All Stories

  1. De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

    Article • Autophagy, September 2019, Taylor & Francis

    Gigin Lin, Professor Martin O Leach

  2. Post-radiotherapy apparent diffusion coefficient (ADC) in children and young adults with high-grade gliomas and diffuse intrinsic pontine gliomas

    Article • Pediatric Hematology and Oncology, April 2019, Taylor & Francis

    Professor Martin O Leach

  3. Synthetic 4D-CT of the thorax for treatment plan adaptation on MR-guided radiotherapy systems

    Article • Physics in Medicine and Biology, March 2019, Institute of Physics Publishing

    Professor Martin O Leach

  4. Reproducibility of the lung anatomy under active breathing coordinator control: Dosimetric consequences for scanned proton treatments

    Article • Medical Physics, October 2018, Wiley

    Professor Martin O Leach

  5. Quantitative evaluation of contrast agent uptake in standard fat-suppressed dynamic contrast-enhanced MRI examinations of the breast

    Article • Medical Physics, November 2017, Wiley

    Professor Martin O Leach

  6. Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Professor Martin O Leach

  7. Breast MRI segmentation for density estimation: Do different methods give the same results and how much do differences matter?

    Article • Medical Physics, July 2017, Wiley

    Professor Martin O Leach

  8. Visualizing whole-body treatment response heterogeneity using multi-parametric magnetic resonance imaging

    Article • Journal of Algorithms & Computational Technology, December 2016, SAGE Publications

    Professor Martin O Leach

  9. Rapid development of image analysis research tools: Bridging the gap between researcher and clinician with pyOsiriX

    Article • Computers in Biology and Medicine, February 2016, Elsevier

    Professor Martin O Leach

  10. Repeatability and sensitivity of measurements in patients with head and neck squamous cell carcinoma at 3T

    Article • Journal of Magnetic Resonance Imaging, January 2016, Wiley

    Professor Martin O Leach

  11. Evaluating the diagnostic sensitivity of computed diffusion-weighted MR imaging in the detection of breast cancer

    Article • Journal of Magnetic Resonance Imaging, January 2016, Wiley

    Professor Martin O Leach

  12. Response evaluation in mesothelioma: Beyond RECIST

    Article • Lung Cancer, December 2015, Elsevier

    Professor Martin O Leach

  13. Quality assurance in MRI breast screening: comparing signal-to-noise ratio in dynamic contrast-enhanced imaging protocols

    Article • Physics in Medicine and Biology, November 2015, Institute of Physics Publishing

    Professor Martin O Leach

  14. Acting on incidental findings in research imaging

    Article • BMJ, November 2015, BMJ

    Professor Martin O Leach

  15. Characterizing Heterogeneity within Head and Neck Lesions Using Cluster Analysis of Multi-Parametric MRI Data

    Article • PLoS ONE, September 2015, PLOS

    Professor Martin O Leach

  16. Detecting microvascular changes in the mouse spleen using optical computed tomography

    Article • Microvascular Research, September 2015, Elsevier

    Professor Martin O Leach

  17. Diffusion-weighted MR imaging of metastatic abdominal and pelvic tumours is sensitive to early changes induced by a VEGF inhibitor using alternative diffusion attenuation models

    Article • European Radiology, August 2015, Springer Science + Business Media

    Professor Martin O Leach

  18. Evaluation of diffusion models in breast cancer

    Article • Medical Physics, July 2015, Wiley

    Professor Martin O Leach

  19. Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

    Article • Lymphatic Research and Biology, June 2015, Mary Ann Liebert Inc

    Professor Martin O Leach

  20. Prospective, longitudinal, multi-modal functional imaging for radical chemo-IMRT treatment of locally advanced head and neck cancer: the INSIGHT study

    Article • Radiation Oncology, May 2015, Springer Science + Business Media

    Professor Martin O Leach

  21. Diffusion-weighted MR neurography for the assessment of brachial plexopathy in oncological practice

    Article • Cancer Imaging, May 2015, Springer Science + Business Media

    Professor Martin O Leach

  22. Phase I Study of Nintedanib Incorporating Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients With Advanced Solid Tumors

