All Stories

  1. CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition

    Article • Cell Death and Disease, March 2026, Springer Science + Business Media

    Dr Leyuan Xu

  2. Arginase-1 Expressing Macrophages and Myofibroblasts Interact to Regulate IGF1-Dependent Tubule Repair

    Article • Kidney360, February 2026, Wolters Kluwer Health

    Dr Leyuan Xu

  3. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction

    Article • Nature Communications, December 2025, Springer Science + Business Media

    Dr Leyuan Xu

  4. Engineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury

    Article • Journal of Controlled Release, December 2025, Elsevier

    Dr Leyuan Xu

  5. Adamts1 and Cyst Expansion in Polycystic Kidney Disease

    Article • Journal of the American Society of Nephrology, November 2024, Wolters Kluwer Health

    Dr Leyuan Xu

  6. VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition

    Article • AJP Renal Physiology, October 2024, American Physiological Society

    Dr Leyuan Xu

  7. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

    Article • Science Translational Medicine, December 2023, American Association for the Advancement of Science

    Dr Leyuan Xu

  8. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events

    Article • Kidney International, December 2023, Elsevier

    Dr Leyuan Xu

  9. Longitudinal biomarkers and kidney disease progression after acute kidney injury

    Article • JCI Insight, May 2023, American Society for Clinical Investigation

    Dr Leyuan Xu

  10. Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease Transition

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Leyuan Xu

  11. Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages—Too Many To Be True

    Article • Journal of the American Society of Nephrology, September 2022, American Society of Nephrology

    Dr Leyuan Xu

  12. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

    Article • Nature Communications, August 2022, Springer Science + Business Media

    Dr Leyuan Xu

  13. Uromodulin is a biomarker of kidney fibrosis

    Article • Clinical Journal of the American Society of Nephrology, August 2022, American Society of Nephrology

    Dennis Moledina, Dr Leyuan Xu

  14. Immune-mediated Tubule Atrophy Promotes Acute Kidney Injury to Chronic Kidney Disease Transition

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Dr Leyuan Xu

  15. Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration

    Article • Journal of the American Society of Nephrology, May 2022, American Society of Nephrology

    Dr Leyuan Xu

  16. Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury

    Article • AJP Renal Physiology, March 2022, American Physiological Society

    Dr Leyuan Xu

  17. New treatment for kidney injury caused by cisplatin, a widely used anti-cancer drug

    Article • Journal of the American Society of Nephrology, December 2021, American Society of Nephrology

    Gary Desir, Dr Leyuan Xu

  18. The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair

    Article • Kidney360, November 2021, Wolters Kluwer Health

    Dr Leyuan Xu

  19. Biomarkers of inflammation and repair in kidney disease progression

    Article • Journal of Clinical Investigation, February 2021, American Society for Clinical Investigation

    Dr Leyuan Xu

  20. Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury

    Article • Journal of the American Society of Nephrology, July 2019, American Society of Nephrology

    Dr Leyuan Xu

  21. Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy

    Article • January 2019, Springer Science + Business Media

    Dr Leyuan Xu

  22. Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery

    Article • ACS Biomaterials Science & Engineering, July 2017, American Chemical Society (ACS)

    Dr Leyuan Xu

  23. Breast Regression Protein–39/Chitinase 3–Like 1 Promotes Renal Fibrosis after Kidney InjuryviaActivation of Myofibroblasts

    Article • Journal of the American Society of Nephrology, July 2017, American Society of Nephrology

    Dr Leyuan Xu

  24. Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery

    Article • Acta Biomaterialia, July 2017, Elsevier

    Dr Leyuan Xu

  25. Folate-mediated chemotherapy and diagnostics: An updated review and outlook

    Article • Journal of Controlled Release, April 2017, Elsevier

    Dr Leyuan Xu

  26. The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

    Article • Biomaterials Science, January 2015, Royal Society of Chemistry

    Dr Leyuan Xu

  27. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Dr Leyuan Xu, Hu Yang

  28. Nanopreparations for Central Nervous System Diseases

    Article • September 2014, World Scientific Pub Co Pte Lt

    Dr Leyuan Xu

  29. Semi-Interpenetrating Network (sIPN) Co-Electrospun Gelatin/Insulin Fiber Formulation for Transbuccal Insulin Delivery

    Article • Pharmaceutical Research, July 2014, Springer Science + Business Media

    Dr Leyuan Xu

  30. Click Hybridization of Immune Cells and Polyamidoamine Dendrimers

    Article • Advanced Healthcare Materials, February 2014, Wiley

    Dr Leyuan Xu

  31. Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

    Article • ACS Chemical Neuroscience, January 2014, American Chemical Society (ACS)

    Dr Leyuan Xu

  32. Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4 

    Article • Molecular and Cellular Biology, November 2013, ASM Journals

    Dr Leyuan Xu, Mengxi Jiang

  33. Dendrimer-Based RNA Interference Delivery for Cancer Therapy

    Article • January 2013, American Chemical Society (ACS)

    Dr Leyuan Xu

  34. 5-Cholesten-3β,25-Diol 3-Sulfate Decreases Lipid Accumulation in Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model

    Article • Molecular Pharmacology, December 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Leyuan Xu

  35. Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2012, Elsevier

    Dr Leyuan Xu

  36. Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro

    Article • AJP Gastrointestinal and Liver Physiology, August 2012, American Physiological Society

    Dr Leyuan Xu

  37. Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein–1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease

    Article • Metabolism, June 2012, Elsevier

    Dr Leyuan Xu

  38. 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPAR  signaling in human THP-1 macrophages

    Article • AJP Endocrinology and Metabolism, January 2012, American Physiological Society

    Dr Leyuan Xu

  39. Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

    Article • Atherosclerosis, February 2011, Elsevier

    Dr Leyuan Xu

  40. Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate

    Article • Lipids, August 2010, Wiley

    Dr Leyuan Xu

  41. StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E-deficient Mice

    Article • Lipids, April 2009, Wiley

    Dr Leyuan Xu

  42. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway

    Article • AJP Endocrinology and Metabolism, August 2008, American Physiological Society

    Dr Leyuan Xu