All Stories

  1. Elevated MANF expression in β cells protects mice from streptozotocin-induced diabetes by attenuating islet stress and immunogenicity

    Article • Molecular Therapy, June 2026, Elsevier

    Dr. Maria Lindahl

  2. Modulation of the unfolded protein response with a C-terminal fragment of MANF facilitates recovery in models of multiple sclerosis

    Article • Molecular Therapy, February 2026, Elsevier

    Dr. Maria Lindahl

  3. Mesencephalic Astrocyte-Derived Neurotrophic Factor Orchestrates Endoplasmic Reticulum (ER)-Mitochondrial Calcium Homeostasis in Genetic CKD

    Article • Journal of the American Society of Nephrology, October 2025, Wolters Kluwer Health

    Dr. Maria Lindahl

  4. Stereocilia fusion pathology in the cochlear outer hair cells at the nanoscale level

    Article • The Journal of Physiology, July 2024, Wiley

    Dr. Maria Lindahl

  5. MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

    Article • Acta Neuropathologica Communications, January 2024, Springer Science + Business Media

    Dr. Maria Lindahl

  6. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Stimulates Autophagy and Restores Mitochondrial Homeostasis to Treat Uromodulin-Associated Nephropathy

    Article • Journal of the American Society of Nephrology, November 2023, Wolters Kluwer Health

    Dr. Maria Lindahl

  7. MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

    Article • Nature Communications, October 2023, Springer Science + Business Media

    Dr. Maria Lindahl

  8. Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

    Article • Cell Death and Disease, February 2023, Springer Science + Business Media

    Associate Professor Cheng-Yoong Pang, Li-Chuan Huang, Dr. Maria Lindahl

  9. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival

    Article • International Journal of Molecular Sciences, August 2022, MDPI AG

    Dr. Maria Lindahl

  10. CDNF and MANF regulate ER stress in a tissue-specific manner

    Article • Cellular and Molecular Life Sciences, February 2022, Springer Science + Business Media

    Dr. Maria Lindahl

  11. The overexpression of GDNF in nucleus accumbens suppresses alcohol-seeking behavior in group-housed C57Bl/6J female mice

    Article • Journal of Biomedical Science, December 2021, Springer Science + Business Media

    Dr. Maria Lindahl

  12. MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea

    Article • Life Science Alliance, November 2021, Life Science Alliance, LLC

    Dr. Maria Lindahl

  13. Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

    Article • Diabetes, January 2021, American Diabetes Association

    Dr. Maria Lindahl

  14. Neuroplastin Modulates Anti-inflammatory Effects of MANF

    Article • iScience, December 2020, Elsevier

    Dr. Maria Lindahl

  15. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit

    Article • The Journal of Comparative Neurology, March 2020, Wiley

    Dr. Maria Lindahl

  16. Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

    Article • Cell Death and Disease, February 2020, Springer Science + Business Media

    Dr. Bernd Fritzsch, Dr. Maria Lindahl

  17. Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice

    Article • Neurobiology of Disease, February 2020, Elsevier

    Dr. Maria Lindahl

  18. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

    Article • eNeuro, January 2020, Society for Neuroscience

    Dr. Maria Lindahl

  19. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function

    Article • Frontiers in Endocrinology, November 2019, Frontiers

    Dr. Maria Lindahl

  20. Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

    Article • Proceedings of the National Academy of Sciences, June 2019, Proceedings of the National Academy of Sciences

    Dr. Maria Lindahl

  21. Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in Mice

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2019, Elsevier

    Dr. Maria Lindahl

  22. Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes

    Article • Frontiers in Physiology, October 2018, Frontiers

    Dr. Maria Lindahl

  23. MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice

    Article • Diabetes, October 2018, American Diabetes Association

    Dr. Maria Lindahl

  24. MANF protects human pancreatic beta cells against stress-induced cell death

    Article • Diabetologia, July 2018, Springer Science + Business Media

    Dr. Maria Lindahl

  25. Poststroke delivery of MANF promotes functional recovery in rats

    Article • Science Advances, May 2018, American Association for the Advancement of Science

    Dr. Maria Lindahl

  26. MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

    Article • Molecular Therapy, January 2018, Elsevier

    Dr. Maria Lindahl

  27. MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex

    Article • eNeuro, September 2017, Society for Neuroscience

    Dr. Maria Lindahl

  28. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

    Article • Journal of Biological Chemistry, July 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Maria Lindahl

  29. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

    Article • eNeuro, January 2017, Society for Neuroscience

    Dr. Maria Lindahl

  30. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

    Article • Neurobiology of Disease, January 2017, Elsevier

    Dr. Maria Lindahl

  31. Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Dr. Maria Lindahl

  32. Mesencephalic Astrocyte–Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress–Related Kidney Diseases

    Article • Journal of the American Society of Nephrology, March 2016, American Society of Nephrology

    Dr. Maria Lindahl

  33. GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

    Article • PLoS Genetics, December 2015, PLOS

    Dr. Maria Lindahl

  34. MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

    Article • Cell Reports, April 2014, Elsevier

    Dr. Maria Lindahl

  35. CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery after MPTP Treatment in Mice

    Article • Cell Transplantation, June 2012, SAGE Publications

    Dr. Maria Lindahl

  36. Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease

    Article • Molecular and Cellular Neuroscience, July 2010, Elsevier

    Dr. Maria Lindahl

  37. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

    Article • Nature, July 2007, Springer Science + Business Media

    Dr. Maria Lindahl

  38. Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats

    Article • Molecular Therapy, December 2006, Nature

    Dr GONZALO FLORES, Dr. Maria Lindahl

  39. Ablation of Persephin Receptor Glial Cell Line-Derived Neurotrophic Factor Family Receptor α4 Impairs Thyroid Calcitonin Production in Young Mice

    Article • Endocrinology, May 2006, Endocrine Society

    Dr. Maria Lindahl

  40. PSPN/GFRα4 has a significantly weaker capacity than GDNF/GFRα1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth

    Article • FEBS Letters, June 2004, Wiley

    Dr. Maria Lindahl

  41. Human Glial Cell Line-derived Neurotrophic Factor Receptor α4 Is the Receptor for Persephin and Is Predominantly Expressed in Normal and Malignant Thyroid Medullary Cells

    Article • Journal of Biological Chemistry, December 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Maria Lindahl

  42. Expression and Alternative Splicing of Mouse Gfra4 Suggest Roles in Endocrine Cell Development

    Article • Molecular and Cellular Neuroscience, June 2000, Elsevier

    Dr. Maria Lindahl

  43. Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF

    Article • Science, February 2000, American Association for the Advancement of Science

    Dr. Maria Lindahl

  44. GDNF triggers a novel Ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor α1

    Article • FEBS Letters, December 1999, Wiley

    Dr. Maria Lindahl

  45. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha

    Article • Human Molecular Genetics, August 1997, Oxford University Press (OUP)

    Dr. Maria Lindahl