All Stories

  1. Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration

    Article • Pharmaceutics, December 2022, MDPI AG

    Prof. Maria Vilanova

  2. A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells

    Article • Cancers, August 2021, MDPI AG

    Prof. Maria Vilanova

  3. The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27KIP1

    Article • Molecules, March 2021, MDPI AG

    Prof. Maria Vilanova

  4. Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents

    Article • Pharmaceutics, January 2021, MDPI AG

    Prof. Maria Vilanova

  5. Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases

    Article • Molecules, December 2018, MDPI AG

    Prof. Maria Vilanova

  6. Apoptin, A Versatile Protein with Selective Antitumor Activity

    Article • Current Medicinal Chemistry, September 2018, Bentham Science Publishers

    Prof. Maria Vilanova

  7. Structural Insights into Subunits Assembly and the Oxyester Splicing Mechanism of Neq pol Split Intein

    Article • Cell Chemical Biology, July 2018, Elsevier

    Prof. Maria Vilanova

  8. A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties

    Article • Journal of Inorganic Biochemistry, May 2018, Elsevier

    Prof. Maria Vilanova

  9. Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

    Article • OncoTargets and Therapy, January 2018, Dove Medical Press

    Prof. Maria Vilanova

  10. A truncated apoptin protein variant selectively kills cancer cells

    Article • Investigational New Drugs, January 2017, Springer Science + Business Media

    Prof. Maria Vilanova

  11. Insights into the mechanism of Apoptin's exquisitely selective anti-tumor action from atomic level characterization of its conformation and dynamics

    Article • Archives of Biochemistry and Biophysics, January 2017, Elsevier

    Prof. Maria Vilanova

  12. Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Prof. Maria Vilanova

  13. Approaches to Endow Ribonucleases with Antitumor Activity: Lessons Learned from the Native Cytotoxic Ribonucleases

    Article • December 2016, IntechOpen

    Prof. Maria Vilanova

  14. Structural investigation of ribonuclease A conformational preferences using high pressure protein crystallography

    Article • Chemical Physics, April 2016, Elsevier

    Prof. Maria Vilanova

  15. A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Prof. Maria Vilanova

  16. Investigating the effects of double mutation C30A/C75A on onconase structure: Studies at atomic resolution

    Article • Biopolymers, February 2014, Wiley

    Prof. Maria Vilanova

  17. Towards Tricking a Pathogen’s Protease into Fighting Infection: The 3D Structure of a Stable Circularly Permuted Onconase Variant Cleavedby HIV-1 Protease

    Article • PLoS ONE, January 2013, PLOS

    Prof. Maria Vilanova

  18. Zymogen-FLG of the onconase

    Article • October 2012, Protein Data Bank, Rutgers University

    Prof. Maria Vilanova

  19. Generation of New Cytotoxic Human Ribonuclease Variants Directed to the Nucleus

    Article • Molecular Pharmaceutics, September 2012, American Chemical Society (ACS)

    Prof. Maria Vilanova

  20. 1H, 13C and 15N resonance assignments of the Onconase FL-G zymogen

    Article • Biomolecular NMR Assignments, March 2012, Springer Science + Business Media

    Prof. Maria Vilanova

  21. Interactions Crucial for Three-Dimensional Domain Swapping in the HP-RNase Variant PM8

    Article • Biophysical Journal, July 2011, Elsevier

    Prof. Maria Vilanova

  22. A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines

    Article • Investigational New Drugs, February 2011, Springer Science + Business Media

    Prof. Maria Vilanova

  23. Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers

    Article • Archives of Biochemistry and Biophysics, February 2011, Elsevier

    Prof. Maria Vilanova

  24. A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation

    Article • BMC Cancer, January 2011, Springer Science + Business Media

    Prof. Maria Vilanova

  25. Antitumor Ribonucleases

    Article • January 2011, Springer Science + Business Media

    Prof. Maria Vilanova

  26. The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity

    Article • Investigational New Drugs, March 2010, Springer Science + Business Media

    Prof. Maria Vilanova

  27. NMR Spectroscopy Reveals that RNase A is Chiefly Denatured in 40% Acetic Acid: Implications for Oligomer Formation by 3D Domain Swapping

