImage, February 2005, Elsevier

    Clemens Decristoforo, Nadia Stefanova

  92. In vitro models of multiple system atrophy

    Article • Movement Disorders, January 2005, Wiley

    Nadia Stefanova

  93. Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy)

    Article • Journal of Neural Transmission, December 2004, Springer Science + Business Media

    Nadia Stefanova

  94. Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy)

    Article • Acta Neuropathologica, November 2004, Springer Science + Business Media

    Nadia Stefanova

  95. Effects of pulsatile l-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)

    Article • Neurobiology of Disease, April 2004, Elsevier

    Nadia Stefanova

  96. Neuroprotective agents for clinical trials in Parkinson's disease: A systematic assessment

    Article • Neurology, January 2004, Wolters Kluwer Health

    Nadia Stefanova

  97. Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration

    Article • Journal of Neuroscience Research, January 2004, Wiley

    Nadia Stefanova

  98. Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)

    Article • Acta Neuropathologica, August 2003, Springer Science + Business Media

    Nadia Stefanova

  99. Tumor necrosis factor-?-induced cell death in U373 cells overexpressing ?-synuclein

    Article • Journal of Neuroscience Research, July 2003, Wiley

    Professor Lars P Klimaschewski, Nadia Stefanova

  100. Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys

    Article • Neuroscience Letters, December 2002, Elsevier

    Nadia Stefanova

  101. Freezing of gait in postmortem‐confirmed atypical parkinsonism

    Article • Movement Disorders, April 2002, Wiley

    Professor Irene Litvan, Nadia Stefanova

  102. Ultrastructure of α-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells

    Article • Neuroscience Letters, April 2002, Elsevier

    Nadia Stefanova

  103. Overstimulation of the α1B-adrenergic receptor causes a “seizure plus” syndrome

    Article • Nature Reports Stem Cells, February 2001, Springer Science + Business Media

    Nadia Stefanova

  104. Glial cell death induced by overexpression of ?-synuclein

    Article • Journal of Neuroscience Research, January 2001, Wiley

    Professor Lars P Klimaschewski, Nadia Stefanova

  105. Multiple System Atrophy

    Article • Seminars in Neurology, January 2001, Thieme Publishing Group

    Nadia Stefanova

  106. Failure of Neuroprotection by Embryonic Striatal Grafts in a Double Lesion Rat Model of Striatonigral Degeneration (Multiple System Atrophy)

    Article • Experimental Neurology, July 2000, Elsevier

    Nadia Stefanova

  107. γ-Aminobutyric acid-immunoreactive neurons in the amygdala of the rat – sex differences and effect of early postnatal castration

    Article • Neuroscience Letters, October 1998, Elsevier

    Nadia Stefanova

  108. Sex and age differences of neurons expressing gaba‐immunoreactivity in the rat bed nucleus of the stria terminalis

    Article • International Journal of Developmental Neuroscience, October 1998, Wiley

    Nadia Stefanova