All Stories

  1. AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema

    Article • April 2026, openRxiv

    Michael H Cho

  2. Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives

    Article • January 2026, openRxiv

    Michael H Cho

  3. Interstitial lung abnormalities, coronary heart disease and mortality

    Article • European Respiratory Journal, July 2025, European Respiratory Society (ERS)

    Michael H Cho

  4. Towards early detection and disease interception of COPD across the lifespan

    Article • European Respiratory Review, July 2025, European Respiratory Society (ERS)

    Michael H Cho

  5. Deep Learning of Suboptimal Spirometry to Predict Respiratory Outcomes and Mortality

    Article • June 2025, Springer Science + Business Media

    Michael H Cho

  6. Functional Variant Discovery identifies a novel genetic link between SPRY2, wood smoke, and asthma

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Michael H Cho

  7. Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Michael H Cho

  8. Characterisation of a COPD-associated nephronectin (NPNT) functional splicing genetic variant in human lung tissuevialong-read sequencing

    Article • European Respiratory Journal, February 2025, European Respiratory Society (ERS)

    Michael H Cho

  9. The Association of Interstitial Lung Abnormalities and Preserved Ratio Impaired Spirometry With Mortality

    Article • CHEST Journal, February 2025, Elsevier

    Michael H Cho

  10. Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals

    Article • PLoS Computational Biology, October 2024, PLOS

    Michael H Cho

  11. B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Michael H Cho

  12. Overlap between COPD genetic association results and transcriptional quantitative trait loci

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Michael H Cho

  13. Airway Mucus Plugs in Community-Living Adults: A Study Protocol

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Michael H Cho

  14. Breathing new life into the study of COPD with genes identified from genome-wide association studies

    Article • European Respiratory Review, April 2024, European Respiratory Society (ERS)

    Michael H Cho

  15. Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Michael H Cho

  16. Bik promotes proteasomal degradation to control low-grade inflammation

    Article • Journal of Clinical Investigation, February 2024, American Society for Clinical Investigation

    Michael H Cho

  17. Genome-wide association study of preserved ratio impaired spirometry (PRISm)

    Article • European Respiratory Journal, December 2023, European Respiratory Society (ERS)

    Michael H Cho

  18. Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors

    Article • Nature Communications, December 2023, Springer Science + Business Media

    Michael H Cho

  19. Clinical relevance of lung function trajectory clusters in middle-aged and older adults

    Article • ERJ Open Research, December 2023, European Respiratory Society (ERS)

    Michael H Cho

  20. Genome-wide association study of susceptibility to hospitalised respiratory infections

    Article • Wellcome Open Research, November 2023, Faculty of 1000, Ltd.

    Michael H Cho

  21. Hierarchical association of COPD to principal genetic components of biological systems

    Article • PLOS One, May 2023, PLOS

    Michael H Cho

  22. Traction Bronchiectasis/Bronchiolectasis in Interstitial Lung Abnormality: Follow-up in the COPDGene Study

    Article • American Review of Respiratory Disease, May 2023, American Thoracic Society

    Michael H Cho

  23. Variability in MUC5B Expression Is Dependent on Genotype and Endotype in Idiopathic Pulmonary Fibrosis

    Article • American Review of Respiratory Disease, May 2023, American Thoracic Society

    Michael H Cho

  24. Who Modifies the Modifiers: A High-Resolution View of the Genetic Modifiers of Cystic Fibrosis

    Article • American Review of Respiratory Disease, May 2023, American Thoracic Society

    Michael H Cho

  25. Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models

    Article • Nature Genetics, April 2023, Springer Science + Business Media

    Michael H Cho

  26. Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Michael H Cho

  27. Clinical Features of Genetic Resilience in Chronic Obstructive Pulmonary Disease

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Michael H Cho

  28. Bronchial Gene Expression Alterations Associated with Radiographic Bronchiectasis

    Article • European Respiratory Journal, October 2022, European Respiratory Society (ERS)

    Michael H Cho

  29. A statistical physics approach for disease module detection

    Article • Genome Research, October 2022, Cold Spring Harbor Laboratory Press

    Michael H Cho

  30. Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases

    Article • Thorax, October 2022, BMJ

    Michael H Cho

  31. Fast computation of principal components of genomic similarity matrices

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Michael H Cho

  32. Zinc finger protein 33B demonstrates sex-interaction with atopy-related markers in childhood asthma

    Article • European Respiratory Journal, August 2022, European Respiratory Society (ERS)

    Sanghun Lee, Michael H Cho

  33. GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing

    Article • Communications Biology, August 2022, Springer Science + Business Media

    Michael H Cho

  34. A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts

    Article • ERJ Open Research, June 2022, European Respiratory Society (ERS)