    Article • The Oncologist, March 2015, Alphamed Press

    Professor Martin O Leach

  23. Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain

    Article • NMR in Biomedicine, March 2015, Wiley

    Professor Martin O Leach

  24. Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter

    Article • NMR in Biomedicine, March 2015, Wiley

    Professor Martin O Leach

  25. Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study

    Article • European Radiology, March 2015, Springer Science + Business Media

    Professor Martin O Leach

  26. Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours

    Article • British Journal of Cancer, March 2015, Springer Science + Business Media

    Professor Martin O Leach

  27. Magnetic Resonance Imaging Improves Breast Screening Sensitivity in BRCA Mutation Carriers Age ≥ 50 Years: Evidence From an Individual Patient Data Meta-Analysis

    Article • Journal of Clinical Oncology, February 2015, American Society of Clinical Oncology (ASCO)

    Professor Martin O Leach

  28. First MRI application of an active breathing coordinator

    Article • Physics in Medicine and Biology, January 2015, Institute of Physics Publishing

    Professor Martin O Leach

  29. Evaluation of lactate detection using selective multiple quantum coherence in phantoms and brain tumours

    Article • NMR in Biomedicine, January 2015, Wiley

    Professor Martin O Leach

  30. Use of the temporal median and trimmed mean mitigates effects of respiratory motion in multiple-acquisition abdominal diffusion imaging

    Article • Physics in Medicine and Biology, January 2015, Institute of Physics Publishing

    Professor Martin O Leach

  31. Investigating the Influence of Flip Angle and k-Space Sampling on Dynamic Contrast-Enhanced MRI Breast Examinations

    Article • Academic Radiology, November 2014, Elsevier

    Professor Martin O Leach

  32. Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers

    Article • Clinical Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  33. Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

    Article • PLoS ONE, August 2014, PLOS

    Professor Martin O Leach

  34. Dichloroacetate induces autophagy in colorectal cancer cells and tumours

    Article • British Journal of Cancer, June 2014, Nature

    Gigin Lin, Professor Martin O Leach

  35. Assessment of Treatment Response by Total Tumor Volume and Global Apparent Diffusion Coefficient Using Diffusion-Weighted MRI in Patients with Metastatic Bone Disease: A Feasibility Study

    Article • PLoS ONE, April 2014, PLOS

    Professor Martin O Leach

  36. MRI breast screening in high-risk women: cancer detection and survival analysis

    Article • Breast Cancer Research and Treatment, April 2014, Springer Science + Business Media

    Professor Martin O Leach

  37. Clinical Proton MR Spectroscopy in Central Nervous System Disorders

    Article • Radiology, March 2014, Radiological Society of North America (RSNA)

    Professor Risto A Kauppinen, Professor Martin O Leach

  38. Quantitative PET and SPECT performance characteristics of the Albira Trimodal pre-clinical tomograph

    Article • Physics in Medicine and Biology, January 2014, Institute of Physics Publishing

    Professor Martin O Leach

  39. Development of a Hybrid Magnetic Resonance and Ultrasound Imaging System

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Martin O Leach

  40. Profiling metabolite changes in the neuronal differentiation of human striatal neural stem cells using 1H-magnetic resonance spectroscopy

    Article • Neuroreport, December 2013, Wolters Kluwer Health

    Professor Martin O Leach

  41. Comparison of three reference methods for the measurement of intracellular pH using 31 P MRS in healthy volunteers and patients with lymphoma

    Article • NMR in Biomedicine, November 2013, Wiley

    Professor Martin O Leach

  42. The role of pre-treatment diffusion-weighted MRI in predicting long-term outcome of colorectal liver metastasis

    Article • British Journal of Radiology, October 2013, British Institute of Radiology

    Professor Martin O Leach

  43. Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized 13C Magnetic Resonance Spectroscopy Data

    Article • PLoS ONE, September 2013, PLOS

    Professor Martin O Leach

  44. Noninvasive Phosphorus Magnetic Resonance Spectroscopic Imaging Predicts Outcome to First-line Chemotherapy in Newly Diagnosed Patients with Diffuse Large B-Cell Lymphoma

    Article • Academic Radiology, September 2013, Elsevier

    Professor Martin O Leach

  45. Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI

    Article • British Journal of Cancer, August 2013, Springer Science + Business Media

    Professor Martin O Leach

  46. Stacked Autoencoders for Unsupervised Feature Learning and Multiple Organ Detection in a Pilot Study Using 4D Patient Data

    Article • IEEE Transactions on Pattern Analysis and Machine Intelligence, August 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Martin O Leach

  47. 1 H NMR and hyperpolarized 13 C NMR assays of pyruvate–lactate: a comparative study

    Article • NMR in Biomedicine, May 2013, Wiley

    Professor Martin O Leach

  48. MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells

    Article • Cancer Research, May 2013, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  49. Multi-Frame SPRITE: A method for resolution enhancement of multiple-point SPRITE data

    Article • Journal of Magnetic Resonance, May 2013, Elsevier

    Professor Martin O Leach

  50. Comparison of free-breathing with navigator-controlled acquisition regimes in abdominal diffusion-weighted magnetic resonance images: Effect on ADC and IVIM statistics

    Article • Journal of Magnetic Resonance Imaging, April 2013, Wiley

    Professor Martin O Leach

  51. Reproducibility of Dynamic Contrast-enhanced MR Imaging: Why We Should Care

    Article • Radiology, March 2013, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  52. Improved intravoxel incoherent motion analysis of diffusion weighted imaging by data driven Bayesian modeling

    Article • Magnetic Resonance in Medicine, February 2013, Wiley

    Professor Martin O Leach

  53. Optimal age to start preventive measures in women withBRCA1/2mutations or high familial breast cancer risk

    Article • International Journal of Cancer, February 2013, Wiley

    Professor Martin O Leach

  54. First-in-Human Phase I Trial of Two Schedules of OSI-930, a Novel Multikinase Inhibitor, Incorporating Translational Proof-of-Mechanism Studies

    Article • Clinical Cancer Research, February 2013, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  55. The utility of whole-body diffusion-weighted MRI for delineating regions of interest in PET

    Article • Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, February 2013, Elsevier

    Professor Martin O Leach

  56. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

    Article • Breast Cancer Research, January 2013, Springer Science + Business Media

    Professor Martin O Leach

  57. Breast dynamic contrast-enhanced examinations with fat suppression: Are contrast-agent uptake curves affected by magnetic field inhomogeneity?

    Article • European Radiology, December 2012, Springer Science + Business Media

    Professor Martin O Leach

  58. Functional imaging in adult and paediatric brain tumours

    Article • Nature Reviews Clinical Oncology, November 2012, Springer Science + Business Media

    Professor Martin O Leach

  59. Advanced Solid Tumors Treated with Cediranib: Comparison of Dynamic Contrast-enhanced MR Imaging and CT as Markers of Vascular Activity

    Article • Radiology, November 2012, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  60. Informatics in Radiology: Development of a Research PACS for Analysis of Functional Imaging Data in Clinical Research and Clinical Trials

    Article • Radiographics, November 2012, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  61. Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases

    Article • European Radiology, October 2012, Springer Science + Business Media

    Professor Martin O Leach

  62. Whole-Body Diffusion-Weighted MRI: Tips, Tricks, and Pitfalls

    Article • American Journal of Roentgenology, August 2012, American Roentgen Ray Society

    Professor Martin O Leach

  63. Differences in Natural History between Breast Cancers in BRCA1 and BRCA2 Mutation Carriers and Effects of MRI Screening-MRISC, MARIBS, and Canadian Studies Combined

    Article • Cancer Epidemiology Biomarkers & Prevention, June 2012, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  64. Combination of chemical suppression techniques for dual suppression of fat and silicone at diffusion-weighted MR imaging in women with breast implants

    Article • European Radiology, June 2012, Springer Science + Business Media

    Professor Martin O Leach

  65. Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer

    Article • Clinical Cancer Research, May 2012, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  66. Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging

    Article • European Radiology, May 2012, Springer Science + Business Media

    Professor Martin O Leach

  67. Neuroendocrine Tumor Liver Metastases: Use of Dynamic Contrast-enhanced MR Imaging to Monitor and Predict Radiolabeled Octreotide Therapy Response

    Article • Radiology, April 2012, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  68. Assessment of colorectal hepatic metastases by quantitative T2 relaxation time

    Article • European Journal of Radiology, April 2012, Elsevier

    Professor Martin O Leach

  69. Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

    Article • Cancer Epidemiology Biomarkers & Prevention, March 2012, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  70. Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

