All Stories

  1. Profiling of Alzheimer’s disease related genes in mild to moderate vitamin D hypovitaminosis

    Article • The Journal of Nutritional Biochemistry, May 2019, Elsevier

    Dr. Marcus Grimm, Daniel Janitschke

  2. Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer’s disease

    Article • Cellular and Molecular Life Sciences, January 2019, Springer Science + Business Media

    Dr. Marcus Grimm

  3. Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model

    Article • Neurobiology of Aging, December 2018, Elsevier

    Dr. Marcus Grimm

  4. Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

    Article • International Journal of Molecular Sciences, December 2017, MDPI AG

    Dr. Marcus Grimm, Daniel Janitschke

  5. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

    Article • The Lancet Neurology, December 2017, Elsevier

    Dr. Marcus Grimm

  6. Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

    Article • Journal of Lipid Research, May 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  7. APP Function and Lipids: A Bidirectional Link

    Article • Frontiers in Molecular Neuroscience, March 2017, Frontiers

    Dr. Marcus Grimm

  8. Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

    Article • Journal of Alzheimer s Disease, January 2017, IOS Press

    Dr. Marcus Grimm

  9. Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease

    Article • International Journal of Molecular Sciences, October 2016, MDPI AG

    Dr. Marcus Grimm

  10. Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

    Article • PLoS ONE, October 2016, PLOS

    Dr. Marcus Grimm

  11. The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease

    Article • International Journal of Molecular Sciences, October 2016, MDPI AG

    Dr. Marcus Grimm

  12. Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing

    Article • Current Alzheimer Research, October 2016, Bentham Science Publishers

    Dr. Marcus Grimm

  13. Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice

    Article • BMC Neuroscience, July 2016, Springer Science + Business Media

    Dr. Marcus Grimm

  14. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increase Aβ-degradation by affecting insulin-degrading enzyme (IDE)

    Article • Biochemistry and Cell Biology, April 2016, Canadian Science Publishing

    Dr. Marcus Grimm

  15. The Effects of Glycerophospholipids and Fatty Acids on APP Processing

    Article • January 2016, Elsevier

    Dr. Marcus Grimm

  16. Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

    Article • Neurodegenerative Diseases, December 2015, Karger Publishers

    Dr. Marcus Grimm

  17. Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model

    Article • Annals of Neurology, May 2015, Wiley

    Dr. Marcus Grimm

  18. APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

    Article • Frontiers in Aging Neuroscience, May 2015, Frontiers

    Dr. Marcus Grimm

  19. Vitamin E: Curse or benefit in Alzheimer’s disease? A systematic investigation of the impact of α-, γ- and δ-tocopherol on Aβ generation and degradation in neuroblastoma cells

    Article • The journal of nutrition health & aging, March 2015, Springer Science + Business Media

    Dr. Marcus Grimm

  20. Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

    Article • Journal of Biological Chemistry, May 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  21. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

    Article • The Journal of Nutritional Biochemistry, February 2014, Elsevier

    Dr. Marcus Grimm

  22. PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

    Article • Cellular Physiology and Biochemistry, January 2014, Karger Publishers

    Dr. Marcus Grimm

  23. Upregulation of PGC ‐1α expression by A lzheimer's disease‐associated pathway: presenilin 1/amyloid precursor protein ( APP )/intracellular domain of APP

    Article • Aging Cell, December 2013, Wiley

    Dr. Marcus Grimm

  24. Impact of Vitamin D on Amyloid Precursor Protein Processing and Amyloid-β Peptide Degradation in Alzheimer's Disease

    Article • Neurodegenerative Diseases, October 2013, Karger Publishers

    Dr. Marcus Grimm

  25. Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease

    Article • The FASEB Journal, October 2013, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Marcus Grimm

  26. Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

    Article • Journal of Neuroscience, October 2013, Society for Neuroscience

    Dr. Marcus Grimm

  27. Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

    Article • International Journal of Molecular Sciences, March 2013, MDPI AG

    Dr. Marcus Grimm

  28. The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Dr. Marcus Grimm

  29. Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

    Article • Frontiers in Aging Neuroscience, January 2013, Frontiers

    Dr. Marcus Grimm

  30. Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP)

