All Stories

  1. The bacterialmeta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily

    Article • Journal of Biological Chemistry, September 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  2. Surface-layer protein fromCaulobacter crescentus: expression, purification and X-ray crystallographic analysis

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2016, International Union of Crystallography

    Michael Murphy

  3. A Bacterial Cell Shape-Determining Inhibitor

    Article • ACS Chemical Biology, April 2016, American Chemical Society (ACS)

    Michael Murphy

  4. Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Michael Murphy

  5. Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis

    Article • Biochemistry, February 2016, American Chemical Society (ACS)

    Michael Murphy

  6. A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage

    Article • Journal of Biological Chemistry, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  7. A Ferric–Peroxo Intermediate in the Oxidation of Heme by IsdI

    Article • Biochemistry, April 2015, American Chemical Society (ACS)

    Michael Murphy

  8. A Single-Crystal EPR Study at 95 GHz of the Type-2 Copper Site of Nitrite Reductase From Alcaligenes faecalis

    Article • Applied Magnetic Resonance, January 2015, Springer Science + Business Media

    Michael Murphy

  9. The B-type Channel Is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritin

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  10. Helical Shape ofHelicobacter pyloriRequires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  11. SbnG, a Citrate Synthase in Staphylococcus aureus

    Article • Journal of Biological Chemistry, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  12. Hemoglobin Binding and Catalytic Heme Extraction by IsdB Near Iron Transporter Domains

    Article • Biochemistry, April 2014, American Chemical Society (ACS)

    Michael Murphy

  13. Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6

    Article • Journal of Molecular Biology, April 2014, Elsevier

    Michael Murphy

  14. Synthesis of L-2,3-Diaminopropionic Acid, a Siderophore and Antibiotic Precursor

    Article • Chemistry & Biology, March 2014, Elsevier

    Dr David E Heinrichs, Michael Murphy

  15. Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, March 2014, Elsevier

    Michael Murphy

  16. IruO Is a Reductase for Heme Degradation by IsdI and IsdG Proteins in Staphylococcus aureus

    Article • Journal of Biological Chemistry, July 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  17. Improved Manganese-Oxidizing Activity of DypB, a Peroxidase from a Lignolytic Bacterium

    Article • ACS Chemical Biology, April 2013, American Chemical Society (ACS)

    Michael Murphy

  18. Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom

    Article • Journal of Biological Chemistry, April 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  19. Role ofRhodobacter sphaeroidesPhotosynthetic Reaction Center Residue M214 in the Composition, Absorbance Properties, and Conformations of HAand BACofactors

    Article • Biochemistry, April 2013, American Chemical Society (ACS)

    Michael Murphy

  20. The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans

    Article • The Journal of Infectious Diseases, January 2013, Oxford University Press (OUP)

    Michael Murphy

  21. Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus

    Article • Chemistry & Biology, December 2012, Elsevier

    Dr David E Heinrichs, Michael Murphy

  22. Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  23. Monomer-Dimer Control and Crystal Engineering in TASPs

    Article • Chemistry - A European Journal, July 2012, Wiley

    Michael Murphy

  24. Distal Heme Pocket Residues of B-type Dye-decolorizing Peroxidase: ARGININE BUT NOT ASPARTATE IS ESSENTIAL FOR PEROXIDASE ACTIVITY

    Article • Journal of Biological Chemistry, February 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  25. Iron-Coordinating Tyrosine Is a Key Determinant of NEAT Domain Heme Transfer

    Article • Journal of Molecular Biology, October 2011, Elsevier

    Michael Murphy

  26. Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI

    Article • Proceedings of the National Academy of Sciences, July 2011, Proceedings of the National Academy of Sciences

    Michael Murphy

  27. Unique Heme-Iron Coordination by the Hemoglobin Receptor IsdB ofStaphylococcus aureus

    Article • Biochemistry, June 2011, American Chemical Society (ACS)

    Michael Murphy

  28. Characterization of Dye-Decolorizing Peroxidases fromRhodococcus jostiiRHA1

    Article • Biochemistry, June 2011, American Chemical Society (ACS)

    Michael Murphy

  29. Characterization of a Dipartite Iron Uptake System from Uropathogenic Escherichia coli Strain F11

    Article • Journal of Biological Chemistry, May 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  30. Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  31. Structure and Function of P19, a High-Affinity Iron Transporter of the Human Pathogen Campylobacter jejuni

