All Stories

  1. The Expression of Shmt Genes in Amphioxus Suggests a Role in Tissue Proliferation Rather than in Neurotransmission

    Article • Cells, July 2025, MDPI AG

    Dr Michael Schubert

  2. Editorial: Model organisms in embryonic development

    Article • Frontiers in Cell and Developmental Biology, July 2025, Frontiers

    Dr Michael Schubert

  3. The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development

    Article • Frontiers in Cell and Developmental Biology, February 2025, Frontiers

    Dr Michael Schubert

  4. Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Dr Michael Schubert

  5. Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis

    Article • PLoS Biology, November 2024, PLOS

    Dr Michael Schubert

  6. A feather star is born: embryonic development and nervous system organization in the crinoid Antedon mediterranea

    Article • Open Biology, August 2024, Royal Society Publishing

    Dr Michael Schubert

  7. Amphioxus (Branchiostoma lanceolatum) in the North Adriatic Sea: ecological observations and spawning behavior

    Article • Integrative Zoology, June 2024, Wiley

    Dr Michael Schubert

  8. Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

    Article • Communications Biology, April 2024, Springer Science + Business Media

    Dr Michael Schubert

  9. The Mediterranean mussel Mytilus galloprovincialis: a novel model for developmental studies in mollusks

    Article • Development, February 2024, The Company of Biologists

    Dr Michael Schubert

  10. First characterization of the nuclear receptor superfamily in the Mediterranean mussel Mytilus galloprovincialis : developmental expression dynamics and potential susceptibility to environmental chemicals

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, February 2024, Royal Society Publishing

    Dr Michael Schubert

  11. Retinoic Acid and Retinoid X Receptors

    Article • Cells, March 2023, MDPI AG

    Dr Michael Schubert

  12. Retinoic Acid and POU Genes in Developing Amphioxus: A Focus on Neural Development

    Article • Cells, February 2023, MDPI AG

    Dr Michael Schubert

  13. Developmental atlas of the indirect-developing sea urchin Paracentrotus lividus: From fertilization to juvenile stages

    Article • Frontiers in Cell and Developmental Biology, October 2022, Frontiers

    Dr Michael Schubert

  14. Evolutionary Transition in the Regulation of Vertebrate Pronephros Development: A New Role for Retinoic Acid

    Article • Cells, April 2022, MDPI AG

    Dr Michael Schubert

  15. Gain of gene regulatory network interconnectivity at the origin of vertebrates

    Article • Proceedings of the National Academy of Sciences, March 2022, Proceedings of the National Academy of Sciences

    Dr Michael Schubert

  16. Functional Conservation and Genetic Divergence of Chordate Glycinergic Neurotransmission: Insights from Amphioxus Glycine Transporters

    Article • Cells, December 2021, MDPI AG

    Dr Michael Schubert

  17. An Updated Staging System for Cephalochordate Development: One Table Suits Them All

    Article • Frontiers in Cell and Developmental Biology, May 2021, Frontiers

    Dr Michael Schubert

  18. The Ontology of the Amphioxus Anatomy and Life Cycle (AMPHX)

    Article • Frontiers in Cell and Developmental Biology, April 2021, Frontiers

    Dr Michael Schubert

  19. Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)

    Article • Journal of Molecular Biology, April 2021, Elsevier

    Dr Michael Schubert, William Bourguet

  20. Amphioxus neuroglia: Molecular characterization and evidence for early compartmentalization of the developing nerve cord

    Article • Glia, February 2021, Wiley

    Dr Michael Schubert

  21. Nuclear Receptors and Development of Marine Invertebrates

    Article • Genes, January 2021, MDPI AG

    Dr Michael Schubert

  22. Neural anatomy of echinoid early juveniles and comparison of nervous system organization in echinoderms

    Article • The Journal of Comparative Neurology, September 2020, Wiley

    Dr Michael Schubert

  23. Retinoids in Embryonic Development

    Article • Biomolecules, September 2020, MDPI AG

    Dr Michael Schubert

  24. An updated staging system for cephalochordate development: one table suits them all

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Michael Schubert

  25. Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus

    Article • January 2020, Elsevier

    Dr Michael Schubert

  26. A wnt2 ortholog in the sea urchin Paracentrotus lividus

    Article • genesis, September 2019, Wiley

    Dr Michael Schubert

  27. A Behavioral Assay to Study Effects of Retinoid Pharmacology on Nervous System Development in a Marine Annelid

    Article • January 2019, Springer Science + Business Media

    Dr Michael Schubert

  28. Ambulacrarians and the Ancestry of Deuterostome Nervous Systems

    Article • January 2019, Springer Science + Business Media

    Dr Michael Schubert

  29. Amphioxus functional genomics and the origins of vertebrate gene regulation

    Article • Nature, November 2018, Springer Science + Business Media

    Piero Carninci, Dr Michael Schubert

  30. Correction to: Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System

    Article • Molecular Neurobiology, February 2018, Springer Science + Business Media

