All Stories

  1. Cell permeable affinity- and activity-based probes

    Article • Future Medicinal Chemistry, October 2015, Future Science

    Dr Lyn H Jones

  2. Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

    Article • ACS Chemical Biology, April 2015, American Chemical Society (ACS)

    Dr Lyn H Jones

  3. Sulfonyl fluorides as privileged warheads in chemical biology

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Dr Lyn H Jones

  4. TAK1 selective inhibition: state of the art and future opportunities

    Article • Future Medicinal Chemistry, January 2015, Future Science

    Dr Lyn H Jones

  5. Chemical biology & drug discovery

    Article • European Journal of Medicinal Chemistry, December 2014, Elsevier

    Dr Lyn H Jones

  6. Biotherapeutics: Recent Developments using Chemical and Molecular Biology. Edited by Lyn H. Jones, Andrew J. McKnight

    Article • ChemMedChem, September 2014, Wiley

    Dr Lyn H Jones

  7. Rare diseases

    Article • Future Medicinal Chemistry, June 2014, Future Science

    Dr Lyn H Jones

  8. Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

    Article • Journal of the American Chemical Society, February 2014, American Chemical Society (ACS)

    Dr Lyn H Jones

  9. Target validation using in-cell small molecule clickable imaging probes

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Lyn H Jones

  10. Understanding and applying tyrosine biochemical diversity

    Article • Molecular BioSystems, January 2014, Royal Society of Chemistry

    Dr Lyn H Jones

  11. Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr Lyn H Jones

  12. TAK1 Inhibition in the DFG-Out Conformation

    Article • Chemical Biology & Drug Design, October 2013, Wiley

    Dr Lyn H Jones

  13. Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

    Article • PLoS ONE, October 2013, PLOS

    Dr Lyn H Jones

  14. A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

    Article • Tetrahedron Letters, July 2013, Elsevier

    Dr Lyn H Jones

  15. Target validation using chemical probes

    Article • Nature Chemical Biology, March 2013, Springer Science + Business Media

    Dr Lyn H Jones

  16. Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

    Article • Chemistry & Biology, February 2013, Elsevier

    Dr Lyn H Jones

  17. Biotherapeutics

    Article • January 2013, Royal Society of Chemistry

    Dr Lyn H Jones

  18. Chemical motifs that redox cycle and their associated toxicity

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Dr Lyn H Jones

  19. Chemistry and Biology of Biomolecule Nitration

    Article • Chemistry & Biology, September 2012, Elsevier

    Dr Lyn H Jones

  20. ChemInform Abstract: Molecular Scaffolds Using Multiple Orthogonal Conjugations: Applications in Chemical Biology and Drug Discovery

    Article • ChemInform, August 2012, Wiley

    Dr Lyn H Jones

  21. Mehrfache orthogonale Konjugationen mit Molekülgerüsten: Anwendung in der chemischen Biologie und Wirkstoff-Forschung

    Article • Angewandte Chemie, April 2012, Wiley

    Dr Lyn H Jones

  22. Molecular Scaffolds Using Multiple Orthogonal Conjugations: Applications in Chemical Biology and Drug Discovery

    Article • Angewandte Chemie International Edition, April 2012, Wiley

    Dr Lyn H Jones

  23. Welcome to Pharmaceutical Patent Analyst

    Article • Pharmaceutical Patent Analyst, March 2012, Future Science

    Dr Lyn H Jones

  24. Quantitative affinity-based chemical proteomics of TrkA inhibitors

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Lyn H Jones

  25. Click-enabled heterotrifunctional template for sequential bioconjugations

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Mr Cris Lapthorn, Dr Lyn H Jones

  26. Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

    Article • Molecular Therapy, December 2011, Elsevier

    Mr Cris Lapthorn, Dr Lyn H Jones

  27. Efficient Conversion of a Nonselective Norepinephrin Reuptake Inhibitor into a Dual Muscarinic Antagonist−β 2 -Agonist for the Treatment of Chronic Obstructive Pulmonary Disease

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Dr Lyn H Jones

  28. Inhalation by design

    Article • Future Medicinal Chemistry, October 2011, Future Science

    Dr Lyn H Jones

  29. Dual-pharmacology muscarinic antagonist and β2agonist molecules for the treatment of chronic obstructive pulmonary disease

    Article • Future Medicinal Chemistry, October 2011, Future Science

    Dr Lyn H Jones

  30. ChemInform Abstract: Squaramides: Physical Properties, Synthesis and Applications

    Article • ChemInform, September 2011, Wiley

    Dr Lyn H Jones

  31. Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD

    Article • Bioorganic & Medicinal Chemistry Letters, May 2011, Elsevier

    Dr Lyn H Jones

  32. ChemInform Abstract: Aromatic Chloride to Nitrile Transformation: Medicinal and Synthetic Chemistry

    Article • ChemInform, April 2011, Wiley

    Dr Lyn H Jones

  33. Comparison of the Non-Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers

    Article • Chemical Biology & Drug Design, March 2011, Wiley

    Dr Lyn H Jones

  34. Squaramides: physical properties, synthesis and applications

    Article • Chemical Society Reviews, January 2011, Royal Society of Chemistry

    Dr Lyn H Jones

  35. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Lyn H Jones

  36. In-cell click labelling of small molecules to determine subcellular localisation

    Article • Journal of Chemical Biology, November 2010, Springer Science + Business Media

