All Stories

  1. Quasi-brittle fracture mechanics to assess ex vivo Raloxifene treatment of human cortical bone

    Article • International Journal of Solids and Structures, September 2025, Elsevier

    Dr Matthew R Allen

  2. A measure of intrinsic strength, not nominal strength, reflects effects of ex-vivo cortical bone matrix modulation by raloxifene

    Article • Journal of the Mechanical Behavior of Biomedical Materials, June 2025, Elsevier

    Dr Matthew R Allen

  3. Pathophysiology of Medication‐Related Osteonecrosis of the Jaw—A Minireview

    Article • JBMR Plus, June 2023, Oxford University Press (OUP)

    Dr Matthew R Allen

  4. Doris Duke Charitable Foundation Fund to Retain Clinical Scientists: innovating support for early-career family caregivers

    Article • Journal of Clinical Investigation, December 2022, American Society for Clinical Investigation

    Dr Matthew R Allen

  5. Non‐Additive Effects of Combined NOX1/4 Inhibition and Calcimimetic Treatment on a Rat Model of Chronic Kidney Disease‐Mineral and Bone Disorder (CKD‐MBD)

    Article • JBMR Plus, February 2022, Oxford University Press (OUP)

    Dr Matthew R Allen

  6. The Effect of Single Versus Group μCT on the Detection of Trabecular and Cortical Disease Phenotypes in Mouse Bones

    Article • JBMR Plus, March 2021, Oxford University Press (OUP)

    Dr Matthew R Allen

  7. N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder

    Article • PLOS One, March 2020, PLOS

    Dr Matthew R Allen

  8. Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study

    Article • Osteoporosis International, May 2019, Springer Science + Business Media

    Dr Matthew R Allen

  9. Time course of rapid bone loss and cortical porosity formation observed by longitudinal μCT in a rat model of CKD

    Article • Bone, May 2019, Elsevier

    Dr Matthew R Allen

  10. Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD

    Article • JCI Insight, February 2019, American Society for Clinical Investigation

    Dr Matthew R Allen

  11. Mechanics of Linear Microcracking in Trabecular Bone

    Article • Journal of Biomechanics, November 2018, Elsevier

    Dr Matthew R Allen

  12. Reversal of loss of bone mass in old mice treated with mefloquine

    Article • Bone, September 2018, Elsevier

    Dr Matthew R Allen, Dr. Lilian I. Plotkin

  13. Skeletal vascular perfusion is altered in chronic kidney disease

    Article • Bone Reports, May 2018, Elsevier

    Dr Matthew R Allen

  14. Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone

    Article • Toxicologic Pathology, September 2017, SAGE Publications

    Dr Matthew R Allen

  15. Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model

    Article • PLOS One, August 2017, PLOS

    Dr Matthew R Allen

  16. Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism

    Article • Endocrinology, June 2017, Endocrine Society

    Dr Matthew R Allen, Dr Stuart J Warden, Dr. Lilian I. Plotkin

  17. Assessment of regional bone tissue perfusion in rats using fluorescent microspheres

    Article • Bone Reports, April 2017, Elsevier

    Dr Matthew R Allen

  18. Assessing the inter- and intra-animal variability of in vivo OsteoProbe skeletal measures in untreated dogs

    Article • Bone Reports, August 2016, Elsevier

    Dr Matthew R Allen

  19. Reference point indentation is insufficient for detecting alterations in traditional mechanical properties of bone under common experimental conditions

    Article • Bone, June 2016, Elsevier

    Dr Matthew R Allen

  20. Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta

    Article • Matrix Biology, May 2016, Elsevier

    Dr Matthew R Allen

  21. Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements

    Article • Journal of Cardiovascular Electrophysiology, March 2015, Wiley

    Dr Matthew R Allen, James Tisdale

  22. Absence of Exposed Bone Following Dental Extraction in Beagle Dogs Treated With 9 Months of High-Dose Zoledronic Acid Combined With Dexamethasone

    Article • Journal of Oral and Maxillofacial Surgery, June 2013, Elsevier

    Dr Matthew R Allen

  23. Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

    Article • PLOS One, May 2013, PLOS

    Dr Matthew R Allen

  24. Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent

    Article • Journal of Orthopaedic Research®, March 2013, Wiley

    Dr Matthew R Allen

  25. Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing

    Article • Bone, March 2013, Elsevier

    Dr Matthew R Allen, Jason Organ

  26. Microcrack density and nanomechanical properties in the subchondral region of the immature piglet femoral head following ischemic osteonecrosis

