All Stories

  1. Spatial Transcriptomics, Proteomics, and Epigenomics as Tools in Tissue Engineering and Regenerative Medicine
  2. Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration
  3. Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration
  4. Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination
  5. Identification of N-Glycoproteins of Knee Cartilage from Adult Osteoarthritis and Kashin-Beck Disease Based on Quantitative Glycoproteomics, Compared with Normal Control Cartilage
  6. Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels
  7. Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China
  8. Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents
  9. The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway
  10. Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study
  11. Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis
  12. Roles of glycoprotein glycosylation in the pathogenesis of an endemic osteoarthritis, Kashin–Beck disease, and effectiveness evaluation of sodium hyaluronate treatment
  13. Cell cycle-related lncRNAs and mRNAs in osteoarthritis chondrocytes in a Northwest Chinese Han Population
  14. Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease
  15. Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis
  16. Screening for differentially expressed circRNA between Kashin–Beck disease and osteoarthritis patients based on circRNA chips
  17. Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin–Beck disease
  18. Inhibiting the aberrant activation of Wnt/β‐catenin signaling by selenium supplementation ameliorates deoxynivalenol‐induced toxicity and catabolism in chondrocytes
  19. Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T3 Inhibit Toxicity of HT-2?
  20. Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value
  21. Preliminary Exploration of hsa_circ_0032131 Levels in Peripheral Blood as a Potential Diagnostic Biomarker of Osteoarthritis
  22. Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency
  23. Changes in the NF-κB signaling pathway in juvenile and adult patients with Kashin-Beck disease
  24. A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis
  25. Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure
  26. Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease
  27. Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee
  28. Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes
  29. Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes
  30. Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly
  31. Selenium-Related Transcriptional Regulation of Gene Expression
  32. Chondrocyte-Specific Gene Expressions in Human Embryonic Stem Cells Differentiated Under Feeder-Free Culture Conditions
  33. Selenium-Related Transcriptional Regulation of Gene Expression
  34. Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis
  35. The Importance of Se-Related Genes in the Chondrocyte of Kashin–Beck Disease Revealed by Whole Genomic Microarray and Network Analysis
  36. Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease
  37. Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease
  38. Gene expression profiles and molecular mechanism of cultured human chondrocytes' exposure to T-2 toxin and deoxynivalenol
  39. Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
  40. Selenium promotes metabolic conversion of T-2 toxin to HT-2 toxin in cultured human chondrocytes
  41. Inflammatory cytokine of IL-1β is involved in T-2 toxin-triggered chondrocyte injury and metabolism imbalance by the activation of Wnt/β-catenin signaling
  42. Effects of long-term low oxygen tension in human chondrosarcoma cells
  43. Associations Between Selenium Content in Hair and Kashin-Beck Disease/Keshan Disease in Children in Northwestern China: a Prospective Cohort Study
  44. Nutrients Other than Selenium Are Important for Promoting Children’s Health in Kashin-Beck Disease Areas
  45. Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease
  46. Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease
  47. Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells
  48. Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes
  49. Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease
  50. The potential of induced pluripotent stem cells as a tool to study skeletal dysplasias and cartilage-related pathologic conditions
  51. Infrared microspectroscopic determination of collagen cross-links in articular cartilage
  52. Scaffold-free approach produces neocartilage tissue of similar quality as the use of HyStem™ and Hydromatrix™ scaffolds
  53. Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography
  54. Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin–Beck disease
  55. Behavior of Human Bone Marrow-Derived Mesenchymal Stem Cells on Various Titanium-Based Coatings
  56. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells
  57. Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin–Beck disease, an endemic osteoarthropathy in China
  58. The potential biochemical markers of Kashin–Beck disease: a meta-analysis
  59. Cross-cultural adaptation and validation of the osteoporosis assessment questionnaire short version (OPAQ-SV) for Chinese osteoporotic fracture females
  60. Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells
  61. Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis
  62. Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions
  63. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease
  64. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds
  65. Chondrocyte behavior on nanostructured micropillar polypropylene and polystyrene surfaces
  66. In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner
  67. Collagen and Chondrocyte Concentrations Control Ultrasound Scattering in Agarose Scaffolds
  68. Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures
  69. Determination of Mechanical Properties of Chondrocytes in Articular Cartilage Using Atomic Force Microscopy
  70. Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3
  71. Effects of Freeze–Thaw Cycle with and without Proteolysis Inhibitors and Cryopreservant on the Biochemical and Biomechanical Properties of Articular Cartilage
  72. Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking—Contribution of steric and electrostatic effects
  73. Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture
  74. The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease
  75. TiO2coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation
  76. Osteoblast behavior on various ultra short pulsed laser deposited surface coatings
  77. Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit
  78. Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China
  79. Identification of differentially expressed genes and pathways between primary osteoarthritis and endemic osteoarthritis (Kashin–Beck disease)
  80. Adhesion and spreading of different skeletal cell types on variable surface coatings
  81. Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage
  82. Effects of Medium and Temperature on Cellular Responses in the Superficial Zone of Hypo-Osmotically Challenged Articular Cartilage
  83. The effect of collagen degradation on chondrocyte volume and morphology in bovine articular cartilage following a hypotonic challenge
  84. Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage
  85. Five percent oxygen tension is not beneficial for neocartilage formation in scaffold-free cell cultures
  86. Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death
  87. Genome-Wide Gene Expression Analysis Suggests an Important Role of Suppressed Immunity in Pathogenesis of Kashin-Beck Disease
  88. Hypotonic challenge modulates cell volumes differently in the superficial zone of intact articular cartilage and cartilage explant
  89. Proteomic changes in articular cartilage of human endemic osteoarthritis in China
  90. The effect of loading and material on the biomechanical properties and vitality of bovine cartilage in vitro
  91. Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo
  92. Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells
  93. Quantitative Evaluation of Spontaneously and Surgically Repaired Rabbit Articular Cartilage Using Intra-Articular Ultrasound Method in situ
  94. Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films
  95. Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to Northwestern China, Kashin-Beck disease
  96. Quantitative Analysis of Collagen Network Structure and Fibril Dimensions in Cartilage Repair with Autologous Chondrocyte Transplantation
  97. Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage
  98. Interactions between Saos-2 cells and microtextured amorphous diamond or amorphous diamond hybrid coated surfaces with different wettability properties
  99. Strain-Dependent Modulation of Ultrasound Speed in Articular Cartilage Under Dynamic Compression
  100. Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating
  101. Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension
  102. Contrast agent-enhanced computed tomography of articular cartilage: Association with tissue composition and properties
  103. Quantitative analysis of spatial proteoglycan content in articular cartilage with Fourier transform infrared imaging spectroscopy: Critical evaluation of analysis methods and specificity of the parameters
  104. Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis
  105. Ultrasound Induced Activation of Cell Signaling on Human MG-63 Osteoblastic Cells
  106. pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage – associations to matrix composition and integrity
  107. Stress–relaxation of human patellar articular cartilage in unconfined compression: Prediction of mechanical response by tissue composition and structure
  108. Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold
  109. Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound
  110. Proteomics of chondrocytes with special reference to phosphorylation changes of proteins in stretched human chondrosarcoma cells
  111. Recombinant human collagens as scaffold materials for chondrocyte cultures
  112. Effect of human trabecular bone composition on its electrical properties
  113. Acoustic Properties of Trabecular Bone—Relationships to Tissue Composition
  114. Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes
  115. Poly-L-D-Lactic Acid Scaffold in the Repair of Porcine Knee Cartilage Lesions
  116. Contrast agent enhanced pQCT of articular cartilage
  117. Cellular Signaling in Cartilage Tissue Engineering
  118. Human Articular Cartilage Proteoglycans Are Not Undersulfated in Osteoarthritis
  119. Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation
  120. A mouse model for Stickler's syndrome: Ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1)
  121. Proteomic analysis of cartilage- and bone-associated samples
  122. The lack of effect of glucosamine sulphate on aggrecan mRNA expression and 35S-sulphate incorporation in bovine primary chondrocytes
  123. Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells
  124. Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
  125. Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure
  126. Does oral glucosamine prevent the loss of proteoglycans in a rabbit model of osteoarthritis? Comment on the article by Tiraloche et al
  127. High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2
  128. A humanCOL2A1gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice
  129. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization
  130. Ultrasound indentation of normal and spontaneously degenerated bovine articular cartilage
  131. EGF Upregulates, Whereas TGF-β Downregulates, the Hyaluronan Synthases Has2 and Has3 in Organotypic Keratinocyte Cultures: Correlations with Epidermal Proliferation and Differentiation
  132. Speed of sound in normal and degenerated bovine articular cartilage
  133. Subchondral Bone Reaction Associated with Chondral Defect and Attempted Cartilage Repair in Goats
  134. Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate
  135. Site-specific immunostaining for type X collagen in noncalcified articular cartilage of canine stifle knee joint
  136. Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes
  137. cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure
  138. Neuronal cells show regulatory differences in the hsp70 gene response
  139. EGF REGULATES HAS2 EXPRESSION, CONTROLS EPIDERMAL THICKNESS AND STIMULATES KERATINOCYTE MIGRATION
  140. HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY
  141. HYALURONAN SYNTHASE 2 (HAS2) REGULATES MIGRATION OF EPIDERMAL KERATINOCYTES
  142. Premature Vertebral Endplate Ossification and Mild Disc Degeneration in Mice After Inactivation of One Allele Belonging to the Col2a1 Gene for Type II Collagen
  143. Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading
  144. Epidermal Growth Factor Activates Hyaluronan Synthase 2 in Epidermal Keratinocytes and Increases Pericellular and Intracellular Hyaluronan
  145. Extracellular Matrix Composition of Full-Thickness Defect Repair Tissue is Little Influenced by Exercise in Rat Articular Cartilage
  146. Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response
  147. Regular joint loading in youth assists in the establishment and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis
  148. Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature
  149. The Role of Microtubules in the Regulation of Proteoglycan Synthesis in Chondrocytes under Hydrostatic Pressure
  150. Elevated Protein Content and Prolyl 4-Hydroxylase Activity in Severely Degenerated Human Annulus Fibrosus
  151. Type X collagen in human enamel development: a possible role in mineralization
  152. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells
  153. Remobilization Does Not Fully Restore Immobilization Induced Articular Cartilage Atrophy
  154. Cytoskeleton and Proteoglycan Synthesis in Chondrocytes Under Hydrostatic Pressure
  155. Localization of type X collagen in the intervertebral disc of mature beagle dogs
  156. Type X collagen, a natural component of mouse articular cartilage: Association with growth, aging, and osteoarthritis
  157. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation
  158. Increase of Decorin Content in Articular Cartilage Following Running
  159. Polyamine-dependent alterations in the structure of microfilaments, golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells
  160. Polyamine‐dependent alterations in the structure of microfilaments, golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells
  161. Expression of Small Extracellular Chondroitin/Dermatan Sulfate Proteoglycans Is Differentially Regulated in Human Endothelial Cells
  162. Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes
  163. Sequence analysis of regulatory regions of the human collagen X gene
  164. Distribution of hyaluronan in articular cartilage as probed by a biotinylated binding region of aggrecan
  165. Safranin O reduces loss of glycosaminoglycans from bovine articular cartilage during histological specimen preparation
  166. Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes
  167. Effects of Tiaprofenic Acid and Indomethacin on Proteoglycans in the Degenerating Porcine Intervertebral Disc
  168. Proteoglycans in the Intervertebral Disc of Young Dogs Following Strenuous Running Exercise
  169. Proteoglycan synthesis in canine intervertebral discs after long-distance running training
  170. A High sensitivity dot blot assay for proteoglycans by cuprolinic blue precipitation
  171. Effects of Cyclic Hydrostatic Pressure on Proteoglycan Synthesis in Cultured Chondrocytes and Articular Cartilage Explants
  172. Flat bed scanner in the quantitative assay of 35SO4-incorporation by X-ray film autoradiography of intervertebral disc sections
  173. Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro
  174. Autoradiographic quantitation of radiolabeled proteoglycans
  175. Quantitation of autoradiographic grains in different zones of articular cartilage with image analyzer
  176. A mechanical apparatus with microprocessor controlled stress profile for cyclic compression of cultured articular cartilage explants
  177. Densitometric assay of nanogram quantities of proteoglycans precipitated on nitrocellulose membrane with Safranin O