All Stories

  1. Allosteric ensembles elucidate mechanisms of inhibition in the human soluble epoxide hydrolase

    Article • Communications Biology, May 2026, Springer Science + Business Media

    Prof Maria Rosaria Conte

  2. Germline sequence variation within the ribosomal DNA is associated with human complex traits

    Article • Cell Genomics, April 2026, Elsevier

    Prof Maria Rosaria Conte

  3. An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6

    Article • Nature Communications, February 2026, Springer Science + Business Media

    Prof Maria Rosaria Conte

  4. Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

    Article • December 2025, Springer Science + Business Media

    Prof Maria Rosaria Conte

  5. Dimethoxybenzohomoadamantane-based soluble epoxide hydrolase inhibitors: in vivo efficacy in a murine model of chemotherapy-induced neuropathic pain

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, October 2025, Taylor & Francis

    Prof Maria Rosaria Conte

  6. Erratum to “Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial” [J Infect 91 (2025) 106504]

    Article • Journal of Infection, September 2025, Elsevier

    Prof Maria Rosaria Conte

  7. Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial

    Article • Journal of Infection, July 2025, Elsevier

    Prof Maria Rosaria Conte

  8. The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation

    Article • Nucleic Acids Research, January 2025, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  9. The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Prof Maria Rosaria Conte

  10. Meeting reports

    Article • The Biochemist, October 2024, Portland Press Ltd.

    Prof Maria Rosaria Conte

  11. An intrinsically disordered RNA-binding region provides local target selectivity and is essential for LARP6 function

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Prof Maria Rosaria Conte

  12. The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis

    Article • iScience, April 2024, Elsevier

    Prof Maria Rosaria Conte

  13. The metabolic effects of intermittent versus continuous feeding in critically ill patients

    Article • Scientific Reports, November 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  14. LARP4A and LARP4B in cancer: The new kids on the block

    Article • The International Journal of Biochemistry & Cell Biology, August 2023, Elsevier

    Prof Maria Rosaria Conte

  15. AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

    Article • Nature Communications, May 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  16. Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition

    Article • Scientific Reports, January 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  17. Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach

    Article • Journal of Molecular Biology, April 2022, Elsevier

    Prof Maria Rosaria Conte

  18. Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

    Article • Nucleic Acids Research, December 2021, Oxford University Press (OUP)

    Prof Maria Rosaria Conte, Dr. Santosh Panjikar

  19. A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

    Article • Redox Biology, October 2021, Elsevier

    Prof Maria Rosaria Conte

  20. LARP6C orchestrates posttranscriptional reprogramming of gene expression during hydration to promote pollen tube guidance

    Article • The Plant Cell, May 2021, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  21. Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein–Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α–TAB1 Complexes

    Article • Journal of Medicinal Chemistry, July 2020, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  22. Structural dynamics in the La-module of La-related proteins

    Article • RNA Biology, March 2020, Taylor & Francis

    Prof Maria Rosaria Conte

  23. Maternal Larp6 controls oocyte development, chorion formation and elevation

    Article • Development, February 2020, The Company of Biologists

    Prof Maria Rosaria Conte

  24. The La-related proteins: Structures and interactions of a versatile superfamily of RNA binding proteins

    Article • RNA Biology, November 2019, Taylor & Francis

    Prof Maria Rosaria Conte

  25. Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase

    Article • Analytical Chemistry, November 2019, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  26. PDXK mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation

    Article • Annals of Neurology, July 2019, Wiley

    Prof Maria Rosaria Conte, Professor Kyproula Christodoulou, Nourelhoda Haridy

  27. 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

    Article • Communications Biology, May 2019, Springer Science + Business Media

    Prof Maria Rosaria Conte

  28. The new molecular mechanisms of LARP4A

    Article • Nucleic Acids Research, March 2019, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  29. Resonance assignment of human LARP4A La module

    Article • Biomolecular NMR Assignments, January 2019, Springer Science + Business Media

    Prof Maria Rosaria Conte

  30. Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain

    Article • Protein Expression and Purification, January 2019, Elsevier

    Prof Maria Rosaria Conte

  31. TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185

    Article • Molecular and Cellular Biology, December 2017, ASM Journals

    michael marber, Gian De Nicola, Prof Maria Rosaria Conte

  32. Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins

    Article • PLOS One, October 2017, PLOS

    Prof Maria Rosaria Conte

  33. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

    Article • Wiley Interdisciplinary Reviews - RNA, August 2017, Wiley

    Prof Maria Rosaria Conte

  34. Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

    Article • Nature Communications, October 2016, Springer Science + Business Media

    Prof Maria Rosaria Conte

  35. The RNA-binding protein LARP4 regulates cancer cell migration and invasion

    Article • Cytoskeleton, September 2016, Wiley

    Prof Maria Rosaria Conte

  36. A crystallographic study of human NONO (p54nrb): overcoming pathological problems with purification, data collection and noncrystallographic symmetry

    Article • Acta Crystallographica Section D Structural Biology, May 2016, International Union of Crystallography

    Gavin Knott, Prof Maria Rosaria Conte, Dr. Santosh Panjikar

  37. 1H, 15N and 13C chemical shift assignments of the La motif and RRM1 from human LARP6

    Article • Biomolecular NMR Assignments, April 2015, Springer Science + Business Media

    Prof Maria Rosaria Conte

  38. Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module

    Article • Nucleic Acids Research, December 2014, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  39. Solution Structure of the SGTA Dimerisation Domain and Investigation of Its Interactions with the Ubiquitin-Like Domains of BAG6 and UBL4A