    Article • Bone, February 2013, Elsevier

    Dr Matthew R Allen

  27. Orthodontic mini-implant diameter does not affect in-situ linear microcrack generation in the mandible or the maxilla

    Article • American Journal of Orthodontics and Dentofacial Orthopedics, December 2012, Elsevier

    Dr Matthew R Allen

  28. Circulating αKlotho influences phosphate handling by controlling FGF23 production

    Article • Journal of Clinical Investigation, November 2012, American Society for Clinical Investigation

    Dr Matthew R Allen

  29. Aging and Estrogen Status: A Possible Endothelium-Dependent Vascular Coupling Mechanism in Bone Remodeling

    Article • PLOS One, November 2012, PLOS

    Dr Matthew R Allen

  30. Skeletal effects of zoledronic acid in an animal model of chronic kidney disease

    Article • Osteoporosis International, August 2012, Springer Science + Business Media

    Dr Matthew R Allen

  31. Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

    Article • Journal of Bone and Mineral Research, January 2012, Wiley

    Dr Matthew R Allen

  32. Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits

    Article • Calcified Tissue International, January 2012, Springer Science + Business Media

    Dr Matthew R Allen

  33. Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year

    Article • Osteoporosis International, January 2012, Springer Science + Business Media

    Dr Matthew R Allen

  34. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

    Article • Bone, January 2012, Elsevier

    Dr Matthew R Allen

  35. Dietary Phosphate Restriction Normalizes Biochemical and Skeletal Abnormalities in a Murine Model of Tumoral Calcinosis

    Article • Endocrinology, December 2011, Endocrine Society

    Dr Matthew R Allen

  36. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

    Article • Proceedings of the National Academy of Sciences, October 2011, Proceedings of the National Academy of Sciences

    Dr Matthew R Allen

  37. Bisphosphonates do not alter the rate of secondary mineralization

    Article • Bone, October 2011, Elsevier

    Dr Matthew R Allen

  38. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride

    Article • Journal of Synchrotron Radiation, September 2011, International Union of Crystallography

    Dr Matthew R Allen

  39. Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate

    Article • Bone, July 2011, Elsevier

    Dr Matthew R Allen

  40. Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: What we think we know and what we know that we don't know

    Article • Bone, July 2011, Elsevier

    Dr Matthew R Allen

  41. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling

    Article • Journal of Bone and Mineral Research, May 2011, Wiley

    Dr Matthew R Allen

  42. Introduction

    Article • Clinical Reviews in Bone and Mineral Metabolism, March 2011, Springer Science + Business Media

    Dr Matthew R Allen

  43. Animal Models of Osteonecrosis

    Article • Clinical Reviews in Bone and Mineral Metabolism, March 2011, Springer Science + Business Media

    Dr Matthew R Allen

  44. The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing

    Article • Odontology, January 2011, Springer Science + Business Media

    Dr Matthew R Allen

  45. Lack of Correlation Between Duration of Osteonecrosis of the Jaw and Sequestra Tissue Morphology: What It Tells Us About the Condition and What It Means for Future Studies

    Article • Journal of Oral and Maxillofacial Surgery, November 2010, Elsevier

    Dr Matthew R Allen

  46. Ovariectomy stimulates and bisphosphonates inhibit intracortical remodeling in the mouse mandible

    Article • Orthodontics and Craniofacial Research, October 2010, Wiley

    Dr Matthew R Allen

  47. In vivo effects of zoledronic acid on oral mucosal epithelial cells

    Article • Oral Diseases, September 2010, Wiley

    Dr Matthew R Allen

  48. Reply to: Fatigue in bone: A novel phenomenon attributable to bisphosphonate use

    Article • Bone, August 2010, Elsevier

    Dr Matthew R Allen

  49. One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation

    Article • Bone, August 2010, Elsevier

    Dr Matthew R Allen

  50. Can deterministic mechanical size effects contribute to fracture and microdamage accumulation in trabecular bone?

    Article • Journal of Theoretical Biology, July 2010, Elsevier

    Dr Matthew R Allen

  51. Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs

    Article • Osteoporosis International, May 2010, Springer Science + Business Media

    Dr Matthew R Allen

  52. Increased nitric oxide-mediated vasodilation of bone resistance arteries is associated with increased trabecular bone volume after endurance training in rats

