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  1. EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma

    Article • Journal of Investigative Dermatology, December 2020, Elsevier

    Mike Eccles

  2. A MicroRNA Cluster in the DLK1-DIO3 Imprinted Region on Chromosome 14q32.2 Is Dysregulated in Metastatic Hepatoblastomas

    Article • Frontiers in Oncology, November 2020, Frontiers

    Mike Eccles

  3. Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma

    Article • Pigment Cell & Melanoma Research, July 2020, Wiley

    Mike Eccles

  4. Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy

    Article • Molecules, June 2020, MDPI AG

    Mike Eccles

  5. Reawakening the Developmental Origins of Cancer Through Transposable Elements

    Article • Frontiers in Oncology, May 2020, Frontiers

    Mike Eccles

  6. Promoter DNA Hypermethylation and Paradoxical Gene Activation

    Article • Trends in Cancer, May 2020, Elsevier

    Mike Eccles

  7. Extensive Inter-Cyst DNA Methylation Variation in Autosomal Dominant Polycystic Kidney Disease Revealed by Genome Scale Sequencing

    Article • Frontiers in Genetics, April 2020, Frontiers

    Mike Eccles

  8. Designing phantoms to accurately replicate circular depolarization in biological scattering media

    Article • Applied Optics, December 2019, Optical Society of America (OSA)

    Mike Eccles

  9. Targeted Therapies for Autosomal Dominant Polycystic Kidney Disease

    Article • Current Medicinal Chemistry, August 2019, Bentham Science Publishers

    Mike Eccles

  10. Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types

    Article • Clinical Epigenetics, August 2019, Springer Science + Business Media

    Mike Eccles

  11. Genome-wide miRNA methylome analysis in oral cancer: possible biomarkers associated with patient survival

    Article • Epigenomics, April 2019, Future Medicine

    Mike Eccles

  12. Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

    Article • Trends in Immunology, April 2019, Elsevier

    Mike Eccles

  13. MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells

    Article • Nucleic Acid Therapeutics, August 2018, Mary Ann Liebert Inc

    Mike Eccles

  14. Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

    Article • iScience, June 2018, Elsevier

    Mike Eccles

  15. SMAD proteins directly suppressPAX2transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma

    Article • Oncotarget, June 2018, Impact Journals, LLC

    Mike Eccles

  16. Genome-Scale Single Nucleotide Resolution Analysis of DNA Methylation in Human Autosomal Dominant Polycystic Kidney Disease

    Article • American Journal of Nephrology, January 2018, Karger Publishers

    Mike Eccles

  17. A Guide for Designing and Analyzing RNA-Seq Data

    Article • January 2018, Springer Science + Business Media

    Mike Eccles

  18. The Genes of Life and Death: A Potential Role for Placental-Specific Genes in Cancer

    Article • BioEssays, October 2017, Wiley

    Mike Eccles

  19. Identifying drivers of metastasis; towards a systematic approach

    Article • Translational Cancer Research, October 2017, AME Publishing Company

    Mike Eccles

  20. A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA

    Article • BMC Medical Genomics, August 2017, Springer Science + Business Media

    Mike Eccles

  21. Epigenetic drivers of tumourigenesis and cancer metastasis

    Article • Seminars in Cancer Biology, August 2017, Elsevier

    Mike Eccles

  22. Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis

    Article • Epigenomics, June 2017, Future Medicine

    Mike Eccles

  23. The Slow Cycling Phenotype: A Growing Problem for Treatment Resistance in Melanoma

    Article • Molecular Cancer Therapeutics, June 2017, American Association for Cancer Research (AACR)

    Mike Eccles

  24. An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Mr John C McEwan, Mike Eccles

  25. PAX2 (Paired box gene 2)

    Article • Atlas of Genetics and Cytogenetics in Oncology and Haematology, April 2017, INIST-CNRS

    Mike Eccles

  26. MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours

    Article • Molecular Cancer, January 2017, Springer Science + Business Media

    Mike Eccles

  27. Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Mike Eccles

  28. Tools and Strategies for Analysis of Genome-Wide and Gene-Specific DNA Methylation Patterns

    Article • December 2016, Springer Science + Business Media

    Mike Eccles

  29. Repression of CMIP transcription by WT1 is relevant to podocyte health

    Article • Kidney International, December 2016, Elsevier

    Mike Eccles

  30. scan_tcga tools for integrated epigenomic and transcriptomic analysis of tumor subgroups

    Article • Epigenomics, October 2016, Future Medicine

    Mike Eccles

  31. The Paired Box (PAX) Gene Family: Introduction to Paired Box Genes

    Article • June 2016, Oxford University Press (OUP)

    Mike Eccles

  32. PAX2 and the Renal-Coloboma Syndrome

    Article • June 2016, Oxford University Press (OUP)

    Mike Eccles

  33. Faculty of 1000 evaluation for Primary cilia are not calcium-responsive mechanosensors.

    Article • May 2016, Faculty of 1000, Ltd.

    Mike Eccles

  34. NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Mike Eccles

  35. Bridging Small Molecules to Modified Bacterial Microparticles Using a Disulphide Linkage: MIS416 as a Cargo Delivery System

    Article • PLoS ONE, December 2015, PLOS

    Mike Eccles

  36. Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples

    Article • GigaScience, November 2015, Oxford University Press (OUP)

    Mike Eccles

  37. Erratum: A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients

    Article • Scientific Reports, September 2015, Nature

    Mike Eccles

  38. Large animal models of rare genetic disorders: sheep as phenotypically relevant models of human genetic disease

    Article • Orphanet Journal of Rare Diseases, September 2015, Springer Science + Business Media

    Mr John C McEwan, Mike Eccles

  39. A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients

    Article • Scientific Reports, June 2015, Nature

    Mike Eccles

  40. DNA methylation and epigenomics: new technologies and emerging concepts

    Article • Genome Biology, May 2015, Springer Science + Business Media

    Mike Eccles

  41. Correction: G-Quadruplex Structures and CpG Methylation Cause Drop-Out of the Maternal Allele in Polymerase Chain Reaction Amplification of the Imprinted MEST Gene Promoter

    Article • PLoS ONE, March 2015, PLOS

    Mike Eccles

  42. G-Quadruplex Structures and CpG Methylation Cause Drop-Out of the Maternal Allele in Polymerase Chain Reaction Amplification of the Imprinted MEST Gene Promoter

    Article • PLoS ONE, December 2014, PLOS

    Mike Eccles

  43. Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media

    Article • Journal of Biophotonics, October 2014, Wiley

    Professor Igor Meglinski, Mike Eccles

  44. Polycystic kidney disease – where gene dosage counts

    Article • F1000Prime Reports, April 2014, Faculty of 1000, Ltd.

    Mike Eccles

  45. Diffusing-wave polarimetry for tissue diagnostics

    Article • March 2014, SPIE

    Professor Igor Meglinski, Mike Eccles

  46. Faculty Opinions recommendation of Multilocus polycystic disease.

    Article • March 2014, F1000Research

    Mike Eccles

  47. Melanoma genetics/genomics

    Article • January 2014, Frontiers

    Mike Eccles

  48. Increased paired box transcription factor 8 has a survival function in Glioma

    Article • BMC Cancer, January 2014, Springer Science + Business Media

    Dr Noelyn Anne Hung, Mike Eccles

  49. Biallelic DICER1 mutations occur in Wilms tumours

    Article • The Journal of Pathology, May 2013, Wiley

    Mike Eccles

  50. Screening Cancer Aggressiveness by Using Circularly Polarized Light

    Article • January 2013, Optical Society of America (OSA)

    Professor Igor Meglinski, Mike Eccles

  51. Melanoma Genetics/Genomics

    Article • Frontiers in Oncology, January 2013, Frontiers

    Mike Eccles

  52. Targeted Therapy; From Advanced Melanoma to the Adjuvant Setting

    Article • Frontiers in Oncology, January 2013, Frontiers

    Mike Eccles

  53. MITF and PAX3 Play Distinct Roles in Melanoma Cell Migration; Outline of a “Genetic Switch” Theory Involving MITF and PAX3 in Proliferative and Invasive Phenotypes of Melanoma

