All Stories

  1. Renoprotection by 5-Methoxytryptophan in Kidney Disease

    Article • December 2025, MDPI AG

    Professor Liang-Jun Yan

  2. The Role of Sirt3 in Kidney Health and Disease

    Article • Pharmaceuticals, November 2025, MDPI AG

    Professor Liang-Jun Yan

  3. Beneficial Effects of Butyrate on Kidney Disease

    Article • Nutrients, February 2025, MDPI AG

    Professor Liang-Jun Yan

  4. Mitigating Oxidative Stress and Inflammation: The Protective Role of β-lapachone in Kidney Disease

    Article • January 2025, Springer Science + Business Media

    Professor Liang-Jun Yan

  5. Diabetic Kidney Disease: Contribution of Phenyl Sulfate Derived from Dietary Tyrosine upon Gut Microbiota Catabolism

    Article • Biomolecules, September 2024, MDPI AG

    Professor Liang-Jun Yan

  6. Rodent Models of Streptozotocin-Induced Diabetes as Suitable Paradigms for Studying Diabetic Kidney Disease

    Article • Free Radicals and Antioxidants, September 2024, EManuscript Services

    Professor Liang-Jun Yan

  7. Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease—Volume II

    Article • Biomolecules, August 2024, MDPI AG

    Professor Liang-Jun Yan

  8. Orientin Protects BV-2 Microglial Cells against Hypoxia Reoxygenation Injury through Inhibiting Oxidative Stress

    Article • Free Radicals and Antioxidants, February 2024, EManuscript Services

    Professor Liang-Jun Yan

  9. Editorial: Diabetes and obesity effects on lung function, volume II

    Article • Frontiers in Endocrinology, December 2023, Frontiers

    Professor Liang-Jun Yan

  10. Roles of Dihydrolipoamide Dehydrogenase in Health and Disease

    Article • Antioxidants & Redox Signaling, October 2023, SAGE Publications

    Professor Liang-Jun Yan

  11. Renal-Protective Roles of Lipoic Acid in Kidney Disease

    Article • Nutrients, April 2023, MDPI AG

    Professor Liang-Jun Yan

  12. Long-term intermittent fasting improves neurological function by promoting angiogenesis after cerebral ischemia via growth differentiation factor 11 signaling activation

    Article • PLOS One, March 2023, PLOS

    Professor Liang-Jun Yan

  13. The Role of Ketone Bodies in Various Animal Models of Kidney Disease

    Article • Endocrines, March 2023, MDPI AG

    Professor Liang-Jun Yan

  14. The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

    Article • Biomolecules, September 2022, MDPI AG

    Professor Liang-Jun Yan

  15. Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products

    Article • Biomolecules, August 2022, MDPI AG

    Professor Liang-Jun Yan

  16. Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease

    Article • Biomolecules, March 2022, MDPI AG

    Professor Liang-Jun Yan

  17. Folic acid‐induced animal model of kidney disease

    Article • Animal Models and Experimental Medicine, November 2021, Wiley

    Professor Liang-Jun Yan

  18. Activation of peripheral group III metabotropic glutamate receptors suppressed formalin‐induced nociception

    Article • Clinical and Experimental Pharmacology and Physiology, November 2021, Wiley

    Professor Liang-Jun Yan

  19. Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

    Article • Biomolecules, October 2021, MDPI AG

    Professor Liang-Jun Yan

  20. Comment on Kobroob et al. Effectiveness of N-Acetylcysteine in the Treatment of Renal Deterioration Caused by Long-Term Exposure to Bisphenol A. Biomolecules 2021, 11, 655

