All Stories

  1. Biology and structure of leukocyte β2 integrins and their role in inflammation

    Article • F1000Research, October 2016, Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  2. The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish

    Article • Mechanisms of Development, November 2015, Elsevier

    Dr. M. Amin Arnaout

  3. Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury

    Article • PLoS ONE, June 2015, PLOS

    Dr. M. Amin Arnaout

  4. Collective Epithelial Migration Drives Kidney Repair after Acute Injury

    Article • PLoS ONE, July 2014, PLOS

    Dr. M. Amin Arnaout

  5. AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.

    Article • April 2014, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  6. Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin

    Article • March 2014, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  7. Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin

    Article • March 2014, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  8. Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif

    Article • March 2014, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  9. Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin

    Article • Nature Structural & Molecular Biology, March 2014, Nature

    Dr. M. Amin Arnaout

  10. Stress Hematopoiesis Is Regulated by the Krüppel-Like Transcription Factor ZBP-89

    Article • Stem Cells, February 2014, Wiley

    Dr. M. Amin Arnaout

  11. Abatacept in B7-1–Positive Proteinuric Kidney Disease

    Article • New England Journal of Medicine, December 2013, New England Journal of Medicine (NEJM/MMS)

    Dr. M. Amin Arnaout

  12. EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of Its Ligand-Binding Site Relative to the Plasma Membrane

    Article • PLoS ONE, February 2013, PLOS

    Dr. M. Amin Arnaout

  13. Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers

    Article • Lab on a Chip, January 2013, Royal Society of Chemistry

    Dr. M. Amin Arnaout

  14. Cystic Kidney Diseases

    Article • January 2012, Elsevier

    Dr. M. Amin Arnaout

  15. Crystal Structure of A-domain in complex with antibody

    Article • November 2011, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  16. Crystal Structure of A-domain in complex with antibody

    Article • November 2011, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  17. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, January 2011, Elsevier

    Dr. M. Amin Arnaout

  18. Autosomal Dominant Polycystic Kidney Disease

    Article • September 2010, Wiley

    Dr. M. Amin Arnaout

  19. Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis

    Article • Clinical & Experimental Immunology, March 2010, Wiley

    Dr. M. Amin Arnaout

  20. Integrin beta 2

    Article • AfCS-Nature Molecule Pages, December 2009, Nature

    Dr. M. Amin Arnaout

  21. Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

    Article • The Journal of Cell Biology, August 2009, Rockefeller University Press

    Dr. M. Amin Arnaout

  22. Hereditary Xanthinuria

    Article • December 2008, Karger Publishers

    Dr. M. Amin Arnaout

  23. Structure and mechanics of integrin-based cell adhesion

    Article • Current Opinion in Cell Biology, October 2007, Elsevier

    Dr. M. Amin Arnaout

  24. The  -tail domain ( TD) regulates physiologic ligand binding to integrin CD11b/CD18

    Article • Blood, April 2007, American Society of Hematology

    Dr. M. Amin Arnaout

  25. 151

    Article • American Journal of Kidney Diseases, April 2007, Elsevier

    Dr. M. Amin Arnaout

  26. A case management model to improve hemodialysis outpatient outcomes

    Article • Hemodialysis International, April 2007, Wiley

    Dr. M. Amin Arnaout

  27. A Simple, No-Wash Cell Adhesion-Based High-Throughput Assay for the Discovery of Small-Molecule Regulators of the Integrin CD11b/CD18

    Article • SLAS DISCOVERY, January 2007, SAGE Publications

    Dr. M. Amin Arnaout

  28. Purification, Analysis, and Crystal Structure of Integrins

    Article • January 2007, Elsevier

    Dr. M. Amin Arnaout

  29. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli

    Article • Protein Expression and Purification, September 2006, Elsevier

    Dr. M. Amin Arnaout

  30. Autosomal Dominant Polycystic Kidney Disease

    Article • January 2006, Wiley

    Dr. M. Amin Arnaout

  31. INTEGRIN STRUCTURE, ALLOSTERY, AND BIDIRECTIONAL SIGNALING

    Article • Annual Review of Cell and Developmental Biology, November 2005, Annual Reviews

    Dr. M. Amin Arnaout

  32. Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin

    Article • The Journal of Cell Biology, March 2005, Rockefeller University Press

    Dr. M. Amin Arnaout

  33. A novel adaptation of the integrin PSI domain revealed from its crystal structure

    Article • December 2004, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  34. A Novel Adaptation of the Integrin PSI Domain Revealed from Its Crystal Structure