    Article • Frontiers in Oncology, January 2013, Frontiers

    Mike Eccles

  54. Cohesin Is Required for Activation of MYC by Estradiol

    Article • PLoS ONE, November 2012, PLOS

    Mike Eccles

  55. Primary cilia defects in the polycystic kidneys from an ovine model of Meckel Gruber syndrome

    Article • Cilia, November 2012, Springer Science + Business Media

    Mike Eccles

  56. Feasibility of preventing of renal cyst formation in utero studied in mice

    Article • Nephrology, October 2012, Wiley

    Mike Eccles

  57. PAX2 is an antiapoptotic molecule with deregulated expression in medulloblastoma

    Article • International Journal of Oncology, April 2012, Spandidos Publications

    Mike Eccles

  58. Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database

    Article • Human Mutation, January 2012, Hindawi Publishing Corporation

    Dr Regen Drouin, Dr Francesco Benedicenti, Mike Eccles

  59. The Mapping of Tissues Scattering Properties on the Poincaré Sphere

    Article • January 2012, Optical Society of America (OSA)

    Professor Igor Meglinski, Mike Eccles

  60. Senescence Associated �-galactosidase Staining

    Article • BIO-PROTOCOL, January 2012, Bio-Protocol, LLC

    Mike Eccles

  61. PAX Genes in Cancer; Friends or Foes?

    Article • Frontiers in Genetics, January 2012, Frontiers

    Mike Eccles

  62. Somatic Reactivation of Expression of the Silent Maternal Mest Allele and Acquisition of Normal Reproductive Behaviour in a Colony of Peg1/Mest Mutant Mice

    Article • Journal of Reproduction and Development, January 2012, Japanese Society of Animal Reproduction

    Mike Eccles

  63. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein

    Article • Oncogene, May 2011, Springer Science + Business Media

    Mike Eccles

  64. Abstract 2940: A role for PAX8 in promoting tumor cell type-specific proliferation through positively regulating E2F1 transcription and stabilizing RB protein

    Article • April 2011, American Association for Cancer Research (AACR)

    Mike Eccles

  65. Clinical utility gene card for: renal coloboma (Papillorenal) syndrome

    Article • European Journal of Human Genetics, February 2011, Nature

    Mike Eccles

  66. PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression

    Article • Melanoma Research, February 2011, Wolters Kluwer Health

    Mike Eccles

  67. PAX3 Is Extensively Expressed in Benign and Malignant Tissues of the Melanocytic Lineage in Humans

    Article • Journal of Investigative Dermatology, May 2010, Elsevier

    Mike Eccles

  68. A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells

    Article • PLoS ONE, December 2009, PLOS

    Mike Eccles

  69. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin

    Article • Gene Expression Patterns, December 2009, Elsevier

    Mike Eccles

  70. PAX3 is Expressed in the Stromal Compartment of the Developing Kidney and in Wilms Tumors with Myogenic Phenotype

    Article • Pediatric and Developmental Pathology, September 2009, SAGE Publications

    Mike Eccles

  71. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease

    Article • Human Molecular Genetics, January 2009, Oxford University Press (OUP)

    Mike Eccles

  72. PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma

    Article • Cancer Research, July 2008, American Association for Cancer Research (AACR)

    Mike Eccles

  73. Molecular and clinical studies of three cases of female pseudohermaphroditism with caudal dysplasia suggest multiple etiologies

    Article • Clinical Genetics, June 2008, Wiley

    Mike Eccles

  74. In vivo validation of PAX2 as a target for renal cancer therapy

    Article • Cancer Letters, June 2008, Elsevier

    Mike Eccles

  75. Self-RegulatedPaxGene Expression and Modulation by the TGFβ Superfamily

    Article • Critical Reviews in Biochemistry and Molecular Biology, January 2008, Taylor & Francis

    Mike Eccles

  76. Disruption of ROBO2 Is Associated with Urinary Tract Anomalies and Confers Risk of Vesicoureteral Reflux

    Article • The American Journal of Human Genetics, April 2007, Elsevier

    Mike Eccles

  77. A novel Cys1638Tyr NC1 domain substitution in  5(IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities

    Article • Nephrology Dialysis Transplantation, March 2007, Oxford University Press (OUP)

    Mike Eccles

  78. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease

    Article • Human Molecular Genetics, November 2006, Oxford University Press (OUP)