    Article • Journal of the American Chemical Society, January 2010, American Chemical Society (ACS)

    Prof. Maria Vilanova

  28. ChemInform Abstract: Asymmetric Kinetics of Protein Structural Changes

    Article • ChemInform, September 2009, Wiley

    Prof. Maria Vilanova

  29. Ribonucleases directed to the nucleus as a novel proapoptotic anticancer strategy

    Article • New Biotechnology, September 2009, Elsevier

    Prof. Maria Vilanova

  30. Carbodiimide EDC Induces Cross-Links That Stabilize RNase A C-Dimer against Dissociation: EDC Adducts Can Affect Protein Net Charge, Conformation, and Activity

    Article • Bioconjugate Chemistry, July 2009, American Chemical Society (ACS)

    Prof. Maria Vilanova

  31. Asymmetric Kinetics of Protein Structural Changes

    Article • Accounts of Chemical Research, June 2009, American Chemical Society (ACS)

    Prof. Maria Vilanova

  32. X-ray crystallographic studies of RNase A variants engineered at the most destabilizing positions of the main hydrophobic core: Further insight into protein stability

    Article • Proteins Structure Function and Bioinformatics, May 2009, Wiley

    Prof. Maria Vilanova

  33. Mapping the stability clusters in bovine pancreatic ribonuclease A

    Article • Biopolymers, April 2009, Wiley

    Prof. Maria Vilanova

  34. Bactericidal Activity Engineered on Human Pancreatic Ribonuclease and Onconase†

    Article • Molecular Pharmaceutics, April 2009, American Chemical Society (ACS)

    Prof. Maria Vilanova

  35. The Structural Determinants that Lead to the Formation of Particular Oligomeric Structures in the Pancreatic-Type Ribonuclease Family

    Article • Current Protein and Peptide Science, August 2008, Bentham Science Publishers

    Prof. Maria Vilanova

  36. Intracellular Routing of Cytotoxic Pancreatic-Type Ribonucleases

    Article • Current Pharmaceutical Biotechnology, June 2008, Bentham Science Publishers

    Prof. Maria Vilanova

  37. Distinct Unfolding and Refolding Pathways of Ribonuclease A Revealed by Heating and Cooling Temperature Jumps

    Article • Biophysical Journal, May 2008, Elsevier

    Prof. Maria Vilanova

  38. Destabilizing Mutations Alter the Hydrogen Exchange Mechanism in Ribonuclease A

    Article • Biophysical Journal, March 2008, Elsevier

    Prof. Maria Vilanova

  39. Human pancreatic ribonuclease presents higher endonucleolytic activity than ribonuclease A

    Article • Archives of Biochemistry and Biophysics, March 2008, Elsevier

    Prof. Maria Vilanova

  40. Contribution of the C30/C75 disulfide bond to the biological properties of onconase

    Article • Biological Chemistry, January 2008, De Gruyter

    Prof. Maria Vilanova

  41. Intracellular pathway of Onconase that enables its delivery to the cytosol

    Article • Journal of Cell Science, April 2007, The Company of Biologists

    Prof. Maria Vilanova

  42. Thermal unfolding of eosinophil cationic protein/ribonuclease 3: A nonreversible process

    Article • Protein Science, December 2006, Wiley

    Prof. Maria Vilanova

  43. Pressure-Jump-Induced Kinetics Reveals a Hydration Dependent Folding/Unfolding Mechanism of Ribonuclease A

    Article • Biophysical Journal, September 2006, Elsevier

    Prof. Maria Vilanova

  44. A Cytotoxic Ribonuclease Variant with a Discontinuous Nuclear Localization Signal Constituted by Basic Residues Scattered Over Three Areas of the Molecule

    Article • July 2006, Elsevier

    Prof. Maria Vilanova

  45. The contribution of the residues from the main hydrophobic core of ribonuclease A to its pressure-folding transition state

    Article • Protein Science, May 2006, Wiley

    Prof. Maria Vilanova

  46. Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer .

    Article • Journal of Biological Chemistry, April 2006, Elsevier

    Prof. Maria Vilanova

  47. Characterization of the dimerization process of a domain-swapped dimeric variant of human pancreatic ribonuclease

    Article • FEBS Journal, March 2006, Wiley

    Prof. Maria Vilanova

  48. Pressure as a tool to study protein-unfolding/refolding processes: The case of ribonuclease A

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2006, Elsevier

    Prof. Maria Vilanova

  49. The use of pressure-jump relaxation kinetics to study protein folding landscapes

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2006, Elsevier

    Prof. Maria Vilanova

  50. Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A

    Article • Biological Chemistry, January 2006, De Gruyter

    Prof. Maria Vilanova

  51. On the track of antitumour ribonucleases

    Article • Molecular BioSystems, January 2005, Royal Society of Chemistry

    Prof. Maria Vilanova

  52. Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation process of onconase

    Article • European Journal of Biochemistry, February 2004, Wiley

    Prof. Maria Vilanova

  53. A Nuclear Localization Sequence Endows Human Pancreatic Ribonuclease with Cytotoxic Activity

    Article • Biochemistry, February 2004, American Chemical Society (ACS)

    Prof. Maria Vilanova

  54. Exploring the Energy Landscape of Protein Unfolding under High Pressure

    Article • January 2003, Springer Science + Business Media

    Prof. Maria Vilanova

  55. Stabilization of human pancreatic ribonuclease through mutation at its N-terminal edge

    Article • Protein Engineering Design and Selection, November 2002, Oxford University Press (OUP)

    Prof. Maria Vilanova

  56. The Structure of an Engineered Domain-Swapped Ribonuclease Dimer and Its Implications for the Evolution of Proteins toward Oligomerization

    Article • Structure, October 2001, Elsevier

    Prof. Maria Vilanova

  57. Pressure versus temperature unfolding of ribonuclease A: An FTIR spectroscopic characterization of 10 variants at the carboxy-terminal site

    Article • Protein Science, April 2001, Wiley

    Prof. Maria Vilanova

  58. Purification of Engineered Human Pancreatic Ribonuclease

    Article • January 2001, Elsevier

    Prof. Maria Vilanova

  59. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases

    Article • Journal of Molecular Biology, October 2000, Elsevier

    Prof. Maria Vilanova

  60. Pressure versus Heat-Induced Unfolding of Ribonuclease A:  The Case of Hydrophobic Interactions within a Chain-Folding Initiation Site†

    Article • Biochemistry, November 1999, American Chemical Society (ACS)

    Prof. Maria Vilanova

  61. Valine 108, a Chain-Folding Initiation Site-Belonging Residue, Crucial for the Ribonuclease A Stability

    Article • Biochemical and Biophysical Research Communications, November 1999, Elsevier

    Prof. Maria Vilanova

  62. Production of Engineered Human Pancreatic Ribonucleases, Solving Expression and Purification Problems, and Enhancing Thermostability

    Article • Protein Expression and Purification, October 1999, Elsevier

    Prof. Maria Vilanova

  63. The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A

    Article • Cellular and Molecular Life Sciences, August 1998, Springer Science + Business Media

    Prof. Maria Vilanova

  64. Pancreatic Ribonucleases

    Article • January 1997, Elsevier

    Prof. Maria Vilanova

  65. Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, November 1995, Elsevier

    Prof. Maria Vilanova

  66. Analysis of the thermal unfolding of porcine procarboxypeptidase A and its functional pieces by differential scnning calorimetry

    Article • European Journal of Biochemistry, September 1988, Wiley

    Prof. Maria Vilanova

  67. Conformational predictive studies on the activation seoment of pancreatic procarboxypeptidases

    Article • Biochemical and Biophysical Research Communications, December 1987, Elsevier

    Prof. Maria Vilanova

  68. Urea-gradient gel electrophoresis studies on the association of procarboxypeptidases A and B, proproteinase E, and their tryptic activation products

    Article • FEBS Letters, October 1985, Wiley

    Prof. Maria Vilanova

  69. The activation segment of procarboxypeptidase A from porcine pancreas constitutes a folded structural domain

    Article • FEBS Letters, November 1982, Wiley

    Prof. Maria Vilanova

  70. The severed activation segment of porcine pancreatic procarboxypeptidase a is a powerful inhibitor of the active enzyme Isolation and characterisation of the activation peptide

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, September 1982, Elsevier

    Prof. Maria Vilanova