    Michael H Cho

  35. Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Michael H Cho

  36. SciViewer- An interactive browser for visualizing single cell datasets

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Michael H Cho

  37. A polygenic risk score and age of diagnosis of COPD

    Article • European Respiratory Journal, February 2022, European Respiratory Society (ERS)

    Matthew Moll, Michael H Cho

  38. Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts

    Article • American Review of Respiratory Disease, February 2022, American Thoracic Society

    Michael H Cho

  39. A Statistical Physics Approach for Disease Module Detection

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Michael H Cho

  40. CFTR variants are associated with chronic bronchitis in smokers

    Article • European Respiratory Journal, January 2022, European Respiratory Society (ERS)

    Craig Hersh, Michael H Cho

  41. A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data

    Article • Genes, January 2022, MDPI AG

    Michael H Cho

  42. Expanding the pool of public controls for GWAS via a method for combining genotypes from arrays and sequencing

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Michael H Cho

  43. An interferon-inducible signature of airway disease from blood gene expression profiling

    Article • European Respiratory Journal, October 2021, European Respiratory Society (ERS)

    Craig Hersh, Michael H Cho

  44. Improved prediction of smoking status via isoform-aware RNA-seq deep learning models

    Article • PLoS Computational Biology, October 2021, PLOS

    Michael H Cho

  45. HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk

    Article • JCI Insight, October 2021, American Society for Clinical Investigation

    Michael H Cho

  46. Chromatin Landscapes of Human Lung Cells Predict Potentially Functional Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Variants

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2021, American Thoracic Society

    Christopher Benway, Michael H Cho

  47. Lung proteomic biomarkers associated with chronic obstructive pulmonary disease

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Michael H Cho

  48. Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function: Discovery and validation in two TOPMed Cohorts

    Article • March 2021, Springer Science + Business Media

    Michael H Cho

  49. A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Michael H Cho

  50. Mutations in SARS-CoV-2 spike protein and RNA polymerase complex are associated with COVID-19 mortality risk

    Article • November 2020, Springer Science + Business Media

    Michael H Cho

  51. A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19

    Article • EBioMedicine, November 2020, Elsevier

    Michael H Cho

  52. Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Michael H Cho

  53. Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study

    Article • Thorax, August 2020, BMJ

    Michael H Cho

  54. A fast and efficient smoothing approach to Lasso regression and an application in statistical genetics: polygenic risk scores for chronic obstructive pulmonary disease (COPD)

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Michael H Cho

  55. locStra: Fast analysis of regional/global stratification in whole genome sequencing (WGS) studies

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Michael H Cho

  56. Integrated transcriptomic correlation network analysis identifies COPD molecular determinants

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Michael H Cho

  57. Mixed-model admixture mapping identifies smoking-dependent loci of lung function in African Americans

    Article • European Journal of Human Genetics, December 2019, Springer Science + Business Media

    Michael H Cho

  58. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

    Article • CHEST Journal, December 2019, Elsevier

    Michael H Cho, Erick Forno

  59. High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report

    Article • Annals of the American Thoracic Society, January 2019, American Thoracic Society

    Michael H Cho

  60. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene

    Article • JCI Insight, November 2018, American Society for Clinical Investigation

    Michael H Cho, Dr Robert A Oster

  61. Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Michael H Cho

  62. GWAS and Systems Biology Analysis of Depressive Symptoms among Smokers from the COPDGene Cohort

    Article • Journal of Affective Disorders, September 2018, Elsevier

    Michael H Cho

  63. Genome-wide assessment of gene-by-smoking interactions in COPD

    Article • Scientific Reports, June 2018, Springer Science + Business Media

    Michael H Cho

  64. Exome Array Analysis Identifies a Common Variant inIL27Associated with Chronic Obstructive Pulmonary Disease

    Article • American Review of Respiratory Disease, July 2016, American Thoracic Society

    Michael H Cho

  65. COPD subtypes identified by network-based clustering of blood gene expression

    Article • Genomics, March 2016, Elsevier

    Michael H Cho

  66. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility

    Article • Human Genetics, January 2013, Springer Science + Business Media

    Michael H Cho

  67. Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report

    Article • COPD Journal of Chronic Obstructive Pulmonary Disease, April 2011, Taylor & Francis

    Michael H Cho

  68. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations

    Article • Human Molecular Genetics, November 2009, Oxford University Press (OUP)

    Michael H Cho

  69. Folliculin mutations are not associated with severe COPD

    Article • BMC Medical Genetics, December 2008, Springer Science + Business Media

    Michael H Cho