All Stories

  1. Structural Activation of DNA Unwinding by MCM8/9/HROB

    Article • April 2026, openRxiv

    Michael Trakselis

  2. Response Factor Correction for Quantitative Determination of Homooligomeric Sso SSB Binding to ssDNA by Native Mass Spectrometry

    Article • Journal of the American Society for Mass Spectrometry, February 2026, American Chemical Society (ACS)

    Michael Trakselis

  3. MCM8/9 and FANCD2 interact within a shared pathway in response to replication stress caused by DNA crosslinks

    Article • DNA Repair, November 2025, Elsevier

    Michael Trakselis

  4. Residues in the little finger domain of the Y-family Dpo4 DNA polymerase communicate to restrict synthesis past 8-oxoguanine lesions

    Article • Nucleic Acids Research, September 2025, Oxford University Press (OUP)

    Michael Trakselis

  5. Response Factor Correction for Quantitative Determination of Homooligomeric Protein Binding to DNA by Native Protein Mass Spectrometry

    Article • September 2025, American Chemical Society (ACS)

    Michael Trakselis

  6. MCM8/9 and FANCD2 interact within a shared pathway in response to replication stress caused by DNA crosslinks

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  7. Tau-mediated coupling between Pol III synthesis and DnaB helicase unwinding helps maintain genomic stability

    Article • Journal of Biological Chemistry, October 2024, Elsevier

    Michael Trakselis

  8. Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization

    Article • Nucleic Acids Research, May 2024, Oxford University Press (OUP)

    Michael Trakselis

  9. Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity

    Article • Analytical and Bioanalytical Chemistry, August 2023, Springer Science + Business Media

    Michael Trakselis

  10. Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  11. Activity, substrate preference and structure of the HsMCM8/9 helicase

    Article • Nucleic Acids Research, June 2023, Oxford University Press (OUP)

    Michael Trakselis

  12. A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

    Article • Nature Communications, August 2022, Springer Science + Business Media

    Michael Trakselis

  13. In vivo fluorescent TUNEL detection of single stranded DNA gaps and breaks induced by dnaB helicase mutants in Escherichia coli

    Article • January 2022, Elsevier

    Michael Trakselis

  14. A novel multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  15. Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness

    Article • PLoS Genetics, November 2021, PLOS

    Michael Trakselis

  16. Division of Chemical Toxicology Program at the American Chemical Society National Meeting: Celebrating 25 Years!

    Article • Chemical Research in Toxicology, October 2021, American Chemical Society (ACS)

    Michael Trakselis

  17. A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization

    Article • Integrative and Comparative Biology, July 2021, Oxford University Press (OUP)

    Michael Trakselis

  18. Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  19. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Michael Trakselis

  20. A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine

    Article • Nucleic Acids Research, September 2020, Oxford University Press (OUP)

    Michael Trakselis

  21. Motifs of the C-terminal Domain of MCM9 Direct Localization to Sites of Mitomycin-C Damage for RAD51 Recruitment

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  22. A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Michael Trakselis

  23. Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

    Article • eLife, October 2019, eLife

    Michael Trakselis

  24. Fine-tuning of the replisome: Mcm10 regulates fork progression and regression

    Article • Cell Cycle, May 2019, Taylor & Francis

    Michael Trakselis

  25. The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance

    Article • DNA Repair, February 2019, Elsevier

    Michael Trakselis

  26. Contacts and context that regulate DNA helicase unwinding and replisome progression

    Article • January 2019, Elsevier

    Michael Trakselis

  27. Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase

    Article • Biochemistry, September 2018, American Chemical Society (ACS)

    Michael Trakselis

  28. Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding

    Article • Journal of Biological Chemistry, September 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  29. Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles

    Article • Chemical Research in Toxicology, September 2017, American Chemical Society (ACS)

    Michael Trakselis

  30. Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks

    Article • DNA Repair, July 2017, Elsevier

    Michael Trakselis

  31. Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase

    Article • Journal of Biological Chemistry, May 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  32. DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase

    Article • Journal of Biological Chemistry, April 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  33. The excluded DNA strand is SEW important for hexameric helicase unwinding

    Article • Methods, April 2016, Elsevier

    Michael Trakselis

  34. Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding

    Article • F1000Research, January 2016, Faculty of 1000, Ltd.

    Michael Trakselis

  35. Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble

    Article • Molecular Cell, July 2015, Elsevier

    Michael Trakselis

  36. Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability

    Article • Journal of Clinical Investigation, December 2014, American Society for Clinical Investigation

    Dr Sulman Basit, Michael Trakselis

  37. MCM9 Mutations Are Associated with Ovarian Failure, Short Stature, and Chromosomal Instability

    Article • The American Journal of Human Genetics, December 2014, Elsevier

    Michael Trakselis

  38. Corrigendum to “Identification, quantification, and evolutionary analysis of a novel isoform of MCM9” [Gene 519 (2013) 41–49]

    Article • Gene, January 2014, Elsevier

    Michael Trakselis

  39. Structure of a Highly Conserved Domain of Rock1 Required for Shroom-Mediated Regulation of Cell Morphology

    Article • PLOS One, December 2013, PLOS

    Michael Trakselis

  40. Assembly and Distributive Action of an Archaeal DNA Polymerase Holoenzyme

    Article • Journal of Molecular Biology, November 2013, Elsevier

    Michael Trakselis

  41. A clamp-like biohybrid catalyst for DNA oxidation

    Article • Nature Chemistry, September 2013, Nature

    Michael Trakselis

  42. Novel Interaction of the Bacterial-Like DnaG Primase with the MCM Helicase in Archaea

    Article • Journal of Molecular Biology, April 2013, Elsevier

    Michael Trakselis

  43. Identification, quantification, and evolutionary analysis of a novel isoform of MCM9

    Article • Gene, April 2013, Elsevier

    Michael Trakselis

  44. Biochemistry: Molecular hurdles cleared with ease

    Article • Nature, November 2012, Nature

    Michael Trakselis

  45. Differential Temperature-Dependent Multimeric Assemblies of Replication and Repair Polymerases on DNA Increase Processivity

    Article • Biochemistry, September 2012, American Chemical Society (ACS)

    Michael Trakselis

  46. Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction

    Article • Molecular Biology of the Cell, April 2012, American Society for Cell Biology (ASCB)

    Michael Trakselis

  47. Kinetics and Fidelity of Polymerization by DNA Polymerase III from Sulfolobus solfataricus

    Article • Biochemistry, March 2012, American Chemical Society (ACS)

    Michael Trakselis

  48. Strand Annealing and Terminal Transferase Activities of a B-family DNA Polymerase

    Article • Biochemistry, June 2011, American Chemical Society (ACS)

    Michael Trakselis

  49. Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

    Article • Nucleic Acids Research, May 2011, Oxford University Press (OUP)

    Michael Trakselis

  50. Characterization of a Functional DnaG-Type Primase in Archaea: Implications for a Dual-Primase System

    Article • Journal of Molecular Biology, April 2010, Elsevier

    Michael Trakselis

  51. A trimeric DNA polymerase complex increases the native replication processivity

    Article • Nucleic Acids Research, September 2009, Oxford University Press (OUP)

    Michael Trakselis

  52. MCM Forked Substrate Specificity Involves Dynamic Interaction with the 5'-Tail

    Article • Journal of Biological Chemistry, October 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  53. Correction

    Article • Proceedings of the National Academy of Sciences, September 2005, Proceedings of the National Academy of Sciences

    Michael Trakselis

  54. Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism

    Article • Nature Structural & Molecular Biology, August 2005, Nature

    Michael Trakselis

  55. Identification and Mapping of Protein−Protein Interactions by a Combination of Cross-Linking, Cleavage, and Proteomics

    Article • Bioconjugate Chemistry, July 2005, American Chemical Society (ACS)

    Michael Trakselis

  56. Architecture of the bacteriophage T4 primosome: Electron microscopy studies of helicase (gp41) and primase (gp61)

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Michael Trakselis

  57. Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Michael Trakselis

  58. On the Solution Structure of the T4 Sliding Clamp (gp45) †

    Article • Biochemistry, October 2004, American Chemical Society (ACS)

    Michael Trakselis

  59. 'Screw-cap' clamp loader proteins that thread

    Article • Nature Structural & Molecular Biology, July 2004, Nature

    Michael Trakselis

  60. Molecular biology: The loader of the rings

    Article • Nature, June 2004, Nature

    Michael Trakselis

  61. The dynamic processivity of the T4 DNA polymerase during replication

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Michael Trakselis

  62. The Application of a Minicircle Substrate in the Study of the Coordinated T4 DNA Replication

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  63. Dissociative Properties of the Proteins within the Bacteriophage T4 Replisome

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  64. Examination of the Role of the Clamp-loader and ATP Hydrolysis in the Formation of the Bacteriophage T4 Polymerase Holoenzyme

    Article • Journal of Molecular Biology, February 2003, Elsevier

    Michael Trakselis

  65. Protein-Protein Interactions in the Bacteriophage T4 Replisome: THE LEADING STRAND HOLOENZYME IS PHYSICALLY LINKED TO THE LAGGING STRAND HOLOENZYME AND THE PRIMOSOME

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  66. Intricacies in ATP-Dependent Clamp Loading

    Article • Structure, November 2001, Elsevier

    Michael Trakselis

  67. Dynamic protein interactions in the bacteriophage T4 replisome

    Article • Trends in Biochemical Sciences, September 2001, Elsevier

    Michael Trakselis

  68. Building a Replisome Solution Structure by Elucidation of Protein-Protein Interactions in the Bacteriophage T4 DNA Polymerase Holoenzyme

    Article • Journal of Biological Chemistry, August 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Trakselis

  69. Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer

    Article • Proceedings of the National Academy of Sciences, July 2001, Proceedings of the National Academy of Sciences

    Michael Trakselis

  70. Faculty of 1000 evaluation for A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis

  71. Faculty of 1000 evaluation for CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis

  72. Faculty of 1000 evaluation for Dynamic look at DNA unwinding by a replicative helicase.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis

  73. Faculty of 1000 evaluation for Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis

  74. Faculty of 1000 evaluation for Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis

  75. Faculty of 1000 evaluation for The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker.

    Article • Faculty of 1000, Ltd.

    Michael Trakselis