All Stories

  1. From transcription to export: mRNA’s winding path to the cytoplasm
  2. Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
  3. MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
  4. Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus
  5. Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
  6. Polyadenylation and nuclear export of mRNAs
  7. Structure–function relationships in the Nab2 polyadenosine‐RNA binding Zn finger protein family
  8. Structure and Function of the TREX-2 Complex
  9. Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex
  10. Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae
  11. Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
  12. Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
  13. The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region
  14. 1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex
  15. Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2
  16. Structural characterization of the principal mRNA-export factor Mex67–Mtr2 fromChaetomium thermophilum
  17. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  18. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  19. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  20. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  21. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  22. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  23. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  24. IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
  25. Selective Targeting of the TPX2 Site of Importin‐α Using Fragment‐Based Ligand Design
  26. Structure of the LRR and NTF2-like domains of NXF1 complexed with NXT1
  27. Promiscuous Binding of Karyopherinβ1 Modulates FG Nucleoporin Barrier Function and Expedites NTF2 Transport Kinetics
  28. The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA
  29. Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface
  30. Structural basis for P an3 binding to P an2 and its function in mRNA recruitment and deadenylation
  31. Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export
  32. Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
  33. Ran in Nucleocytoplasmic Transport
  34. Nab2 Zn fingers complexed with polyadenosine
  35. Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers
  36. Choreography of importin-α/CAS complex assembly and disassembly at nuclear pores
  37. Structural biology of the PCI-protein fold
  38. Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export
  39. Structural basis for the assembly and disassembly of mRNA nuclear export complexes
  40. Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex
  41. Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
  42. Electron Tomography of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum
  43. Role of Major Sperm Protein (MSP) in the Protrusion and Retraction of Ascaris Sperm
  44. Reconstitution of Amoeboid Motility In Vitro Identifies a Motor-Independent Mechanism for Cell Body Retraction
  45. Single Molecule Studies of Nuclear Transport
  46. Cryo-Electron Microscopy, Tomography, and Single-Particle Analysis of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum
  47. Nuclear export of mRNA
  48. GANP enhances the efficiency of mRNA nuclear export in mammalian cells
  49. Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures
  50. Nab-bing onto Gfd1♦
  51. Structural Basis for the Function of the Saccharomyces cerevisiae Gfd1 Protein in mRNA Nuclear Export
  52. Simulation of cell motility that reproduces the force–velocity relationship
  53. TPX2:importin-alpha complex
  54. Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin- 
  55. Choreography of Importin α/CAS Complex Assembly and Disassembly at the Nuclear Pore Complex
  56. mRNA Export from Mammalian Cell Nuclei Is Dependent on GANP
  57. Structural Basis for the Interaction between Yeast Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex Components Sgf11 and Sus1
  58. Dephosphorylation of Major Sperm Protein (MSP) Fiber Protein 3 by Protein Phosphatase 2A during Cell Body Retraction in the MSP-based Amoeboid Motility of Ascaris Sperm
  59. Structural Requirements for the Ubiquitin-associated Domain of the mRNA Export Factor Mex67 to Bind Its Specific Targets, the Transcription Elongation THO Complex Component Hpr1 and Nucleoporin FXFG Repeats
  60. Mutational Uncoupling of the Role of Sus1 in Nuclear Pore Complex Targeting of an mRNA Export Complex and Histone H2B Deubiquitination
  61. Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export
  62. Mechanism of MSP-based Cell Body Retraction in the Amoeboid Sperm of Nematodes
  63. Kap95p Binding Induces the Switch Loops of RanGDP to Adopt the GTP-Bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics
  64. Functional Significance of the Interaction between the mRNA-binding Protein, Nab2, and the Nuclear Pore-associated Protein, Mlp1, in mRNA Export
  65. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T
  66. Crystal structure of the head-to-tail junction of tropomyosin
  67. Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT
  68. The role of filament-packing dynamics in powering amoeboid cell motility
  69. Structural basis for the nuclear import of the human androgen receptor
  70. Quality control of mRNA export: An evolutionarily conserved zinc finger protein mediates preferential export of properly processed mRNA to the cytoplasm
