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  1. Possible treatment for Gulf War Illness mood and memory disturbances with levetiracetam

    Article • Toxicological Sciences, March 2019, Oxford University Press (OUP)

    Dr. Laxmikant Deshpande

  2. Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis

    Article • Neurobiology of Disease, March 2019, Elsevier

    Dr. Laxmikant Deshpande

  3. Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats

    Article • Frontiers in Neurology, June 2018, Frontiers

    Dr. Laxmikant Deshpande

  4. Altered Calcium Dynamics in a Rat Model of Gulf War Illness

    Article • Military Medicine, March 2018, Oxford University Press (OUP)

    Dr. Laxmikant Deshpande

  5. Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats

    Article • Neurotoxicology and Teratology, July 2016, Elsevier

    Dr. Laxmikant Deshpande

  6. Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication

    Article • Annals of the New York Academy of Sciences, June 2016, Wiley

    Dr. Laxmikant Deshpande

  7. Rat model of Gulf War Illness

    Article • NeuroToxicology, January 2016, Elsevier

    Dr. Laxmikant Deshpande

  8. Cannabinoids: is there a potential treatment role in epilepsy?

    Article • Expert Opinion on Pharmacotherapy, August 2015, Informa Healthcare

    Dr. Laxmikant Deshpande

  9. Endocannabinoids and epilepsy

    Article • January 2015, Elsevier

    Dr. Laxmikant Deshpande

  10. Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity

    Article • NeuroToxicology, September 2014, Elsevier

    Dr. Laxmikant Deshpande

  11. Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication

    Article • NeuroToxicology, September 2014, Elsevier

    Dr. Laxmikant Deshpande

  12. Mechanisms of Levetiracetam in the Control of Status Epilepticus and Epilepsy

    Article • Frontiers in Neurology, January 2014, Frontiers

    Dr. Laxmikant Deshpande

  13. Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons

    Article • European Journal of Pharmacology, January 2013, Elsevier

    Dr. Laxmikant Deshpande

  14. Prolonged cannabinoid exposure alters GABAA receptor mediated synaptic function in cultured hippocampal neurons

    Article • Experimental Neurology, June 2011, Elsevier

    Dr. Laxmikant Deshpande

  15. Characterization of spontaneous recurrent epileptiform discharges in hippocampal–entorhinal cortical slices prepared from chronic epileptic animals

    Article • Seizure, April 2011, Elsevier

    Dr. Laxmikant Deshpande

  16. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons

    Article • Neuroreport, January 2011, Wolters Kluwer Health

    Dr. Laxmikant Deshpande

  17. An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges

    Article • Brain Research, January 2011, Elsevier

    Dr. Laxmikant Deshpande

  18. Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus

    Article • European Journal of Neuroscience, June 2010, Wiley

    Dr. Laxmikant Deshpande

  19. Development of a Prolonged Calcium Plateau in Hippocampal Neurons in Rats Surviving Status Epilepticus Induced by the Organophosphate Diisopropylfluorophosphate

    Article • Toxicological Sciences, May 2010, Oxford University Press (OUP)

    Dr. Laxmikant Deshpande

  20. Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy

    Article • Neuropharmacology, September 2009, Elsevier

    Dr. Laxmikant Deshpande

  21. Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia

    Article • Seizure, July 2009, Elsevier

    Dr. Laxmikant Deshpande

  22. Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis

    Article • Expert Review of Neurotherapeutics, June 2009, Informa Healthcare

    Dr. Laxmikant Deshpande

  23. Age-dependent mortality in the pilocarpine model of status epilepticus

    Article • Neuroscience Letters, April 2009, Elsevier

    Dr. Laxmikant Deshpande

  24. CELL DAMAGE/EXCITOTOXICITY | Basic Mechanisms of Neuronal Injury from Seizures and Status Epilepticus

    Article • January 2009, Elsevier

    Dr. Laxmikant Deshpande

  25. PLASTICITY | The Role of Calcium in Mediating Neuronal Plasticity in Epileptogenesis

    Article • January 2009, Elsevier

    Dr. Laxmikant Deshpande

  26. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons

    Article • Epilepsia, October 2008, Wiley

    Dr. Laxmikant Deshpande

  27. Availability and Characteristics of Betel Products in the U.S.

    Article • Journal of Psychoactive Drugs, September 2008, Taylor & Francis

    Dr. Laxmikant Deshpande

  28. Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury

    Article • Neuroscience Letters, August 2008, Elsevier

    Dr. Laxmikant Deshpande

  29. Levetiracetam Inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture

    Article • Neuroscience Letters, May 2008, Elsevier

    Dr. Laxmikant Deshpande

  30. The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons

    Article • Epilepsy Research, May 2008, Elsevier

    Dr. Laxmikant Deshpande

  31. Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+homeostatic mechanisms in hippocampal neurons surviving brain injury

    Article • European Journal of Neuroscience, April 2008, Wiley

    Dr. Laxmikant Deshpande

  32. Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry

    Article • European Journal of Pharmacology, March 2008, Elsevier

    Dr. Laxmikant Deshpande

  33. In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons

    Article • Epilepsy Research, July 2007, Elsevier

    Dr. Laxmikant Deshpande

  34. Activation of a Novel Injury-Induced Calcium-Permeable Channel That Plays a Key Role in Causing Extended Neuronal Depolarization and Initiating Neuronal Death in Excitotoxic Neuronal Injury

    Article • Journal of Pharmacology and Experimental Therapeutics, May 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Laxmikant Deshpande

  35. Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

    Article • Neuroscience Letters, May 2007, Elsevier

    Dr. Laxmikant Deshpande

  36. Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus

    Article • Experimental Neurology, April 2007, Elsevier

    Dr. Laxmikant Deshpande

  37. Endocannabinoids block status epilepticus in cultured hippocampal neurons

    Article • European Journal of Pharmacology, March 2007, Elsevier

    Dr. Laxmikant Deshpande

  38. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy

    Article • Neuroscience Letters, January 2007, Elsevier

    Dr. Laxmikant Deshpande

  39. Altered Calcium/Calmodulin Kinase II Activity Changes Calcium Homeostasis That Underlies Epileptiform Activity in Hippocampal Neurons in Culture

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Laxmikant Deshpande

  40. Erratum to “Cellular mechanisms underlying acquired epilepsy: The calcium hypothesis of the induction and maintenance of epilepsy” [Pharmacol. Ther. 105(3) (2005) 229–266]

    Article • Pharmacology & Therapeutics, July 2006, Elsevier

    Dr. Laxmikant Deshpande

  41. Erratum to “Cellular mechanisms underlying acquired epilepsy: The calcium hypothesis of the induction and maintenance of epilepsy” [Pharmacol. Ther. 105(3) (2005) 229–266]

    Article • Pharmacology & Therapeutics, July 2006, Elsevier

    Dr. Laxmikant Deshpande

  42. Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus

    Article • Journal of Pharmacology and Experimental Therapeutics, February 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Laxmikant Deshpande

  43. Cellular mechanisms underlying acquired epilepsy: The calcium hypothesis of the induction and maintainance of epilepsy

    Article • Pharmacology & Therapeutics, March 2005, Elsevier

    David A Sun, Dr. Laxmikant Deshpande

  44. Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy

    Article • Proceedings of the National Academy of Sciences, December 2004, Proceedings of the National Academy of Sciences

    Dr. Laxmikant Deshpande

  45. The neurosteroid 3α-hydroxy-5α-pregnan-20-one affects dopamine-mediated behavior in rodents

    Article • Psychopharmacology, May 2002, Springer Science + Business Media

    Dr. Laxmikant Deshpande

  46. Cataleptic effect of neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice: modulation by serotonergic agents

    Article • Brain Research, April 2001, Elsevier

    Dr. Laxmikant Deshpande