    Article • BMC Research Notes, January 2012, Springer Science + Business Media

    Professor Martin O Leach

  71. An evaluation of motion compensation strategies and repeatability for abdominal 1H MR spectroscopy measurements in volunteer studies and clinical trials

    Article • NMR in Biomedicine, December 2011, Wiley

    Professor Martin O Leach

  72. Histone Deacetylase Inhibition Increases Levels of Choline Kinase   and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

    Article • Cancer Research, December 2011, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  73. Computerized detection of breast lesions in multi-centre and multi-instrument DCE-MR data using 3D principal component maps and template matching

    Article • Physics in Medicine and Biology, November 2011, Institute of Physics Publishing

    Professor Martin O Leach

  74. Computed Diffusion-weighted MR Imaging May Improve Tumor Detection

    Article • Radiology, November 2011, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  75. Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents

    Article • Cell Cycle, September 2011, Taylor & Francis

    Professor Martin O Leach

  76. Phase I Trial of a Selective c-MET Inhibitor ARQ 197 Incorporating Proof of Mechanism Pharmacodynamic Studies

    Article • Journal of Clinical Oncology, April 2011, American Society of Clinical Oncology (ASCO)

    Professor Martin O Leach

  77. Assessment of the effect of haematocrit-dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast-enhanced MRI

    Article • NMR in Biomedicine, February 2011, Wiley

    Professor Martin O Leach

  78. Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

    Article • Neoplasia, February 2011, Elsevier

    Professor Martin O Leach

  79. Psychological impact and acceptability of magnetic resonance imaging and X-ray mammography: the MARIBS Study

    Article • British Journal of Cancer, February 2011, Springer Science + Business Media

    Professor Martin O Leach

  80. A Bayesian hierarchical model for DCE-MRI to evaluate treatment response in a phase II study in advanced squamous cell carcinoma of the head and neck

    Article • Magnetic Resonance Materials in Physics Biology and Medicine, January 2011, Springer Science + Business Media

    Professor Martin O Leach

  81. Noninvasive detection of carboxypeptidase G2 activity in vivo

    Article • NMR in Biomedicine, October 2010, Wiley

    Professor Martin O Leach

  82. Dynamic contrast-enhanced MRI of neuroendocrine hepatic metastases: A feasibility study using a dual-input two-compartment model

    Article • Magnetic Resonance in Medicine, September 2010, Wiley

    Professor Martin O Leach

  83. The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

    Article • Cancer Research, June 2010, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  84. Robustness of interactive intensity thresholding based breast density assessment in MR-mammography

    Article • March 2010, SPIE

    Professor Martin O Leach

  85. Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

    Article • British Journal of Cancer, November 2009, Springer Science + Business Media

    Professor Martin O Leach

  86. A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

    Article • British Journal of Cancer, November 2009, Springer Science + Business Media

    Professor Martin O Leach

  87. Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

    Article • November 2009, Springer Science + Business Media

    Professor Martin O Leach

  88. Hyperpolarized 13 C magnetic resonance detection of carboxypeptidase G2 activity

    Article • Magnetic Resonance in Medicine, September 2009, Wiley

    Professor Martin O Leach

  89. Cancers in BRCA1 and BRCA2 Carriers and in Women at High Risk for Breast Cancer: MR Imaging and Mammographic Features 1

    Article • Radiology, August 2009, Radiological Society of North America (RSNA)

    Dr Anna Middleton, Professor Martin O Leach

  90. Motion artifact correction in free-breathing abdominal MRI using overlapping partial samples to recover image deformations

    Article • Magnetic Resonance in Medicine, August 2009, Wiley

    Professor Martin O Leach

  91. Phase-cycled averaging for the suppression of residual magnetisation in SPI sequences

    Article • Journal of Magnetic Resonance, August 2009, Elsevier

    Professor Martin O Leach

  92. Eligibility for Magnetic Resonance Imaging Screening in the United Kingdom: Effect of Strict Selection Criteria and Anonymous DNA Testing on Breast Cancer Incidence in the MARIBS Study

    Article • Cancer Epidemiology Biomarkers & Prevention, June 2009, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  93. Quantitative imaging biomarkers in neuro-oncology

    Article • Nature Reviews Clinical Oncology, June 2009, Springer Science + Business Media

