All Stories

  1. CD39L1 levels in refractory/unexplained chronic cough patients, and relationship to cough counts

    Article • September 2024, European Respiratory Society (ERS)

    Michael Wortley

  2. Plasma and bronchoalveolar lavage ATP in refractory/unexplained chronic cough

    Article • September 2024, European Respiratory Society (ERS)

    Michael Wortley

  3. TRP channels in respiratory disorders

    Article • January 2024, Elsevier

    Michael Wortley

  4. P216 Whole blood and plasma ATP levels in refractory/unexplained chronic cough

    Article • November 2023, BMJ

    Michael Wortley

  5. Comparing neuronal phenotypes in two preclinical models of chronic lung disease

    Article • September 2023, European Respiratory Society (ERS)

    Michael Wortley

  6. Cough responses to inhaled hypotonic solutions correlate with other measures of refractory chronic cough

    Article • September 2023, European Respiratory Society (ERS)

    Michael Wortley

  7. Investigating the efficacy of a NaV1.7 channel blocker on airway sensory nerve activation and cough

    Article • September 2023, European Respiratory Society (ERS)

    Michael Wortley

  8. Surfactant found in cleaning products, 4-tert-octylphenol, causes airway sensory nerves firing and airway smooth muscle contraction

    Article • September 2023, European Respiratory Society (ERS)

    Michael Wortley

  9. A Novel Mechanism of Action for the NK1 Receptor in Airway Sensory Nerves

    Article • May 2021, American Thoracic Society

    Michael Wortley

  10. EPAC drives the anti-tussive effect of EP4 receptors on airway sensory nerves

    Article • September 2020, European Respiratory Society (ERS)

    Michael Wortley

  11. Modelling IPF-associated chronic cough: role for oxidative stress?

    Article • September 2020, European Respiratory Society (ERS)

    Michael Wortley

  12. Novel airway smooth muscle–mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma

    Article • European Respiratory Journal, April 2020, European Respiratory Society (ERS)

    Michael Wortley

  13. “Truth is ever to be found in simplicity, and not in the multiplicity and confusion of things” — Sir Isaac Newton

    Article • European Respiratory Journal, February 2020, European Respiratory Society (ERS)

    Michael Wortley

  14. Transforming Growth Factor-β1: A Novel Cause of Resistance to Bronchodilators in Asthma?

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2019, American Thoracic Society

    Michael Wortley

  15. Agonism of EP4 Receptors Expressed on Airway Sensory Nerves Inhibits Cough

    Article • May 2019, American Thoracic Society

    Michael Wortley

  16. Monitoring Cough in a Preclinical Guinea Pig Model of Idiopathic Pulmonary Fibrosis

    Article • May 2019, American Thoracic Society

    Michael Wortley

  17. The anti-tussive effects of an inhaled LABA are maintained after chronic treatment

    Article • September 2018, European Respiratory Society (ERS)

    Michael Wortley

  18. XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough

    Article • American Review of Respiratory Disease, November 2017, American Thoracic Society

    Michael Wortley, Dr Imran Satia

  19. T1 Bacteria can trigger airway sensory nerves via the activation of tlr2

    Article • November 2017, BMJ

    Michael Wortley

  20. T2 Oestrogen: an endogenous agonist for trpm3 triggered sensory nerve activation in the airway?

    Article • November 2017, BMJ

    Michael Wortley

  21. Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy

    Article • European Respiratory Journal, September 2017, European Respiratory Society (ERS)

    Michael Wortley

  22. EP2 & EP4 receptor agonists inhibit the airway sensory nerves that cause cough, a potential protective control that is lost in human smokers and a pre-clinical COPD model

    Article • September 2017, European Respiratory Society (ERS)

    Michael Wortley

  23. TRPM3, P2X2 and P2X3 expression patterns in single airway sensory nerves

    Article • September 2017, European Respiratory Society (ERS)

    Michael Wortley

  24. Activation of transient receptor potential (TRP) channels by hypoosmolar solution: an endogenous mechanism of ATP release and afferent nerve activation

    Article • September 2017, European Respiratory Society (ERS)

    Michael Wortley

  25. Phthalates trigger respiratory reflexes

    Article • September 2017, European Respiratory Society (ERS)

    Michael Wortley

  26. TRPM3: A regulator of airway sensory nerves and respiratory reflexes

    Article • September 2016, European Respiratory Society (ERS)

    Michael Wortley

  27. Direct activation of sensory afferents by diesel exhaust particles can trigger respiratory symptoms

    Article • September 2016, European Respiratory Society (ERS)

    Michael Wortley

  28. Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies

    Article • American Review of Respiratory Disease, June 2016, American Thoracic Society

    Michael Wortley

  29. Drugs Affecting TRP Channels

    Article • January 2016, Springer Science + Business Media

    Michael Wortley

  30. TRPV4 and activation of airway sensory nerves: The role of ATP

    Article • September 2015, European Respiratory Society (ERS)

    Michael Wortley

  31. Beneficial effects of menthol are mediated via a TRPM8-independent mechanism

    Article • September 2015, European Respiratory Society (ERS)

    Michael Wortley

  32. Cromoglycate: Breathing life into an old asthma drug

    Article • September 2015, European Respiratory Society (ERS)

    Michael Wortley

  33. Organic components of diesel exhaust particles (DEP) activate airway sensory nerves via transient receptor potential ankrin-1 (TRPA1) ion channels

    Article • September 2015, European Respiratory Society (ERS)

    Michael Wortley

  34. Anti-tussive effects of FAAH inhibition: The role of endocannabinoids and downstream signalling pathways in the inhibition of vagal sensory nerve activation

    Article • September 2015, European Respiratory Society (ERS)

    Michael Wortley

  35. The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways

    Article • British Journal of Pharmacology, November 2014, Wiley

    Michael Wortley

  36. P2 Characterisation Of A - And C-fibres Innervating Guinea-pig Airways

    Article • Thorax, November 2014, BMJ

    Michael Wortley

  37. P4 Establishing A Role For Trpv1 On Sensory Nerves In Copd Associated Chronic Cough

    Article • Thorax, November 2014, BMJ

    Michael Wortley

  38. P6 Menthol Has Beneficial Effects In The Airways Through A Trpm8-independent Mechanism

    Article • Thorax, November 2014, BMJ

    Michael Wortley

  39. Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events

    Article • European Respiratory Journal, October 2014, European Respiratory Society (ERS)

    Michael Wortley

  40. Theophylline inhibits the cough reflex through a novel mechanism of action

    Article • Journal of Allergy and Clinical Immunology, June 2014, Elsevier

    Michael Wortley

  41. Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?⋆

    Article • Journal of Allergy and Clinical Immunology, March 2014, Elsevier

    Michael Wortley

  42. Harvesting, Isolation, and Functional Assessment of Primary Vagal Ganglia Cells

    Article • Current Protocols in Pharmacology, October 2013, Wiley

    Michael Wortley

  43. Pharmacology of Cough

    Article • Autonomic Neuroscience, August 2013, Elsevier

    Michael Wortley

  44. Changes In Vagal Afferent Responses And Cough Reflex Sensitivity To PGE2 In Smokers And COPD Patients And In A Guinea Pig Cigarette-Smoke Exposure Model

    Article • May 2012, American Thoracic Society

    Michael Wortley

  45. Inhibition Of Fatty Acid Amide Hydrolase Produces Anti-Tussive Effects In Guinea-Pigs: Evidence For Elevated Fatty Acid Amides Acting Via Cannabinoid Receptors On Airway Sensory Nerves

    Article • May 2012, American Thoracic Society

    Michael Wortley

  46. Theophylline And Theobromine Block Excitation Of Sensory Nerves And Prevent Cough

    Article • May 2011, American Thoracic Society

    Michael Wortley