    Mike Eccles

  79. Correction to "PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells"

    Article • Kidney International, November 2006, Elsevier

    Mike Eccles

  80. Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2

    Article • AJP Renal Physiology, October 2006, American Physiological Society

    Mike Eccles

  81. Suppression of Ureteric Bud Apoptosis Rescues Nephron Endowment and Adult Renal Function inPax2Mutant Mice

    Article • Journal of the American Society of Nephrology, May 2006, American Society of Nephrology

    Mike Eccles

  82. PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells

    Article • Kidney International, April 2006, Elsevier

    Mike Eccles

  83. A PANorama of PAX genes in cancer and development

    Article • Nature Reviews Drug Discovery, January 2006, Nature

    Mike Eccles

  84. Identification of the first AHI1 gene mutations in nephronophthisis-associated Joubert syndrome

    Article • Pediatric Nephrology, October 2005, Springer Science + Business Media

    Professor John A Sayer, Mike Eccles

  85. Congenital polycystic kidney disease in lambs

    Article • New Zealand Veterinary Journal, October 2005, Taylor & Francis

    Mike Eccles

  86. Corrigendum to: Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells (FEBS 28019) [FEBS Letters 558 (2004) 63-68]

    Article • FEBS Letters, May 2004, Wiley

    Mike Eccles

  87. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells

    Article • FEBS Letters, January 2004, Wiley

    Mike Eccles

  88. Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation

    Article • FEBS Letters, December 2003, Wiley

    Mike Eccles

  89. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

    Article • Oncogene, September 2003, Nature

    Mike Eccles

  90. PAX2 and Renal-Coloboma Syndrome

    Article • January 2003, Elsevier

    Mike Eccles

  91. Embryonal hyperplasia of Bowman's capsular epithelium in patients with WT1 mutations

    Article • Pediatric Nephrology, January 2003, Springer Science + Business Media

    Mike Eccles

  92. PAX2 mutations in renal–coloboma syndrome: mutational hotspot and germline mosaicism

    Article • European Journal of Human Genetics, October 2000, Springer Science + Business Media

    Mike Eccles

  93. PAX2 Suppresses Apoptosis in Renal Collecting Duct Cells

    Article • American Journal Of Pathology, September 2000, Elsevier

    Mike Eccles

  94. Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations

    Article • Clinical Genetics, July 1999, Wiley

    Mike Eccles

  95. The role of PAX2 in normal and abnormal development of the urinary tract

    Article • Pediatric Nephrology, November 1998, Springer Science + Business Media

    Mike Eccles

  96. Cloning and Characterization of the HumanPAX2Promoter

    Article • Journal of Biological Chemistry, September 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Mike Eccles

  97. Unravelling the genetics of vesicoureteric reflux: a common familial disorder

    Article • Human Molecular Genetics, September 1996, Oxford University Press (OUP)

    Mike Eccles

  98. Genomic Structure of the HumanPAX2Gene

    Article • Genomics, July 1996, Elsevier

    Mike Eccles

  99. Erratum: Corrigendum: Mutation of the gene in a family with optic nerve colobomas, renal anomolies and vesicoureteral reflux

    Article • Nature Genetics, May 1996, Nature

    Mike Eccles

  100. Mutation of PAX2 in two siblings with renal-coloboma syndrome

    Article • Human Molecular Genetics, November 1995, Oxford University Press (OUP)

    Mike Eccles

  101. Erratum: Corrigendum: Jackson–Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

    Article • Nature Genetics, April 1995, Nature

    Mike Eccles

  102. Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux

    Article • Nature Genetics, April 1995, Nature

    Mike Eccles

  103. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

    Article • Nature Genetics, November 1994, Nature

    Mike Eccles

  104. Genes encoding the platelet-derived growth factor (PDGF) receptor and colony-stimulating factor 1 (CSF-1) receptor are physically associated in mice as in humans

    Article • Gene, December 1991, Elsevier

    Mike Eccles

  105. Studies of Secondary Transforming Events in Murine c-myc Retrovirus-Induced Monocyte Tumors

    Article • January 1989, Springer Science + Business Media

    Mike Eccles

  106. Expression of insulin-like growth factor-II transcripts in Wilms' tumour

    Article • Nature, September 1985, Nature

    Mike Eccles

  107. Harvey-ras allele deletion detected by in situ hybridization to Wilms' tumor chromosomes

    Article • Human Genetics, July 1984, Springer Science + Business Media

    Mike Eccles