    Article • Biomolecules, June 2021, MDPI AG

    Professor Liang-Jun Yan

  21. NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

    Article • Biomolecules, May 2021, MDPI AG

    Professor Liang-Jun Yan

  22. <p>Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes</p>

    Article • Diabetes Metabolic Syndrome and Obesity, June 2020, Taylor & Francis

    Professor Liang-Jun Yan

  23. Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy

    Article • Oxidative Medicine and Cellular Longevity, May 2020, Wiley

    Professor Liang-Jun Yan

  24. Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses

    Article • Frontiers in Cell and Developmental Biology, May 2020, Frontiers

    Professor Liang-Jun Yan

  25. Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity

    Article • Toxicology Letters, April 2020, Elsevier

    Professor Liang-Jun Yan

  26. Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

    Article • Neural Regeneration Research, January 2020, Medknow

    Professor Liang-Jun Yan

  27. Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia

    Article • Neuroscience Letters, January 2020, Elsevier

    Professor Liang-Jun Yan

  28. Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

    Article • Behavioural Brain Research, January 2020, Elsevier

    Professor Liang-Jun Yan

  29. Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke

    Article • Neurochemistry International, December 2019, Elsevier

    Professor Liang-Jun Yan

  30. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

    Article • Oxidative Medicine and Cellular Longevity, November 2019, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  31. Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases

    Article • Brain Research Bulletin, November 2019, Elsevier

    Professor Liang-Jun Yan

  32. Role of pseudohypoxia in the pathogenesis of type 2 diabetes

    Article • Hypoxia, June 2019, Dove Medical Press

    Professor Liang-Jun Yan

  33. The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

    Article • Diabetes Metabolic Syndrome and Obesity, May 2019, Dove Medical Press

    Professor Liang-Jun Yan

  34. Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

    Article • Antioxidants, February 2019, MDPI AG

    Professor Liang-Jun Yan

  35. Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

    Article • International Journal of Molecular Sciences, September 2018, MDPI AG

    Professor Liang-Jun Yan

  36. Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

    Article • Diabetes Metabolic Syndrome and Obesity, May 2018, Dove Medical Press

    Professor Liang-Jun Yan

  37. Mitochondrial protein sulfenation during aging in the rat brain

    Article • Biophysics Reports, April 2018, Springer Science + Business Media

    Professor Liang-Jun Yan

  38. Redox imbalance stress in diabetes mellitus: Role of the polyol pathway

    Article • Animal Models and Experimental Medicine, March 2018, Wiley

    Professor Liang-Jun Yan

  39. Post-ischemic administration of 5-methoxyindole-2-carboxylic acid at the onset of reperfusion affords neuroprotection against stroke injury by preserving mitochondrial function and attenuating oxidative stress

    Article • Biochemical and Biophysical Research Communications, February 2018, Elsevier

    Professor Liang-Jun Yan

  40. Role and Possible Mechanisms of Sirt1 in Depression

    Article • Oxidative Medicine and Cellular Longevity, January 2018, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  41. Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury

    Article • Free Radical Biology and Medicine, December 2017, Elsevier

    Professor Liang-Jun Yan

  42. Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

    Article • Antioxidants & Redox Signaling, October 2017, Mary Ann Liebert Inc

    Professor Liang-Jun Yan

  43. Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

    Article • Biochemistry and Biophysics Reports, September 2017, Elsevier

    Professor Liang-Jun Yan

  44. Redox imbalance and mitochondrial abnormalities in the diabetic lung

    Article • Redox Biology, April 2017, Elsevier

    Professor Liang-Jun Yan

  45. Non‐Gradient Blue Native Polyacrylamide Gel Electrophoresis

    Article • Current Protocols in Protein Science, February 2017, Wiley

    Professor Liang-Jun Yan

  46. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  47. Potential Biochemical Mechanisms of Lung Injury in Diabetes