  71. Structure of the N-Terminal Mlp1-Binding Domain of the Saccharomyces cerevisiae mRNA-Binding Protein, Nab2
  72. Coordination of Hpr1 and Ubiquitin Binding by the UBA Domain of the mRNA Export Factor Mex67
  73. Inflammation and polyamine catabolism: the good, the bad and the ugly: Figure 1
  74. A Ser/Thr Kinase Required for Membrane-associated Assembly of the Major Sperm Protein Motility Apparatus in the Amoeboid Sperm of Ascaris
  75. Molecular mechanism of the nuclear protein import cycle
  76. Ratcheting mRNA out of the Nucleus
  77. Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin  
  78. Structural basis for the nuclear protein import cycle: Figure 1
  79. Karyopherin flexibility in nucleocytoplasmic transport
  80. 270: The Nuclear Import Receptor Importin α Binds to the Human Androgen Receptor Through a Region Encompassing its DNA Binding and Hinge Domains
  81. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling
  82. Structural Basis for the High-affinity Binding of Nucleoporin Nup1p to the Saccharomyces cerevisiae Importin-β Homologue, Kap95p
  83. Structural basis for nuclear import complex dissociation by RanGTP
  84. Structure of MFP2 and its Function in Enhancing MSP Polymerization in Ascaris Sperm Amoeboid Motility
  85. Cytoskeleton Dynamics Powers Nematode Sperm Motility
  86. Structural Basis for Vertebrate Filamin Dimerization
  87. Structural basis for the assembly of a nuclear export complex
  88. Retraction in Amoeboid Cell Motility Powered by Cytoskeletal Dynamics
  89. Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import
  90. Solution NMR Study of the Interaction Between NTF2 and Nucleoporin FxFG Repeats
  91. A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm
  92. Structural Basis for the Interaction Between the Tap/NXF1 UBA Domain and FG Nucleoporins at 1Å Resolution
  93. GLFG and FxFG Nucleoporins Bind to Overlapping Sites on Importin-beta
  94. The molecular mechanism of translocation through the nuclear pore complex is highly conserved
  95. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats
  96. Molecular machinery of nuclear trafficking
  97. 2.6Å Resolution Crystal Structure of Helices of the Motile Major Sperm Protein (MSP) of Caenorhabditis elegans
  98. Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1
  99. How nematode sperm crawl
  100. Coils and Supercoils in Proteins
  101. NTF2 monomer-dimer equilibrium 1 1Edited by B. Holland
  102. Interaction between Ran and Mog1 Is Required for Efficient Nuclear Protein Import
  103. Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo
  104. Structural basis for bending tropomyosin around actin in muscle thin filaments
  105. Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import
  106. How the assembly dynamics of the nematode major sperm protein generate amoeboid cell motility
  107. Crystallization and Initial X-Ray Diffraction Characterization of Complexes of FxFG Nucleoporin Repeats with Nuclear Transport Factors
  108. Structural Basis for the Interaction between FxFG Nucleoporin Repeats and Importin-β in Nuclear Trafficking
  109. The Molecular Mechanism of Transport of Macromolecules Through Nuclear Pore Complexes
  110. 1.9 Å resolution crystal structure of the Saccharomyces cerevisiae ran-binding protein mog1p 1 1Edited by I. B. Holland
  111. Acting like Actin
  112. Structural basis for the higher Ca2+-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras
  113. Crystallization and preliminary X-ray diffraction analysis of theSaccharomyces cerevisiaeRan-binding protein Mog1p
  114. Dissecting the Interactions between NTF2, RanGDP, and the Nucleoporin XFXFG Repeats
  115. Insights into the Molecular Mechanism of Nuclear Trafficking Using Nuclear Transport Factor 2 (NTF2).
  116. Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP 1 1Edited by I. B. Holland
  117. Localized Depolymerization of the Major Sperm Protein Cytoskeleton Correlates with the Forward Movement of the Cell Body in the Amoeboid Movement of Nematode Sperm
  118. Molecular architecture of the rod domain of the Dictyostelium gelation factor (ABP120)
  119. Structures of nuclear transport components
  120. Major sperm protein
  121. Engineered mutants in the switch II loop of ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import
  122. The crystal structure of mutant actin that affects calcium regulation of muscle contraction
  123. The structure of the Q69L mutant of GDP-ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2) 1 1Edited by I. B. Holland
  124. Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation 1 1Edited by P. E. Wright
  125. Location of the binding site of the mannose-specific lectin comitin on F-actin 1 1Edited by I. B. Holland
  126. NTF2 mediates nuclear import of Ran
  127. Amoeboid Motility without Actin: Insights into the Molecular Mechanism of Locomotion Using the Major Sperm Protein (MSP) of Nematodes
  128. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the ras-family GTPase ran 1 1Edited by I. B. Holland
  129. Structural cell biology — functional integration in macromolecular assemblages
  130. Structural basis for amoeboid motility in nematode sperm
  131. Crystallization and Preliminary X-Ray Diffraction Characterization of a Dimerizing Fragment of the Rod Domain of theDictyosteliumGelation Factor (ABP-120)
  132. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
  133. Nematode sperm: amoeboid movement without actin
  134. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport.
