All Stories

  1. Over-Represented DNA Libraries Containing Two Hydrophobic (Het)aryl-Linked Nucleotides for Expedient Single-Round Selection of a Specific Aptamer Targeting Human Insulin Receptor

    Article • November 2025, Springer Science + Business Media

    Professor Michal Hocek

  2. Enzymatic Synthesis of Modified RNA Containing 5-Methyl- or 5-Ethylpyrimidines or Substituted 7-Deazapurines and Influence of the Modifications on Stability, Translation, and CRISPR-Cas9 Cleavage

    Article • ACS Chemical Biology, November 2025, American Chemical Society (ACS)

    Professor Michal Hocek

  3. Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase‐Modified Aptamers Demonstrated on Indole‐Modified β‐Conglutin Aptamer

    Article • ChemBioChem, September 2025, Wiley

    Professor Michal Hocek

  4. Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

    Article • Advanced Science, September 2025, Wiley

    Professor Michal Hocek

  5. Milligram‐Scale Enzymatic Synthesis of Base‐Modified DNA through Primer Extension: Polymerase Synthesis and NMR Structures of DNA Containing Phenyl‐Substituted Nucleobases

    Article • ChemistryEurope, July 2025, Wiley

    Professor Michal Hocek

  6. Identification of 6-Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5′-Nucleotidase (CD73)

    Article • ACS Pharmacology & Translational Science, July 2025, American Chemical Society (ACS)

    Professor Michal Hocek

  7. Synthesis of 2‐Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA

    Article • ChemBioChem, May 2025, Wiley

    Professor Michal Hocek

  8. Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove

    Article • Chemistry - A European Journal, May 2025, Wiley

    Professor Michal Hocek

  9. Zwitterionic DNA: enzymatic synthesis of hypermodified DNA bearing four different cationic substituents at all four nucleobases

    Article • Nucleic Acids Research, February 2025, Oxford University Press (OUP)

    Professor Michal Hocek

  10. Super-resolution compatible DNA labeling technique reveals chromatin mobility and organization changes during differentiation

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Michal Hocek

  11. Synthesis and Biological Activity of 2,6‐Disubstituted 7‐Deazapurine Ribonucleosides

    Article • European Journal of Organic Chemistry, January 2025, Wiley

    Professor Michal Hocek

  12. Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins

    Article • Communications Chemistry, January 2025, Springer Science + Business Media

    Professor Michal Hocek

  13. Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein–DNA complexes

    Article • RSC Chemical Biology, January 2025, Royal Society of Chemistry

    Professor Michal Hocek

  14. Hydrophobic alkyl-linked base-modified pyrimidine and 7-deazapurine 2′-deoxyribonucleoside phosphoramidites: synthesis and application in solid-phase synthesis of modified and hypermodified oligonucleotides

    Article • RSC Advances, January 2025, Royal Society of Chemistry

    Professor Michal Hocek

  15. Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase

    Article • Communications Chemistry, November 2024, Springer Science + Business Media

    Professor Michal Hocek

  16. ABNOH‐Linked Nucleotides and DNA for Bioconjugation and Cross‐linking with Tryptophan‐Containing Peptides and Proteins

    Article • Chemistry - A European Journal, August 2024, Wiley

    Professor Michal Hocek

  17. Enzymatic Synthesis of Reactive RNA Probes Containing Squaramate-Linked Cytidine for Bioconjugations and Cross-Linking with Lysine-Containing Peptides and Proteins

    Article • August 2024, Springer Science + Business Media

    Professor Michal Hocek

  18. Glyco‐DNA: Enzymatic Synthesis of Base‐Modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove

    Article • Chemistry - A European Journal, August 2024, Wiley

    Professor Michal Hocek

  19. Addendum: Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases

    Article • Nature Communications, May 2024, Springer Science + Business Media

    Professor Michal Hocek

  20. Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides

    Article • ACS Omega, April 2024, American Chemical Society (ACS)

    Professor Michal Hocek

  21. Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases

    Article • Nature Communications, April 2024, Springer Science + Business Media

    Professor Michal Hocek

  22. Synthesis and Biological Profiling of Benzofuro‐Fused 7‐Deazapurine Nucleosides

    Article • European Journal of Organic Chemistry, October 2023, Wiley

    Professor Michal Hocek

  23. Superanionic DNA: enzymatic synthesis of hypermodified DNA bearing four different anionic substituents at all four nucleobases

    Article • Nucleic Acids Research, October 2023, Oxford University Press (OUP)

    Professor Michal Hocek

  24. Arylethynyl- or Alkynyl-Linked Pyrimidine and 7-Deazapurine 2′-Deoxyribonucleoside 3′-Phosphoramidites for Chemical Synthesis of Hypermodified Hydrophobic Oligonucleotides

    Article • ACS Omega, October 2023, American Chemical Society (ACS)

    Professor Michal Hocek

  25. Normalized Multipotential Redox Coding of DNA Bases for Determination of Total Nucleotide Composition

    Article • Analytical Chemistry, August 2023, American Chemical Society (ACS)

    Professor Michal Hocek

  26. Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides

    Article • Angewandte Chemie, August 2023, Wiley

    Professor Michal Hocek

  27. Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides

    Article • Angewandte Chemie, August 2023, Wiley

    Professor Michal Hocek

  28. Generic Platform for the Multiplexed Targeted Electrochemical Detection of Osteoporosis-Associated Single Nucleotide Polymorphisms Using Recombinase Polymerase Solid-Phase Primer Elongation and Ferrocene-Modified Nucleoside Triphosphates

    Article • ACS Central Science, July 2023, American Chemical Society (ACS)

    Professor Michal Hocek

  29. The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70

    Article • Communications Chemistry, April 2023, Springer Science + Business Media

    Professor Michal Hocek

  30. trans-Cyclooctene- and Bicyclononyne-Linked Nucleotides for Click Modification of DNA with Fluorogenic Tetrazines and Live Cell Metabolic Labeling and Imaging

    Article • Bioconjugate Chemistry, March 2023, American Chemical Society (ACS)

    Professor Michal Hocek

  31. Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins

    Article • Angewandte Chemie, January 2023, Wiley

    Professor Michal Hocek

  32. Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins

    Article • Angewandte Chemie, January 2023, Wiley

    Professor Michal Hocek

  33. Lipid-linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency

    Article • Chemical Science, January 2023, Royal Society of Chemistry

    Professor Michal Hocek

  34. Nucleotides Bearing Red Viscosity-Sensitive Dimethoxy-Bodipy Fluorophore for Enzymatic Incorporation and DNA Labeling

    Article • Bioconjugate Chemistry, December 2022, American Chemical Society (ACS)

    Professor Michal Hocek

  35. The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70

    Article • December 2022, Springer Science + Business Media

    Professor Michal Hocek

  36. Lipid linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency

    Article • December 2022, American Chemical Society (ACS)

    Professor Michal Hocek

  37. Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling

    Article • Journal of the American Chemical Society, October 2022, American Chemical Society (ACS)

    Professor Michal Hocek

  38. Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

    Article • Journal of Medicinal Chemistry, October 2022, American Chemical Society (ACS)