    Article • Aging and Disease, January 2017, Aging and Disease

    Professor Liang-Jun Yan

  48. Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes

    Article • Free Radical Biology and Medicine, October 2016, Elsevier

    Professor Liang-Jun Yan

  49. Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

    Article • Diabetes Metabolic Syndrome and Obesity, May 2016, Dove Medical Press

    Professor Liang-Jun Yan, Dr Zhen Jin

  50. Two-dimensional gel electrophoretic detection of protein carbonyls derivatized with biotin-hydrazide

    Article • Journal of Chromatography B, April 2016, Elsevier

    Professor Liang-Jun Yan

  51. Comparison of antioxidant and antiproliferative activity between Kunlun Chrysanthemum flowers polysaccharides (KCCP) and fraction PII separated by column chromatography

    Article • Journal of Chromatography B, April 2016, Elsevier

    Professor Liang-Jun Yan

  52. Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target

    Article • International Journal of Molecular Sciences, March 2016, MDPI AG

    Professor Liang-Jun Yan

  53. Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications

    Article • Biochemistry Insights, March 2016, SAGE Publications

    Professor Liang-Jun Yan

  54. Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

    Article • Aging and Disease, January 2016, Aging and Disease

    Professor Liang-Jun Yan

  55. Cerebral small vessel disease and Alzheimer’s disease

    Article • Clinical Interventions in Aging, October 2015, Dove Medical Press

    Dr Zhiyou Cai, Professor Liang-Jun Yan

  56. Role of RAGE in Alzheimer’s Disease

    Article • Cellular and Molecular Neurobiology, July 2015, Springer Science + Business Media

    Professor Liang-Jun Yan

  57. Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

    Article • Diabetes Metabolic Syndrome and Obesity, April 2015, Taylor & Francis

    Professor Liang-Jun Yan

  58. Activation of mTOR: a culprit of Alzheimer’s disease?

    Article • April 2015, Taylor & Francis

    Professor Liang-Jun Yan, Dr Zhiyou Cai

  59. Two dimensional blue native/SDS-PAGE to identify mitochondrial complex I subunits modified by 4-hydroxynonenal (HNE)

    Article • Frontiers in Physiology, March 2015, Frontiers

    Professor Liang-Jun Yan

  60. Antioxidant Activity, Antitumor Effect, and Antiaging Property of Proanthocyanidins Extracted fromKunlun ChrysanthemumFlowers

    Article • Oxidative Medicine and Cellular Longevity, January 2015, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  61. Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance inβCell Function and Dysfunction

    Article • Journal of Diabetes Research, January 2015, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  62. Mitochondrial Dihydrolipoamide Dehydrogenase Is Upregulated in Response to Intermittent Hypoxic Preconditioning

    Article • International Journal of Medical Sciences, January 2015, Ivyspring International Publisher

    Professor Liang-Jun Yan

  63. Role of insulin resistance in Alzheimer’s disease

    Article • Metabolic Brain Disease, November 2014, Springer Science + Business Media

    Professor Liang-Jun Yan

  64. PTEN degradation after ischemic stroke: A double-edged sword

    Article • Neuroscience, August 2014, Elsevier

    Professor Liang-Jun Yan

  65. Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and D-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

    Article • Journal of Biological Chemistry, July 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Liang-Jun Yan

  66. Protein Redox Modification as a Cellular Defense Mechanism against Tissue Ischemic Injury

    Article • Oxidative Medicine and Cellular Longevity, January 2014, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  67. Positive oxidative stress in aging and aging-related disease tolerance

    Article • Redox Biology, January 2014, Elsevier

    Professor Liang-Jun Yan

  68. Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

    Article • Journal of Diabetes Research, January 2014, Hindawi Publishing Corporation

    Professor Liang-Jun Yan

  69. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

    Article • International Journal of Neuroscience, September 2013, Taylor & Francis

    Professor Liang-Jun Yan

  70. Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide

    Article • Free Radical Research, December 2012, Taylor & Francis

    Professor Liang-Jun Yan

  71. Telomere Shortening and Alzheimer’s Disease

    Article • NeuroMolecular Medicine, November 2012, Springer Science + Business Media

