All Stories

  1. Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species
  2. Spotting of external calibration standards on blank dried blood spots as a resource sparing protocol
  3. A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays
  4. Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate
  5. Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human
  6. Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations
  7. Simultaneous and stereospecific analysis of warfarin oxidative metabolism using 2D LC/Q-TOF
  8. A Systematic Evaluation of Solubility Enhancing Excipients to Enable the Generation of Permeability Data for Poorly Soluble Compounds in Caco-2 Model
  9. Drug-Drug Interactions 1: Inhibition
  10. Methods for Determination of Enzyme Kinetics and Metabolic Rates
  11. Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3
  12. Allosteric Enzyme- and Transporter-Based Interactions
  13. High-Speed Simultaneous Determination of Nine Antiepileptic Drugs Using Liquid Chromatography-Mass Spectrometry
  14. Synthesis of deuterium-labelled 5′-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d4) as an internal standard for quantitation of Sal-AMS
  15. Enhanced Transformation of TNT by Tobacco Plants Expressing a Bacterial Nitroreductase