    Article • PLOS One, November 2014, PLOS

    Prof Maria Rosaria Conte

  40. Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

    Article • Nature Structural & Molecular Biology, September 2013, Nature

    Dr Pierre Sicard, Prof Maria Rosaria Conte

  41. The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins

    Article • RNA, November 2012, Cold Spring Harbor Laboratory Press

    Prof Maria Rosaria Conte

  42. RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Maria Rosaria Conte

  43. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein

    Article • Nucleic Acids Research, October 2011, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  44. A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies

    Article • Biochimie, August 2011, Elsevier

    Prof Maria Rosaria Conte

  45. Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7 

    Article • Journal of Virology, May 2011, ASM Journals

    Prof Maria Rosaria Conte

  46. La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability

    Article • Molecular and Cellular Biology, November 2010, ASM Journals

    Prof Maria Rosaria Conte

  47. Resonance assignment of nsp7α from arterivirus

    Article • Biomolecular NMR Assignments, August 2010, Springer Science + Business Media

    Prof Maria Rosaria Conte

  48. Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA

    Article • Nucleic Acids Research, March 2010, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  49. Letter to the Editor: Resonance assignment of SlyD from E. coli

    Article • Biomolecular NMR Assignments, September 2009, Springer Science + Business Media

    Prof Maria Rosaria Conte

  50. Getting to the end of RNA: Structural analysis of protein recognition of 5′ and 3′ termini

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, September 2009, Elsevier

    Prof Maria Rosaria Conte

  51. The interaction of theEscherichia coliprotein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity

    Article • European Journal of Biochemistry, August 2009, Wiley

    Prof Maria Rosaria Conte

  52. NMR assignment of the N-terminal region of human La free and in complex with RNA

    Article • Biomolecular NMR Assignments, June 2008, Springer Science + Business Media

    Prof Maria Rosaria Conte

  53. Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

    Article • Structure, June 2008, Elsevier

    Prof Maria Rosaria Conte

  54. A terminal affair: 3′-end recognition by the human La protein

    Article • Trends in Biochemical Sciences, June 2006, Elsevier

    Prof Maria Rosaria Conte

  55. Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5)

    Article • Journal of Biomolecular NMR, June 2006, Springer Science + Business Media

    Prof Maria Rosaria Conte

  56. Structure of the Eukaryotic Initiation Factor (eIF) 5 Reveals a Fold Common to Several Translation Factors†,‡

    Article • Biochemistry, April 2006, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  57. Structure and RNA Interactions of the N-Terminal RRM Domains of PTB

    Article • Structure, September 2004, Elsevier

    Professor Stephen Curry, Prof Maria Rosaria Conte

  58. Letter to the Editor: Resonance Assignment and Secondary Structure of the La Motif

    Article • Journal of Biomolecular NMR, July 2004, Springer Science + Business Media

    Prof Maria Rosaria Conte

  59. Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

    Article • Nature Structural & Molecular Biology, March 2004, Springer Science + Business Media

    Prof Maria Rosaria Conte

  60. Letter to the Editor: Resonance assignment and secondary structure of an N-terminal fragment of the human La protein

    Article • Journal of Biomolecular NMR, September 2003, Springer Science + Business Media

    Prof Maria Rosaria Conte

  61. Structure of the C-Terminal Domain of Human La Protein Reveals a Novel RNA Recognition Motif Coupled to a Helical Nuclear Retention Element

    Article • Structure, July 2003, Elsevier

    Prof Maria Rosaria Conte

  62. Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein

    Article • Nucleic Acids Research, January 2002, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  63. Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold

    Article • The EMBO Journal, June 2000, Springer Science + Business Media

    Prof Maria Rosaria Conte

  64. Letter to the Editor: Resonance assignment and topology of a 22 kDa C-terminal fragment of the polypyrimidine tract binding protein (PTB) containing two RNA binding domains

    Article • Journal of Biomolecular NMR, August 1999, Springer Science + Business Media

    Prof Maria Rosaria Conte

  65. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR

    Article • Nucleic Acids Research, October 1996, Oxford University Press (OUP)

    Dr Graeme L Conn, Prof Maria Rosaria Conte

  66. Stereostructures of new bioactive sesterterpenes isolated from the Caribbean sponge Cacospongia cf. linteiformis

    Article • Tetrahedron, September 1995, Elsevier

    Prof Maria Rosaria Conte

  67. Interaction of Minor-Groove-Binding Diamidine Ligands with an Asymmetric DNA Duplex. NMR and Molecular Modelling Studies

    Article • European Journal of Biochemistry, April 1995, Wiley

    Prof Maria Rosaria Conte

  68. Synthesis of Two Distamycin Analogs and Their Binding Mode to d(CGCAAATTTGCG)2 in the 2:1 Solution Complexes as Determined by Two-Dimensional 1H-NMR

    Article • Journal of Medicinal Chemistry, March 1995, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  69. Lintenolides, new pentacyclic bioactive sesterterpenes from the caribbean sponge Cacospongia cf. linteiformis

    Article • Tetrahedron, January 1994, Elsevier

    Prof Maria Rosaria Conte

  70. Automated Synthesis of Cyclic Oligodeoxyribonucleotides via Phosphoramidite Method

    Article • Nucleosides and Nucleotides, March 1993, Taylor & Francis

    Prof Maria Rosaria Conte

  71. 1H-NMR studies of the interactions of two distamycin analogues with the dodecamer d(CGCGAATTCGCG)2.

    Article • Bioorganic & Medicinal Chemistry Letters, October 1992, Elsevier

    Prof Maria Rosaria Conte

  72. Solid phase synthesis of 5-hydroxymethyluracil containing DNA

    Article • Bioorganic & Medicinal Chemistry Letters, January 1992, Elsevier

    Prof Maria Rosaria Conte