    Article • Journal of Molecular Biology, August 2010, Elsevier

    Dr Joanna K MacKichan, Michael Murphy

  32. Iron core mineralisation in prokaryotic ferritins

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, August 2010, Elsevier

    Michael Murphy

  33. The IsdG-family of haem oxygenases degrades haem to a novel chromophore

    Article • Molecular Microbiology, March 2010, Wiley

    Dr Eric P Skaar, Michael Murphy

  34. Structural biology of heme binding in the Staphylococcus aureus Isd system

    Article • Journal of Inorganic Biochemistry, March 2010, Elsevier

    Michael Murphy

  35. The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket

    Article • Journal of Biological Chemistry, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  36. Directed evolution of copper nitrite reductase to a chromogenic reductant

    Article • Protein Engineering Design and Selection, January 2010, Oxford University Press (OUP)

    Michael Murphy

  37. X-ray Crystal Analysis of a TASP: Structural Insights of a Cavitein Dimer

    Article • Journal of the American Chemical Society, June 2009, American Chemical Society (ACS)

    Michael Murphy

  38. Crystallographic characterization of the passenger domain of theBordetellaautotransporter BrkA

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, May 2009, International Union of Crystallography

    Michael Murphy

  39. Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation

    Article • Journal of Biological Chemistry, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  40. Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus

    Article • Molecular Microbiology, May 2009, Wiley

    Dr David E Heinrichs, Michael Murphy

  41. Ferritin is used for iron storage in bloom-forming marine pennate diatoms

    Article • Nature, November 2008, Nature

    Michael Murphy

  42. Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes in Staphylococcus aureus

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  43. Conserved Active Site Residues Limit Inhibition of a Copper-Containing Nitrite Reductase by Small Molecules†‡

    Article • Biochemistry, April 2008, American Chemical Society (ACS)

    Michael Murphy

  44. Stable Copper−Nitrosyl Formation by Nitrite Reductase in Either Oxidation State†

    Article • Biochemistry, October 2007, American Chemical Society (ACS)

    Michael Murphy

  45. Type-2 copper-containing enzymes

    Article • Cellular and Molecular Life Sciences, September 2007, Springer Science + Business Media

    Michael Murphy

  46. Heme Coordination by Staphylococcus aureus IsdE

    Article • Journal of Biological Chemistry, July 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David E Heinrichs, Michael Murphy

  47. Effect of the Methionine Ligand on the Reorganization Energy of the Type-1 Copper Site of Nitrite Reductase

    Article • Journal of the American Chemical Society, January 2007, American Chemical Society (ACS)

    Michael Murphy

  48. Haem recognition by a Staphylococcus aureus NEAT domain

    Article • Molecular Microbiology, November 2006, Wiley

    Dr David E Heinrichs, Michael Murphy

  49. Cofacial Heme Binding is Linked to Dimerization by a Bacterial Heme Transport Protein

    Article • Journal of Molecular Biology, October 2006, Elsevier

    Michael Murphy

  50. Structures of Ternary Complexes of BphK, a Bacterial GlutathioneS-Transferase That Reductively Dechlorinates Polychlorinated Biphenyl Metabolites

    Article • Journal of Biological Chemistry, August 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  51. A Rearranging Ligand Enables Allosteric Control of Catalytic Activity in Copper-containing Nitrite Reductase

    Article • Journal of Molecular Biology, May 2006, Elsevier

    Michael Murphy

  52. Anion-independent Iron Coordination by the Campylobacter jejuni Ferric Binding Protein

    Article • Journal of Biological Chemistry, December 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  53. A Caged Lanthanide Complex as a Paramagnetic Shift Agent for Protein NMR

    Article • Chemistry - A European Journal, July 2004, Wiley

    Michael Murphy

  54. Specificity of the Synergistic Anion for Iron Binding by Ferric Binding Protein fromNeisseria gonorrhoeae†

    Article • Biochemistry, July 2004, American Chemical Society (ACS)

