All Stories

  1. Smart Magnetic Drug Delivery System for Targeted, Intracellular Delivery of Irinotecan and Platinum-Based Antitumoral Drugs

    Article • Materials, February 2026, MDPI AG

    Manuela Calin

  2. Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease

    Article • Journal of Translational Medicine, January 2026, Springer Science + Business Media

    Manuela Calin

  3. Targeting Insulin Resistance in Hepatocytes: A Novel Insulin-Mimetic Agent Delivered via an Advanced Nanocarrier System

    Article • ACS Pharmacology & Translational Science, September 2025, American Chemical Society (ACS)

    Manuela Calin

  4. Nanocarrier-driven dual targeting VCAM-1/Collagen IV enables RNA interference-mediated silencing of Smad3 and Runx2 to mitigate aortic valve disease

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Manuela Calin

  5. Inflammation resolution-based treatment of atherosclerosis using biomimetic nanocarriers loaded with specialized pro-resolving lipid mediators

    Article • Materials Today Bio, June 2025, Elsevier

    Manuela Calin

  6. Nanotherapeutic Strategies to Reduce Vascular Inflammation in Cardiovascular Diseases

    Article • April 2024, Avestia Publishing

    Manuela Calin

  7. Advances in Natural and Bio-Inspired Nanoparticles for the Treatment of Cardiovascular Diseases

    Article • Nanomaterials, November 2023, MDPI AG

    Professor Ille C Gebeshuber, Manuela Calin

  8. Tri-Component Hydrogel as Template for Nanocrystalline Hydroxyapatite Deposition Using Alternate Soaking Method for Bone Tissue Engineering Applications

    Article • Gels, November 2023, MDPI AG

    Manuela Calin

  9. Biomimetic Nanocarriers of Pro‐Resolving Lipid Mediators for Resolution of Inflammation in Atherosclerosis

    Article • Advanced Healthcare Materials, November 2023, Wiley

    Manuela Calin

  10. Nanocarriers of shRNA-Runx2 directed to collagen IV as a nanotherapeutic system to target calcific aortic valve disease

    Article • Materials Today Bio, June 2023, Elsevier

    Manuela Calin

  11. Multilayer gold nanoparticles as non-viral vectors for targeting MCF-7 cancer cells

    Article • Biomaterials Advances, January 2023, Elsevier

    Manuela Calin

  12. Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic–Inorganic Structure with High Medicinal Significance

    Article • Pharmaceutics, December 2022, MDPI AG

    Manuela Calin

  13. Folic acid-decorated PEGylated magnetite nanoparticles as efficient drug carriers to tumor cells overexpressing folic acid receptor

    Article • International Journal of Pharmaceutics, September 2022, Elsevier

    Manuela Calin

  14. Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand

    Article • Biomedicines, May 2022, MDPI AG

    Manuela Calin

  15. Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells

    Article • Pharmaceutics, April 2022, MDPI AG

    Manuela Calin

  16. VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

    Article • International Journal of Molecular Sciences, March 2022, MDPI AG

    Manuela Calin

  17. Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications

    Article • Journal of Polymer Research, October 2021, Springer Science + Business Media

    Manuela Calin

  18. P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation

    Article • Journal of Controlled Release, October 2021, Elsevier

    Manuela Calin

  19. Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy

    Article • Pharmaceutics, September 2021, MDPI AG

    Manuela Calin

  20. A novel platform for drug testing: Biomimetic three-dimensional hyaluronic acid-based scaffold seeded with human hepatocarcinoma cells

    Article • International Journal of Biological Macromolecules, August 2021, Elsevier

    Manuela Calin

  21. Alginate/poloxamer hydrogel obtained by thiol-acrylate photopolymerization for the alleviation of the inflammatory response of human keratinocytes

    Article • International Journal of Biological Macromolecules, June 2021, Elsevier

    Manuela Calin

  22. Synthesis, Characterization, and In Vitro Insulin-Mimetic Activity Evaluation of Valine Schiff Base Coordination Compounds of Oxidovanadium(V)

    Article • Biomedicines, May 2021, MDPI AG

    Manuela Calin

  23. Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High‐Resolution Near‐Infrared Fluorescence Imaging Using VCAM‐1‐Targeted Liposomes Entrapping a Fluorogenic Redox‐Sensitive Probe

    Article • Oxidative Medicine and Cellular Longevity, January 2021, Wiley

    Manuela Calin

  24. A new sponge-type hydrogel based on hyaluronic acid and poly(methylvinylether-alt-maleic acid) as a 3D platform for tumor cell growth