    Dr Lyn H Jones

  37. Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

    Article • MedChemComm, January 2010, Royal Society of Chemistry

    Dr Lyn H Jones

  38. Chapter 6. Chemologics

    Article • January 2010, Royal Society of Chemistry

    Dr Lyn H Jones

  39. Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors

    Article • ChemMedChem, October 2009, Wiley

    Dr Lyn H Jones

  40. Pyrazole NNRTIs 3: Optimisation of physicochemical properties

    Article • Bioorganic & Medicinal Chemistry Letters, October 2009, Elsevier

    Dr Lyn H Jones

  41. ChemInform Abstract: Relaying Stereochemistry Through Aromatic Ureas: 1,9 and 1,15 Remote Stereocontrol.

    Article • ChemInform, June 2009, Wiley

    Dr Lyn H Jones

  42. Physicochemical drug properties associated within vivotoxicological outcomes: a review

    Article • Expert Opinion on Drug Metabolism & Toxicology, June 2009, Informa Healthcare

    Dr Lyn H Jones

  43. Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays †

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Dr Lyn H Jones

  44. Relaying stereochemistry through aromatic ureas: 1,9 and 1,15 remote stereocontrol

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Dr Lyn H Jones

  45. Optimization of 5-Aryloxyimidazole Non-Nucleoside Reverse Transcriptase Inhibitors

    Article • ChemMedChem, November 2008, Wiley

    Dr Lyn H Jones

  46. Helix Persistence and Breakdown in Oligoureas of Metaphenylenediamine: Apparent Diastereotopicity as a Spectroscopic Marker of Helix Length in Solution

    Article • Journal of the American Chemical Society, November 2008, American Chemical Society (ACS)

    Dr Tim J Snape, Dr Lyn H Jones

  47. ChemInform Abstract: Synthetic Chemistry-Led Creation of a Difluorinated Biaryl Ether Non-Nucleoside Reverse Transcriptase Inhibitor.

    Article • ChemInform, March 2008, Wiley

    Dr Lyn H Jones

  48. Conformation and stereodynamics of 2,2′-disubstituted N,N′-diaryl ureas

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Dr Lyn H Jones

  49. Design and synthesis of a fluorescent muscarinic antagonist

    Article • Bioorganic & Medicinal Chemistry Letters, January 2008, Elsevier

    Dr Lyn H Jones

  50. Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Dr Lyn H Jones

  51. Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    Dr Lyn H Jones

  52. A Concise Synthesis of Trifluoromethyl-Substituted 4-Aryloxy Pyrazoles

    Article • Synlett, June 2006, Thieme Publishing Group

    Dr Lyn H Jones

  53. A Concise and Selective Synthesis of Novel 5-Aryloxyimidazole NNRTIs

    Article • Organic Letters, April 2006, American Chemical Society (ACS)

    Dr Lyn H Jones

  54. Oxaziridine-Mediated Amination of Primary Amines: Scope and Application to a One-Pot Pyrazole Synthesis.

    Article • ChemInform, July 2005, Wiley

    Dr Lyn H Jones

  55. Oxaziridine-Mediated Amination of Primary Amines: Scope and Application to a One-Pot Pyrazole Synthesis

    Article • Organic Letters, February 2005, American Chemical Society (ACS)

    Dr Lyn H Jones

  56. Active Immunization with a Glycolipid Transition State Analogue Protects against Endotoxic Shock

    Article • Angewandte Chemie International Edition, November 2002, Wiley

    Dr Lyn H Jones

  57. Antibody Catalysis of the Oxidation of Water

    Article • Science, September 2001, American Association for the Advancement of Science

    Dr Lyn H Jones

  58. The Therapeutic Potential for Catalytic Antibodies From a Concept to a Promise

    Article • Mini-Reviews in Medicinal Chemistry, July 2001, Bentham Science Publishers

    Dr Lyn H Jones

  59. Conversion of Enediynes into Quinones by Antibody Catalysis and in Aqueous Buffers:  Implications for an Alternative Enediyne Therapeutic Mechanism

    Article • Journal of the American Chemical Society, April 2001, American Chemical Society (ACS)

    Dr Lyn H Jones

  60. ChemInform Abstract: Total Synthesis of (+)-Zaragozic Acid C.

    Article • ChemInform, February 2001, Wiley

    Dr Lyn H Jones

  61. Total Synthesis of (+)-Zaragozic Acid C

    Article • The Journal of Organic Chemistry, October 2000, American Chemical Society (ACS)

    Dr Lyn H Jones

  62. Antibodies have the intrinsic capacity to destroy antigens

    Article • Proceedings of the National Academy of Sciences, September 2000, Proceedings of the National Academy of Sciences

    Dr Lyn H Jones

  63. Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity

    Article • Bioorganic & Medicinal Chemistry Letters, February 1999, Elsevier

    Dr Lyn H Jones

  64. Total synthesis of (+)-zaragozic acid C

    Article • Tetrahedron Letters, May 1998, Elsevier

    Dr Lyn H Jones