    Professor Michal Hocek

  39. Epigenetic Pyrimidine Nucleotides in Competition with Natural dNTPs as Substrates for Diverse DNA Polymerases

    Article • ACS Chemical Biology, June 2022, American Chemical Society (ACS)

    Professor Michal Hocek

  40. Glucosylated 5‐Hydroxymethylpyrimidines as Epigenetic DNA Bases Regulating Transcription and Restriction Cleavage

    Article • Chemistry - A European Journal, April 2022, Wiley

    Professor Michal Hocek

  41. Glyoxal‐Linked Nucleotides and DNA for Bioconjugations and Crosslinking with Arginine‐Containing Peptides and Proteins

    Article • Chemistry - A European Journal, February 2022, Wiley

    Professor Michal Hocek

  42. Solid-phase recombinase polymerase amplification using ferrocene-labelled dNTPs for electrochemical detection of single nucleotide polymorphisms

    Article • Biosensors and Bioelectronics, February 2022, Elsevier

    Professor Michal Hocek

  43. Correction: Traceless enzymatic synthesis of monodispersed hypermodified oligodeoxyribonucleotide polymers from RNA templates

    Article • Chemical Communications, January 2022, Royal Society of Chemistry

    Professor Michal Hocek

  44. Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase

    Article • RSC Chemical Biology, January 2022, Royal Society of Chemistry

    Professor Michal Hocek

  45. Traceless enzymatic synthesis of monodispersed hypermodified oligodeoxyribonucleotide polymers from RNA templates

    Article • Chemical Communications, January 2022, Royal Society of Chemistry

    Professor Michal Hocek

  46. Polymerase Synthesis of DNA Containing Iodinated Pyrimidine or 7‐Deazapurine Nucleobases and Their Post‐synthetic Modifications through the Suzuki‐Miyaura Cross‐Coupling Reactions

    Article • ChemBioChem, December 2021, Wiley

    Professor Michal Hocek

  47. Electrochemical Detection of Single-Nucleotide Polymorphism Associated with Rifampicin Resistance in Mycobacterium tuberculosis Using Solid-Phase Primer Elongation with Ferrocene-Linked Redox-Labeled Nucleotides

    Article • ACS Sensors, November 2021, American Chemical Society (ACS)

    Professor Miguel Viveiros, Professor Michal Hocek

  48. 1,3‐Diketone‐Modified Nucleotides and DNA for Cross‐Linking with Arginine‐Containing Peptides and Proteins

    Article • Angewandte Chemie, July 2021, Wiley

    Professor Michal Hocek

  49. 1,3‐Diketone‐Modified Nucleotides and DNA for Cross‐Linking with Arginine‐Containing Peptides and Proteins

    Article • Angewandte Chemie, July 2021, Wiley

    Professor Michal Hocek

  50. Synthesis and anti-trypanosomal activity of 3′-fluororibonucleosides derived from 7-deazapurine nucleosides

    Article • Bioorganic & Medicinal Chemistry Letters, May 2021, Elsevier

    Professor Michal Hocek

  51. Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing

    Article • Journal of the American Chemical Society, April 2021, American Chemical Society (ACS)

    Professor Michal Hocek

  52. Acetophenyl‐thienyl‐aniline‐Linked Nucleotide for Construction of Solvatochromic Fluorescence Light‐Up DNA Probes Sensing Protein‐DNA Interactions

    Article • Chemistry - A European Journal, April 2021, Wiley

    Professor Michal Hocek

  53. Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides

    Article • ACS Infectious Diseases, March 2021, American Chemical Society (ACS)

    Professor Michal Hocek

  54. Ferrocene-Containing DNA Monolayers: Influence of Electrostatics on the Electron Transfer Dynamics

    Article • Langmuir, March 2021, American Chemical Society (ACS)

    Professor Michal Hocek

  55. Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

    Article • ACS Infectious Diseases, January 2021, American Chemical Society (ACS)

    Professor Michal Hocek

  56. Nucleotides bearing aminophenyl- or aminonaphthyl-3-methoxychromone solvatochromic fluorophores for the enzymatic construction of DNA probes for the detection of protein–DNA binding

    Article • Organic & Biomolecular Chemistry, January 2021, Royal Society of Chemistry

    Professor Michal Hocek

  57. Celebrating Czech Chemistry

    Article • ChemPlusChem, December 2020, Wiley

    Professor Michal Hocek

  58. Photocaged 5-(Hydroxymethyl)pyrimidine Nucleoside Phosphoramidites for Specific Photoactivatable Epigenetic Labeling of DNA

    Article • Organic Letters, November 2020, American Chemical Society (ACS)

    Professor Michal Hocek

  59. Enzymatic synthesis of hypermodified DNA polymers for sequence-specific display of four different hydrophobic groups

    Article • Nucleic Acids Research, November 2020, Oxford University Press (OUP)

    Professor Michal Hocek

  60. Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines

    Article • ACS Omega, October 2020, American Chemical Society (ACS)

    Professor Michal Hocek

  61. Synthesis and Cytotoxic and Antiviral Activity Profiling of All‐Four Isomeric Series of Pyrido‐Fused 7‐Deazapurine Ribonucleosides

    Article • Chemistry - A European Journal, September 2020, Wiley

    Professor Michal Hocek

  62. Cover Feature: Nucleotide‐Bearing Benzylidene‐Tetrahydroxanthylium Near‐IR Fluorophore for Sensing DNA Replication, Secondary Structures and Interactions (Chem. Eur. J. 52/2020)

    Article • Chemistry - A European Journal, August 2020, Wiley

    Professor Michal Hocek

  63. Nucleotide‐Bearing Benzylidene‐Tetrahydroxanthylium Near‐IR Fluorophore for Sensing DNA Replication, Secondary Structures and Interactions

    Article • Chemistry - A European Journal, August 2020, Wiley

    Professor Michal Hocek

  64. Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides

    Article • The Journal of Organic Chemistry, July 2020, American Chemical Society (ACS)

    Professor Michal Hocek

  65. 2‐Formyl‐dATP as Substrate for Polymerase Synthesis of Reactive DNA Bearing an Aldehyde Group in the Minor Groove

    Article • ChemPlusChem, June 2020, Wiley

    Professor Michal Hocek

  66. Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides

    Article • The Journal of Organic Chemistry, May 2020, American Chemical Society (ACS)

    Professor Michal Hocek

  67. Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA

    Article • Chemistry - A European Journal, January 2020, Wiley

    Professor Michal Hocek

  68. 2-Substituted 2′-deoxyinosine 5′-triphosphates as substrates for polymerase synthesis of minor-groove-modified DNA and effects on restriction endonuclease cleavage

    Article • Organic & Biomolecular Chemistry, January 2020, Royal Society of Chemistry

    Professor Michal Hocek

  69. Thiophene-linked tetramethylbodipy-labeled nucleotide for viscosity-sensitive oligonucleotide probes of hybridization and protein–DNA interactions

    Article • Organic & Biomolecular Chemistry, January 2020, Royal Society of Chemistry