    Michael Murphy, Professor Masaru Tanokura

  55. Characterization of a Nucleotide-Binding Domain Associated with Neisserial Iron Transport

    Article • Journal of Bacteriology, May 2004, ASM Journals

    Michael Murphy

  56. Side-On Copper-Nitrosyl Coordination by Nitrite Reductase

    Article • Science, May 2004, American Association for the Advancement of Science

    Michael Murphy

  57. Reconstitution of the Type-1 Active Site of the H145G/A Variants of Nitrite Reductase by Ligand Insertion

    Article • Biochemistry, March 2003, American Chemical Society (ACS)

    Michael Murphy

  58. Directing the mode of nitrite binding to a copper-containing nitrite reductase from Alcaligenes faecalis S-6: Characterization of an active site isoleucine

    Article • Protein Science, February 2003, Wiley

    Michael Murphy

  59. S-Nitrosation of Ca2+-Loaded and Ca2+-Free Recombinant Calbindin D28K from Human Brain

    Article • Biochemistry, April 2002, American Chemical Society (ACS)

    Michael Murphy

  60. Crystal structure of the soluble domain of the major anaerobically induced outer membrane protein (AniA) from pathogenic Neisseria: a new class of copper-containing nitrite reductases

    Article • Journal of Molecular Biology, February 2002, Elsevier

    Michael Murphy

  61. Alternate Substrate Binding Modes to Two Mutant (D98N and H255N) Forms of Nitrite Reductase fromAlcaligenes faecalisS-6:  Structural Model of a Transient Catalytic Intermediate†,‡

    Article • Biochemistry, August 2001, American Chemical Society (ACS)

    Michael Murphy

  62. Structure and Site-directed Mutagenesis of a Flavoprotein fromEscherichia coli That Reduces Nitrocompounds: ALTERATION OF PYRIDINE NUCLEOTIDE BINDING BY A SINGLE AMINO ACID SUBSTITUTION

    Article • Journal of Biological Chemistry, October 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy, Professor Masaru Tanokura

  63. Catalytic Roles for Two Water Bridged Residues (Asp-98 and His-255) in the Active Site of Copper-containing Nitrite Reductase

    Article • Journal of Biological Chemistry, May 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  64. X-ray Crystallography and Mass Spectroscopy Reveal that the N-lobe of Human Transferrin Expressed inPichia pastorisIs Folded Correctly but Is Glycosylated on Serine-32†,‡

    Article • Biochemistry, February 1999, American Chemical Society (ACS)

    Michael Murphy

  65. A domain mutations in 65 haemophilia A families and molecular modelling of dysfunctional factor VIII proteins

    Article • British Journal of Haematology, December 1998, Wiley

    Michael Murphy

  66. 1.8 Å crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins

    Article • Journal of Molecular Biology, July 1998, Elsevier

    Michael Murphy, Professor Masaru Tanokura

  67. Two High-Resolution Crystal Structures of the Recombinant N-Lobe of Human Transferrin Reveal a Structural Change Implicated in Iron Release†,‡

    Article • Biochemistry, June 1998, American Chemical Society (ACS)

    Michael Murphy

  68. Consequences of factor IX mutations in 26 families with haemophilia B

    Article • British Journal of Haematology, January 1998, Wiley

    Michael Murphy

  69. Structure of Nitrite Bound to Copper-containing Nitrite Reductase from Alcaligenes faecalis: MECHANISTIC IMPLICATIONS

    Article • Journal of Biological Chemistry, November 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Murphy

  70. Site-directed mutagenesis of azurin fromPseudomonas aeruginosaenhances the formation of an electron-transfer complex with a copper-containing nitrite reductase fromAlcaligenes faecalisS-6

    Article • FEBS Letters, September 1996, Wiley

    Michael Murphy, Professor Masaru Tanokura

  71. Structure of Alcaligenes faecalis Nitrite Reductase and a Copper Site Mutant, M150E, That Contains Zinc

    Article • Biochemistry, September 1995, American Chemical Society (ACS)

    Michael Murphy, Professor Masaru Tanokura

  72. Raster3D Version 2.0. A program for photorealistic molecular graphics

    Article • Acta Crystallographica Section D Biological Crystallography, November 1994, International Union of Crystallography

    Michael Murphy

  73. Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein

    Article • Journal of Molecular Biology, September 1992, Elsevier

    Michael Murphy