    Article • International Journal of Biological Macromolecules, December 2020, Elsevier

    Manuela Calin

  25. Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation

    Article • Pharmaceutics, November 2020, MDPI AG

    Manuela Calin

  26. Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells

    Article • Pharmaceutics, June 2020, MDPI AG

    Manuela Calin

  27. Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation

    Article • Pharmaceutics, August 2019, MDPI AG

    Manuela Calin

  28. Drug Delivery Platforms for Cardiovascular Applications Based on Alginate-Based Hollow Structures

    Article • August 2019, Avestia Publishing

    Manuela Calin

  29. Smart Alginate-Based Magnetic Platforms for Drug Delivery

    Article • August 2019, Avestia Publishing

    Manuela Calin

  30. The impact of photocatalytic Ag/TiO2 and Ag/N-TiO2 nanoparticles on human keratinocytes and epithelial lung cells

    Article • Toxicology, March 2019, Elsevier

    Manuela Calin

  31. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells

    Article • Pharmaceutics, January 2019, MDPI AG

    Manuela Calin

  32. Squalene/polyethylenimine based non-viral vectors: synthesis and use in systems for sustained gene release

    Article • Polymer Chemistry, January 2018, Royal Society of Chemistry

    Manuela Calin

  33. Monocyte/macrophages inflammation is inhibited by a Gi-protein inhibitor encapsulated in liposomes

    Article • International Journal of Nanomedicine, December 2017, Dove Medical Press

    Ileana Manduteanu, mariana Deleanu, Manuela Calin

  34. Biopolymers/poly(ε-caprolactone)/polyethylenimine functionalized nano-hydroxyapatite hybrid cryogel: Synthesis, characterization and application in gene delivery

    Article • Materials Science and Engineering C, December 2017, Elsevier

    Manuela Calin

  35. Emerging Nanocarriers-based Approaches to Diagnose and Red uce Vascular Inflammation in Atherosclerosis

    Article • Current Medicinal Chemistry, March 2017, Bentham Science Publishers

    Manuela Calin

  36. Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway

    Article • Journal of Materials Chemistry B, January 2017, Royal Society of Chemistry

    Manuela Calin

  37. Amendment of the cytokine profile in macrophages subsequent to their interaction with smooth muscle cells: Differential modulation by fractalkine and resistin

    Article • Cytokine, July 2016, Elsevier

    Manuela Calin

  38. Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2016, Elsevier

    Manuela Calin

  39. Conjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cells

    Article • Journal of Pharmacy and Pharmacology, January 2016, Wiley

    Manuela Calin

  40. P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

    Article • Mediators of Inflammation, January 2016, Hindawi Publishing Corporation

    Manuela Calin

  41. Dynameric Frameworks for DNA Transfection

    Article • ACS Biomaterials Science & Engineering, December 2015, American Chemical Society (ACS)

    Manuela Calin, Dr. Habil. Luminita Marin

  42. Inhibition of chemokine receptor CCR2 reduces sarcoma cell transendothelial migration and metastasis to the lungs

    Article • International Journal of Clinical Pharmacology and Therapeutics, December 2015, Dustri-Verlgag Dr. Karl Feistle

    Manuela Calin

  43. Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis

    Article • Journal of Controlled Release, December 2015, Elsevier

    Manuela Calin

  44. Hybrid fullerene conjugates as vectors for DNA cell-delivery

    Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

    Manuela Calin

  45. Flexible cyclic siloxane core enhances the transfection efficiency of polyethylenimine-based non-viral gene vectors

    Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

    Manuela Calin

  46. VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2015, Elsevier

    Manuela Calin

  47. Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions

    Article • European Journal of Biochemistry, July 2014, Wiley

    Manuela Calin

  48. Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine, MCP-1 and activation of TLR4 and Gi/o proteins signaling

    Article • The International Journal of Biochemistry & Cell Biology, May 2014, Elsevier

    Manuela Calin

  49. Erratum to “Monocytes and smooth muscle cells cross‐talk activates STAT3 and induces resistin and reactive oxygen species production”

    Article • Journal of Cellular Biochemistry, January 2014, Wiley

    Manuela Calin

  50. Heparin-Anthranoid Conjugates Associated with Nanomagnetite Particles and Their Cytotoxic Effect on Cancer Cells

    Article • Journal of Biomedical Nanotechnology, January 2014, American Scientific Publishers

