All Stories

  1. Educational outcomes of a clinical and translational summer research internship program between a private university and a medical school
  2. Institutional Experience with Post-Publication Research Integrity Signals
  3. Quasi-brittle fracture mechanics to assess ex vivo Raloxifene treatment of human cortical bone
  4. A measure of intrinsic strength, not nominal strength, reflects effects of ex-vivo cortical bone matrix modulation by raloxifene
  5. Pathophysiology of Medication‐Related Osteonecrosis of the Jaw—A Minireview
  6. Doris Duke Charitable Foundation Fund to Retain Clinical Scientists: innovating support for early-career family caregivers
  7. Non‐Additive Effects of Combined NOX1/4 Inhibition and Calcimimetic Treatment on a Rat Model of Chronic Kidney Disease‐Mineral and Bone Disorder (CKD‐MBD)
  8. The Effect of Single Versus Group μCT on the Detection of Trabecular and Cortical Disease Phenotypes in Mouse Bones
  9. N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder
  10. Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study
  11. Time course of rapid bone loss and cortical porosity formation observed by longitudinal μCT in a rat model of CKD
  12. Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD
  13. Mechanics of Linear Microcracking in Trabecular Bone
  14. Reversal of loss of bone mass in old mice treated with mefloquine
  15. Skeletal vascular perfusion is altered in chronic kidney disease
  16. Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone
  17. Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model
  18. Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism
  19. Assessment of regional bone tissue perfusion in rats using fluorescent microspheres
  20. Assessing the inter- and intra-animal variability of in vivo OsteoProbe skeletal measures in untreated dogs
  21. Reference point indentation is insufficient for detecting alterations in traditional mechanical properties of bone under common experimental conditions
  22. Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta
  23. Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements
  24. Absence of Exposed Bone Following Dental Extraction in Beagle Dogs Treated With 9 Months of High-Dose Zoledronic Acid Combined With Dexamethasone
  25. Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)
  26. Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent
  27. Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing
  28. Microcrack density and nanomechanical properties in the subchondral region of the immature piglet femoral head following ischemic osteonecrosis
  29. Orthodontic mini-implant diameter does not affect in-situ linear microcrack generation in the mandible or the maxilla
  30. Circulating αKlotho influences phosphate handling by controlling FGF23 production
  31. Aging and Estrogen Status: A Possible Endothelium-Dependent Vascular Coupling Mechanism in Bone Remodeling
  32. Skeletal effects of zoledronic acid in an animal model of chronic kidney disease
  33. Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
  34. Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
  35. Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year
  36. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
  37. Dietary Phosphate Restriction Normalizes Biochemical and Skeletal Abnormalities in a Murine Model of Tumoral Calcinosis
  38. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
  39. Bisphosphonates do not alter the rate of secondary mineralization
  40. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride
  41. Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate
  42. Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: What we think we know and what we know that we don't know
  43. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
  44. Introduction
  45. Animal Models of Osteonecrosis
  46. The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing
  47. Lack of Correlation Between Duration of Osteonecrosis of the Jaw and Sequestra Tissue Morphology: What It Tells Us About the Condition and What It Means for Future Studies
  48. Ovariectomy stimulates and bisphosphonates inhibit intracortical remodeling in the mouse mandible
  49. In vivo effects of zoledronic acid on oral mucosal epithelial cells
  50. Reply to: Fatigue in bone: A novel phenomenon attributable to bisphosphonate use
  51. One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation
  52. Can deterministic mechanical size effects contribute to fracture and microdamage accumulation in trabecular bone?
  53. Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs
  54. Increased nitric oxide-mediated vasodilation of bone resistance arteries is associated with increased trabecular bone volume after endurance training in rats
  55. Heritability of lumbar trabecular bone mechanical properties in baboons
  56. Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity
  57. Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading
  58. Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs
  59. Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone
  60. Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: Implications for subtrochanteric femoral fracture risk
  61. Studying the role of microcracks in the pathophysiology of BRONJ
  62. Mandibular necrosis in beagle dogs treated with bisphosphonates
  63. Higher Bone Matrix Density Exists in Only a Subset of Patients With Bisphosphonate-Related Osteonecrosis of the Jaw
  64. Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage
  65. The Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw: So Many Hypotheses, So Few Data
  66. Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body
  67. Corrigendum to “Failure of mineralized collagen fibrils: Modeling the role of collagen cross-linking” (J. Biomech. 41 (2008) 1427–1435)
  68. Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models
  69. Methodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy
  70. Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment
  71. Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
  72. Identification of material parameters based on Mohr–Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone
  73. Calculating clinically relevant drug doses to use in animal studies
  74. Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
  75. Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
  76. Bisphosphonates and Osteonecrosis of the Jaw: Moving from the Bedside to the Bench
  77. Surface-specific Bone Formation Effects of Osteoporosis Pharmacological Treatments
  78. Skeletal Microdamage: Less About Biomechanics and More About Remodeling
  79. Mandible Matrix Necrosis in Beagle Dogs After 3 Years of Daily Oral Bisphosphonate Treatment
  80. Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment
  81. Strontium ranelate does not stimulate bone formation in ovariectomized rats
  82. Low Bone Turnover and Microdamage? How and Where to Assess It?
  83. Food restriction and simulated microgravity: effects on bone and serum leptin
  84. In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy
  85. Failure of mineralized collagen fibrils: Modeling the role of collagen cross-linking
  86. Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra
  87. Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
  88. Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs
  89. Raloxifene Enhances Material-Level Mechanical Properties of Femoral Cortical and Trabecular Bone
  90. Three Years of Alendronate Treatment Results in Similar Levels of Vertebral Microdamage as After One Year of Treatment
  91. Aging Reduces Skeletal Blood Flow, Endothelium-Dependent Vasodilation, and NO Bioavailability in Rats
  92. Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific
  93. Nanometer resolution hard X-ray microscopy of bone and mineralized tissue
  94. A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
  95. Raloxifene enhances vertebral mechanical properties independent of bone density
  96. Antiremodeling Agents Influence Osteoblast Activity Differently in Modeling and Remodeling Sites of Canine Rib
  97. Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
  98. The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific
  99. Parathyroid Hormone and Bone Biomechanics
  100. Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis
  101. Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone
  102. Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficient mouse
  103. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
  104. Periosteum: biology, regulation, and response to osteoporosis therapies
  105. Functional recovery of the plantarflexor muscle group after hindlimb unloading in the rat
  106. Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089)
  107. Biglycan Deficiency Interferes With Ovariectomy-Induced Bone Loss
  108. Biglycan-Deficient Mice Have Delayed Osteogenesis after Marrow Ablation
  109. Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats