All Stories

  1. Molecular mechanism of menthol-induced TRPV5 channel inhibition

    Article • Nature Communications, March 2026, Springer Science + Business Media

    Leon Islas

  2. Calcium-permeable channel in corals might help in calcification

    Article • PLOS One, October 2025, PLOS

    Leon Islas

  3. Contradicting Markov

    Article • Biophysical Journal, May 2025, Elsevier

    Leon Islas

  4. Protector Role of Cx30.2 in Pancreatic β-Cell against Glucotoxicity-Induced Apoptosis

    Article • Biology, June 2024, MDPI AG

    Leon Islas

  5. Permeant cations modulate pore dynamics and gating of TRPV1 ion channels

    Article • Journal of General Physiology, December 2023, Rockefeller University Press

    Leon Islas

  6. Cation permeability and pore dynamics in TRPV1 ion channels

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Leon Islas

  7. Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid

    Article • eLife, January 2023, eLife

    Leon Islas

  8. TRP channels: a journey towards a molecular understanding of pain

    Article • Nature Reviews Neuroscience, July 2022, Springer Science + Business Media

    Leon Islas

  9. Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Leon Islas

  10. Discovery and characterization of Hv1-type proton channels in reef-building corals

    Article • eLife, August 2021, eLife

    Leon Islas

  11. Discovery and characterization of H v 1-type proton channels in reef-building corals

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Leon Islas

  12. A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids

    Article • Heliyon, October 2020, Elsevier

    Leon Islas

  13. KV1.2 channels inactivate through a mechanism similar to C-type inactivation

    Article • Journal of General Physiology, February 2020, Rockefeller University Press

    Leon Islas

  14. A novel origin for calcium selectivity

    Article • eLife, February 2020, eLife

    Leon Islas

  15. KV1.2 channels inactivate through a mechanism similar to C-type inactivation

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Leon Islas

  16. The contribution of the ankyrin repeat domain of TRPV1 as a thermal module

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Leon Islas

  17. What is new about mild temperature sensing? A review of recent findings

    Article • Temperature, April 2019, Taylor & Francis

    Leon Islas

  18. TRP ion channels: Proteins with conformational flexibility

    Article • Channels, January 2019, Taylor & Francis

    Mr Francisco Torres-Quiroz, Luis B Tovar-y-Romo, Tamara Rosenbaum, Leon Islas

  19. Different agonists induce distinct single-channel conductance states in TRPV1 channels

    Article • Journal of General Physiology, November 2018, Rockefeller University Press

    Leon Islas

  20. Manipulating transient receptor potential vanilloid 1 antagonists: How to cool down a hot molecule?

    Article • Acta Physiologica, June 2018, Wiley

    Leon Islas

  21. Irreversible temperature gating in trpv1 sheds light on channel activation

    Article • eLife, June 2018, eLife

    Leon Islas

  22. The acid test for pH-dependent gating in cloned HV1 channels

    Article • Journal of General Physiology, May 2018, Rockefeller University Press

    Leon Islas

  23. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain

    Article • Proceedings of the National Academy of Sciences, January 2018, Proceedings of the National Academy of Sciences

    Leon Islas

  24. Irreversible temperature gating in trpv1 sheds light on channel activation

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Leon Islas

  25. Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

    Article • Nature Communications, October 2016, Springer Science + Business Media

    Leon Islas

  26. Functional diversity of potassium channel voltage-sensing domains

    Article • Channels, March 2016, Taylor & Francis

    Leon Islas

  27. Currents through Hv1 channels deplete protons in their vicinity

    Article • Journal of General Physiology, January 2016, Rockefeller University Press

    Leon Islas

  28. Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel

    Article • Journal of General Physiology, March 2015, Rockefeller University Press

    Leon Islas

  29. A simple method for fast temperature changes and its application to thermal activation of TRPV1 ion channels

    Article • Journal of Neuroscience Methods, March 2015, Elsevier

    Leon Islas

  30. Membrane pacman: small steps for the voltage‐sensitive phosphatases

    Article • The Journal of Physiology, February 2014, Wiley

    Leon Islas

  31. Thermal Effects and Sensitivity of Biological Membranes

    Article • January 2014, Elsevier

    Leon Islas

  32. Preface

    Article • January 2014, Elsevier

    Leon Islas

  33. The assembly and distribution in vivo of the Escherichia coli RNA degradosome

    Article • Biochimie, November 2013, Elsevier

    Dr. en C. Jaime García-Mena, Leon Islas

  34. Coarse Architecture of the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel Determined by Fluorescence Resonance Energy Transfer

    Article • Journal of Biological Chemistry, October 2013, Elsevier

    Leon Islas

  35. Effects of electrical polarization on the opening rate constant of a voltage-gated ion channel

    Article • Physical Review E, July 2013, American Physical Society (APS)

    Leon Islas

  36. The Role of Allosteric Coupling on Thermal Activation of Thermo-TRP Channels

    Article • Biophysical Journal, May 2013, Elsevier

    Leon Islas

  37. Shab K+channel slow inactivation

    Article • Channels, March 2013, Taylor & Francis

    Leon Islas

  38. The electric heart of hERG

    Article • Journal of General Physiology, March 2013, Rockefeller University Press

    Leon Islas

  39. Erratum: Corrigendum: Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

    Article • Nature Chemical Biology, July 2012, Springer Science + Business Media

    Leon Islas

  40. Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

    Article • Nature Chemical Biology, November 2011, Springer Science + Business Media

    Leon Islas

  41. Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

    Article • Journal of Biological Chemistry, July 2011, Elsevier

    Leon Islas

  42. Uncoupling Charge Movement from Channel Opening in Voltage-gated Potassium Channels by Ruthenium Complexes

    Article • Journal of Biological Chemistry, May 2011, Elsevier

    Leon Islas

  43. Ion Channels in Analgesia Research

    Article • January 2010, Springer Science + Business Media

    Leon Islas

  44. Structural determinants of gating in the TRPV1 channel

    Article • Nature Structural & Molecular Biology, June 2009, Springer Science + Business Media

    Leon Islas

  45. Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums

    Article • Journal of General Physiology, October 2008, Rockefeller University Press

    Leon Islas

  46. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

    Article • Nature Neuroscience, February 2008, Springer Science + Business Media

    Leon Islas

  47. Thrombin increases hyposmotic taurine efflux and accelerates % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX! % MathType!MTEF!2!1!+- % feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX % garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip...

    Article • Pflügers Archiv - European Journal of Physiology, September 2007, Springer Science + Business Media

    Leon Islas

  48. On the Mechanism of TBA Block of the TRPV1 Channel

    Article • Biophysical Journal, June 2007, Elsevier

    Leon Islas

  49. Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels

    Article • Structure, June 2007, Elsevier

    Leon Islas

  50. Short-range Molecular Rearrangements in Ion Channels Detected by Tryptophan Quenching of Bimane Fluorescence

    Article • Journal of General Physiology, August 2006, Rockefeller University Press

    Leon Islas

  51. Single molecule fluorescence studies of surface-adsorbed fibronectin

    Article • Biomaterials, February 2006, Elsevier

    Leon Islas

  52. K+-dependent stability and ion conduction of Shab K+ channels: a comparison with Shaker channels

    Article • Pflügers Archiv - European Journal of Physiology, May 2005, Springer Science + Business Media

    Leon Islas

  53. State-dependent Block of CNG Channels by Dequalinium

    Article • Journal of General Physiology, February 2004, Rockefeller University Press

    Leon Islas

  54. Dequalinium

    Article • Journal of General Physiology, December 2002, Rockefeller University Press

    Leon Islas

  55. Electrostatics and the Gating Pore of Shaker Potassium Channels

    Article • Journal of General Physiology, January 2001, Rockefeller University Press

    Leon Islas

  56. Voltage Sensitivity and Gating Charge in Shaker and Shab Family Potassium Channels

    Article • Journal of General Physiology, October 1999, Rockefeller University Press

    Leon Islas

  57. Characterization of stretch‐activated ion channels in cultured astrocytes

    Article • Glia, June 1993, Wiley

    Leon Islas