All Stories

  1. Time-resolved ligand dynamics revealed in a β-lactamase using room-temperature serial crystallography

    Article • December 2025, openRxiv

    Matthew Rodrigues

  2. Development and structure-guided characterization of a novel ACE2-binding macrocyclic peptide

    Article • December 2025, openRxiv

    Matthew Rodrigues

  3. Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers

    Article • Proceedings of the National Academy of Sciences, May 2025, Proceedings of the National Academy of Sciences

    Matthew Rodrigues

  4. Radiation damage to ligands and inhibitors in protein crystal structures

    Article • Journal of Applied Crystallography, November 2024, International Union of Crystallography

    Rob van Montfort, Matthew Rodrigues

  5. Active state structures of a bistable visual opsin bound to G proteins

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Matthew Rodrigues

  6. Activating invertebrate visual receptors without light

    Article • Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences

    Matthew Rodrigues

  7. Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs

    Article • British Journal of Pharmacology, April 2024, Wiley

    Matthew Rodrigues

  8. A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus

    Article • Proceedings of the National Academy of Sciences, March 2024, Proceedings of the National Academy of Sciences

    Ivo Tews, Matthew Rodrigues, Dr Simon J Coles

  9. Cyclic peptide inhibitors stabilize Gq/11 heterotrimers

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Matthew Rodrigues

  10. Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

    Article • Proceedings of the National Academy of Sciences, April 2023, Proceedings of the National Academy of Sciences

    Matthew Rodrigues

  11. Ultrafast structural changes direct the first molecular events of vision

    Article • Nature, March 2023, Springer Science + Business Media

    Matthew Rodrigues

  12. Correction of rhodopsin serial crystallography diffraction intensities for a lattice-translocation defect

    Article • Acta Crystallographica Section D Structural Biology, February 2023, International Union of Crystallography

    Matthew Rodrigues

  13. Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

    Article • Scientific Reports, November 2022, Springer Science + Business Media

    Matthew Rodrigues

  14. ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Matthew Rodrigues

  15. Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

    Article • Journal of Medicinal Chemistry, June 2022, American Chemical Society (ACS)

    Matthew Rodrigues

  16. Trapping and structural characterisation of a covalent intermediate in vitamin B6 biosynthesis catalysed by the Pdx1 PLP synthase

    Article • RSC Chemical Biology, January 2022, Royal Society of Chemistry

    Matthew Rodrigues

  17. Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

    Article • Journal of Medicinal Chemistry, November 2021, American Chemical Society (ACS)

    Matthew Rodrigues

  18. Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

    Article • Journal of Medicinal Chemistry, April 2020, American Chemical Society (ACS)

    Matthew Rodrigues

  19. Crystal structure of human BCL6 BTB domain in complex with compound 1

    Article • December 2019, Protein Data Bank, Rutgers University

    Matthew Rodrigues

  20. Crystal structure of Arabidopsis thaliana Pdx1-R5P complex

    Article • January 2017, Protein Data Bank, Rutgers University

    Matthew Rodrigues

  21. Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis

    Article • Nature Chemical Biology, January 2017, Nature

    Dr Gwyndaf Evans, Matthew Rodrigues