All Stories

  1. Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis

    Article • American Journal of Respiratory and Critical Care Medicine, November 2023, American Thoracic Society

    Dr. Mark Murphy

  2. Effect of elexacaftor/tezacaftor/ivacaftor on airway and systemic inflammation in cystic fibrosis

    Article • Thorax, May 2023, BMJ

    Dr. Mark Murphy

  3. A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19

    Article • Med, April 2022, Elsevier

    Dr. Mark Murphy

  4. Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

    Article • EBioMedicine, March 2022, Elsevier

    Dr. Mark Murphy

  5. Attitudes Towards Vaccination for Coronavirus Disease 2019 in Patients with Severe Alpha-1 Antitrypsin Deficiency

    Article • Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation, January 2022, COPD Foundation

    Dr. Mark Murphy

  6. C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

    Article • Biomedicines, December 2021, MDPI AG

    Dr. Mark Murphy

  7. In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin

    Article • ERJ Open Research, September 2021, European Respiratory Society (ERS)

    Dr. Mark Murphy

  8. Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

    Article • Medicina, August 2021, MDPI AG

    Dr. Mark Murphy

  9. Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

    Article • Frontiers in Immunology, December 2020, Frontiers

    Dr. Mark Murphy

  10. Characterization of the Inflammatory Response to Severe COVID-19 Illness

    Article • American Journal of Respiratory and Critical Care Medicine, September 2020, American Thoracic Society

    Dr. Mark Murphy

  11. Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis

    Article • Frontiers in Pharmacology, July 2020, Frontiers

    Dr. Mark Murphy

  12. Clinical presentation and immune characteristics in first-lactation Holstein-Friesian cows following intramammary infection with genotypically distinct Staphylococcus aureus strains

    Article • Journal of Dairy Science, July 2020, American Dairy Science Association

    Dr. Mark Murphy

  13. α1 Antitrypsin therapy modulates the neutrophil membrane proteome and secretome

    Article • European Respiratory Journal, February 2020, European Respiratory Society (ERS)

    Dr. Mark Murphy

  14. Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency

    Article • Thorax, January 2020, BMJ

    Dr. Mark Murphy, Associate Professor Cormac McCarthy

  15. Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency

    Article • Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation, January 2020, COPD Foundation

    Dr. Mark Murphy

  16. Targeting airway inflammation in cystic fibrosis

    Article • Expert Review of Respiratory Medicine, October 2019, Taylor & Francis

    Oliver McElvaney, Noel G McElvaney, Dr. Mark Murphy, Patricia Wade

  17. The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Dr. Mark Murphy

  18. EHS matrix incubated in media containing penicillin retains sufficient concentrations of antibiotic to inhibit growth of susceptible microorganisms

    Article • Journal of Microbiological Methods, August 2017, Elsevier

    Dr. Mark Murphy

  19. Current and Emerging Therapies for the Treatment of Cystic Fibrosis or Mitigation of Its Symptoms

    Article • Drugs in R&D, January 2016, Springer Science + Business Media

    Dr. Mark Murphy

  20. Residence in biofilms allows Burkholderia cepacia complex (Bcc) bacteria to evade the anti-microbial activities of neutrophil-like dHL60 cells

    Article • Pathogens and Disease, September 2015, Oxford University Press (OUP)

    Dr. Mark Murphy

  21. Mcl-1 is vital for neutrophil survival

    Article • Immunologic Research, May 2015, Springer Science + Business Media

    Dr. Mark Murphy

  22. Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review

    Article • Drug Resistance Updates, June 2011, Elsevier

    Dr. Mark Murphy