All Stories

  1. A Small Molecule Antagonist of CX3CR1 (KAND567) Inhibited the Tumor Growth-Promoting Effect of Monocytes in Chronic Lymphocytic Leukemia (CLL)
  2. A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells
  3. The prognostic and therapeutic potential of HO-1 in leukemia and MDS
  4. The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies
  5. Myeloid-derived suppressor cells (MDSCs) depletion by cabozantinib improves the efficacy of anti-HER2 antibody-based immunotherapy in a 4T1-HER2 murine breast cancer model
  6. Cloning, expression and characterization of a peptibody to deplete myeloid derived suppressor cells in a murine mammary carcinoma model
  7. Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions
  8. Combined inhibition of EZH2 and CD73 molecules by folic acid-conjugated SPION-TMC nanocarriers loaded with siRNA molecules prevents TNBC progression and restores anti-tumor responses
  9. Increased susceptibility to doxorubicin-induced cell death in acute lymphocytic leukemia cells by inhibiting serine/threonine WEE1 kinase expression using the chitosan-carboxymethyl dextran-polyethylene glycol-TAT nanoparticles
  10. A ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells
  11. Preeclampsia-Derived Exosomes Imbalance the Activity of Th17 and Treg in PBMCs from Healthy Pregnant Women
  12. Evaluation of CD39, CD73, HIF-1α, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women
  13. Expression level of immune checkpoint inhibitory factors in preeclampsia
  14. The molecular biology and therapeutic potential of Nrf2 in leukemia
  15. The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia
  16. RETRACTED ARTICLE: Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model
  17. Early stage evaluation of colon cancer using tungsten disulfide quantum dots and bacteriophage nano-biocomposite as an efficient electrochemical platform
  18. RETRACTED: Simultaneous silencing of the A2aR and PD-1 immune checkpoints by siRNA-loaded nanoparticles enhances the immunotherapeutic potential of dendritic cell vaccine in tumor experimental models
  19. Influence of Pattern Recognition Receptor Ligands on Induction of Innate Immunity and Control of Hepatitis B Virus Infection
  20. RETRACTED: Blockade of CD73 using siRNA loaded chitosan lactate nanoparticles functionalized with TAT-hyaluronate enhances doxorubicin mediated cytotoxicity in cancer cells both in vitro and in vivo
  21. Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung
  22. Silencing STAT3 enhances sensitivity of cancer cells to doxorubicin and inhibits tumor progression
  23. A ROR1 small molecule inhibitor (KAN0441571C) induced significant apoptosis of ibrutinib‐resistant ROR1+ CLL cells
  24. Altered Th17/Treg ratio as a possible mechanism in pathogenesis of idiopathic membranous nephropathy
  25. TIGIT and CD155 as Immune-Modulator Receptor and Ligand on CD4+T cells in Preeclampsia Patients
  26. T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer
  27. Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems
  28. Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules
  29. EP4 receptor as a novel promising therapeutic target in colon cancer
  30. Oncostatin M: A mysterious cytokine in cancers
  31. Immunoreactivity pattern of monoclonal antibodies against Hepatitis B vaccine with global Hepatitis B virus genotypes
  32. RETRACTED: Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression
  33. Intrauterine administration of autologous hCG- activated peripheral blood mononuclear cells improves pregnancy outcomes in patients with recurrent implantation failure; A double-blind, randomized control trial study
  34. Small-Molecule Inhibitors Targeting Receptor Tyrosine Kinases in Cancer
  35. IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss
  36. Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy
  37. Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment
  38. Berberine: A novel therapeutic strategy for cancer
  39. An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein
  40. CDK1 in Breast Cancer: Implications for Theranostic Potential
  41. Tumor associated macrophages in the molecular pathogenesis of ovarian cancer
  42. Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article
  43. ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells
  44. Concomitant blockade of A2AR and CTLA‐4 by siRNA‐loaded polyethylene glycol‐chitosan‐alginate nanoparticles synergistically enhances antitumor T‐cell responses
  45. Nanomedicine for improvement of dendritic cell-based cancer immunotherapy
  46. Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer
  47. Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression
  48. PD-L1/PD-1 axis as a potent therapeutic target in breast cancer
  49. Identification of genes and miRNAs associated with angiogenesis, metastasis, and apoptosis in colorectal cancer
  50. The Association between Inflammatory Cytokines and miRNAs with Slow Coronary Flow Phenomenon
  51. E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions
  52. Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine
  53. Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer
  54. Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome
  55. Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway
  56. S1PR1 as a Novel Promising Therapeutic Target in Cancer Therapy
  57. Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior
  58. Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia
  59. CD73 as a potential opportunity for cancer immunotherapy
  60. Promising immunotherapy: Highlighting cytokine‐induced killer cells
  61. Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis
  62. Smac mimetics as novel promising modulators of apoptosis in the treatment of breast cancer
  63. Polymorphism of Foxp3 gene affects the frequency of regulatory T cells and disease activity in patients with rheumatoid arthritis in Iranian population
  64. The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer
  65. The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer
  66. The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia
  67. Altered T-cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities
  68. A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
  69. Anti-angiogenic effects of CD73-specific siRNA-loaded nanoparticles in breast cancer-bearing mice
  70. First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
  71. Kisspeptin serum levels in acute myocardial infarction patients and healthy individuals
  72. Autologous T cells expressing the oncogenic transcription factor KLF6-SV1 prevent apoptosis of chronic lymphocytic leukemia cells
  73. Nanoparticles in cancer therapy
  74. Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg)
  75. Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer
  76. Recent advances in targeting mTOR signaling pathway using small molecule inhibitors
  77. First generation of a small chemical molecule ROR1 RTK tyrosine kinase inhibitor
  78. Targeting Receptor Tyrosine Kinases Using Monoclonal Antibodies: The Most Specific Tools for Targeted-Based Cancer Therapy
  79. Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis
  80. Mechanisms of tumor cell resistance to the current targeted-therapy agents
  81. Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia
  82. Sero-Epidemiological Study of Hepatitis E Virus among Thalassemia as High Risk Patients: A Cross-Sectional Survey in Jahrom, Southern, Iran
  83. Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia
  84. Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy
  85. Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran
  86. Ibrutinib-A double-edge sword in cancer and autoimmune disorders
  87. Targeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances
  88. Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy
  89. The skewed balance between Tregs and Th17 in chronic lymphocytic leukemia
  90. Novel and emerging targeted-based cancer therapy agents and methods
  91. The receptor tyrosine kinase ROR1 – An oncofetal antigen for targeted cancer therapy
  92. The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies
  93. Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling
  94. Abstract 4770: Anti-ROR1 monoclonal antibodies induce apoptosis in pancreatic cancer cells via the PI3-kinase/AKT/mTOR pathway
  95. Small-Molecule Inhibitors of the Receptor Tyrosine Kinases: Promising Tools for Targeted Cancer Therapies
  96. Frequency analysis of HLA class I alleles in Iranian patients with progressive and non-progressive chronic lymphocytic leukemia
  97. The Tyrosine Kinase Receptor ROR1 Is Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) Cells
  98. Construction and characterization of a new chimeric antibody against HER2
  99. Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia
  100. Differential regulation of B-cell proliferation by IL21 in different subsets of chronic lymphocytic leukemia
  101. Inhibition of the Receptor Tyrosine Kinase ROR1 by Anti-ROR1 Monoclonal Antibodies and siRNA Induced Apoptosis of Melanoma Cells
  102. Increased Frequency of CD8+and CD4+Regulatory T Cells in Chronic Lymphocytic Leukemia: Association with Disease Progression
  103. Construction and characterization of a new chimeric antibody against HER2
  104. Dishevelled Proteins of Wnt Signaling Pathways Are Highly Expressed in Chronic Lymphocytic Leukemia
  105. Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies
  106. 162 Investigation of TLR7/8 and 9 Agonists and CD40-ligand Costimulation on EBV Transformation of B Cells of Chronic Lymphocytic Leukemia
  107. T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile
  108. Induction of IgM, IgA and IgE Antibodies in Colorectal Cancer Patients Vaccinated with a Recombinant CEA Protein
  109. Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis
  110. Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells
  111. ROR1 Isoforms Are Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) - a Survival Factor for CLL Cells
  112. 1.7 Telomere Length and Expression of Human Telomerase Reverse Transcriptase Splice Variants in Chronic Lymphocytic Leukemia
  113. 9209 POSTER Unbalanced Frequency of Regulatory T Cells in Different Subsets of Chronic Lymphocytic Leukemia
  114. Ror1 Targeting Monoclonal Antibodies Induced Apoptosis of Chronic Lymphocytic Leukemia Cells– A Potential Novel Therapeutic Approach
  115. Expression Profile of Galectin-1 and Galectin-3 Molecules in Different Subtypes of Chronic Lymphocytic Leukemia
  116. Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia
  117. Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia
  118. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia
  119. Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia
  120. Analysis of the immunoglobulin heavy chain variable region gene expression in Iranian patients with chronic lymphocytic leukemia
  121. Assessment of the immune system in 55 Iranian patients with vitiligo