    Article • Bone, March 2010, Elsevier

    Dr Matthew R Allen

  53. Heritability of lumbar trabecular bone mechanical properties in baboons

    Article • Bone, March 2010, Elsevier

    Dr Matthew R Allen

  54. Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity

    Article • Bone, March 2010, Elsevier

    Dr Matthew R Allen

  55. Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading

    Article • Bone, January 2010, Elsevier

    Dr Matthew R Allen

  56. Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs

    Article • Journal of Bone and Mineral Research, December 2009, Wiley

    Dr Matthew R Allen

  57. Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone

    Article • Calcified Tissue International, December 2009, Springer Science + Business Media

    Dr Matthew R Allen

  58. Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: Implications for subtrochanteric femoral fracture risk

    Article • Journal of Orthopaedic Research®, October 2009, Wiley

    Dr Matthew R Allen

  59. Studying the role of microcracks in the pathophysiology of BRONJ

    Article • Clinical Oral Investigations, August 2009, Springer Science + Business Media

    Dr Matthew R Allen

  60. Mandibular necrosis in beagle dogs treated with bisphosphonates

    Article • Orthodontics and Craniofacial Research, August 2009, Wiley

    Dr Matthew R Allen

  61. Higher Bone Matrix Density Exists in Only a Subset of Patients With Bisphosphonate-Related Osteonecrosis of the Jaw

    Article • Journal of Oral and Maxillofacial Surgery, July 2009, Elsevier

    Dr Matthew R Allen

  62. Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage

    Article • Journal of Biomechanics, May 2009, Elsevier

    Dr Matthew R Allen

  63. The Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw: So Many Hypotheses, So Few Data

    Article • Journal of Oral and Maxillofacial Surgery, May 2009, Elsevier

    Dr Matthew R Allen

  64. Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body

    Article • Journal of Biomechanics, March 2009, Elsevier

    Dr Matthew R Allen

  65. Corrigendum to “Failure of mineralized collagen fibrils: Modeling the role of collagen cross-linking” (J. Biomech. 41 (2008) 1427–1435)

    Article • Journal of Biomechanics, February 2009, Elsevier

    Dr Matthew R Allen

  66. Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models

    Article • AJP Endocrinology and Metabolism, January 2009, American Physiological Society

    Dr Matthew R Allen

  67. Methodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy

    Article • Microscopy Research and Technique, January 2009, Wiley

    Dr Matthew R Allen

  68. Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment

    Article • Expert Opinion on Drug Metabolism & Toxicology, October 2008, Informa Healthcare

    Dr Matthew R Allen

  69. Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate

    Article • Osteoporosis International, October 2008, Springer Science + Business Media

    Dr Matthew R Allen

  70. Identification of material parameters based on Mohr–Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone

    Article • Bone, October 2008, Elsevier

    Dr Matthew R Allen

  71. Calculating clinically relevant drug doses to use in animal studies

    Article • Osteoporosis International, September 2008, Springer Science + Business Media

    Dr Matthew R Allen

  72. Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra

    Article • Osteoporosis International, August 2008, Springer Science + Business Media

    Dr Matthew R Allen

  73. Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

    Article • PLOS One, August 2008, PLOS

    Dr Matthew R Allen

  74. Bisphosphonates and Osteonecrosis of the Jaw: Moving from the Bedside to the Bench

    Article • Cells Tissues Organs, August 2008, Karger Publishers

    Dr Matthew R Allen

  75. Surface-specific Bone Formation Effects of Osteoporosis Pharmacological Treatments

    Article • Clinical Reviews in Bone and Mineral Metabolism, June 2008, Springer Science + Business Media

    Dr Matthew R Allen

  76. Skeletal Microdamage: Less About Biomechanics and More About Remodeling

    Article • Clinical Reviews in Bone and Mineral Metabolism, May 2008, Springer Science + Business Media

    Dr Matthew R Allen

  77. Mandible Matrix Necrosis in Beagle Dogs After 3 Years of Daily Oral Bisphosphonate Treatment

    Article • Journal of Oral and Maxillofacial Surgery, May 2008, Elsevier

    Dr Matthew R Allen

  78. Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment

    Article • Calcified Tissue International, May 2008, Springer Science + Business Media

    Dr Matthew R Allen

  79. Strontium ranelate does not stimulate bone formation in ovariectomized rats

    Article • Osteoporosis International, April 2008, Springer Science + Business Media