    Professor Liang-Jun Yan

  72. Neuroprotective Actions of Methylene Blue and Its Derivatives

    Article • PLOS One, October 2012, PLOS

    Professor Liang-Jun Yan

  73. Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

    Article • NeuroMolecular Medicine, February 2012, Springer Science + Business Media

    Professor Liang-Jun Yan

  74. Ethanol withdrawal acts as an age-specific stressor to activate cerebellar P38 kinase

    Article • Neurobiology of Aging, December 2011, Elsevier

    Professor Liang-Jun Yan

  75. Chemical probes for analysis of carbonylated proteins: A review

    Article • Journal of Chromatography B, May 2011, Elsevier

    Professor Liang-Jun Yan

  76. Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

    Article • Journal of Biological Chemistry, March 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Liang-Jun Yan

  77. Nongradient blue native gel analysis of serum proteins and in-gel detection of serum esterase activities

    Article • Journal of Chromatography B, February 2011, Elsevier

    Professor Liang-Jun Yan

  78. Resolving mitochondrial protein complexes using nongradient blue native polyacrylamide gel electrophoresis

    Article • Analytical Biochemistry, June 2009, Elsevier

    Professor Liang-Jun Yan

  79. Analysis of Oxidative Modification of Proteins

    Article • Current Protocols in Protein Science, April 2009, Wiley

    Professor Liang-Jun Yan

  80. Estrogen Receptor   as a Mitochondrial Vulnerability Factor

    Article • Journal of Biological Chemistry, February 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Liang-Jun Yan

  81. Analysis of Oxidative Modification of Proteins

    Article • Current Protocols in Protein Science, February 2009, Wiley

    Professor Liang-Jun Yan

  82. Changes in dihydrolipoamide dehydrogenase expression and activity during postnatal development and aging in the rat brain

    Article • Mechanisms of Ageing and Development, May 2008, Elsevier

    Professor Liang-Jun Yan

  83. Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner

    Article • Journal of Bioenergetics and Biomembranes, January 2008, Springer Science + Business Media

    Professor Liang-Jun Yan

  84. Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice

    Article • Cell, August 2007, Elsevier

    Professor Liang-Jun Yan

  85. Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE

    Article • Electrophoresis, April 2007, Wiley

    Professor Liang-Jun Yan

  86. Hypoxia-inducible Factor 2  Regulates Expression of the Mitochondrial Aconitase Chaperone Protein Frataxin

    Article • Journal of Biological Chemistry, February 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Liang-Jun Yan

  87. Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells

    Article • Brain Research, February 2007, Elsevier

    Professor Liang-Jun Yan

  88. Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria

    Article • Journal of Mass Spectrometry, January 2007, Wiley

    Professor Liang-Jun Yan

  89. Mouse HSF1 Disruption Perturbs Redox State and Increases Mitochondrial Oxidative Stress in Kidney

    Article • Antioxidants & Redox Signaling, March 2005, Mary Ann Liebert Inc

    Professor Liang-Jun Yan

  90. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice

    Article • Nature Genetics, November 2003, Springer Science + Business Media

    Professor Liang-Jun Yan

  91. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage

    Article • The EMBO Journal, October 2002, Wiley

    Professor Liang-Jun Yan

  92. Analysis of Oxidative Modification of Proteins

    Article • Current Protocols in Cell Biology, April 2002, Wiley

    Professor Liang-Jun Yan

  93. Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury

    Article • Critical Care Medicine, January 2002, Wolters Kluwer Health

    Professor Liang-Jun Yan

  94. Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

    Article • Free Radical Biology and Medicine, December 2000, Elsevier

    Professor Liang-Jun Yan

  95. Effects of aging and hyperoxia on oxidative damage to cytochrome c in the housefly, Musca domestica1

    Article • Free Radical Biology and Medicine, July 2000, Elsevier

    Professor Liang-Jun Yan

  96. Analysis of Oxidative Modification of Proteins

    Article • Current Protocols in Protein Science, June 2000, Wiley

    Professor Liang-Jun Yan

  97. Gel Electrophoretic Quantitation of Protein Carbonyls Derivatized with Tritiated Sodium Borohydride

    Article • Analytical Biochemistry, December 1998, Elsevier

    Professor Liang-Jun Yan

  98. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

    Article • Proceedings of the National Academy of Sciences, October 1998, Proceedings of the National Academy of Sciences