    Professor Michal Hocek

  70. Oxidative DNA Cleavage with Clip‐Phenanthroline Triplex‐Forming Oligonucleotide Hybrids

    Article • ChemBioChem, December 2019, Wiley

    Professor Michal Hocek

  71. Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA

    Article • Chemistry - A European Journal, December 2019, Wiley

    Professor Michal Hocek

  72. Duplex Electrochemical DNA Sensor to Detect Bacillus anthracis CAP and PAG DNA Targets Based on the Incorporation of Tailed Primers and Ferrocene-Labeled dATP

    Article • ACS Omega, December 2019, American Chemical Society (ACS)

    Professor Michal Hocek

  73. Reactive modifications of DNA nucleobases for labelling, bioconjugations, and cross-linking

    Article • Current Opinion in Chemical Biology, October 2019, Elsevier

    Professor Michal Hocek

  74. Squaramate-Modified Nucleotides and DNA for Specific Cross-Linking with Lysine-Containing Peptides and Proteins

    Article • Angewandte Chemie, August 2019, Wiley

    Professor Michal Hocek

  75. Squaramate‐Modified Nucleotides and DNA for Specific Cross‐Linking with Lysine‐Containing Peptides and Proteins

    Article • Angewandte Chemie, August 2019, Wiley

    Professor Michal Hocek

  76. Vicinal Diol‐Tethered Nucleobases as Targets for DNA Redox Labeling with Osmate Complexes

    Article • ChemBioChem, August 2019, Wiley

    Professor Michal Hocek

  77. Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein–DNA Binding and Transcription

    Article • Accounts of Chemical Research, June 2019, American Chemical Society (ACS)

    Professor Michal Hocek

  78. Electrochemical genosensor for the direct detection of tailed PCR amplicons incorporating ferrocene labelled dATP

    Article • Biosensors and Bioelectronics, June 2019, Elsevier

    Professor Michal Hocek

  79. Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6-(Thiophen-2-yl)-7-fluoro-7-deazapurine

    Article • European Journal of Organic Chemistry, May 2019, Wiley

    Professor Michal Hocek

  80. Dual redox labeling of DNA as a tool for electrochemical detection of p53 protein-DNA interactions

    Article • Analytica Chimica Acta, March 2019, Elsevier

    Professor Michal Hocek

  81. Correction to “Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides”

    Article • Journal of Medicinal Chemistry, January 2019, American Chemical Society (ACS)

    Professor Michal Hocek

  82. Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA

    Article • Chemical Science, January 2019, Royal Society of Chemistry

    Professor Michal Hocek

  83. Synthesis of Base-Modified dNTPs Through Cross-Coupling Reactions and Their Polymerase Incorporation to DNA

    Article • January 2019, Springer Science + Business Media

    Professor Michal Hocek

  84. Synthesis of 2′-deoxycytidine and its triphosphate bearing tryptophan-based imidazolinone fluorophore for environment sensitive fluorescent labelling of DNA

    Article • Tetrahedron, November 2018, Elsevier

    Professor Michal Hocek

  85. Brightly Fluorescent 2′-Deoxyribonucleoside Triphosphates Bearing Methylated Bodipy Fluorophore for in Cellulo Incorporation to DNA, Imaging, and Flow Cytometry

    Article • Bioconjugate Chemistry, October 2018, American Chemical Society (ACS)

    Professor Michal Hocek

  86. Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides

    Article • Journal of Medicinal Chemistry, October 2018, American Chemical Society (ACS)

    Professor Michal Hocek

  87. 2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA

    Article • Chemistry - A European Journal, September 2018, Wiley

    Professor Michal Hocek

  88. Thienopyrrolo[2, 3-d ]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities

    Article • ChemistrySelect, August 2018, Wiley

    Professor Michal Hocek

  89. Synthesis of Dihydroxyalkynyl and Dihydroxyalkyl Nucleotides as Building Blocks or Precursors for Introduction of Diol or Aldehyde Groups to DNA for Bioconjugations

    Article • Chemistry - A European Journal, July 2018, Wiley

    Professor Michal Hocek

  90. Voltammetric and adsorption study of 4-nitrophenyl-triazole-labeled 2′-deoxycytidine and 7-deazaadenosine nucleosides at boron-doped diamond electrode

    Article • Journal of Electroanalytical Chemistry, July 2018, Elsevier

    Professor Michal Hocek

  91. Synthesis of Dihydroxyalkynyl and Dihydroxyalkyl Nucleotides as Building Blocks or Precursors for Introduction of Diol or Aldehyde Groups to DNA for Bioconjugations

    Article • Chemistry - A European Journal, June 2018, Wiley

    Professor Michal Hocek

  92. Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition

    Article • Organic Letters, June 2018, American Chemical Society (ACS)

    Professor Michal Hocek

  93. Turning Off Transcription with Bacterial RNA Polymerase through CuAAC Click Reactions of DNA Containing 5-Ethynyluracil

    Article • Chemistry - A European Journal, May 2018, Wiley

    Professor Michal Hocek

  94. Isomeric Naphtho-Fused 7-Deazapurine Nucleosides and Nucleotides: Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids

    Article • European Journal of Organic Chemistry, May 2018, Wiley

    Professor Michal Hocek

  95. C–H Imidation of 7-Deazapurines

    Article • ACS Omega, April 2018, American Chemical Society (ACS)

    Professor Michal Hocek

  96. Electrochemical reduction of azidophenyl-deoxynucleoside conjugates at mercury surface

    Article • Electrochimica Acta, January 2018, Elsevier

    Professor Michal Hocek

  97. Protected 2′-deoxyribonucleoside triphosphate building blocks for the photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Professor Michal Hocek

  98. Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Professor Michal Hocek

  99. Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Professor Michal Hocek

  100. Butylacrylate-nucleobase Conjugates as Targets for Two-step Redox Labeling of DNA with an Osmium Tetroxide Complex

    Article • Electroanalysis, December 2017, Wiley

    Professor Michal Hocek

  101. Carborane-linked 2′-deoxyuridine 5′- O -triphosphate as building block for polymerase synthesis of carborane-modified DNA

    Article • Bioorganic & Medicinal Chemistry Letters, November 2017, Elsevier

    Professor Michal Hocek

  102. Trifluoroacetophenone-Linked Nucleotides and DNA for Studying of DNA–Protein Interactions by 19F NMR Spectroscopy

    Article • The Journal of Organic Chemistry, October 2017, American Chemical Society (ACS)

    Professor Michal Hocek

  103. Pyrrolo[2,3-d ]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

    Article • Medicinal Research Reviews, August 2017, Wiley

    Professor Michal Hocek

  104. Strategies toward protecting group-free glycosylation through selective activation of the anomeric center

    Article • Beilstein Journal of Organic Chemistry, June 2017, Beilstein Institut

    Professor Michal Hocek

  105. Synthesis of 2,6-Substituted 7-(Het)aryl-7-deazapurine Nucleobases (2,4-Disubstituted 5-(Het)aryl-pyrrolo[2,3-d]pyrimidines)

    Article • Synthesis, June 2017, Thieme Publishing Group

    Professor Michal Hocek

  106. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides

    Article • Journal of Medicinal Chemistry, March 2017, American Chemical Society (ACS)