  135. Molecular interactions between the importin α/β heterodimer and proteins involved in vertebrate nuclear protein import
  136. Separate Binding Sites on Nuclear Transport Factor 2 (NTF2) for GDP-Ran and the Phenylalanine-rich Repeat Regions of Nucleoporins p62 and Nsp1p
  137. 2.5 Å Resolution Crystal Structure of the Motile Major Sperm Protein (MSP) ofAscaris suum
  138. The Motile Major Sperm Protein (MSP) fromAscaris suumis a Symmetric Dimer in Solution
  139. The 1.6 Å Resolution Crystal Structure of Nuclear Transport Factor 2 (NTF2)
  140. New Crystal Forms of the Motile Major Sperm Protein (MSP) ofAscaris suum
  141. Nuclear pores and macromolecular assemblies involved in nucleocytoplasmic transport
  142. Macromolecular assemblages atomic-resolution structural biology of the cell: a progress report
  143. Crystallization and Preliminary X-Ray Diffraction Analysis of Nuclear Transport Factor 2
  144. STRUCTURE AND FUNCTION OF THE SALACHIAN EGG CASE
  145. Reconstitution In Vitro of the Motile Apparatus from the Amoeboid Sperm of Ascaris Shows That Filament Assembly and Bundling Move Membranes
  146. Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62
  147. Nematode sperm locomotion
  148. Expression and localization of annexin VII (synexin) in muscle cells
  149. The Motile Major Sperm Protein (MSP) of Ascaris suum Forms Filaments Constructed from Two Helical Subfilaments
  150. Supramolecular assemblies of the Ascaris suum major sperm protein (MSP) associated with amoeboid cell motility
  151. Procedures in electron microscopy
  152. Role of different domains in the self-association of rat nucleoporin p62
  153. Analysis of Repeated Motifs in the Talin Rod
  154. Macromolecular assemblages
  155. Crystallization of the Motile Major Sperm Protein (MSP) of the Nematode Ascaris suum
  156. The relaxed crossbridge pattern in isolated rabbit psoas muscle thick filaments
  157. Intermediate filament structure and assembly
  158. Pathway of incorporation of microinjected lamin A into the nuclear envelope
  159. Structure of tropomyosin at 9 Ångstroms resolution
  160. Nuclear pore structure and function
  161. Molecular interactions in myosin assembly
  162. Transmission electron microscopy of vitrified biological macromolecular assemblies
  163. Molecular interactions in intermediate filaments
  164. Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil
  165. Groping in the dark
  166. Nuclear envelope dynamics and nucleocytoplasmic transport
  167. Selective digestion of nuclear envelopes from Xenopus oocyte germinal vesicles: possible structural role for the nuclear lamina
  168. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring
  169. Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence.
  170. Expression and characterization of human lamin C
  171. Association of gold-labelled nucleoplasmin with the centres of ring components of Xenopus oocyte nuclear pore complexes
  172. Structural predictions for the central domain of dystrophin
  173. Intermediate filaments: structure, assembly and molecular interactions
  174. Structural and chemical characterization of the S layer of a Pseudomonas-like bacterium
  175. Resolution A Biological Perspective
  176. Electron Microscopy of Biological Macromolecules
  177. An ultrastructural study of crossbridge arrangement in the fish skeletal muscle thick filament
  178. The Dictyostelium gelation factor shares a putative actin binding site with alpha-actinins and dystrophin and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation
  179. Molecular interactions in paracrystals of a fragment corresponding to the alpha-helical coiled-coil rod portion of glial fibrillary acidic protein: evidence for an antiparallel packing of molecules and polymorphism related to intermediate filament stru...