    Professor Martin O Leach

  94. Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial

    Article • European Radiology, June 2009, Springer Science + Business Media

    Professor Martin O Leach

  95. A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using19F magnetic resonance spectroscopy

    Article • NMR in Biomedicine, June 2009, Wiley

    Professor Martin O Leach

  96. Modulation of choline kinase activity in human cancer cells observed by dynamic31P NMR

    Article • NMR in Biomedicine, May 2009, Wiley

    Professor Martin O Leach

  97. Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents

    Article • Contrast Media & Molecular Imaging, May 2009, Wiley

    Professor Martin O Leach

  98. An Exploratory Study Into the Role of Dynamic Contrast-Enhanced Magnetic Resonance Imaging or Perfusion Computed Tomography for Detection of Intratumoral Hypoxia in Head-and-Neck Cancer

    Article • International Journal of Radiation Oncology*Biology*Physics, May 2009, Elsevier

    Professor Martin O Leach

  99. Changes in choline metabolism as potential biomarkers of phospholipase C 1 inhibition in human prostate cancer cells

    Article • Molecular Cancer Therapeutics, May 2009, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  100. Optimizing functional parameter accuracy for breath-hold DCE-MRI of liver tumours

    Article • Physics in Medicine and Biology, March 2009, Institute of Physics Publishing

    Professor Martin O Leach

  101. Dynamic contrast-enhanced MRI for prostate cancer localization

    Article • British Journal of Radiology, February 2009, British Institute of Radiology

    Professor Martin O Leach

  102. Breast cancer screening in women at high risk using MRI

    Article • NMR in Biomedicine, January 2009, Wiley

    Professor Martin O Leach

  103. 80 POSTER Inhibition of MEK1/2 signalling results in decreased levels of intracellular lactate in human melanoma and colorectal cancer cells as observed with magnetic resonance spectroscopy

    Article • European Journal of Cancer Supplements, October 2008, Elsevier

    Professor Martin O Leach

  104. A Pilot Study of Compositional Analysis of the Breast and Estimation of Breast Mammographic Density Using Three-Dimensional T1-Weighted Magnetic Resonance Imaging

    Article • Cancer Epidemiology Biomarkers & Prevention, September 2008, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  105. The value of magnetic resonance spectroscopy in tumour imaging

    Article • Archives of Disease in Childhood, September 2008, BMJ

    Professor Martin O Leach

  106. Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

    Article • Neoplasia, April 2008, Elsevier

    Professor Martin O Leach

  107. Therapeutic Target Metabolism Observed Using Hyperpolarized15N Choline

    Article • Journal of the American Chemical Society, April 2008, American Chemical Society (ACS)

    Professor Martin O Leach

  108. Quantitative mapping of hepatic perfusion index using MR imaging: a potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor

    Article • European Radiology, March 2008, Springer Science + Business Media

    Professor Martin O Leach

  109. Computationally efficient vascular input function models for quantitative kinetic modelling using DCE-MRI

    Article • Physics in Medicine and Biology, February 2008, Institute of Physics Publishing

    Professor Martin O Leach

  110. Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination

    Article • European Radiology, January 2008, Springer Science + Business Media

    Professor Martin O Leach

  111. BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials

    Article • Clinical Cancer Research, December 2007, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  112. Distortion-correctedT2weighted MRI: a novel approach to prostate radiotherapy planning

    Article • British Journal of Radiology, November 2007, British Institute of Radiology

    Professor Martin O Leach

  113. Registration of dynamic contrast-enhanced MRI using a progressive principal component registration (PPCR)

    Article • Physics in Medicine and Biology, August 2007, Institute of Physics Publishing

    Professor Martin O Leach

  114. Multiscale analysis of MR-mammography data

    Article • Zeitschrift für Medizinische Physik, August 2007, Elsevier

    Professor Martin O Leach

  115. Selective homonuclear Hartmann–Hahn for13C→13C polarization transfer in solution state NMR

    Article • Molecular Physics, July 2007, Taylor & Francis

    Professor Martin O Leach

  116. EU Directive 2004/40: field measurements of a 1.5 T clinical MR scanner

    Article • British Journal of Radiology, June 2007, British Institute of Radiology

    Professor Martin O Leach

  117. Bayesian estimation of pharmacokinetic parameters for DCE-MRI with a robust treatment of enhancement onset time

    Article • Physics in Medicine and Biology, April 2007, Institute of Physics Publishing

    Professor Martin O Leach

  118. Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion Coefficients

    Article • American Journal of Roentgenology, April 2007, American Roentgen Ray Society

    Professor Martin O Leach

  119. Quantitative evaluation of free-form deformation registration for dynamic contrast-enhanced MR mammography

    Article • Medical Physics, March 2007, Wiley

    Professor Martin O Leach

  120. Reference tissue quantification of DCE-MRI data without a contrast agent calibration

    Article • Physics in Medicine and Biology, January 2007, Institute of Physics Publishing

    Professor Martin O Leach

  121. Conformational exchange in pimonidazole—a hypoxia marker

    Article • Magnetic Resonance in Chemistry, January 2007, Wiley

    Professor Martin O Leach

  122. Dynamic MRI for imaging tumor microvasculature: Comparison of susceptibility and relaxivity techniques in pelvic tumors

    Article • Journal of Magnetic Resonance Imaging, January 2007, Wiley

    Professor Martin O Leach

  123. Measurements of occupational exposure to switched gradient and spatially-varying magnetic fields in areas adjacent to 1.5T clinical MRI systems

    Article • Journal of Magnetic Resonance Imaging, January 2007, Wiley

    Professor Martin O Leach

  124. Reproducibility of reference tissue quantification of dynamic contrast-enhanced data: comparison with a fixed vascular input function

    Article • Physics in Medicine and Biology, December 2006, Institute of Physics Publishing

    Professor Martin O Leach

  125. Cost-effectiveness of screening with contrast enhanced magnetic resonance imaging vs X-ray mammography of women at a high familial risk of breast cancer

    Article • British Journal of Cancer, October 2006, Springer Science + Business Media

    Professor Martin O Leach

  126. A test of performance of breast MRI interpretation in a multicentre screening study

    Article • Magnetic Resonance Imaging, September 2006, Elsevier

    Professor Martin O Leach

  127. Applications of magnetic resonance spectroscopy in radiotherapy treatment planning

    Article • British Journal of Radiology, September 2006, British Institute of Radiology

    Professor Martin O Leach

  128. MRI for breast cancer screening

    Article • Annals of Oncology, September 2006, Oxford University Press (OUP)

    Professor Martin O Leach

  129. Evaluation of response to treatment using DCE-MRI: the relationship between initial area under the gadolinium curve (IAUGC) and quantitative pharmacokinetic analysis

    Article • Physics in Medicine and Biology, July 2006, Institute of Physics Publishing

    Professor Martin O Leach

  130. Magnetic resonance spectroscopy (MRS) in the investigation of cancer at The Royal Marsden Hospital and The Institute of Cancer Research

    Article • Physics in Medicine and Biology, June 2006, Institute of Physics Publishing

    Professor Martin O Leach

  131. Factors influencing the accuracy of biomechanical breast models

    Article • Medical Physics, May 2006, Wiley

    Professor Martin O Leach

  132. Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging

    Article • European Radiology, May 2006, Springer Science + Business Media

    Professor Martin O Leach

  133. Minimally Invasive Pharmacokinetic and Pharmacodynamic Technologies in Hypothesis-Testing Clinical Trials of Innovative Therapies

    Article • JNCI Journal of the National Cancer Institute, May 2006, Oxford University Press (OUP)

    Professor Martin O Leach

  134. Prediction of Clinicopathologic Response of Breast Cancer to Primary Chemotherapy at Contrast-enhanced MR Imaging: Initial Clinical Results

    Article • Radiology, May 2006, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  135. Magnetic Resonance Imaging Workbench: Analysis and Visualization of Dynamic Contrast-enhanced MR Imaging Data

    Article • Radiographics, March 2006, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  136. Application of the chirp z-transform to MRI data

    Article • Journal of Magnetic Resonance, January 2006, Elsevier

    Professor Martin O Leach

  137. Evaluation of31P high-resolution magic angle spinning of intact tissue samples

    Article • NMR in Biomedicine, January 2006, Wiley

    Professor Martin O Leach

  138. Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

    Article • Molecular Cancer Therapeutics, January 2006, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  139. In vivo31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial

    Article • NMR in Biomedicine, January 2006, Wiley

    Professor Martin O Leach

  140. Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

    Article • Cancer Research, January 2006, American Association for Cancer Research (AACR)