    Professor Michal Hocek

  107. Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism

    Article • Chemistry - A European Journal, February 2017, Wiley

    Professor Michal Hocek

  108. Phenothiazine-linked nucleosides and nucleotides for redox labelling of DNA

    Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

    Professor Michal Hocek

  109. Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    Professor Michal Hocek

  110. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Michal Hocek

  111. 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove

    Article • Angewandte Chemie, November 2016, Wiley

    Professor Michal Hocek

  112. 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove

    Article • Angewandte Chemie, November 2016, Wiley

    Professor Michal Hocek

  113. Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2′-Deoxyadenosine, dATP and DNA

    Article • The Journal of Organic Chemistry, November 2016, American Chemical Society (ACS)

    Professor Michal Hocek

  114. 5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs

    Article • ACS Chemical Biology, November 2016, American Chemical Society (ACS)

    Professor Michal Hocek

  115. C–H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives

    Article • The Journal of Organic Chemistry, October 2016, American Chemical Society (ACS)

    Professor Michal Hocek

  116. 6-Aryl-4-amino-pyrimido[4,5-b]indole 2′-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study

    Article • Bioorganic & Medicinal Chemistry, October 2016, Elsevier

    Professor Michal Hocek

  117. Voltammetric analysis of 5-(4-Azidophenyl)-2′-deoxycytidine nucleoside and azidophenyl-labelled single- and double-stranded DNAs

    Article • Electrochimica Acta, October 2016, Elsevier

    Professor Michal Hocek

  118. Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins

    Article • Bioconjugate Chemistry, September 2016, American Chemical Society (ACS)

    Professor Michal Hocek

  119. Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases

    Article • Nucleic Acids Research, March 2016, Oxford University Press (OUP)

    Professor Michal Hocek

  120. Flexible double-headed cytosine-linked 2′-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases

    Article • Bioorganic & Medicinal Chemistry, March 2016, Elsevier

    Professor Michal Hocek

  121. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action

    Article • Molecular Cancer Therapeutics, January 2016, American Association for Cancer Research (AACR)

    Professor Michal Hocek

  122. Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurine Bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions

    Article • Synthesis, January 2016, Thieme Publishing Group

    Professor Michal Hocek

  123. Inhibition of non-templated nucleotide addition by DNA polymerases in primer extension using twisted intercalating nucleic acid modified templates

    Article • Bioorganic & Medicinal Chemistry Letters, January 2016, Elsevier

    Professor Michal Hocek

  124. Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Professor Michal Hocek

  125. Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Professor Michal Hocek

  126. Polymerase Synthesis of Base-Modified DNA

    Article • January 2016, Springer Science + Business Media

    Professor Michal Hocek

  127. Innentitelbild: A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy (Angew. Chem. 1/2016)

    Article • Angewandte Chemie, December 2015, Wiley

    Professor Michal Hocek

  128. Inside Cover: A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy (Angew. Chem. Int. Ed. 1/2016)

    Article • Angewandte Chemie, December 2015, Wiley

    Professor Michal Hocek

  129. Ir-catalyzed C–H silylations of phenyldeazapurines

    Article • Tetrahedron Letters, December 2015, Elsevier

    Professor Michal Hocek

  130. Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides

    Article • Bioorganic & Medicinal Chemistry, December 2015, Elsevier

    Professor Michal Hocek

  131. A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy

    Article • Angewandte Chemie, November 2015, Wiley

    Professor Michal Hocek

  132. A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy

    Article • Angewandte Chemie, November 2015, Wiley

    Professor Michal Hocek

  133. Synthesis of Benzene and Pyridine 2′-C-Methyl-C-ribonucleosides and -nucleotides

    Article • European Journal of Organic Chemistry, November 2015, Wiley

    Professor Michal Hocek

  134. Modification of Pyrrolo[2,3-d]pyrimidines by C-H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases

    Article • European Journal of Organic Chemistry, November 2015, Wiley

    Professor Michal Hocek

  135. Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases

    Article • Bioorganic & Medicinal Chemistry, November 2015, Elsevier

    Professor Michal Hocek

  136. Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases

    Article • ChemBioChem, September 2015, Wiley

    Professor Michal Hocek

  137. Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotectedd-Ribose

    Article • Organic Letters, September 2015, American Chemical Society (ACS)

    Professor Michal Hocek

  138. Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking

    Article • Chemistry - A European Journal, September 2015, Wiley

    Professor Michal Hocek

  139. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity

    Article • ChemMedChem, April 2015, Wiley

    Professor Michal Hocek

  140. Fluorescence Quenching in Oligonucleotides Containing 7-Substituted 7-Deazaguanine Bases Prepared by the Nicking Enzyme Amplification Reaction

    Article • Bioconjugate Chemistry, February 2015, American Chemical Society (ACS)

    Professor Michal Hocek

  141. Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA–protein interactions

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Professor Michal Hocek

  142. Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Professor Michal Hocek

  143. Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Michal Hocek

  144. Bodipy-Labeled Nucleoside Triphosphates for Polymerase Synthesis of Fluorescent DNA

    Article • Bioconjugate Chemistry, November 2014, American Chemical Society (ACS)

    Professor Michal Hocek

  145. Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

    Article • The Journal of Organic Chemistry, November 2014, American Chemical Society (ACS)

    Professor Michal Hocek

  146. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides

    Article • Journal of Medicinal Chemistry, October 2014, American Chemical Society (ACS)

    Professor Michal Hocek

  147. Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings

    Article • European Journal of Organic Chemistry, October 2014, Wiley

    Professor Michal Hocek

  148. Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA

    Article • ChemPlusChem, September 2014, Wiley

    Professor Michal Hocek

  149. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases

    Article • ChemBioChem, September 2014, Wiley

    Professor Michal Hocek

  150. Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet

    Article • Nucleic Acids Research, August 2014, Oxford University Press (OUP)

    Professor Michal Hocek

  151. 7-Aryl-7-deazaadenine 2′-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations

    Article • Angewandte Chemie, May 2014, Wiley

    Professor Michal Hocek

  152. 7-Aryl-7-deazaadenine 2′-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations

    Article • Angewandte Chemie, May 2014, Wiley

    Professor Michal Hocek

  153. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases

    Article • Angewandte Chemie, May 2014, Wiley

    Professor Michal Hocek

  154. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases

    Article • Angewandte Chemie, May 2014, Wiley

    Professor Michal Hocek

  155. Voltammetric Study of dsDNA Modified by Multi-redox Label Based on N-methyl-4-hydrazino-7-nitrobenzofurazan

    Article • Electrochimica Acta, May 2014, Elsevier

    Professor Michal Hocek

  156. Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne as multi-redox centre DNA label at mercury meniscus modified silver solid amalgam electrode

    Article • Electrochimica Acta, April 2014, Elsevier

    Professor Michal Hocek

  157. Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides

    Article • Journal of Medicinal Chemistry, February 2014, American Chemical Society (ACS)

    Professor Michal Hocek

  158. Direct C–H amination and C–H chloroamination of 7-deazapurines

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Michal Hocek

  159. C-H Trifluoromethylations of 1,3-Dimethyluracil and Reactivity of the Products in C-H Arylations

    Article • Heterocycles, January 2014, Japan Institute of Heterocyclic Chemistry

    Professor Michal Hocek

  160. Aqueous Heck Cross-Coupling Preparation of Acrylate-Modified Nucleotides and Nucleoside Triphosphates for Polymerase Synthesis of Acrylate-Labeled DNA