    Article • The Journal of Nutritional Biochemistry, October 2012, Elsevier

    Dr. Marcus Grimm

  31. Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

    Article • PLoS ONE, March 2012, PLOS

    Dr. Marcus Grimm

  32. Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

    Article • Journal of Lipid Research, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  33. Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease

    Article • The Scientific World JOURNAL, January 2012, Hindawi Publishing Corporation

    Dr. Marcus Grimm

  34. The role of APP proteolytic processing in lipid metabolism

    Article • Experimental Brain Research, December 2011, Springer Science + Business Media

    Dr. Marcus Grimm

  35. From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

    Article • Journal of Chromatography A, October 2011, Elsevier

    Dr. Marcus Grimm

  36. Docosahexaenoic Acid Reduces Amyloid   Production via Multiple Pleiotropic Mechanisms

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  37. Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

    Article • Journal of Neurochemistry, January 2011, Wiley

    Dr. Marcus Grimm

  38. Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease

    Article • International Journal of Alzheimer s Disease, January 2011, Hindawi Publishing Corporation

    Dr. Marcus Grimm

  39. Recent Understanding of the Molecular Mechanisms of Alzheimer?s Disease

    Article • Journal of Addiction Research & Therapy, January 2011, OMICS Publishing Group

    Dr. Marcus Grimm

  40. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology

    Article • Brain, November 2010, Oxford University Press (OUP)

    Dr. Marcus Grimm

  41. Role of amyloid beta in lipid homeostasis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, August 2010, Elsevier

    Dr. Marcus Grimm

  42. Amyloid beta influences myenteric plexus and enteric neural stem cells in vitro

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr. Marcus Grimm

  43. B-vitamin supplementation is necessary for the brain gamma-secretase activity reducing effects of docosahexaenoic acid and uridine monophosphate

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Dr. Marcus Grimm

  44. Alzheimer's disease amyloid precursor protein and amyloid beta peptides are key regulators of brain lipid composition

    Article • Frontiers in Neuroscience, January 2010, Frontiers

    Dr. Marcus Grimm

  45. Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

    Article • Journal of Biological Chemistry, February 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  46. Alzheimer’s disease: the lipid connection

    Article • Journal of Neurochemistry, November 2007, Wiley

    Dr. Marcus Grimm

  47. Amyloid beta-protein and lipid metabolism

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2007, Elsevier

    Dr. Marcus Grimm

  48. Amyloid beta as a regulator of lipid homeostasis

    Article • Trends in Molecular Medicine, August 2007, Elsevier

    Dr. Marcus Grimm

  49. Alzheimer’s disease prevention – The emerging role of lipids and diet

    Article • Oléagineux Corps gras Lipides, May 2007, EDP Sciences

    Dr. Marcus Grimm

  50. Altered membrane fluidity and lipid raft composition in presenilin-deficient cells

    Article • Acta Neurologica Scandinavica, August 2006, Wiley

    Dr. Marcus Grimm

  51. Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

    Article • Nature, October 2005, Nature

    Dr. Marcus Grimm

  52. Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42

    Article • Neurobiology of Aging, June 2005, Elsevier

    Dr. Marcus Grimm

  53. Linking Alzheimer’s Disease, B-Amyloid, and Lipids

    Article • December 2004, Taylor & Francis

    Dr. Marcus Grimm

  54. P1-238 Amyloid beta 42 is the major factor determining onset age in presenilin-I FAD

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr. Marcus Grimm

  55. P4-254 Dual function of γ-secretase in lipid-homeostasis and Aβ-production

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr. Marcus Grimm

  56. The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Marcus Grimm

  57. Potential external source of Aβ in biological samples

    Article • Nature, July 2002, Nature

    Dr. Marcus Grimm

  58. Optimized Maximum Intensity Projection (MIP)

    Article • January 1995, Springer Science + Business Media

    Dr. Marcus Grimm

  59. Cholesterol and Aβ Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis

    Article • Springer Science + Business Media

    Dr. Marcus Grimm