    Dr Matthew R Allen

  80. Low Bone Turnover and Microdamage? How and Where to Assess It?

    Article • Journal of Bone and Mineral Research, March 2008, Wiley

    Dr Matthew R Allen

  81. Food restriction and simulated microgravity: effects on bone and serum leptin

    Article • Journal of Applied Physiology, February 2008, American Physiological Society

    Dr Matthew R Allen

  82. In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy

    Article • Matrix Biology, January 2008, Elsevier

    Dr Matthew R Allen

  83. Failure of mineralized collagen fibrils: Modeling the role of collagen cross-linking

    Article • Journal of Biomechanics, January 2008, Elsevier

    Dr Matthew R Allen

  84. Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra

    Article • Osteoporosis International, December 2007, Springer Science + Business Media

    Dr Matthew R Allen

  85. Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

    Article • Journal of Biological Chemistry, December 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Matthew R Allen

  86. Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs

    Article • Osteoporosis International, August 2007, Springer Science + Business Media

    Dr Matthew R Allen

  87. Raloxifene Enhances Material-Level Mechanical Properties of Femoral Cortical and Trabecular Bone

    Article • Endocrinology, August 2007, Endocrine Society

    Dr Matthew R Allen

  88. Three Years of Alendronate Treatment Results in Similar Levels of Vertebral Microdamage as After One Year of Treatment

    Article • Journal of Bone and Mineral Research, July 2007, Wiley

    Dr Matthew R Allen

  89. Aging Reduces Skeletal Blood Flow, Endothelium-Dependent Vasodilation, and NO Bioavailability in Rats

    Article • Journal of Bone and Mineral Research, April 2007, Wiley

    Dr Matthew R Allen

  90. Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific

    Article • Bone, April 2007, Elsevier

    Dr Matthew R Allen

  91. Nanometer resolution hard X-ray microscopy of bone and mineralized tissue

    Article • March 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Matthew R Allen

  92. A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover

    Article • Journal of Biomechanics, January 2007, Elsevier

    Dr Matthew R Allen

  93. Raloxifene enhances vertebral mechanical properties independent of bone density

    Article • Bone, November 2006, Elsevier

    Dr Matthew R Allen

  94. Antiremodeling Agents Influence Osteoblast Activity Differently in Modeling and Remodeling Sites of Canine Rib

    Article • Calcified Tissue International, October 2006, Springer Science + Business Media

    Dr Matthew R Allen

  95. Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate

    Article • Bone, October 2006, Elsevier

    Dr Matthew R Allen

  96. The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific

    Article • Bone, July 2006, Elsevier

    Dr Matthew R Allen

  97. Parathyroid Hormone and Bone Biomechanics

    Article • Clinical Reviews in Bone and Mineral Metabolism, January 2006, Springer Science + Business Media

    Dr Matthew R Allen

  98. Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis

    Article • Proceedings of the National Academy of Sciences, September 2005, Proceedings of the National Academy of Sciences

    Dr Matthew R Allen

  99. Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone

    Article • Bone, February 2005, Elsevier

    Dr Matthew R Allen

  100. Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficient mouse

    Article • Journal of Applied Physiology, January 2005, American Physiological Society

    Dr Matthew R Allen

  101. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

    Article • Journal of Clinical Investigation, December 2004, American Society for Clinical Investigation

    Dr Matthew R Allen

  102. Periosteum: biology, regulation, and response to osteoporosis therapies

    Article • Bone, November 2004, Elsevier

    Dr Janet M Hock, Dr Matthew R Allen

  103. Functional recovery of the plantarflexor muscle group after hindlimb unloading in the rat

    Article • European Journal of Applied Physiology and Occupational Physiology, July 2004, Springer Science + Business Media

    Dr Matthew R Allen, Dr Gordon L Warren

  104. Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089)

    Article • Bone, July 2004, Elsevier

    Dr Matthew R Allen

  105. Biglycan Deficiency Interferes With Ovariectomy-Induced Bone Loss

    Article • Journal of Bone and Mineral Research, December 2003, Wiley

    Dr Matthew R Allen

  106. Biglycan-Deficient Mice Have Delayed Osteogenesis after Marrow Ablation

    Article • Calcified Tissue International, May 2003, Springer Science + Business Media

    Dr Matthew R Allen

  107. Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats

    Article • Bone, July 2002, Elsevier

    Dr Matthew R Allen