    Article • The Journal of Organic Chemistry, October 2013, American Chemical Society (ACS)

    Professor Michal Hocek

  161. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides

    Article • Bioorganic & Medicinal Chemistry, September 2013, Elsevier

    Professor Michal Hocek

  162. Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins

    Article • Angewandte Chemie, August 2013, Wiley

    Professor Michal Hocek

  163. Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins

    Article • Angewandte Chemie, August 2013, Wiley

    Professor Michal Hocek

  164. Benzofurazane as a New Redox Label for Electrochemical Detection of DNA: Towards Multipotential Redox Coding of DNA Bases

    Article • Chemistry - A European Journal, August 2013, Wiley

    Professor Michal Hocek

  165. Scope and Limitations of the Nicking Enzyme Amplification Reaction for the Synthesis of Base-Modified Oligonucleotides and Primers for PCR

    Article • Bioconjugate Chemistry, June 2013, American Chemical Society (ACS)

    Professor Michal Hocek

  166. Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines

    Article • ChemMedChem, April 2013, Wiley

    Professor Michal Hocek

  167. Nucleobase Protection Strategy for Gene Cloning and Expression

    Article • ChemBioChem, March 2013, Wiley

    Professor Michal Hocek

  168. Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Michal Hocek

  169. Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Michal Hocek

  170. Synthesis of 2,6-disubstituted pyridin-3-yl C-2′-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Michal Hocek

  171. Direct C–H sulfenylation of purines and deazapurines

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Michal Hocek

  172. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Professor Michal Hocek

  173. Editorial: A Smooth Transition …

    Article • ChemPlusChem, January 2013, Wiley

    Professor Michal Hocek

  174. Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

    Article • Bioorganic & Medicinal Chemistry, October 2012, Elsevier

    Professor Michal Hocek

  175. GFP-like Fluorophores as DNA Labels for Studying DNA–Protein Interactions

    Article • The Journal of Organic Chemistry, September 2012, American Chemical Society (ACS)

    Professor Michal Hocek

  176. Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines

    Article • Tetrahedron, September 2012, Elsevier

    Professor Michal Hocek

  177. Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

    Article • Bioorganic & Medicinal Chemistry, September 2012, Elsevier

    Professor Michal Hocek

  178. Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba Analogues of Phosphoribosylanthranilate

    Article • European Journal of Organic Chemistry, July 2012, Wiley

    Professor Michal Hocek

  179. A General Regioselective Synthesis of 2,4-Diarylpyrimidines from 2- Thiouracil through Two Orthogonal Cross-Coupling Reactions

    Article • Synlett, May 2012, Thieme Publishing Group

    Professor Michal Hocek

  180. Synthesis of Hydrazone-Modified Nucleotides and Their Polymerase Incorporation onto DNA for Redox Labeling

    Article • ChemPlusChem, April 2012, Wiley

    Professor Michal Hocek

  181. Synthesis of Aldehyde-Linked Nucleotides and DNA and Their Bioconjugations with Lysine and Peptides through Reductive Amination

    Article • Chemistry - A European Journal, February 2012, Wiley

    Professor Michal Hocek

  182. A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides

    Article • Synthesis, February 2012, Thieme Publishing Group

    Professor Michal Hocek

  183. Synthesis of 6-Substituted 2(1H)-Pyridon-3-yl C-2′-Deoxyribonucleosides

    Article • European Journal of Organic Chemistry, February 2012, Wiley

    Professor Michal Hocek

  184. Synthesis and Photophysical Properties of Biaryl-Substituted Nucleos(t)ides. Polymerase Synthesis of DNA Probes Bearing Solvatochromic and pH-Sensitive Dual Fluorescent and19F NMR Labels

    Article • The Journal of Organic Chemistry, January 2012, American Chemical Society (ACS)

    Professor Michal Hocek

  185. Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Michal Hocek

  186. Synthesis of nucleoside mono- and triphosphates bearing oligopyridine ligands, their incorporation into DNA and complexation with transition metals

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Professor Michal Hocek

  187. Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA–protein interactions

    Article • Chemical Science, January 2012, Royal Society of Chemistry

    Professor Michal Hocek

  188. Anthraquinone as a Redox Label for DNA: Synthesis, Enzymatic Incorporation, and Electrochemistry of Anthraquinone-Modified Nucleosides, Nucleotides, and DNA

    Article • Chemistry - A European Journal, November 2011, Wiley

    Professor Michal Hocek

  189. A Modular Approach to Aryl-C-ribonucleosides via the Allylic Substitution and Ring-Closing Metathesis Sequence. A Stereocontrolled Synthesis of All Four α-/β- andd-/l-C-Nucleoside Stereoisomers

    Article • The Journal of Organic Chemistry, October 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  190. Redox Labels and Indicators Based on Transition Metals and Organic Electroactive Moieties for Electrochemical Nucleic Acids Sensing

    Article • Current Organic Chemistry, September 2011, Bentham Science Publishers

    Professor Michal Hocek

  191. B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines

    Article • Biochemistry, August 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  192. General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-ylC-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups

    Article • The Journal of Organic Chemistry, August 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  193. Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines

    Article • Journal of Medicinal Chemistry, August 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  194. Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases

    Article • Angewandte Chemie, July 2011, Wiley

    Professor Michal Hocek

  195. Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases

    Article • Angewandte Chemie, July 2011, Wiley

    Professor Michal Hocek

  196. Regioselective Direct C–H Arylations of Protected Uracils. Synthesis of 5- and 6-Aryluracil Bases

    Article • The Journal of Organic Chemistry, July 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  197. Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone

    Article • Chemistry - A European Journal, May 2011, Wiley

    Professor Michal Hocek

  198. Synthesis of Acetylene Linked Double-Nucleobase Nucleos(t)ide Building Blocks and Polymerase Construction of DNA Containing Cytosines in the Major Groove

    Article • The Journal of Organic Chemistry, May 2011, American Chemical Society (ACS)

    Professor Michal Hocek

  199. Alkylsulfanylphenyl Derivatives of Cytosine and 7-Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study

    Article • Chemistry - A European Journal, April 2011, Wiley

    Professor Michal Hocek

  200. Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases

    Article • ChemBioChem, January 2011, Wiley

    Professor Michal Hocek

  201. Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines

    Article • Physical Chemistry Chemical Physics, January 2011, Royal Society of Chemistry

    Michal Straka, Professor Radek Marek, Professor Michal Hocek

  202. Nucleobase modification as redox DNA labelling for electrochemical detection

    Article • Chemical Society Reviews, January 2011, Royal Society of Chemistry

    Professor Michal Hocek

  203. Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2′-deoxyribose C-nucleosides

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Professor Michal Hocek

  204. Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl tranferase. Application in electrochemical DNA hybridization and protein-DNA binding assays

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Professor Michal Hocek

  205. Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2′-C-methylribonucleosides, arabinonucleosides and 2′-deoxy-2′-fluoroarabinonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2011, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  206. Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides

    Article • Bioorganic & Medicinal Chemistry, January 2011, Elsevier

    Professor Michal Hocek

  207. Synthesis of 4-(het)aryl pyrimido[4,5-b]indole ribonucleosides

    Article • January 2011, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  208. Synthesis of Phenol and Pyridone C-Ribo- and 2′-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides

    Article • Synthesis, October 2010, Thieme Publishing Group

    Professor Michal Hocek

  209. Modular Synthesis of 5-Substituted Furan-2-yl C-2′-Deoxyribonucleosides and Biaryl Covalent Base-Pair Analogues

    Article • European Journal of Organic Chemistry, August 2010, Wiley

    Professor Michal Hocek

  210. Interpretation of Indirect Nuclear Spin−Spin Couplings in Isomers of Adenine: Novel Approach to Analyze Coupling Electron Deformation Density Using Localized Molecular Orbitals

    Article • The Journal of Physical Chemistry A, June 2010, American Chemical Society (ACS)

    Professor Radek Marek, Professor Michal Hocek

  211. CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases

    Article • ChemMedChem, June 2010, Wiley

    Professor Michal Hocek

  212. Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides

    Article • Tetrahedron Letters, May 2010, Elsevier

    Professor Michal Hocek

  213. Intramolecular Direct C−H Arylation Approach to Fused Purines. Synthesis of Purino[8,9-f]phenanthridines and 5,6-Dihydropurino[8,9-a]isoquinolines§§ Dedicated to the memory of Keith Fagnou.

    Article • The Journal of Organic Chemistry, April 2010, American Chemical Society (ACS)

    Professor Michal Hocek

  214. Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2′-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides

    Article • European Journal of Organic Chemistry, March 2010, Wiley

    Professor Michal Hocek

  215. Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate

    Article • Biochemistry, February 2010, American Chemical Society (ACS)

    Professor Michal Hocek

  216. Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines

    Article • Angewandte Chemie, February 2010, Wiley

    Professor Michal Hocek

  217. A General and Efficient Synthesis of Pyridin-2-ylC-Ribonucleosides Bearing Diverse Alkyl, Aryl, Amino, and Carbamoyl Groups in Position 6

    Article • The Journal of Organic Chemistry, January 2010, American Chemical Society (ACS)

    Professor Michal Hocek

  218. 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents

    Article • Journal of Medicinal Chemistry, January 2010, American Chemical Society (ACS)

    Professor Michal Hocek

  219. Understanding the NMR chemical shifts for 6-halopurines: role of structure, solvent and relativistic effects

    Article • Physical Chemistry Chemical Physics, January 2010, Royal Society of Chemistry

    Michal Straka, Professor Radek Marek, Professor Michal Hocek

  220. Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Professor Michal Hocek

  221. [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes

    Article • Heterocycles, January 2010, Japan Institute of Heterocyclic Chemistry

    Professor Michal Hocek

  222. Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides

    Article • Tetrahedron, January 2010, Elsevier

    Professor Michal Hocek

  223. Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines

    Article • Angewandte Chemie, December 2009, Wiley

    Professor Michal Hocek

  224. C-Nucleosides: Synthetic Strategies and Biological Applications

    Article • Chemical Reviews, December 2009, American Chemical Society (ACS)

    Professor Michal Hocek

  225. Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase

    Article • Biochemistry, November 2009, American Chemical Society (ACS)

    Professor Michal Hocek

  226. Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases

    Article • Nucleic Acids Research, October 2009, Oxford University Press (OUP)

    Professor Michal Hocek

  227. Theoretical Study of the Stability of the DNA Duplexes Modified by a Series of Hydrophobic Base Analogues

    Article • Chemistry - A European Journal, August 2009, Wiley

    Professor Michal Hocek

  228. Switching the Regioselectivity of Direct C-H Arylation of 1,3-Dimethyluracil

    Article • European Journal of Organic Chemistry, August 2009, Wiley

    Professor Michal Hocek

  229. Tetrathiafulvalene-Labelled Nucleosides and Nucleoside Triphosphates: Synthesis, Electrochemistry and the Scope of Their Polymerase Incorporation into DNA

    Article • European Journal of Organic Chemistry, July 2009, Wiley

    Professor Michal Hocek

  230. Synthesis of benzamide-C-ribonucleosides by Pd-catalyzed aminocarbonylations

    Article • Tetrahedron, June 2009, Elsevier

    Professor Michal Hocek

  231. Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoro­borates; The Scope and Limitations in the Synthesis of Modified Purines

    Article • Synthesis, March 2009, Thieme Publishing Group

    Professor Michal Hocek

  232. Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Michal Hocek

  233. Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)- and 6-(carbamoylmethyl)purines

    Article • Collection of Czechoslovak Chemical Communications, January 2009, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  234. Base-Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications

    Article • Chemistry - A European Journal, December 2008, Wiley

    Professor Michal Hocek

  235. Synthesis of 2′-Deoxyuridine and 2′-Deoxycytidine Nucleosides Bearing Bipyridine and Terpyridine Ligands at Position 5

    Article • Synthesis, December 2008, Thieme Publishing Group

    Professor Michal Hocek

  236. Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication

    Article • ChemBioChem, November 2008, Wiley

    Professor Michal Hocek

  237. Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C−H Arylation Reactions

    Article • The Journal of Organic Chemistry, November 2008, American Chemical Society (ACS)

    Professor Michal Hocek

  238. Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines

    Article • Tetrahedron, November 2008, Elsevier

    Professor Michal Hocek

  239. 6-Aryl- and 6-Heteroarylpurines via Cyclotrimerization

    Article • Nucleic Acids Symposium Series, September 2008, Oxford University Press (OUP)

    Professor Michal Hocek

  240. Novel base-functionalized DNA. Efficient methodology for construction and bioanalytical applications

    Article • Nucleic Acids Symposium Series, September 2008, Oxford University Press (OUP)

    Professor Michal Hocek

  241. Effect of Spin−Orbit Coupling on Reduction Potentials of Octahedral Ruthenium(II/III) and Osmium(II/III) Complexes

    Article • Journal of the American Chemical Society, August 2008, American Chemical Society (ACS)

    Professor Michal Hocek

  242. Cobalt‐Induced Synthesis of 6‐(Pyridin‐2‐yl)purines by Microwave‐Enhanced [2+2+2] Cyclotrimerization

    Article • European Journal of Organic Chemistry, July 2008, Wiley

    Professor Michal Hocek

  243. Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C-2′-Deoxyribonucleosides

    Article • Synthesis, June 2008, Thieme Publishing Group

    Professor Michal Hocek

  244. Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides

    Article • European Journal of Organic Chemistry, June 2008, Wiley

    Professor Michal Hocek

  245. Modular Synthesis of 5-Substituted Thiophen-2-ylC-2′-Deoxyribonucleosides

    Article • The Journal of Organic Chemistry, May 2008, American Chemical Society (ACS)

