All Stories

  1. Protocol to probe how promoters decode TF dynamics in Saccharomyces cerevisiae by combining optogenetic control with microscopy

    Article • STAR Protocols, September 2024, Elsevier

    Dr Megan Nicole McClean

  2. Live-cell analysis of IMPDH protein levels during yeast colony growth provides insights into the regulation of GTP synthesis

    Article • mBio, August 2024, ASM Journals

    Dr Megan Nicole McClean

  3. Tuning interdomain conjugation to enable in situ population modification in yeasts

    Article • mSystems, June 2024, ASM Journals

    Dr Megan Nicole McClean

  4. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro

    Article • ACS Synthetic Biology, April 2024, American Chemical Society (ACS)

    Dr Megan Nicole McClean

  5. Correction to “Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit”

    Article • ACS Synthetic Biology, October 2023, American Chemical Society (ACS)

    Dr Megan Nicole McClean

  6. Tuning Interdomain Conjugation Towardin situPopulation Modification in Yeast

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Dr Megan Nicole McClean

  7. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit

    Article • ACS Synthetic Biology, July 2023, American Chemical Society (ACS)

    Dr Megan Nicole McClean

  8. Transcription factor localization dynamics and DNA binding drive distinct promoter interpretations

    Article • Cell Reports, May 2023, Elsevier

    Dr Megan Nicole McClean

  9. Lustro: High-throughput optogenetic experiments enabled by automation and a yeast optogenetic toolkit

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Dr Megan Nicole McClean

  10. Strain‐dependent differences in coordination of yeast signalling networks

    Article • FEBS Journal, December 2022, Wiley

    Dr Megan Nicole McClean

  11. Cellular context alters EGF-induced ERK dynamics and reveals potential crosstalk with GDF-15

    Article • Biomicrofluidics, September 2022, American Institute of Physics

    Dr Megan Nicole McClean

  12. Transcription Factor Localization Dynamics and DNA Binding Drive Distinct Promoter Interpretations

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Dr Megan Nicole McClean

  13. Strain dependent differences in coordination of yeast signaling networks

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Dr Megan Nicole McClean

  14. Give and take in the exometabolome

    Article • Nature Microbiology, March 2022, Springer Science + Business Media

    Dr Megan Nicole McClean

  15. Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway

    Article • APL Bioengineering, December 2021, American Institute of Physics

    Dr Megan Nicole McClean

  16. Optogenetic Tools for Control of Public Goods in Saccharomyces cerevisiae

    Article • mSphere, August 2021, ASM Journals

    Dr Megan Nicole McClean

  17. Optogenetic tools for public goods control in Saccharomyces cerevisiae

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr Megan Nicole McClean

  18. Shining light on molecular communication

    Article • September 2020, ACM (Association for Computing Machinery)

    Dr Megan Nicole McClean

  19. Automated Calibration of Optoplate LEDs to Reduce Light Dose Variation in Optogenetic Experiments

    Article • BioTechniques, July 2020, Taylor & Francis

    Dr Megan Nicole McClean

  20. Under oil open-channel microfluidics empowered by exclusive liquid repellency

    Article • Science Advances, April 2020, American Association for the Advancement of Science

    Dr Megan Nicole McClean

  21. A Microfluidic Device for Imaging Samples from Microbial Suspension Cultures

    Article • MethodsX, January 2020, Elsevier

    Dr Megan Nicole McClean

  22. A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae

    Article • Biotechnology and Bioengineering, December 2019, Wiley

    Dr Megan Nicole McClean

  23. Optogenetic Repressors of Gene Expression in Yeasts Using Light-Controlled Nuclear Localization

    Article • Cellular and Molecular Bioengineering, September 2019, Springer Science + Business Media

    Dr Megan Nicole McClean

  24. Easy calibration of the Light Plate Apparatus for optogenetic experiments

    Article • MethodsX, January 2019, Elsevier

    Dr Megan Nicole McClean

  25. Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

    Article • PLoS Biology, December 2017, PLOS

    Dr Megan Nicole McClean

  26. Engineered bacteria self-organize to sense pressure

    Article • Nature Biotechnology, October 2017, Nature

    Dr Megan Nicole McClean

  27. Design and Implementation of an Automated Illuminating, Culturing, and Sampling System for Microbial Optogenetic Applications

    Article • Journal of Visualized Experiments, February 2017, MyJove Corporation

    Dr Megan Nicole McClean

  28. Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae

    Article • BMC Systems Biology, March 2015, Springer Science + Business Media

    Dr Megan Nicole McClean

  29. Real-time optogenetic control of intracellular protein concentration in microbial cell cultures

    Article • Integrative Biology, January 2014, Oxford University Press (OUP)

    Dr Megan Nicole McClean

  30. Microfluidic Platforms for Generating Dynamic Environmental Perturbations to Study the Responses of Single Yeast Cells

    Article • January 2014, Springer Science + Business Media

    Dr Megan Nicole McClean

  31. A New System for Comparative Functional Genomics of Saccharomyces Yeasts

    Article • Genetics, July 2013, Genetics Society of America

    Dr Megan Nicole McClean

  32. Visualization and Analysis of mRNA Molecules Using Fluorescence In Situ Hybridization in Saccharomyces cerevisiae

    Article • Journal of Visualized Experiments, June 2013, MyJove Corporation

    Dr Megan Nicole McClean

  33. Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses

    Article • Molecular Biology of the Cell, April 2013, American Society for Cell Biology (ASCB)

    Dr Megan Nicole McClean

  34. Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    Dr Megan Nicole McClean

  35. Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae

    Article • Molecular Biology of the Cell, September 2011, American Society for Cell Biology (ASCB)

    Dr Megan Nicole McClean

  36. The Dynamical Systems Properties of the HOG Signaling Cascade

    Article • Journal of Signal Transduction, February 2011, Wiley

    Dr Megan Nicole McClean

  37. Measuring In Vivo Signaling Kinetics in a Mitogen-Activated Kinase Pathway Using Dynamic Input Stimulation

    Article • January 2011, Springer Science + Business Media

    Dr Megan Nicole McClean

  38. In vivo measurement of signaling cascade dynamics

    Article • Cell Cycle, February 2009, Taylor & Francis

    Dr Megan Nicole McClean

  39. Analyse dynamique de la signalisation cellulaire

    Article • médecine/sciences, December 2008, EDP Sciences

    Dr Megan Nicole McClean

  40. Signal processing by the HOG MAP kinase pathway

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Megan Nicole McClean

  41. Erratum: Corrigendum: Cross-talk and decision making in MAP kinase pathways

    Article • Nature Genetics, April 2007, Springer Science + Business Media

    Dr Megan Nicole McClean

  42. Cross-talk and decision making in MAP kinase pathways

    Article • Nature Genetics, January 2007, Springer Science + Business Media

    Dr Megan Nicole McClean