All Stories

  1. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors

    Article • Journal of Biomolecular Structure and Dynamics, November 2023, Taylor & Francis

    Mr Muhammad Usman Mirza

  2. Dock-able linear and homodetic di, tri, tetra and pentapeptide library from canonical amino acids: SARS-CoV-2 Mpro as a case study

    Article • Journal of Pharmaceutical Analysis, May 2023, Elsevier

    Mr Muhammad Usman Mirza

  3. An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean–Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target

    Article • Vaccines, December 2022, MDPI AG

    Mr Muhammad Usman Mirza

  4. The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach

    Article • European Journal of Pharmaceutical Sciences, August 2022, Elsevier

    Mr Muhammad Usman Mirza

  5. Structural Elucidation of Rift Valley Fever Virus L Protein towards the Discovery of Its Potential Inhibitors

    Article • Pharmaceuticals, May 2022, MDPI AG

    Mr Muhammad Usman Mirza

  6. Folate Conjugated Polyethylene Glycol Probe for Tumor-Targeted Drug Delivery of 5-Fluorouracil

    Article • Molecules, March 2022, MDPI AG

    Mr Muhammad Usman Mirza, Dr Mahmood Ahmed

  7. Designing multi-epitope vaccine against Staphylococcus aureus by employing subtractive proteomics, reverse vaccinology and immuno-informatics approaches

    Article • Computers in Biology and Medicine, May 2021, Elsevier

    Mr Muhammad Usman Mirza

  8. Effect of Berberis vulgaris L. root extract on ifosfamide-induced in vivo toxicity and in vitro cytotoxicity

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Mr Muhammad Usman Mirza

  9. Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

    Article • Processes, December 2020, MDPI AG

    Dr. Alexandre M.J.J. Bonvin, Mr Muhammad Usman Mirza

  10. Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach

    Article • European Journal of Pharmaceutical Sciences, December 2020, Elsevier

    Mr Muhammad Usman Mirza

  11. Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease

    Article • Computational Biology and Chemistry, December 2020, Elsevier

    Mr Muhammad Usman Mirza

  12. New naphthalene derivative for cost-effective AChE inhibitors for Alzheimer’s treatment: In silico identification, in vitro and in vivo validation

    Article • Computational Biology and Chemistry, December 2020, Elsevier

    Mr Muhammad Usman Mirza

  13. Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

    Article • Journal of Pharmaceutical Analysis, December 2020, Elsevier

    Mr Muhammad Usman Mirza

  14. Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase

    Article • Infection Genetics and Evolution, October 2020, Elsevier

    Mr Muhammad Usman Mirza

  15. A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach

    Article • Biology, September 2020, MDPI AG

    Mr Muhammad Usman Mirza

  16. Enhanced Thermostability and Enzymatic Activity of cel6A Variants from Thermobifida fusca by Empirical Domain Engineering

    Article • Biology, August 2020, MDPI AG

    Mr Muhammad Usman Mirza

  17. Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase

    Article • Journal of Pharmaceutical Analysis, August 2020, Elsevier

    Mr Muhammad Usman Mirza

  18. Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation

    Article • Biology, July 2020, MDPI AG

    Mr Muhammad Usman Mirza

  19. Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro

    Article • Journal of Biomolecular Structure and Dynamics, June 2020, Taylor & Francis

    Mr Muhammad Usman Mirza

  20. Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations

    Article • Immunological Investigations, June 2020, Taylor & Francis

    Mr Muhammad Usman Mirza

  21. A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS‐COV‐2 by Comprehensive Immunoinformatic and Molecular Modelling Approach

    Article • March 2020, MDPI AG

    Mr Muhammad Usman Mirza

  22. Structural Elucidation of SARS-CoV-2 Vital Proteins: Computational Methods Reveal Potential Drug Candidates Against Main Protease, Nsp12 RNA-dependent RNA Polymerase and Nsp13 Helicase

    Article • March 2020, MDPI AG

    Mr Muhammad Usman Mirza

  23. In Vitro Antidiabetic, Anti-Obesity and Antioxidant Analysis of Ocimum basilicum Aerial Biomass and in Silico Molecular Docking Simulations with Alpha-Amylase and Lipase Enzymes

    Article • Biology, December 2019, MDPI AG

    Mr Muhammad Usman Mirza

  24. Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

    Article • Nucleic Acids Research, November 2019, Oxford University Press (OUP)

    Mr Muhammad Usman Mirza

  25. Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations

    Article • International Journal of Molecular Sciences, October 2019, MDPI AG

    Mr Muhammad Usman Mirza, Dr. Sher Alam Khan

  26. A novel pathogenic missense variant in CNNM4 underlying Jalili syndrome: Insights from molecular dynamics simulations

    Article • Molecular Genetics & Genomic Medicine, July 2019, Wiley

    Mr Muhammad Usman Mirza

  27. Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from Pteris cretica L.

    Article • Antioxidants, July 2019, MDPI AG

    Mr Muhammad Usman Mirza

  28. Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity

    Article • Antioxidants, June 2019, MDPI AG

    Mr Muhammad Usman Mirza, Iskandar Abdullah

  29. In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Mr Muhammad Usman Mirza

  30. Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in Escherichia coli: Insights from Molecular Dynamics Simulations

    Article • Biomolecules, April 2019, MDPI AG

    Mr Muhammad Usman Mirza

  31. Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds

    Article • Biomolecules, March 2019, MDPI AG

    Mr Muhammad Usman Mirza

  32. Perspectives towards antiviral drug discovery against Ebola virus

    Article • Journal of Medical Virology, November 2018, Wiley

    Mr Muhammad Usman Mirza

  33. In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

    Article • Drug Design Development and Therapy, May 2018, Dove Medical Press

    Mr Muhammad Usman Mirza, Mr Muhammad Usman Mirza, Tassadaq Hussain Jafar, Mahwish Arooj, Arif Malik

  34. In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer’s Disease

    Article • CNS & Neurological Disorders - Drug Targets, April 2018, Bentham Science Publishers

    Mr Muhammad Usman Mirza, Professor Mohammad A. Kamal, Mr Muhammad Usman Mirza, Imran Irshad

  35. Small Ubiquitin-Like Modifier Protein 3 Enhances the Solubilization of Human Bone Morphogenetic Protein 2 in E. coli

    Article • Applied Biochemistry and Biotechnology, March 2018, Springer Science + Business Media

    Mr Muhammad Usman Mirza

  36. Mutation in DsbA signal sequence hampers the SRP mechanism: A new strategy to combat virulence factor

    Article • February 2018, Cold Spring Harbor Laboratory Press

    Mr Muhammad Usman Mirza

  37. Loss-of-function mutations in ADCY3 cause monogenic severe obesity

    Article • Nature Genetics, January 2018, Nature

    Mr Muhammad Usman Mirza

  38. Structure-based virtual screening and molecular docking for the identification of potential multi-targeted inhibitors against breast cancer

    Article • Breast Cancer Targets and Therapy, June 2017, Dove Medical Press

    Mr Muhammad Usman Mirza, Mr Muhammad Usman Mirza

  39. Medicinal plant phytochemicals and their inhibitory activities against pancreatic lipase: molecular docking combined with molecular dynamics simulation approach

    Article • Natural Product Research, April 2017, Taylor & Francis

    Mr Muhammad Usman Mirza

  40. Erratum: Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

    Article • Scientific Reports, April 2017, Nature

    Mr Muhammad Usman Mirza

  41. Molecular docking and in silico ADMET studies of silibinin and glycyrrhetic acid anti-inflammatory activity

    Article • Tropical Journal of Pharmaceutical Research, February 2017, African Journals Online (AJOL)

    Mr Muhammad Usman Mirza

  42. Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

    Article • Scientific Reports, December 2016, Nature

    Mr Muhammad Usman Mirza

  43. Integrated Computational Approach for Virtual Hit Identification against Ebola Viral Proteins VP35 and VP40

    Article • International Journal of Molecular Sciences, October 2016, MDPI AG

    Mr Muhammad Usman Mirza

  44. Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

    Article • Drug Design Development and Therapy, March 2015, Dove Medical Press

    Mr Muhammad Usman Mirza, Miss Noor-Ul-Huda Ghori, Mr Muhammad Usman Mirza

  45. Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson’s disease: a pharmacoinformatics study

    Article • Drug Design Development and Therapy, December 2014, Dove Medical Press

    Miss Noor-Ul-Huda Ghori, Mr Muhammad Usman Mirza, Dr. Ahmed Hammad Mirza, Mr Muhammad Usman Mirza

  46. Docking Studies reveal Phytochemicals as the long searched Anticancer Drugs for Breast Cancer

    Article • International Journal of Computer Applications, April 2013, Foundation of Computer Science

    Mr Muhammad Usman Mirza