    Professor Martin O Leach

  141. Electromagnetic field exposure limitation and the future of MRI

    Article • British Journal of Radiology, November 2005, British Institute of Radiology

    Professor Martin O Leach

  142. Inversion recovery measurements in the presence of radiation damping and implications for evaluating contrast agents in magnetic resonance

    Article • Physics in Medicine and Biology, November 2005, Institute of Physics Publishing

    Professor Martin O Leach

  143. A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points

    Article • British Journal of Cancer, October 2005, Springer Science + Business Media

    Professor Martin O Leach

  144. Adiabatic half-passage pulses for measuring the polarization of highly non-equilibrium spin-systems

    Article • Chemical Physics Letters, October 2005, Elsevier

    Professor Martin O Leach

  145. Effects of platinum/taxane based chemotherapy on acute perfusion in human pelvic tumours measured by dynamic MRI

    Article • British Journal of Cancer, October 2005, Springer Science + Business Media

    Professor Martin O Leach

  146. Localized COSY and DQF-COSY1H-MRS sequences for investigating human tibial bone marrow in vivo and initial application to patients with acute leukemia

    Article • Journal of Magnetic Resonance Imaging, October 2005, Wiley

    Professor Martin O Leach

  147. Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

    Article • Physics in Medicine and Biology, September 2005, Institute of Physics Publishing

    Dr. Karl Zilles, Professor Martin O Leach

  148. Evaluation of radiological features for breast tumour classification in clinical screening with machine learning methods

    Article • Artificial Intelligence in Medicine, June 2005, Elsevier

    Professor Martin O Leach

  149. A complete distortion correction for MR images: II. Rectification of static-field inhomogeneities by similarity-based profile mapping

    Article • Physics in Medicine and Biology, May 2005, Institute of Physics Publishing

    Professor Martin O Leach

  150. Identification of biliary metabolites of ifosfamide using 31P magnetic resonance spectroscopy and mass spectrometry

    Article • Cancer Chemotherapy and Pharmacology, May 2005, Springer Science + Business Media

    Professor Martin O Leach

  151. Processing of radical prostatectomy specimens for correlation of data from histopathological, molecular biological, and radiological studies: a new whole organ technique

    Article • Journal of Clinical Pathology, May 2005, BMJ

    Professor Martin O Leach

  152. Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

    Article • The Lancet, May 2005, Elsevier

    Professor Martin O Leach

  153. The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

    Article • British Journal of Cancer, May 2005, Springer Science + Business Media

    Professor Martin O Leach

  154. A complete distortion correction for MR images: I. Gradient warp correction

    Article • Physics in Medicine and Biology, March 2005, Institute of Physics Publishing

    Professor Martin O Leach

  155. Antivascular cancer treatments: functional assessments by dynamic contrast-enhanced magnetic resonance imaging

    Article • Abdominal Imaging, February 2005, Springer Science + Business Media

    Professor Martin O Leach

  156. Proceedings of the Engineering and Physical Sciences Research Council Workshop—the development of functional imaging in the diagnosis, management and understanding of childhood brain tumours

    Article • Pediatric Blood & Cancer, February 2005, Wiley

    Professor Martin O Leach

  157. Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivo19F magnetic resonance spectroscopy

    Article • British Journal of Clinical Pharmacology, February 2005, Wiley

    Professor Martin O Leach

  158. Burst imaging—Can it ever be useful in the clinic?

    Article • Concepts in Magnetic Resonance Part A, January 2005, Wiley

    Professor Martin O Leach

  159. Implementation and evaluation of CSI-localizedJ cross-polarization for detection of31P magnetic resonance spectra in vivo

    Article • Magnetic Resonance in Medicine, January 2005, Wiley

    Professor Martin O Leach

  160. Micro-coils for MR spectroscopy by deep silicon etching

    Article • Journal of Physics Conference Series, January 2005, Institute of Physics Publishing

    Professor Martin O Leach

  161. Notices of Duplicate Publication

    Article • Radiology, December 2004, Radiological Society of North America (RSNA)

    Professor Martin O Leach

  162. Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours

    Article • Cancer Chemotherapy and Pharmacology, October 2004, Springer Science + Business Media

    Professor Martin O Leach

  163. Methodological standardization for a multi-institutionalin vivo trial of localized31P MR spectroscopy in human cancer research.In vitro and normal volunteer studies