    Dr Michael Schubert

  31. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

    Article • Science Advances, February 2018, American Association for the Advancement of Science

    Dr Michael Schubert, William Bourguet

  32. Retinoic acid signaling and neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus

    Article • Cellular and Molecular Life Sciences, January 2018, Springer Science + Business Media

    Dr Michael Schubert

  33. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney

    Article • The International Journal of Developmental Biology, January 2018, UBC Press

    Dr Michael Schubert

  34. Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System

    Article • Molecular Neurobiology, September 2017, Springer Science + Business Media

    Dr Michael Schubert

  35. Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles

    Article • BMC Evolutionary Biology, January 2017, Springer Science + Business Media

    Dr Michael Schubert

  36. New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

    Article • January 2017, Elsevier

    Dr Michael Schubert

  37. CYP26 function is required for the tissue-specific modulation of retinoic acid signaling during amphioxus development

    Article • The International Journal of Developmental Biology, January 2017, UBC Press

    Dr Michael Schubert

  38. Keeping amphioxus in the laboratory: an update on available husbandry methods

    Article • The International Journal of Developmental Biology, January 2017, UBC Press

    Dr Michael Schubert

  39. The origin of dopaminergic systems in chordate brains: insights from amphioxus

    Article • The International Journal of Developmental Biology, January 2017, UBC Press

    Dr Michael Schubert

  40. Correction to ‘Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering'

    Article • Royal Society Open Science, December 2016, Royal Society Publishing

    Dr Michael Schubert

  41. The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity

    Article • PLOS One, November 2016, PLOS

    Dr Michael Schubert, William Bourguet

  42. Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering

    Article • Royal Society Open Science, March 2016, Royal Society Publishing

    Dr Michael Schubert, Romain A Studer, William Bourguet

  43. Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus

    Article • Development, October 2015, The Company of Biologists

    Dr Michael Schubert

  44. Evolution of the Retinoic Acid Signaling Pathway

    Article • June 2015, Wiley

    Dr Michael Schubert

  45. Evolution of retinoic acid receptors in chordates: insights from three lamprey species, Lampetra fluviatilis, Petromyzon marinus, and Lethenteron japonicum

    Article • EvoDevo, May 2015, Springer Science + Business Media

    Dr Michael Schubert

  46. Expression of Fluorescent Proteins in Branchiostoma lanceolatum by mRNA Injection into Unfertilized Oocytes

    Article • Journal of Visualized Experiments, January 2015, MyJove Corporation

    Dr Michael Schubert

  47. A Mollusk Retinoic Acid Receptor (RAR) Ortholog Sheds Light on the Evolution of Ligand Binding

    Article • Endocrinology, November 2014, Endocrine Society

    Dr Michael Schubert, William Bourguet

  48. A comprehensive survey ofwntandfrizzledexpression in the sea urchinParacentrotuslividus

    Article • genesis, March 2014, Wiley

    Dr Michael Schubert

  49. Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling

    Article • January 2014, Springer Science + Business Media

    Dr Michael Schubert

  50. Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition

    Article • EvoDevo, January 2014, Springer Science + Business Media

    Dr Michael Schubert

  51. Retinoic acid signaling in spinal cord development

    Article • The International Journal of Biochemistry & Cell Biology, July 2013, Elsevier

    Dr Michael Schubert

  52. Evolution of bilaterian central nervous systems: a single origin?

    Article • EvoDevo, January 2013, Springer Science + Business Media

    Dr Michael Schubert

  53. Programmed Genome Rearrangements: In Lampreys, All Cells Are Not Equal

    Article • Current Biology, August 2012, Elsevier

    Dr Michael Schubert

  54. The cephalochordate amphioxus: a key to reveal the secrets of nuclear receptor evolution

    Article • Briefings in Functional Genomics, March 2012, Oxford University Press (OUP)

    Dr Michael Schubert

  55. An Unauthorized Biography of the Second Heart Field and a Pioneer/Scaffold Model for Cardiac Development

    Article • January 2012, Elsevier

    Alberto Stolfi, Dr Michael Schubert

  56. A neurochemical map of the developing amphioxus nervous system

    Article • BMC Neuroscience, January 2012, Springer Science + Business Media

    Dr Michael Schubert

  57. Tail regression induced by elevated retinoic acid signaling in amphioxus larvae occurs by tissue remodeling, not cell death

    Article • Evolution & Development, September 2011, Wiley

    Dr Michael Schubert

  58. Evolution of Retinoid and Steroid Signaling: Vertebrate Diversification from an Amphioxus Perspective

    Article • Genome Biology and Evolution, August 2011, Oxford University Press (OUP)