    Manuela Calin

  51. Development of curcumin-loaded poly(hydroxybutyrate-co-hydroxyvalerate) nanoparticles as anti-inflammatory carriers to human-activated endothelial cells

    Article • Journal of Nanoparticle Research, November 2013, Springer Science + Business Media

    Manuela Calin

  52. Monocytes and smooth muscle cells cross-talk activates STAT3 and induces resistin and reactive oxygen species and production

    Article • Journal of Cellular Biochemistry, August 2013, Wiley

    Manuela Calin

  53. Stem Cell Regenerative Potential Combined with Nanotechnology and Tissue Engineering for Myocardial Regeneration

    Article • Current Stem Cell Research & Therapy, May 2013, Bentham Science Publishers

    Manuela Calin

  54. Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways

    Article • Cell and Tissue Research, October 2012, Springer Science + Business Media

    Manuela Calin

  55. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: Up-regulation of SOCS3 expression through STAT3 activation

    Article • Biochemical and Biophysical Research Communications, June 2012, Elsevier

    Manuela Calin

  56. Resistin and High Glucose Concentrations-Activation of Human Smooth Muscle Cells Induces Enhanced Monocyte Chemotaxis

    Article • Romanian Journal of Diabetes Nutrition and Metabolic Diseases, January 2012, De Gruyter

    Manuela Calin

  57. Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2011, Elsevier

    Manuela Calin

  58. Curcumin and a Morus alba Extract Reduce Pro‐Inflammatory Effects of Resistin in Human Endothelial Cells

    Article • Phytotherapy Research, March 2011, Wiley

    Manuela Calin

  59. High glucose induces enhanced expression of resistin in human U937 monocyte-like cell line by MAPK- and NF-kB-dependent mechanisms; the modulating effect of insulin

    Article • Cell and Tissue Research, December 2010, Springer Science + Business Media

    Manuela Calin

  60. Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells

    Article • Biochemical and Biophysical Research Communications, January 2010, Elsevier

    Manuela Calin

  61. Effect of depletion of monocytes/macrophages on early aortic valve lesion in experimental hyperlipidemia

    Article • Cell and Tissue Research, March 2009, Springer Science + Business Media

    Manuela Calin

  62. Resistin up-regulates fractalkine expression in human endothelial cells: Lack of additive effect with TNF-α

    Article • Biochemical and Biophysical Research Communications, March 2009, Elsevier

    Manuela Calin

  63. High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells

    Article • Thrombosis and Haemostasis, November 2008, Schattauer GmbH

    Dr Rory R Koenen, Manuela Calin

  64. Enoxaparin Reduces H<sub>2</sub>O<sub>2</sub>-Induced Activation of Human Endothelial Cells by a Mechanism Involving Cell Adhesion Molecules and Nuclear Transcription Factors

    Article • Pharmacology, January 2007, Karger Publishers

    Manuela Calin

  65. Aspirin and PPAR-α activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells

    Article • Vascular Pharmacology, June 2006, Elsevier

    Manuela Calin

  66. Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery

    Article • Pharmaceutical Research, August 2005, Springer Science + Business Media

    Manuela Calin

  67. Aspirin rectifies calcium homeostasis, decreases reactive oxygen species, and increases NO production in high glucose-exposed human endothelial cells

    Article • Journal of Diabetes and its Complications, September 2004, Elsevier

    Manuela Calin

  68. Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes

    Article • European Journal of Pharmacology, January 2004, Elsevier

    Professor Adriana Georgescu, Manuela Calin

  69. Effect of enoxaparin on high glucose-induced activation of endothelial cells

    Article • European Journal of Pharmacology, September 2003, Elsevier

    Manuela Calin

  70. Designing of ?intelligent? liposomes for efficient delivery of drugs

    Article • Journal of Cellular and Molecular Medicine, October 2002, Wiley

    Manuela Calin

  71. Binding and uptake of transferrin-bound liposomes targeted to transferrin receptors of endothelial cells

    Article • Vascular Pharmacology, July 2002, Elsevier

    Manuela Calin

  72. A Novel Attribute of Enoxaparin: Inhibition of Monocyte Adhesion to Endothelial Cells by a Mechanism Involving Cell Adhesion Molecules

    Article • Pharmacology, January 2002, Karger Publishers

    Manuela Calin

  73. High Glucose Induces Enhanced Monocyte Adhesion to Valvular Endothelial Cells Via a Mechanism Involving ICAM-1, VCAM-1 and CD18

    Article • Endothelium, January 1999, Taylor & Francis

    Manuela Calin