All Stories

  1. Integrative Reverse Genetic Analysis Identifies Polymorphisms Contributing to Decreased Antimicrobial Agent Susceptibility in Streptococcus pyogenes

    Article • mBio, February 2022, ASM Journals

    Dr Luchang Zhu

  2. Functional Insights into the High-Molecular-Mass Penicillin-Binding Proteins of Streptococcus agalactiae Revealed by Gene Deletion and Transposon Mutagenesis Analysis

    Article • Journal of Bacteriology, August 2021, ASM Journals

    Dr Luchang Zhu

  3. Genetic Basis Underlying the Hyperhemolytic Phenotype of Streptococcus agalactiae Strain CNCTC10/84

    Article • Journal of Bacteriology, November 2020, ASM Journals

    Dr Luchang Zhu

  4. Genome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and Plasma

    Article • Infection and Immunity, September 2020, ASM Journals

    Dr Luchang Zhu

  5. Surfactant phospholipids act as molecular switches for premature induction of quorum sensing-dependent virulence in Pseudomonas aeruginosa

    Article • Virulence, August 2020, Taylor & Francis

    Dr Luchang Zhu

  6. Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced <...

    Article • Journal of Clinical Microbiology, August 2020, ASM Journals

    Dr Luchang Zhu

  7. A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis

    Article • American Journal Of Pathology, August 2020, Elsevier

    Dr Luchang Zhu

  8. Streptococcus pyogenes genes that promote pharyngitis in primates

    Article • JCI Insight, June 2020, American Society for Clinical Investigation

    Dr Luchang Zhu

  9. Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence

    Article • American Journal Of Pathology, April 2020, Elsevier

    Dr Luchang Zhu

  10. Genetic heterogeneity of the Spy1336/R28—Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis

    Article • PLOS One, March 2020, PLOS

    James Musser, Dr Luchang Zhu

  11. Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

    Article • Journal of Clinical Microbiology, March 2020, ASM Journals

    Dr Luchang Zhu

  12. New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates

    Article • mBio, February 2020, ASM Journals

    Dr Luchang Zhu

  13. Polymorphisms in Regulator of Cov Contribute to the Molecular Pathogenesis of Serotype M28 Group A Streptococcus

    Article • American Journal Of Pathology, October 2019, Elsevier

    Dr Luchang Zhu

  14. Genetic heterogeneity of the Spy1336/R28 – Spy1337 Virulence Axis inStreptococcus pyogenesand Effect on Gene Transcript Levels and Pathogenesis

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Luchang Zhu

  15. Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections

    Article • American Journal Of Pathology, March 2017, Elsevier

    Dr Luchang Zhu

  16. Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes

    Article • mBio, May 2016, ASM Journals

    Dr Luchang Zhu, James Musser

  17. Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream ofrocAAlters Toxin Production and Enhances Virulence in Streptococcus pyogenes

    Article • Infection and Immunity, May 2016, ASM Journals

    Dr Luchang Zhu, James Musser

  18. Musser et al. Reply to “Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions”

    Article • mBio, December 2015, ASM Journals

    Dr Luchang Zhu, James Musser

  19. Trading Capsule for Increased Cytotoxin Production: Contribution to Virulence of a Newly Emerged Clade of emm89 Streptococcus pyogenes

    Article • mBio, October 2015, ASM Journals

    Dr Luchang Zhu, James Musser

  20. Disentangling competence for genetic transformation and virulence in Streptococcus pneumoniae

    Article • Current Genetics, September 2015, Springer Science + Business Media

    Dr Luchang Zhu

  21. A molecular trigger for intercontinental epidemics of group A Streptococcus

    Article • Journal of Clinical Investigation, August 2015, American Society for Clinical Investigation

    Dr Luchang Zhu

  22. Competence-regulated virulence in pneumococcus

    Article • Molecular Microbiology, April 2015, Wiley

    Dr Gee W Lau, Dr Luchang Zhu

  23. Pneumoccocal DNAase required for virulence

    Article • PLOS One, July 2013, PLOS

    Dr Luchang Zhu

  24. Therapeutic potential of theStreptococcus pneumoniaecompetence regulon

    Article • Expert Review of Anti-infective Therapy, March 2013, Taylor & Francis

    Dr Luchang Zhu

  25. Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

    Article • PLOS One, September 2012, PLOS

    Dr Luchang Zhu

  26. Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by a Modified Competence Stimulating Peptide

    Article • PLoS Pathogens, September 2011, PLOS

    Dr Luchang Zhu