    Professor Liang-Jun Yan

  99. Identification of Oxidized Proteins Based on Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis, Immunochemical Detection, Isoelectric Focusing, and Microsequencing

    Article • Analytical Biochemistry, October 1998, Elsevier

    Professor Liang-Jun Yan

  100. Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure?

    Article • FEBS Letters, February 1998, Wiley

    Professor Liang-Jun Yan

  101. UV-Irradiation Depletes Antioxidants and Causes Oxidative Damage in a Model of Human Skin

    Article • Free Radical Biology and Medicine, January 1998, Elsevier

    Professor Liang-Jun Yan

  102. The Lipoic Acid Analogue 1,2-Diselenolane-3-pentanoic Acid Protects Human Low Density Lipoprotein against Oxidative Modification Mediated by Copper Ion

    Article • Biochemical and Biophysical Research Communications, November 1997, Elsevier

    Professor Liang-Jun Yan

  103. Oxidative damage during aging targets mitochondrial aconitase

    Article • Proceedings of the National Academy of Sciences, October 1997, Proceedings of the National Academy of Sciences

    Professor Liang-Jun Yan

  104. Apolipoprotein B Carbonyl Formation Is Enhanced by Lipid Peroxidation during Copper-Mediated Oxidation of Human Low-Density Lipoproteins

    Article • Archives of Biochemistry and Biophysics, March 1997, Elsevier

    Professor Liang-Jun Yan

  105. Efficacy of Hypochlorous Acid Scavengers in the Prevention of Protein Carbonyl Formation

    Article • Archives of Biochemistry and Biophysics, March 1996, Elsevier

    Professor Liang-Jun Yan

  106. Antioxidant Activity of Diethyldithiocarbamate

    Article • Free Radical Research, January 1996, Taylor & Francis

    Professor Liang-Jun Yan

  107. Spectrophotometric Method for Determination of Carbonyls in Oxidatively Modified Apolipoprotein B of Human Low-Density Lipoproteins

    Article • Analytical Biochemistry, July 1995, Elsevier

    Professor Liang-Jun Yan

  108. Ginkgo Biloba Extract (EGb 761) Protects Human Low-Density Lipoproteins against Oxidative Modification Mediated by Copper

    Article • Biochemical and Biophysical Research Communications, July 1995, Elsevier

    Professor Liang-Jun Yan

  109. Oxidative DNA damage and senescence of human diploid fibroblast cells.

    Article • Proceedings of the National Academy of Sciences, May 1995, Proceedings of the National Academy of Sciences

    Professor Liang-Jun Yan

  110. Elucidation of Antioxidant Activity of α-Lipoic Acid Toward Hydroxyl Radical

    Article • Biochemical and Biophysical Research Communications, March 1995, Elsevier

    Professor Liang-Jun Yan

  111. Induction of Protein Oxidation in Human Low Lipoprotein by the Photosensitive Organic Hydroperoxide, N,N′-bis(2-Hydroxyperoxy-2-Methoxyethyl)-1,4,5,8-Naphthalene-Tetra-Carboxylic-Diimide

    Article • Biochemical and Biophysical Research Communications, January 1995, Elsevier

    Professor Liang-Jun Yan

  112. Effects of oxygen radicals on the conformation of sulfhydryl groups on human polymorphonuclear leukocyte membranes

    Article • Cell Biology International Reports, August 1991, Wiley

    Professor Liang-Jun Yan

  113. Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

    Article • Research on Chemical Intermediates, March 1991, Springer Science + Business Media

    Professor Liang-Jun Yan