    Professor Michal Hocek

  246. Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues

    Article • Tetrahedron, May 2008, Elsevier

    Professor Michal Hocek

  247. A Modular Methodology for the Synthesis of 4- and 3-Substituted Benzene and Aniline C-Ribonucleosides

    Article • European Journal of Organic Chemistry, April 2008, Wiley

    Professor Michal Hocek

  248. Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

    Article • Bioorganic & Medicinal Chemistry, March 2008, Elsevier

    Professor Michal Hocek

  249. Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection

    Article • Angewandte Chemie, February 2008, Wiley

    Professor Michal Hocek

  250. Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection

    Article • Angewandte Chemie, February 2008, Wiley

    Professor Michal Hocek

  251. Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide - Scope and Limitations of the Reaction

    Article • Synlett, February 2008, Thieme Publishing Group

    Professor Michal Hocek

  252. Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides

    Article • Bioorganic & Medicinal Chemistry, February 2008, Elsevier

    Professor Michal Hocek

  253. Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Michal Hocek

  254. Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Michal Hocek

  255. Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Michal Hocek

  256. Synthesis and photophysical properties of 7-deaza-2′-deoxyadenosines bearing bipyridine ligands and their Ru(ii)-complexes in position 7

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Michal Hocek

  257. Cytostatic and Antiviral 6-Arylpurine Ribonucleosides IX. Synthesis and Evaluation of 6-Substituted 3-Deazapurine Ribonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2008, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  258. Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry, and Bioanalytical Applications

    Article • Chemistry - A European Journal, November 2007, Wiley

    Professor Michal Hocek

  259. Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent

    Article • Tetrahedron Letters, August 2007, Elsevier

    Professor Michal Hocek

  260. Modular and Practical Synthesis of 6-Substituted Pyridin-3-yl C-Nucleosides

    Article • The Journal of Organic Chemistry, August 2007, American Chemical Society (ACS)

    Professor Michal Hocek

  261. An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross-Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR

    Article • Chemistry - A European Journal, July 2007, Wiley

    Professor Michal Hocek

  262. Purines Bearing Phenanthroline or Bipyridine Ligands and Their RuII Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Ac...

    Article • European Journal of Inorganic Chemistry, April 2007, Wiley

    Professor Michal Hocek

  263. The first direct C–H arylation of purine nucleosides

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Professor Michal Hocek

  264. Synthesis of 2′-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Professor Michal Hocek

  265. Human DNA Polymerase α Uses a Combination of Positive and Negative Selectivity To Polymerize Purine dNTPs with High Fidelity†

    Article • Biochemistry, January 2007, American Chemical Society (ACS)

    Professor Michal Hocek

  266. Direct C−H Arylation of Purines:  Development of Methodology and Its Use in Regioselective Synthesis of 2,6,8-Trisubstituted Purines

    Article • Organic Letters, November 2006, American Chemical Society (ACS)

    Professor Michal Hocek

  267. Synthesis of Purines Bearing Functionalized C-Substituents by the Conjugate Addition of Nucleophiles to 6-Vinylpurines and 6-Ethynylpurines

    Article • European Journal of Organic Chemistry, November 2006, Wiley

    Professor Michal Hocek

  268. Preparation of Highly Substituted 6-Arylpurine Ribonucleosides by Ni-Catalyzed Cyclotrimerization. Scope of the Reaction

    Article • The Journal of Organic Chemistry, November 2006, American Chemical Society (ACS)

    Professor Michal Hocek

  269. Aqueous-Phase Suzuki-Miyaura Cross-Coupling Reactions of Free Halopurine Bases

    Article • Synthesis, October 2006, Thieme Publishing Group

    Professor Michal Hocek

  270. Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine l-ribonucleosides

    Article • Bioorganic & Medicinal Chemistry Letters, October 2006, Elsevier

    Professor Michal Hocek

  271. New Modular and Efficient Approach to 6-Substituted Pyridin-2-yl C-Nucleosides

    Article • The Journal of Organic Chemistry, September 2006, American Chemical Society (ACS)

    Professor Michal Hocek

  272. Synthesis and Cytostatic Activity of Novel 6-(Difluoromethyl)purine Bases and Nucleosides

    Article • Synthesis, June 2006, Thieme Publishing Group

    Professor Michal Hocek

  273. Synthesis of C-Aryldeoxyribosides by [2 + 2 + 2]-Cyclotrimerization Catalyzed by Rh, Ni, Co, and Ru Complexes

    Article • Organic Letters, May 2006, American Chemical Society (ACS)

    Professor Michal Hocek

  274. Exceptional Thermodynamic Stability of DNA Duplexes Modified by Nonpolar Base Analogues Is due to Increased Stacking Interactions and Favorable Solvation: Correlated Ab Initio Calculations and Molecular Dynamics Simulations

    Article • Chemistry - A European Journal, April 2006, Wiley

    Professor Michal Hocek

  275. Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines

    Article • Organic & Biomolecular Chemistry, January 2006, Royal Society of Chemistry

    Professor Michal Hocek

  276. Cytostatic and Antiviral 6-Arylpurine Ribonucleosides VIII. Synthesis and Evaluation of 6-Substituted Purine 3'-Deoxyribonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2006, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  277. Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(hydroxymethyl)purine Bases and Nucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2006, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  278. A New Modular and Practical Methodology for the Synthesis of 4- or 3-Substituted Phenyl C-Nucleosides

    Article • European Journal of Organic Chemistry, November 2005, Wiley

    Professor Michal Hocek

  279. Efficient One-Step Synthesis of Optically Pure (Adenin-8-yl)phenylalanine Nucleosides

    Article • Synlett, October 2005, Thieme Publishing Group

    Professor Michal Hocek

  280. Synthesis of Enantiomerically Pure (Purin-6-yl)phenylalanines and Their Nucleosides, a Novel Type of Purine-Amino Acid Conjugates

    Article • The Journal of Organic Chemistry, September 2005, American Chemical Society (ACS)

    Professor Michal Hocek

  281. Cytostatic 6-Arylpurine Nucleosides. 6.†SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides

    Article • Journal of Medicinal Chemistry, September 2005, American Chemical Society (ACS)

    Professor Michal Hocek

  282. Highly Methylated Purines and Purinium Salts as Analogues of Heteromines

    Article • European Journal of Organic Chemistry, July 2005, Wiley

    Professor Michal Hocek

  283. The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Professor Michal Hocek

  284. Synthesis of 2-Substituted 6-(Hydroxymethyl)purine Bases and Nucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2005, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  285. Novel Method for Preparation of Highly Substituted 6-Arylpurines by Reactions of 6-Alkynylpurines with Zirconacyclopentadienes

    Article • Collection of Czechoslovak Chemical Communications, January 2005, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  286. Cocyclotrimerization of 6-Alkynylpurines with α,ω-Diynes as a Novel Approach to Biologically Active 6-Arylpurines

    Article • The Journal of Organic Chemistry, December 2004, American Chemical Society (ACS)

    Professor Michal Hocek

  287. A Facile and Efficient Synthesis of (Purin-6-yl)alanines

    Article • The Journal of Organic Chemistry, November 2004, American Chemical Society (ACS)

    Professor Michal Hocek

  288. Regioselectivity in Cross-Coupling Reactions of 2,6,8-Trichloro-9-(tetrahydropyran-2-yl)purine: Synthesis of 2,6,8-Trisubstituted Purine Bases

