All Stories

  1. Proteomic Characterization of Primary Human Pancreatic Cancer Cell Lines Following Long-Term Exposure to Gemcitabine

    Article • Proteomes, October 2025, MDPI AG

    Dr Manoj Amrutkar

  2. Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer

    Article • Proteomes, May 2025, MDPI AG

    Dr Manoj Amrutkar

  3. Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma

    Article • Scientific Data, February 2025, Springer Science + Business Media

    Dr Manoj Amrutkar

  4. Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2025, Elsevier

    Dr Manoj Amrutkar

  5. Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer

    Article • Molecular Oncology, November 2024, Wiley

    Dr Manoj Amrutkar

  6. Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems

    Article • Seminars in Cancer Biology, November 2024, Elsevier

    Dr Manoj Amrutkar

  7. Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice

    Article • International Journal of Molecular Sciences, February 2024, MDPI AG

    Dr Manoj Amrutkar

  8. Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma

    Article • Molecular Oncology, December 2022, Wiley

    Dr Manoj Amrutkar

  9. Silencing of STE20‐type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet‐induced nonalcoholic fatty liver disease

    Article • The FASEB Journal, April 2021, Wiley

    Dr Manoj Amrutkar

  10. Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence

    Article • Cancers, February 2021, MDPI AG

    Dr Manoj Amrutkar

  11. Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer

    Article • Cancers, February 2021, MDPI AG

    Dr Manoj Amrutkar

  12. Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing

    Article • Cancers, December 2020, MDPI AG

    Dr Manoj Amrutkar

  13. Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor

    Article • Cells, January 2020, MDPI AG

    Dr Manoj Amrutkar

  14. Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

    Article • BMC Cancer, June 2019, Springer Science + Business Media

    Dr Manoj Amrutkar

  15. Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells

    Article • Cells, January 2019, MDPI AG

    Dr Manoj Amrutkar

  16. Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice against Nonalcoholic Fatty Liver Disease

    Article • Cellular and Molecular Gastroenterology and Hepatology, December 2018, Elsevier

    Dr Manoj Amrutkar

  17. In vitro characterization of different primary and immortalized pancreatic stellate cells

    Article • Pancreatology, June 2018, Elsevier

    Dr Manoj Amrutkar

  18. Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic adenocarcinoma

    Article • Pancreatology, June 2018, Elsevier

    Dr Manoj Amrutkar

  19. STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

    Article • Journal of Endocrinology, May 2018, Bioscientifica

    Dr Manoj Amrutkar

  20. Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice

    Article • Hepatology Communications, November 2017, Wiley

    Dr Manoj Amrutkar

  21. Pancreatic Cancer Chemoresistance to Gemcitabine

    Article • Cancers, November 2017, MDPI AG

    Dr Manoj Amrutkar

  22. Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

    Article • Diabetologia, December 2016, Springer Science + Business Media

    Dr Manoj Amrutkar, Dr Maria E Johansson

  23. STK25 is a critical determinant in nonalcoholic steatohepatitis

    Article • The FASEB Journal, July 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Manoj Amrutkar

  24. Protein Kinase STK25 Controls Lipid Partitioning in Human Hepatocytes and Correlates with Liver Fat Content in Man

    Article • Journal of Hepatology, January 2016, Elsevier

    Dr Manoj Amrutkar

  25. Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans

    Article • Diabetologia, November 2015, Springer Science + Business Media

    Dr Manoj Amrutkar

  26. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model

    Article • Diabetes, April 2015, American Diabetes Association

    Dr Manoj Amrutkar

  27. Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

    Article • The FASEB Journal, January 2015, Wiley

    Dr Manoj Amrutkar

  28. Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

    Article • Molecular and Cellular Endocrinology, August 2014, Elsevier

    Dr Manoj Amrutkar

  29. Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

    Article • Molecular and Cellular Endocrinology, August 2013, Elsevier

    Dr Manoj Amrutkar

  30. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high‐fat diet

    Article • The FASEB Journal, May 2013, Wiley

    Dr Manoj Amrutkar