    Article • NMR in Biomedicine, September 2004, Wiley

    Professor Martin O Leach

  164. Investigation of microenvironmental factors influencing the longitudinal relaxation times of drugs and other compounds

    Article • Magnetic Resonance Imaging, September 2004, Elsevier

    Professor Martin O Leach

  165. Alignment of dynamic contrast-enhanced MR volumes of the breast for a multicenter trial: an exemplar grid application

    Article • May 2004, SPIE

    Professor Martin O Leach

  166. Multiscale entropy analysis in dynamic contrast-enhanced MRI

    Article • May 2004, SPIE

    Professor Martin O Leach

  167. Visualization of multivariate image data using image fusion and perceptually optimized color scales based on sRGB

    Article • May 2004, SPIE

    Professor Martin O Leach

  168. Effects of residual single-quantum coherences in intermolecular multiple-quantum coherence studies

    Article • Journal of Magnetic Resonance, February 2004, Elsevier

    Professor Martin O Leach

  169. Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy

    Article • British Journal of Cancer, February 2004, Springer Science + Business Media

    Professor Martin O Leach

  170. Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials

    Article • British Journal of Radiology, December 2003, British Institute of Radiology

    Professor Martin O Leach

  171. Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Heat Shock Protein 90 Inhibitor 17-Allylamino,17-Demethoxygeldanamycin (17AAG) in Human Colon Cancer Models

    Article • JNCI Journal of the National Cancer Institute, November 2003, Oxford University Press (OUP)

    Professor Martin O Leach

  172. Comparison of polarization transfer sequences for enhancement of signals in clinical31P MRS studies

    Article • Magnetic Resonance in Medicine, August 2003, Wiley

    Professor Martin O Leach

  173. Ifosfamide pharmacokinetics and hepatobiliary uptake in vivo investigated using single- and double-resonance31P MRS

    Article • Magnetic Resonance in Medicine, July 2003, Wiley

    Professor Martin O Leach

  174. Could assessment of glioma methylene lipid resonance byin vivo1H-MRS be of clinical value?

    Article • British Journal of Radiology, July 2003, British Institute of Radiology

    Professor Martin O Leach

  175. Non-invasive study of human gall bladder bilein vivousing1H-MR spectroscopy

    Article • British Journal of Radiology, July 2003, British Institute of Radiology

    Professor Martin O Leach

  176. Hyperpolarising 13C for NMR studies using laser-polarised 129Xe: SPINOE vs thermal mixing

    Article • Chemical Physics Letters, April 2003, Elsevier

    Professor Martin O Leach

  177. Radiotherapy treatment planning of prostate cancer using magnetic resonance imaging alone

    Article • Radiotherapy and Oncology, February 2003, Elsevier

    Professor Martin O Leach

  178. Validation of nonrigid image registration using finite-element methods: application to breast MR images

    Article • IEEE Transactions on Medical Imaging, February 2003, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Martin O Leach

  179. Comparison of biomechanical breast models: a case study

    Article • May 2002, SPIE

    Professor Martin O Leach

  180. Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography

    Article • May 2002, SPIE

    Professor Martin O Leach

  181. Human rectal adenocarcinoma: Demonstration of1H-MR spectra in vivo at 1.5 T

    Article • Magnetic Resonance in Medicine, March 2002, Wiley

    Professor Martin O Leach

  182. Applications of sliding window reconstruction with cartesian sampling for dynamic contrast enhanced MRI

    Article • NMR in Biomedicine, January 2002, Wiley

    Professor Martin O Leach

  183. Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging

    Article • NMR in Biomedicine, January 2002, Wiley

    Professor Martin O Leach

  184. Reproducibility of quantitative dynamic MRI of normal human tissues

    Article • NMR in Biomedicine, January 2002, Wiley

    Professor Martin O Leach

  185. Comparison and evaluation of rigid and nonrigid registration of breast MR images

    Article • May 1999, SPIE

    Professor Martin O Leach

  186. Focused ultrasound surgery-induced vascular occlusion in fetal medicine

    Article • April 1998, SPIE

    Professor Martin O Leach

  187. Visual detectability of elastic contrast in real-time ultrasound images

    Article • April 1997, SPIE

    Professor Martin O Leach