    Dr Michael Schubert

  59. Vitamin A: A multifunctional tool for development

    Article • Seminars in Cell and Developmental Biology, August 2011, Elsevier

    Dr Michael Schubert

  60. Amphioxus spawning behavior in an artificial seawater facility

    Article • Journal of Experimental Zoology Part B Molecular and Developmental Evolution, January 2011, Wiley

    Dr Michael Schubert

  61. microRNA complements in deuterostomes: origin and evolution of microRNAs

    Article • Evolution & Development, January 2011, Wiley

    Dr Michael Schubert

  62. Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans

    Article • Proceedings of the National Academy of Sciences, December 2010, Proceedings of the National Academy of Sciences

    Dr Michael Schubert

  63. From carrot to clinic: an overview of the retinoic acid signaling pathway

    Article • Cellular and Molecular Life Sciences, February 2010, Springer Science + Business Media

    Dr Michael Schubert

  64. Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: Insights into early anterior–posterior patterning of the chordate body plan

    Article • Developmental Biology, February 2010, Elsevier

    Dr Michael Schubert

  65. Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus

    Article • Developmental Biology, August 2009, Elsevier

    Dr Michael Schubert

  66. 01-P014 Complement and genomic distribution of miRNAs in deuterostomes: Conservation and diversification of the miRNA regulatory network

    Article • Mechanisms of Development, August 2009, Elsevier

    Dr Michael Schubert

  67. 15-P010 Evolutionary shifts in ALDH structure suggest transitions between pleiotropic and patterning functions

    Article • Mechanisms of Development, August 2009, Elsevier

    Dr Michael Schubert

  68. Complete mitochondrial genomes defining two distinct lancelet species in the West Pacific Ocean

    Article • Marine Biology Research, May 2009, Taylor & Francis

    Dr Michael Schubert

  69. Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae)

    Article • Developmental Biology, March 2009, Elsevier

    Dr Michael Schubert

  70. Ancestral Vascular Lumen Formation via Basal Cell Surfaces

    Article • PLOS One, January 2009, PLOS

    Dr Michael Schubert

  71. The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway

    Article • Development Genes and Evolution, November 2008, Springer Science + Business Media

    Dr Michael Schubert

  72. Retinoic acid signaling in development: Tissue-specific functions and evolutionary origins

    Article • genesis, November 2008, Wiley

    Dr Michael Schubert

  73. Nuclear hormone receptor signaling in amphioxus

    Article • Development Genes and Evolution, September 2008, Springer Science + Business Media

    Dr Michael Schubert

  74. The amphioxus genome illuminates vertebrate origins and cephalochordate biology

    Article • Genome Research, July 2008, Cold Spring Harbor Laboratory Press

    Dr Michael Schubert

  75. Amphioxus Postembryonic Development Reveals the Homology of Chordate Metamorphosis

    Article • Current Biology, June 2008, Elsevier

    Dr Michael Schubert

  76. An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

    Article • BMC Evolutionary Biology, January 2008, Springer Science + Business Media

    Dr Michael Schubert

  77. Cis-regulation of the amphioxus engrailed gene: Insights into evolution of a muscle-specific enhancer

    Article • Mechanisms of Development, August 2007, Elsevier

    Dr Michael Schubert

  78. Amphioxus AmphiDelta: Evolution of delta protein structure, segmentation, and neurogenesis

    Article • Developmental Biology, June 2007, Elsevier

    Dr Michael Schubert

  79. Pax–Six–Eya–Dach network during amphioxus development: Conservation in vitro but context specificity in vivo

    Article • Developmental Biology, June 2007, Elsevier

    Dr Michael Schubert

  80. Retinoic acid and Hox genes in the patterning of amphioxus

    Article • Developmental Biology, June 2007, Elsevier

    Dr Michael Schubert

  81. Insights into spawning behavior and development of the european amphioxus (Branchiostoma lanceolatum)

    Article • Journal of Experimental Zoology Part B Molecular and Developmental Evolution, January 2007, Wiley

    Dr Michael Schubert

  82. AmphioxusAmphiDelta: evolution of delta protein structure, segmentation, and neurogenesis

    Article • genesis, January 2007, Wiley

    Dr Michael Schubert

  83. Sublimation extraction coupled with gas chromatography-mass spectrometry: A new technique for future in situ analyses of purines and pyrimidines on Mars

    Article • Planetary and Space Science, December 2006, Elsevier

    Dr Michael Schubert

  84. A retinoic acid-Hox hierarchy controls both anterior/posterior patterning and neuronal specification in the developing central nervous system of the cephalochordate amphioxus