    Article • Journal of Biological Chemistry, August 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. M. Amin Arnaout

  35. The Structural Basis of Elasticity in Fibrillin-Based Microfibrils

    Article • Structure, May 2004, Elsevier

    Dr. M. Amin Arnaout

  36. The Structural Basis of Elasticity in Fibrillin-Based Microfibrils

    Article • Structure, May 2004, Elsevier

    Dr. M. Amin Arnaout

  37. Integrin structure: new twists and turns in dynamic cell adhesion

    Article • Immunological Reviews, December 2003, Wiley

    Dr. M. Amin Arnaout

  38. Integrins, cations and ligands: making the connection

    Article • Journal of Thrombosis and Haemostasis, July 2003, Wiley

    Dr. M. Amin Arnaout

  39. Integrins, cations and ligands: making the connection

    Article • Journal of Thrombosis and Haemostasis, July 2003, Wiley

    Dr. M. Amin Arnaout

  40. Coming to grips with integrin binding to ligands

    Article • Current Opinion in Cell Biology, October 2002, Elsevier

    Dr. M. Amin Arnaout

  41. Divalent cations and the relationship between αA and βA domains in integrins

    Article • Biochemical Pharmacology, September 2002, Elsevier

    Dr. M. Amin Arnaout

  42. CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+

    Article • August 2002, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  43. AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN

    Article • August 2002, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  44. Integrin structure: new twists and turns in dynamic cell adhesion

    Article • Immunological Reviews, August 2002, Wiley

    Dr. M. Amin Arnaout

  45. Does the Integrin αA Domain Act as a Ligand for its βA Domain?

    Article • Current Biology, May 2002, Elsevier

    Dr. M. Amin Arnaout

  46. CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND

    Article • April 2002, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  47. CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3

    Article • October 2001, Protein Data Bank, Rutgers University

    Dr. M. Amin Arnaout

  48. Polycystin-1 Interacts with Intermediate Filaments

    Article • Journal of Biological Chemistry, October 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. M. Amin Arnaout

  49. Molecular Genetics and Pathogenesis of Autosomal Dominant Polycystic Kidney Disease

    Article • Annual Review of Medicine, February 2001, Annual Reviews

    Dr. M. Amin Arnaout

  50. The vasculopathy of autosomal dominant polycystic kidney disease: Insights from animal models

    Article • Kidney International, December 2000, Elsevier

    Dr. M. Amin Arnaout

  51. Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers

    Article • European Journal of Biochemistry, March 1999, Wiley

    Dr. M. Amin Arnaout

  52. Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn 2+ -complexed Crystal Structures

    Article • The Journal of Cell Biology, December 1998, Rockefeller University Press

    Dr. M. Amin Arnaout

  53. Mechanisms of Leukocyte Extravasation

    Article • January 1998, Springer Science + Business Media

    Dr. M. Amin Arnaout

  54. Emerging paradigms of integrin ligand binding and activation

    Article • Kidney International, May 1997, Elsevier

    Dr. M. Amin Arnaout

  55. Integrin-ligand interactions

    Article • Current Opinion in Hematology, January 1997, Wolters Kluwer Health

    Dr. M. Amin Arnaout

  56. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis

    Article • Kidney International, June 1995, Elsevier

    Dr. M. Amin Arnaout

  57. Molecular Basis for Leukocyte Adhesion Molecule Deficiency

    Article • January 1993, Springer Science + Business Media

    Dr. M. Amin Arnaout

  58. Function of a Soluble Human β2 Integrin CD11b/CD18

    Article • January 1993, Springer Science + Business Media

    Dr. M. Amin Arnaout

  59. Cell Adhesion Molecules in Inflammation and Thrombosis: Status and Prospects

    Article • American Journal of Kidney Diseases, January 1993, Elsevier

    Dr. M. Amin Arnaout

  60. Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as sjögren's syndrome

    Article • Arthritis & Rheumatism, November 1992, Wiley

    Dr. M. Amin Arnaout

  61. On the Regulation of β2 Integrins

    Article • January 1992, Springer Science + Business Media

    Dr. M. Amin Arnaout

  62. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression.

    Article • Proceedings of the National Academy of Sciences, December 1991, Proceedings of the National Academy of Sciences

    Dr. M. Amin Arnaout

  63. Leukocyte adhesion molecule deficiency

    Article • Current Opinion in Pediatrics, October 1990, Wolters Kluwer Health

    Dr. M. Amin Arnaout

  64. Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response

    Article • Immunological Reviews, April 1990, Wiley

    Dr. M. Amin Arnaout

  65. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact

    Article • Journal of Clinical Immunology, March 1989, Springer Science + Business Media

    Dr. M. Amin Arnaout

  66. Relative contribution of the leukocyte molecules MO1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific

    Article • Journal of Cellular Physiology, November 1988, Wiley

    Dr. M. Amin Arnaout

  67. Human complement receptor type 3

    Article • January 1987, Elsevier

    Dr. M. Amin Arnaout

  68. LFA-1 β-chain synthesis and degradation in patients with leukocyte-adhesive proteins deficiency

    Article • European Journal of Immunology, January 1987, Wiley

    Dr. M. Amin Arnaout

  69. Monoclonal Antibodies That Identify Mo1 and LFA-1, Two Human Leukocyte Membrane Glycoproteins: A Review

    Article • January 1986, Springer Science + Business Media

    Dr. M. Amin Arnaout

  70. Mo1 Surface Glycoprotein: Structure, Function and Clinical Importance

    Article • Pathology and Immunopathology Research, January 1986, Karger Publishers

    Dr. M. Amin Arnaout

  71. Increased Expression of an Adhesion-Promoting Surface Glycoprotein in the Granulocytopenia of Hemodialysis

    Article • New England Journal of Medicine, February 1985, New England Journal of Medicine (NEJM/MMS)

    Dr. M. Amin Arnaout

  72. pl50/95, Third member of the LFA-1/CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody

    Article • European Journal of Immunology, January 1985, Wiley

    Dr. M. Amin Arnaout

  73. Complement C3 receptors: Structure and function

    Article • Molecular Immunology, December 1984, Elsevier

    Dr. M. Amin Arnaout

  74. Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules

    Article • European Journal of Immunology, January 1983, Wiley

    Dr. M. Amin Arnaout

  75. Release of C3c from bound C3bi by C3b inactivator

    Article • Molecular Immunology, November 1982, Elsevier

    Dr. M. Amin Arnaout

  76. Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

    Article • New England Journal of Medicine, March 1982, New England Journal of Medicine (NEJM/MMS)

    Dr. M. Amin Arnaout

  77. Solubilization of C3 fragments deposited on cross-linked dextran gel beads

    Article • Clinical Immunology and Immunopathology, November 1979, Elsevier

    Dr. M. Amin Arnaout

  78. 679 KINETIC ANALYSIS OF SOLID PHASE C3 FRAGMENTS DEPOSITED ON CROSS-LINKED DEXTRAN GEL BEADS

    Article • Pediatric Research, April 1978, Nature

    Dr. M. Amin Arnaout

  79. Transfer of C3 Nephritic Factor from Mother to Fetus

    Article • New England Journal of Medicine, July 1977, New England Journal of Medicine (NEJM/MMS)

    Dr. M. Amin Arnaout

  80. PHENYTOIN IN BENIGN INSULINOMA

    Article • The Lancet, April 1976, Elsevier

    Dr. M. Amin Arnaout

  81. Functional Analysis of the β2 Integrins

    Article • Springer Science + Business Media

    Dr. M. Amin Arnaout

  82. Faculty of 1000 evaluation for The architecture of Tetrahymena telomerase holoenzyme.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  83. Faculty of 1000 evaluation for Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  84. Faculty of 1000 evaluation for Structural mechanism of integrin inactivation by filamin.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  85. Faculty of 1000 evaluation for An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  86. Faculty of 1000 evaluation for Rap1 and its effector RIAM are required for lymphocyte trafficking.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  87. Faculty of 1000 evaluation for High-resolution protein structure determination by serial femtosecond crystallography.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  88. Faculty of 1000 evaluation for Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  89. Faculty of 1000 evaluation for A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  90. Faculty of 1000 evaluation for Improved molecular replacement by density- and energy-guided protein structure optimization.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  91. Faculty of 1000 evaluation for Single mimivirus particles intercepted and imaged with an X-ray laser.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  92. Faculty of 1000 evaluation for The roles of integrins in function of human neutrophils after their migration through endothelium into interstitial matrix.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  93. Faculty of 1000 evaluation for T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  94. Faculty of 1000 evaluation for Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  95. Faculty of 1000 evaluation for CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  96. Faculty of 1000 evaluation for Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  97. Faculty of 1000 evaluation for Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  98. Faculty of 1000 evaluation for The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  99. Faculty of 1000 evaluation for Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  100. Faculty of 1000 evaluation for Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  101. Faculty of 1000 evaluation for Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout

  102. Faculty of 1000 evaluation for Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

    Article • Faculty of 1000, Ltd.

    Dr. M. Amin Arnaout