  180. Expression in Escherichia coli of fragments of glial fibrillary acidic protein: Characterization, assembly properties and paracrystal formation
  181. The Role of Repeating Sequence Motifs in Interactions Between α-Helical Coiled-Coils such as Myosin, Tropomyosin and Intermediate-Filament Proteins
  182. Transmission electron microscopy of frozen hydrated biological material
  183. The real thing
  184. Preparation of shadowed nuclear envelopes from Xenopus
  185. Computer image processing of electron micrographs of biological structures with helical symmetry
  186. Introduction to the computer image processing of electron micrographs of two-dimensionally ordered biological structures
  187. The structure and interactions of components of nuclear envelopes from Xenopus oocyte germinal vesicles observed by heavy metal shadowing
  188. A new crystal form of tropomyosin
  189. Study of molecular interactions between myosin tails in muscle thick filaments using crosslinking
  190. Structure of the nuclear envelope: Interactions between the nuclear lamina and nuclear pores
  191. A model to account for the elastic element in muscle crossbridges in terms of a bending myosin rod
  192. Arrangement of myosin heads in relaxed thick filaments from frog skeletal muscle
  193. Electron microscopy of frozen-hydrated biological material
  194. Computer Analysis of Ordered Microbiological Objects
  195. AN ultrastructural study of cross-bridge arrangement in the frog thigh muscle thick filament
  196. Three-dimensional reconstruction of thick filaments from Limulus and scorpion muscle
  197. Electron microscopic and optical diffraction analysis of the structure of scorpion muscle thick filaments.
  198. Analysis of the Structure of Paired Helical Filaments
  199. Crystalline order to high resolution in the sheath of Methanospirillum hungatei: A cross-beta structure
  200. Subunit structure of paired helical filaments in Alzheimer's disease
  201. Cryo-electron microscopy of tropomyosin magnesium paracrystals
  202. Crystalline order to a resolution of 4.7 A in the sheath of Methanospirilium hungatii: A cross-beta structure
  203. Length of myosin rod and its proteolytic fragments determined by electron microscopy
  204. Crystalline sheets of tropomyosin
  205. Frog skeletal muscle thick filaments are three-stranded
  206. Nuclear magnetic resonance evidence for a flexible region at the C-terminus of α-tropomyosin
  207. Ciliary but not saltatory movements are inhibited by vanadate microinjected into living cultured cells
  208. Periodic charge distribution in the intermediate filament proteins desmin and vimentin
  209. 1 H NMR study of long and short myosin S2 fragments
  210. Chain register in myosin rod
  211. A cytoskeletal role for glycolytic enzymes
  212. Structure of Limulus telson muscle thick filaments
  213. The myosin filament
  214. Porcine platelet tropomyosin
  215. Structure of α-tropomyosin magnesium paracrystals
  216. The myosin filament
  217. Distribution of calcium and other elements in cryosectioned Bacillus cereus T spores, determined by high-resolution scanning electron probe x-ray microanalysis
  218. Structure of the regular surface layer of Spirillum putridiconchylium
  219. High resolution structure of bacterial regular surface layers
  220. Structure of light meromyosin paracrystals
  221. High resolution scanning electron microprobe analysis of biological material
  222. Electron microscopic location of protein thiol residues
  223. Constant and variable regions in glycoprotein hormone beta subunit sequences: Implications for receptor binding specificity
  224. The structure of chicken scale keratin
  225. The troponin binding region of tropomyosin. Evidence for a site near residues 197 to 127
  226. Cross-bridge movement during muscle contraction
  227. Structure of magnesium paracrystals of α-tropomyosin
  228. The 14-fold periodicity in α-tropomyosin and the interaction with actin
  229. Muscle Structure and Function-An Explanation
  230. Paramyosin: Chemical evidence for chain heterogeneity
  231. Tropomyosin coiled-coil interactions: Evidence for an unstaggered structure
  232. Sequence repeats in α-tropomyosin
  233. Fourteen actin-binding sites on tropomyosin?
  234. The Location of the Troponin Binding Site on Tropomyosin
  235. Tropomyosin: Evidence for no stagger between chains
  236. The fracture mechanism of carbon fibres
  237. Organic stains for electron microscopy
  238. Interpretation of Dark Field Electron Micrographs of Carbon Fibres
  239. A kinetic study of the acid autoxidation of tryptophan
  240. A kinetic study of the alkali degradation of tryptophan
  241. Morphology of Carbon Fibres
  242. Bipartite NLS