    Article • Developmental Biology, August 2006, Elsevier

    Dr Michael Schubert

  85. Amphioxus and tunicates as evolutionary model systems

    Article • Trends in Ecology & Evolution, May 2006, Elsevier

    Dr Michael Schubert

  86. Retinoic acid signaling and the evolution of chordates

    Article • International Journal of Biological Sciences, January 2006, Ivyspring International Publisher

    Dr Michael Schubert

  87. Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition

    Article • Evolution & Development, May 2005, Wiley

    Dr Michael Schubert

  88. Nuclear β-catenin promotes non-neural ectoderm and posterior cell fates in amphioxus embryos

    Article • Developmental Dynamics, January 2005, Wiley

    Dr Michael Schubert

  89. Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus

    Article • Development, December 2004, The Company of Biologists

    Dr Michael Schubert

  90. New Method for Estimating Bacterial Cell Abundances in Natural Samples by Use of Sublimation

    Article • Applied and Environmental Microbiology, October 2004, ASM Journals

    Dr Michael Schubert

  91. The chordate amphioxus: an emerging model organism for developmental biology

    Article • Cellular and Molecular Life Sciences, September 2004, Springer Science + Business Media

    Dr Michael Schubert

  92. Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus)

    Article • Proceedings of the National Academy of Sciences, June 2004, Proceedings of the National Academy of Sciences

    Dr Michael Schubert

  93. La pensée à fleur de peau

    Article • médecine/sciences, March 2004, EDP Sciences

    Dr Michael Schubert

  94. Preliminary observations on the spawning conditions of the European amphioxus (Branchiostoma lanceolatum) in captivity

    Article • The Journal of Experimental Zoology, January 2004, Wiley

    Dr Michael Schubert

  95. Differential mesodermal expression of two amphioxus MyoD family members (AmphiMRF1 and AmphiMRF2)

    Article • Gene Expression Patterns, May 2003, Elsevier

    Dr Michael Schubert

  96. Direct Isolation of Purines and Pyrimidines from Nucleic Acids Using Sublimation

    Article • Analytical Chemistry, December 2002, American Chemical Society (ACS)

    Dr Michael Schubert

  97. Functional equivalency of amphioxus and vertebrate Pax258 transcription factors suggests that the activation of mid-hindbrain specific genes in vertebrates occurs via the recruitment of Pax regulatory elements

    Article • Gene, January 2002, Elsevier

    Dr Michael Schubert

  98. Three Amphioxus Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates

    Article • Developmental Biology, December 2001, Elsevier

    Dr Michael Schubert

  99. Detecting pyrolysis products from bacteria on Mars

    Article • Earth and Planetary Science Letters, February 2001, Elsevier

    Dr Michael Schubert

  100. Characterization of amphioxusamphivent, an evolutionarily conserved marker for chordate ventral mesoderm

    Article • genesis, January 2001, Wiley

    Dr Michael Schubert

  101. A Phylogenetic Tree of the Wnt Genes Based on All Available Full-Length Sequences, Including Five from the Cephalochordate Amphioxus

    Article • Molecular Biology and Evolution, December 2000, Oxford University Press (OUP)

    Dr Michael Schubert

  102. Evolutionary Conservation of the Presumptive Neural Plate Markers AmphiSox1/2/3 and AmphiNeurogenin in the Invertebrate Chordate Amphioxus

    Article • Developmental Biology, October 2000, Elsevier

    Dr Michael Schubert

  103. Developmental expression of AmphiWnt1 , an amphioxus gene in the Wnt1 / wingless subfamily

    Article • Development Genes and Evolution, September 2000, Springer Science + Business Media

    Dr Michael Schubert

  104. Characterization of an amphioxus Wnt gene, AmphiWnt11, with possible roles in myogenesis and tail outgrowth

    Article • genesis, May 2000, Wiley

    Dr Michael Schubert

  105. Characterization of amphioxus AmphiWnt8 : insights into the evolution of patterning of the embryonic dorsoventral axis

    Article • Evolution & Development, March 2000, Wiley

    Dr Michael Schubert

  106. Characterization of two amphioxusWnt genes (AmphiWnt4 andAmphiWnt7b) with early expression in the developing central nervous system

    Article • Developmental Dynamics, February 2000, Wiley

    Dr Michael Schubert

  107. AmphiPax3/7, an amphioxus paired box gene: insights into chordate myogenesis, neurogenesis, and the possible evolutionary precursor of definitive vertebrate neural crest

    Article • Evolution & Development, November 1999, Wiley

    Dr Michael Schubert

  108. Amphioxus AmphiDRAL encoding a LIM-domain protein: expression in the epidermis but not in the presumptive neuroectoderm

    Article • Mechanisms of Development, August 1998, Elsevier

    Dr Michael Schubert