    Article • Synthesis, October 2004, Thieme Publishing Group

    Professor Michal Hocek

  289. Facile and Efficient Synthesis of 6-(Hydroxymethyl)purines

    Article • Organic Letters, September 2004, American Chemical Society (ACS)

    Professor Michal Hocek

  290. Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy

    Article • Tetrahedron Letters, August 2004, Elsevier

    Professor Radek Marek, Professor Michal Hocek

  291. Ferrocene-Modified Purines as Potential Electrochemical Markers: Synthesis, Crystal Structures, Electrochemistry and Cytostatic Activity of (Ferrocenylethynyl)- and (Ferrocenylethyl)purines

    Article • Chemistry - A European Journal, April 2004, Wiley

    Professor Michal Hocek

  292. Synthesis of Protected (Purin-6-yl)glycines via Pd-Catalyzed a-Arylation of Ethyl N-(Diphenylmethylidene)glycinate with 6-Iodopurines

    Article • Heterocycles, January 2004, Japan Institute of Heterocyclic Chemistry

    Professor Michal Hocek

  293. Dichotomy in Regioselective Cross-Coupling Reactions of 6,8-Dichloropurines with Phenylboronic Acid and Methylmagnesium Chloride: Synthesis of 6,8-Disubstituted Purines

    Article • Synthesis, January 2004, Thieme Publishing Group

    Professor Michal Hocek

  294. Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2004, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  295. Covalent Analogues of Nucleobase-Pairs

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Professor Michal Hocek

  296. An Efficient Synthesis of 2-Substituted 6-Methylpurine Bases and Nucleosides by Fe- or Pd-Catalyzed Cross-Coupling Reactions of 2,6-Dichloropurines

    Article • The Journal of Organic Chemistry, July 2003, American Chemical Society (ACS)

    Professor Michal Hocek

  297. [2+2+2]-Co-cyclotrimerization 6-alkynylpurines with diynes: a method for preparation of 6-arylpurines

    Article • Tetrahedron Letters, January 2003, Elsevier

    Professor Michal Hocek

  298. Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2003, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  299. Synthesis of carba-analogues of myoseverin by regioselective cross-coupling reactions of 2,6-dichloro-9-isopropylpurine

    Article • Tetrahedron, January 2003, Elsevier

    Professor Michal Hocek

  300. Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal- or Organometal-Mediated C−C Bond-Forming Reactions

    Article • European Journal of Organic Chemistry, January 2003, Wiley

    Professor Michal Hocek

  301. Covalent analogues of DNA base-pairs and triplets. Part 3: Synthesis of 1,4- and 1,3-bis(purin-6-yl)benzenes and 1-(1,3-dimethyluracil-5-yl)-3 or 4-(purin-9-yl)benzenes

    Article • Tetrahedron, September 2002, Elsevier

    Professor Michal Hocek

  302. Covalent analogues of DNA base-Pairs and triplets. Part 2: † †For Part I, see ref 1. Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds

    Article • Bioorganic & Medicinal Chemistry Letters, April 2002, Elsevier

    Professor Michal Hocek

  303. Cytostatic 6-Arylpurine Nucleosides IV. Synthesis of 2-Substituted 6-Phenylpurine Ribonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2002, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  304. Covalent Analogues of DNA Base-Pairs and Triplets IV. Synthesis of Trisubstituted Benzenes Bearing Purine and/or Pyrimidine Rings by Cyclotrimerization of 6-Ethynylpurines and/or 5-Ethynyl-1,3-dimethyluracil

    Article • Collection of Czechoslovak Chemical Communications, January 2002, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  305. Covalent Analogues of DNA Base-Pairs and Triplets V. Synthesis of Purine-Purine and Purine-Pyrimidine Conjugates Connected by Diverse Types of Acyclic Carbon Linkages

    Article • Collection of Czechoslovak Chemical Communications, January 2002, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  306. Cyclotrimerization of 6-ethynylpurines. Synthesis of 1,2,4- and 1,3,5-tris(purin-6-yl)benzenes as novel Hoogsteen-triplet analogues

    Article • Tetrahedron Letters, January 2001, Elsevier

    Professor Michal Hocek

  307. The Suzuki-Miyaura Cross-Coupling Reactionsof 2-, 6- or 8-Halopurines with Boronic Acids Leading to 2-, 6- or 8-Aryl- and -Alkenylpurine Derivatives

    Article • Synthesis, January 2001, Thieme Publishing Group

    Professor Michal Hocek

  308. Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides

    Article • Collection of Czechoslovak Chemical Communications, January 2001, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  309. Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides:  Application of the Suzuki−Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids

    Article • Journal of Medicinal Chemistry, April 2000, American Chemical Society (ACS)

    Professor Michal Hocek

  310. Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6-C-substituted Purines via Cross-Coupling Reactions of 2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with Diverse Organometallic Reagents

    Article • Collection of Czechoslovak Chemical Communications, January 2000, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  311. Cytostatic 6-Arylpurine Nucleosides II. Synthesis of Sugar-Modified Derivatives: 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-Deoxy-β-D-ribofuranosyl)- and 9-(2,3-Dihydroxypropyl)-6-phenylpurines

    Article • Collection of Czechoslovak Chemical Communications, January 2000, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  312. Synthesis and cytostatic activity of nucleosides and acyclic nucleoside analogues derived from 6-(trifluoromethyl)purines

    Article • Tetrahedron, September 1999, Elsevier

    Professor Michal Hocek

  313. The Suzuki-Miyaura Cross-Coupling Reactions of 6-Halopurines with Boronic Acids Leading to 6-Aryl- and 6-Alkenylpurines

    Article • Synlett, July 1999, Thieme Publishing Group

    Professor Michal Hocek

  314. Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues

    Article • Collection of Czechoslovak Chemical Communications, January 1999, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  315. Synthesis of acyclic nucleotide analogues derived from N-substituted 6-(1-aminoethyl)purines via 6-acetylpurine derivatives

    Article • Tetrahedron, February 1997, Elsevier

    Professor Michal Hocek

  316. Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents

    Article • Collection of Czechoslovak Chemical Communications, January 1997, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  317. Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines

    Article • Collection of Czechoslovak Chemical Communications, January 1996, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  318. A Facile Synthesis of 6-Cyanopurine Bases

    Article • Collection of Czechoslovak Chemical Communications, January 1995, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  319. Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl)adenine and 2-(Aminomethyl)hypoxanthine

    Article • Collection of Czechoslovak Chemical Communications, January 1995, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  320. A Facile Synthesis of 2-(Aminomethyl)purines

    Article • Synthesis, January 1994, Thieme Publishing Group

    Professor Michal Hocek

  321. Photocolouration of 2,4,4,6-Tetraaryl-1,4-dihydropyridines: A Semiempirical Quantum Chemical Study

    Article • Collection of Czechoslovak Chemical Communications, January 1994, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek

  322. Preparation and Spectroscopic Properties of Spirocyclic 1-Methyl-2,4,4,6-tetraaryl-1,4-dihydropyridines

    Article • Collection of Czechoslovak Chemical Communications, January 1994, Institute of Organic Chemistry & Biochemistry

    Professor Michal Hocek